Clinical trials: Sedation
Hip Arthroplasty, Spinal Anesthesia
Patient-controlled Remimazolam Sedation Under Spinal Anesthesia
The goal of this clinical trial is to compare the efficacy of patient-controlled sedation (PCS) versus clinician-controlled sedation (CCS) using remimazolam in adult patients undergoing primary hip arthroplasty under spinal…
- Conditions
- Hip Arthroplasty, Spinal Anesthesia, Remimazolam, Patient-controlled Sedation
- Trial name
- NCT07661810
- Testing
- Patient-controlled sedation, Clinician-controlled sedation
- Volunteers
- 104 people
- Sponsor
- Seoul National University Hospital
Gastroscopic and Colonoscopic Sedation
A Non-interventional Study of Remazolam Methyl Benzene Sulfonic Acid for Injection in Real-world Clinical Practice
This is a non-interventional study of remazolam toluenesulfonate (rebenin ®) for injection in Chinese patients. A total of 2000 patients were enrolled in this study based on the preliminary safety assessment of rebenin ®, and all…
- Trial name
- NCT05254366
- Testing
- Remimazolam Tosilate for Injection
- Where
- 19 sites in China
- Volunteers
- 2,022 people, healthy volunteers welcome
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
MRI Sedation, Pediatric Sedation
Propofol-Only Versus Dexmedetomidine-Propofol in Children Undergoing Magnetic Resonance Imaging
The most common imaging procedure requiring sedation/anesthesia for the pediatric population is magnetic resonance imaging (MRI). However, the optimal anesthetic/sedation plan has not been determined for these procedures.
- Conditions
- MRI Sedation, Pediatric Sedation, Propofol Dosage, Emergence Delirium, Anesthesia
- Trial name
- NCT07369128
- Testing
- Dexmedetomidine (IV) 0.5 mcg/kg, Propofol (IV) 2-4 mg/kg, Dexmedetomidine (IV) 1 mcg/kg
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- Boston Children's Hospital
Anesthesia, Sedation
Efficacy and Safety of Anricofen Combined With Ciprofol for Deep Sedation in Elderly Patients Undergoing ERCP
Background: Endoscopic retrograde cholangiopancreatography (ERCP) is a key technique for treating pancreatobiliary diseases in the elderly.
- Conditions
- Anesthesia, Sedation, ERCP, Ciprofol
- Trial name
- Anricofen Cipr (NCT07376577)
- Testing
- Sufentanil, Anricofen, Ciprofol
- Where
- China
- Volunteers
- 141 people
- Sponsor
- The First Affiliated Hospital of Xinxiang Medical College
Aortic Stenosis Treated With TAVI, Sedation; Aged; Hemodynamics
High Flow Nasal Oxygenation in Transcatheter Aortic Valve Replacement Procedures. TAVR-Highflow II
Transcatheter aortic valve replacement (TAVR) has revolutionized the treatment of patients with aortic valve disease. TAVR is a less invasive treatment compared to the conventional surgical approach through median sternotomy.
- Trial name
- NCT07059728
- Testing
- Oxygen therapy during sedation provided via high nasal cannulae (60L/min at 60% FiO2), Oxygen therapy during sedation delivered via nasal cannulae at 5L/min
- Where
- Spain
- Volunteers
- 452 people
- Sponsor
- Hospital Clinic of Barcelona
Procedural Sedation and Analgesia
PRedictors Of Maladaptive Behaviors in Children Undergoing Procedural SEDation
Procedural sedation for children outside of the operating room is a common practice in emergency departments, outpatient clinics, radiology suites, and dental offices for painful and anxiety-provoking procedures.
- Trial name
- PRoSEED (NCT07495826)
- Where
- 2 sites in Canada
- Volunteers
- 2,145 people
- Sponsor
- London Health Sciences Centre Research Institute
Anesthesia, Sedation
Sedation During Endoscopy Using Remimazolam: Efficacy in a Novel Exploration
This study is a pragmatic, randomized controlled pilot trial comparing remimazolam with propofol for endoscopic procedures, designed to assess the feasibility and clinical outcomes associated with implementing a pragmatic…
- Conditions
- Anesthesia, Sedation, Endoscopy
- Trial name
- SERENE (NCT07269808)
- Testing
- Remimazolam, Propofol
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Massachusetts General Hospital
Colonoscopy Procedures, Sedation
Effects of Low-Dose Ketamine Added to Propofol Sedation During Colonoscopy
"This prospective observational study aims to evaluate the effects of adding low-dose ketamine (0.25 mg/kg) to standard propofol sedation on hemodynamic stability, sedation depth, and recovery times in adult patients undergoing…
- Trial name
- NCT07809230
- Testing
- Propofol group, Propofol + Ketamine
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Ankara Etlik City Hospital
Brugada Syndrome (BrS), Ventricular Arrhythmia
Prospective Multicentre Observational Registry of Peri-procedural Anaesthesia, Sedation and Related Medication Exposure in Patients With Brugada Syndrome
The goal of this observational study is to evaluate the perioperative risk of malignant ventricular arrhythmias in adult patients diagnosed with Brugada Syndrome undergoing anaesthetic procedures.
- Conditions
- Brugada Syndrome (BrS), Ventricular Arrhythmia, Anesthesia, Sedation
- Trial name
- PROSP_BRUGANAE (NCT07655102)
- Where
- Spain
- Volunteers
- 200 people
- Sponsor
- Hospital Clinic of Barcelona
Dexmedetomidine, Ketamine
Safety and Efficacy of Esketamine - Dexmedetomidine Combination Versus Dexmedetomidine Monotherapy for Hyperactive Delirium in ICU Patients on Non-Invasive Respiratory Support (SEED-NIRS Trial): Study Protocol of a Randomized Controlled Trial
This investigator-initiated, randomized, controlled, single-blind, superiority trial aims to assess the efficacy and safety of esketamine combined with dexmedetomidine for the management of agitation or delirium in intensive care…
- Conditions
- Dexmedetomidine, Ketamine, Analgesia, Respiratory Therapy
- Trial name
- SEED-NIRS (NCT07377981)
- Testing
- Esketamine combined with dexmedetomidine, Dexmedetomidine
- Where
- China
- Volunteers
- 356 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Ischemic Stroke, Anterior Cerebral Circulation
Anesthesia Management in Endovascular Therapy for Ischemic Stroke - 2
The goal of this clinical trial is to learn what is the best anesthetic management in participants with severe stroke that require a medical intervention called mechanical thrombectomy (MT) done to open the occluded brain vessel.
- Conditions
- Ischemic Stroke, Anterior Cerebral Circulation, General Anesthesia, Procedural Sedation
- Trial name
- AMETIS 2 (NCT07235514)
- Testing
- General Anesthesia, Procedural sedation
- Where
- 16 sites in France
- Volunteers
- 958 people
- Sponsor
- University Hospital, Clermont-Ferrand
Pericardial Effusion, Inflammatory Response After Surgery
Anesthesia Management, Inflammatory Response and Recovery After Non-intubated VATS Pericardial Window
Non-intubated video-assisted thoracoscopic surgery (NIVATS) is performed under spontaneous ventilation and avoids tracheal intubation and one-lung mechanical ventilation.
- Conditions
- Pericardial Effusion, Inflammatory Response After Surgery, Postoperative Complications, Procedural Sedation and Analgesia
- Trial name
- RNIVATS (NCT07800767)
- Testing
- Systemic opioid-based analgesia during NIVATS, Thoracic regional analgesia during NIVATS
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Koşuyolu Kartal Heart Training and Research Hospital
ENDOBRONCHIAL ULTRASOUND - TRANSBRONCHIAL NEEDLE ASPIRATION, Procedural Sedation and Analgesia
Consent Understanding and Propofol Requirement During Endobronchial Ultrasound
The goal of this observational study is to learn whether a participant's understanding of the informed consent information is related to the amount of propofol needed during endobronchial ultrasound (EBUS).
- Conditions
- ENDOBRONCHIAL ULTRASOUND - TRANSBRONCHIAL NEEDLE ASPIRATION, Procedural Sedation and Analgesia, Informed Consent
- Trial name
- NCT07677982
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Uludag University
Pediatric Procedural Sedation
Intranasal Dexmedetomidine vs. Oral Chloral Hydrate for Pediatric Orthopedic Procedural Sedation
This prospective randomized controlled study will compare the effectiveness and safety of intranasal dexmedetomidine with oral chloral hydrate for procedural sedation in children undergoing painful orthopedic manipulation.
- Trial name
- NCT07768566
- Testing
- Dexmedetomidine, Chloral Hydrate
- Where
- South Korea
- Volunteers
- 44 people
- Sponsor
- Seoul National University Childrens Hospital
Procedural Sedation, Dreams
Personalized Music, Dreaming During Propofol Sedation
This randomized clinical trial will evaluate whether music delivered through closed-back headphones during intravenous propofol sedation affects dreaming and the overall sedation experience.
- Trial name
- NCT07638072
- Testing
- Preferred Music, Matched Non-preferred Music, Silence Control
- Where
- South Korea
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Wonkwang University Hospital
Procedural Sedation, Gastrointestinal Endoscopy
Therapeutic Effects of Music on Procedural Outcomes
This study will evaluate whether listening to low-tempo instrumental music during gastroscopy and/or colonoscopy can reduce the amount of sedative medication needed during the procedure.
- Conditions
- Procedural Sedation, Gastrointestinal Endoscopy, Music Intervention
- Trial name
- TEMPO (NCT07763860)
- Testing
- Low-Tempo Instrumental Music, Silent Audio Control
- Where
- Lebanon
- Volunteers
- 180 people
- Sponsor
- Bahaa Bou Dargham
OSAS (Obstructive Sleep Apneas Syndrome), DISE
The Use of Remimazolam Versus Dexmedetomidine for Patients Receiving Drug-Induced Sleep Endoscopy
This study seeks to compare the clinical efficacy and safety of the novel sedative Remimazolam with Dexmedetomidine in Drug-Induced Sleep Endoscopy (DISE), evaluating their performance in sedation depth stability, incidence of…
- Conditions
- OSAS (Obstructive Sleep Apneas Syndrome), DISE, Sedation
- Trial name
- NCT07459322
- Testing
- Remimazolam, Dexmedetomidine
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Fu Jen Catholic University Hospital
High Flow Oxygen Therapy, ENDOBRONCHIAL ULTRASOUND - TRANSBRONCHIAL NEEDLE ASPIRATION
High-Flow Nasal Oxygyen Therapy During Sedated Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration(EBUS-TBNA)
This study aims to evaluate the effects of high-flow nasal oxygen therapy on respiratory complications, blood gas parameters, and post-procedural recovery in patients undergoing sedated endobronchial ultrasound-guided…
- Conditions
- High Flow Oxygen Therapy, ENDOBRONCHIAL ULTRASOUND - TRANSBRONCHIAL NEEDLE ASPIRATION, Sedation, Sedation Complication
- Trial name
- NCT07760727
- Testing
- High-Flow Nasal Oxygen Therapy, Conventional Oxygen Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Pain, Sedation
Effect of Maternal Voice on Pain, Sedation, and Physiological Parameters in Mechanically Ventilated Children
Children in the pediatric intensive care unit often experience pain and stress from medical procedures, even while sedated. This study will test whether playing a recording of the child's mother's voice helps reduce pain and the…
- Conditions
- Pain, Sedation, Mechanical Ventilation
- Trial name
- NCT07753486
- Testing
- Recorded Maternal Voice
- Where
- Turkey (Türkiye)
- Volunteers
- 28 people
- Sponsor
- TC Erciyes University
ICU Patients With Indication of Sedation
A Pharmacokinetic Study of Sevoflurane Inhalation in Burn ICU Patients
Comparing a pharmacokinetic model of a short sevoflurane sedation in burn ICU patients with control ICU patients.
- Trial name
- SEVOBURN (NCT02048683)
- Testing
- Short term sedation with sevoflurane in ICU
- Where
- France
- Volunteers
- 24 people
- Sponsor
- University Hospital, Clermont-Ferrand