Clinical trials: Sedation Complication
Mechanical Ventilation Complication, Severe Acute Respiratory Infection
The REDEEM Pilot Study: A Feasibility RCT of Early ECMO in Severe Acute Respiratory Infection, Including COVID-19, WHO
Patients who are critically ill in intensive care with moderate to severe acute respiratory infection often require mechanical ventilation.
- Conditions
- Mechanical Ventilation Complication, Severe Acute Respiratory Infection, Covid19
- Trial name
- REDEEM (NCT04708457)
- Testing
- VV-ECMO
- Where
- 2 sites in Australia, Germany
- Volunteers
- 6 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Postoperative Pain
Effect of Intravenous Dexmedetomidine on Analgesic Duration of Infraclavicular Block
The study will evaluate the effect of Dexmedetomidine sedation on the duration of infraclavicular block in patients scheduled for surgery of elbow, forearm and/or hand.
- Trial name
- NCT01981369
- Testing
- Dexmedetomidine, Propofol, Infraclavicular block
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Hypoxia, Gastric Cancer
Efficacy and Safety of Remimazolam Tosylate for Sedation in Gastroscopy
Propofol is the most commonly used intravenous anesthetic for painless gastroscopy, but propofol significantly inhibits the respiratory and circulatory systems.
- Conditions
- Hypoxia, Gastric Cancer, Sedation Complication, Propofol Adverse Reaction
- Trial name
- NCT04727034
- Testing
- Remimazolam tosylate, Propofol
- Where
- 5 sites in China
- Volunteers
- 1,800 people
- Sponsor
- RenJi Hospital
COVID-19 Acute Respiratory Distress Syndrome, Sedation Complication
Comparison for the Effect of Neuromuscular Blocking Agents Versus Sedation Alone on Severe ARDS Patients Due to COVID-19
Many questions about management of COVID-19 are still not answered. So, we recruit this study aiming to evaluate improvement of oxygenation in COVID-19 patients with severe ARDS, to improve morbidity and mortality of ICU covid…
- Conditions
- COVID-19 Acute Respiratory Distress Syndrome, Sedation Complication, ICU Acquired Weakness
- Trial name
- NCT04922814
- Testing
- muscle relaxation
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Assiut University
Anxiety, Preoperative Care
A Study of Dexmedetomidine Pharmacokinetics for Preoperative Sedation
Proper preoperative sedation can reduce patients' anxiety, enhance patients' cooperation and reduce perioperative complications.
- Conditions
- Anxiety, Preoperative Care, Pharmacokinetics, Emergence Delirium
- Trial name
- NCT03800641
- Testing
- Dexmedetomidine
- Where
- China
- Volunteers
- 45 people
- Sponsor
- Eye & ENT Hospital of Fudan University
Critical Illness, Mechanical Ventilation Complication
Enteral Versus Intravenous Sedation in Critically Ill High-risk ICU Patients
Recent studies suggest the employment of 'conscious' sedation (1) for critically high - risk patients (2), showing more efficacy then deep sedation (3).
- Trial name
- NCT01360346
- Testing
- Enteral Sedation (EN), Control group: Intravenous Sedation (IV)
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- University of Milan
Pain, Analgesia
EUROpean Pain Audit In Neonates
EUROPAIN Survey is an epidemiological study aimed at assessing current clinical practices regarding the use of sedative and analgesic drugs in newborns admitted to NICUs or PICUs in different countries in Europe.
- Conditions
- Pain, Analgesia, Sedation, Intesive Care
- Trial name
- EUROPAINsurvey (NCT01694745)
- Where
- 242 sites in Austria, Belgium and 16 more
- Volunteers
- 6,489 people
- Sponsor
- Hôpital Armand Trousseau
Cardiac Catheterization, Electrophysiology Procedure
Post Anesthesia Care Unit (PACU) Weighted Blanket Study
This study is being conducted to evaluate the safety and efficacy of weighted blankets to reduce agitation in patients in the post-procedural phase after cardiac catheterization and electrophysiology procedures in the post…
- Conditions
- Cardiac Catheterization, Electrophysiology Procedure, Pediatric Cardiology
- Trial name
- NCT05632640
- Testing
- Standard of Care, Weighted blanket
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- University of Michigan
Sedation Complication
Comparison Between Sevoflurane and Propofol for Maintenance of Sedation During ERCP
After approval of ethical committee of Sindh Institute of Urology \& Transplantation (SIUT), 86 patients were enrolled for the elective endoscopic retrograde cholangiopancreatography (ERCP).
- Trial name
- NCT05996588
- Testing
- Propofol 1 % Injectable Suspension, Sevoflurane
- Where
- Pakistan
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Sindh Institute of Urology and Transplantation
Complications
Thiopental Versus Propofol During Magnetic Resonance Imagining in Children: Something Old, Something New
Magnetic resonance imagining (MRI) in children requires sedation to achieve the degree of cooperation or immobilization, necessary to complete these procedures successfully.
- Trial name
- NCT01318044
- Testing
- Propofol and Thiopental
- Where
- Albania
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Clinical Centre of Kosova
Analgesia, Postoperative Pain
The Availability and Safety Study of Remimazolam Besylate for Injection on Sedation of ERAS Patients
This trial intends to evaluate Remimazolam Besylate's availability and safety compared with propofol.
- Trial name
- NCT04947345
- Testing
- Remimazolam Besylate, Propofol
- Volunteers
- 84 people
- Sponsor
- Peking Union Medical College Hospital
Propofol, Hypoxia
HFNC and Hypoxia/Desaturation During Radiofrequency Ablation Under Moderate Sedation: A Randomized Clinical Trial
Background: Propofol based sedated anesthesia was widely used in percutaneous radiofrequency ablation and hypoxia/desaturation is one of the most frequent adverse events during this procedure.
- Conditions
- Propofol, Hypoxia, Sedation Complication, Desaturation of Blood
- Trial name
- NCT05212064
- Testing
- high-flow oxygen nasal cannula therapy, nasal cannula oxygen therapy
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Zhejiang Cancer Hospital
Drug Safety
Use of Intranasal Midazolam to Reduce Stress and Procedural Pain in Premature Infants During Routine ROP Examination.
The goal of this study is to learn about the safety and effectiveness of intranasal midazolam in newborns and infants born prematurely, undergoing Retinopathy of Prematurity (ROP) screening.
- Trial name
- NCT06889376
- Testing
- Intranasal midazolam administration via the DART™ intranasal atomization device along with routine comfort care.
- Where
- Poland
- Volunteers
- 40 people
- Sponsor
- Polish Mother Memorial Hospital Research Institute
Critical Illness, Complication of Ventilation Therapy
Cerebral Autoregulation in Non Neurological Critical Patients.
Brief Summary Cerebral Autoregulation is a well known physiological response to blood pressure changes to maintain the cerebral perfusion.
- Conditions
- Critical Illness, Complication of Ventilation Therapy, Systemic Inflammatory Response Syndrome, Failed Moderate Sedation During Procedure, Sequela
- Trial name
- NCT01731106
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Althaia Xarxa Assistencial Universitària de Manresa
Postoperative Complications, Respiratory Depression
Comparison of Remimazolam and Propofol in Endoscopic Examinations and Treatments
This study aims to evaluate the efficacy and safety of Remimazolam, either used alone or in combination with Propofol, for moderate sedation anesthesia during endoscopic therapies or examinations.
- Conditions
- Postoperative Complications, Respiratory Depression, Postoperative Nausea, Vomiting
- Trial name
- Remimazolam (NCT06777758)
- Testing
- Remimazolam, Propofol
- Where
- Taiwan
- Volunteers
- 90 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Airway Complication of Anesthesia
Role of Airway Topicalization in Awake Fiberoptic Intubation
Airway management is an integral part of general anesthesia. Difficult airway management may lead to various adverse events such as airway trauma, up to cardiopulmonary arrest.
- Trial name
- NCT06720220
- Testing
- Dexmedetomidine Hydrochloride, Nebulization, Atomization
- Where
- Egypt
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Complication of Anesthesia, Sedation-related Complications
Sedation-related Complications During Gastroenterological Procedures
Applications of non-operating room anesthesia for diagnosis and treatment are required in a variety of disciplines nowadays. Although it is not painful, sedation may be required in the gastrointestinal unit during procedures that…
- Trial name
- NCT05563727
- Where
- Turkey (Türkiye)
- Volunteers
- 693 people, healthy volunteers welcome
- Sponsor
- Gazi University
Encephalopathy, Developmental Delay and Behavioral Changes
RCT for Intermittent Versus Continuous Propofol Sedation for Pediatric Brain and Spine MRI Studies
RCT for Intermittent versus Continuous Propofol Sedation for Pediatric Brain and Spine MRI Studies
- Conditions
- Encephalopathy, Developmental Delay and Behavioral Changes, Cord Tumor Compression or Instability, Cord Tethering or Malformation
- Trial name
- NCT00515359
- Testing
- Intermittent Propofol Sedation, Continuous Propofol Sedation
- Where
- United States
- Volunteers
- 276 people
- Sponsor
- Corewell Health West
High Flow Oxygen Therapy, ENDOBRONCHIAL ULTRASOUND - TRANSBRONCHIAL NEEDLE ASPIRATION
High-Flow Nasal Oxygyen Therapy During Sedated Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration(EBUS-TBNA)
This study aims to evaluate the effects of high-flow nasal oxygen therapy on respiratory complications, blood gas parameters, and post-procedural recovery in patients undergoing sedated endobronchial ultrasound-guided…
- Conditions
- High Flow Oxygen Therapy, ENDOBRONCHIAL ULTRASOUND - TRANSBRONCHIAL NEEDLE ASPIRATION, Sedation, Sedation Complication
- Trial name
- NCT07760727
- Testing
- High-Flow Nasal Oxygen Therapy, Conventional Oxygen Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Postoperative Pain, Postoperative Sedation
Analgesic Effect of Gabapentin in Total Knee Arthroplasty (TKA)
Pain is a major problem after TKA. Gabapentin may reduce acute postoperative pain. The investigators therefore investigate the effect of Gabapentin as a perioperative analgesic.
- Trial name
- NCT01507363
- Testing
- Gabapentin
- Where
- 3 sites in Denmark
- Volunteers
- 300 people
- Sponsor
- Hvidovre University Hospital