Clinical trials: Second Trimester Abortion
Abortion in Second Trimester
OPIOID Study - Pain With Osmotic Dilators
Comparison of pain levels and pain medications utilized following insertion of two different types of osmotic dilators.
- Trial name
- OPIOID (NCT03710239)
- Testing
- Dilapan-S, Laminaria
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Albany Medical College
Abortion Early, Abortion, Complete
Clotting Parameters After Medical Abortion
Venous thromboembolism (VTE - blood clots that form in deep veins or in the lungs) has been identified as a leading cause of death in economically developed countries for pregnant and recently-pregnant women.
- Conditions
- Abortion Early, Abortion, Complete, Abortion, Second Trimester, Termination of Pregnancy Complicated by Embolism
- Trial name
- C-PLAN (NCT04824118)
- Testing
- Thromboelastometry, Clotting Studies, Full Blood Count
- Where
- United Kingdom
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- NHS Lothian
Lactation Suppressed
A Reduced Dose of Cabergoline for Lactation Inhibition After Second-Trimester Abortion or Pregnancy Loss
Most patients seeking abortion care or management of pregnancy loss in the second trimester will lactate, which can be physically and emotionally painful.
- Trial name
- LISTA3 (NCT06909123)
- Testing
- Cabergoline
- Sponsor
- Stanford University
Abortion in Second Trimester
Mifepristone and Misoprostol for Midtrimester Termination of Pregnancy in Uzbekistan
The primary goal is to examine the efficacy and feasibility of a mifepristone-misoprostol medical abortion regimen in terminating pregnancies 13-22 weeks in Uzbekistan.
- Trial name
- NCT02235155
- Where
- 3 sites in Uzbekistan
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Induced; Abortion, Nonmedical
Comparison of Laminaria and Misoprostol for Cervical Preparation Before Second Trimester Surgical Abortion
This study compares the effectiveness of cervical preparation before second trimester abortion using laminaria versus vaginal Misoprostol.
- Trial name
- NCT01678703
- Testing
- Laminaria, MedGyn Products, Inc. USA., Misoprostol
- Where
- Israel
- Volunteers
- 84 people
- Sponsor
- Wolfson Medical Center
Abortion, Dilation and Evacuation
Tranexamic Acid for Second Trimester Dilation and Evacuation and Bleeding Outcomes
Although procedural abortion in the second trimester is extremely safe, hemorrhage is one of the leading causes of morbidity and mortality.
- Conditions
- Abortion, Dilation and Evacuation, Hemorrhage, Prophylactic Tranexamic Acid Use
- Trial name
- NCT06820177
- Testing
- Tranexamic Acid
- Where
- 3 sites in United States
- Volunteers
- 276 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Abortion; Attempted
Misoprostol in Missed Abortion
In this study we compare between the effectiveness of combined Foley's catheter with Misoprostol and intracervical Foley's catheter alone for termination of second trimester abortion.
- Trial name
- NCT06818903
- Testing
- Misopristol, Foley catheter
- Volunteers
- 122 people
- Sponsor
- Assiut University
Second Trimester Abortion, Uterocervical Angle
The Role of Cervical Consistency Index and Uterocervical Angles in Medical Termination
The main aim of the investigator study is the success of predictivity cervical consistency index (CCI), anterior uterocervical angle (aUCA) and posterior uterocervical angle (pUCA) in second trimester terminations.
- Conditions
- Second Trimester Abortion, Uterocervical Angle, Cervical Consistency Index
- Trial name
- NCT06164067
- Testing
- abortus within 24 hours or 24-48 hours
- Where
- Turkey (Türkiye)
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Sanliurfa Mehmet Akif Inan Education and Research Hospital
Termination of Pregnancy
Multi-Media E-Book for Second-Trimester Termination Due to Fetal Anomaly
The subjects of this study are married couples who received termination of pregnancy, the main purpose is to explore the effectiveness of the e-book education model.
- Trial name
- NCT04303949
- Testing
- Behavioral:
- Volunteers
- 96 people
- Sponsor
- China Medical University Hospital
Arrhythmia, ECG Changes
Intra Amniotic Injection of DIGOXIN for Feticide in Second Trimester Termination of Pregnancy
In second trimester abortion above 22 weeks the investigators usually inject intra-cardiac Kcl for feticide. Digoxin intra-amniotic injection has been described in the literature in doses of 1-1.5 mg.
- Conditions
- Arrhythmia, ECG Changes, Hypotension
- Trial name
- NCT01951079
- Testing
- Intra-amniotic injection of DIGOXIN
- Where
- 2 sites in Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
Second Trimester Abortion
TENS Unit To Decrease Pain After Laminaria Insertion
The purpose of the study is to learn more about the transcutaneous nerve stimulation (TENS) unit, an over-the-counter option for pain relief that is not a medication.
- Trial name
- NCT06529003
- Testing
- Transcutaneous Electrical Nerve Stimulation (TENS) unit
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Queen's Medical Center
Lactation Suppressed
Cabergoline for Lactation Inhibition After Second-Trimester Abortion or Loss
This research study investigates the use of a drug, cabergoline, given immediately after second-trimester abortion or perinatal loss to decrease breast engorgement.
- Trial name
- LISTA (NCT04701333)
- Testing
- Cabergoline 1 MG
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- Stanford University
Abortion
Comparative Psychiatric Problems Between First and Second Trimester Miscarriage
Description of the psychiatric impact of miscarriage on women.
- Trial name
- NCT06742632
- Testing
- Symptoms checklist-90
- Where
- Egypt
- Volunteers
- 155 people
- Sponsor
- Assiut University
Induction of Second Trimester Abortion
Use of Ulipristal Acetate in Induction of Second Trimester Missed Abortion
The aim of this work is to assess the effectiveness and safety of Ulipristal Acetate in the management of 2nd trimester missed abortion along with misoprostol in pregnant women with previous caesarean section versus the use of…
- Trial name
- NCT04989400
- Testing
- Ulipristal Acetate, Misoprostol
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Second Trimester Labor Induction
Second Trimester Labor Induction
A superior second trimester medical abortion regimen has not been identified. Studies suggest that a regimen of mifepristone and misoprostol given 36 to 48 hours apart has the shortest median induction-to-abortion interval…
- Trial name
- NCT00592215
- Testing
- Experimental (mifepristone and misoprostol)
- Where
- 2 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Missed Abortion
Evening Primrose Oil Efficacy in Second Trimester Abortion
efficacy of evening primrose oil in shortening the duration of induction in 2nd trimesteric missed abortion
- Trial name
- NCT03698734
- Testing
- Evening primrose oil(EPO)
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Ain Shams University
Second Trimester Medical Abortion
Paracervical Block During II-trimester Abortion
Paracervical blockage can reduce severe pain during second trimester induced medical abortion.
- Trial name
- NCT01617564
- Testing
- bipuvacain, NaCl
- Where
- 2 sites in Sweden
- Volunteers
- 112 people
- Sponsor
- Kristina Gemzell Danielsson
Other Abortion
Misoprostol vs. Sublingual Misoprostol and Laminaria For Second Trimester Termination of Pregnancy
1. Comparison between the duration of time from the beginning of cervical preparation until abortion, between sublingual misoprostol and the combination of sublingual misoprostol with laminaria for second trimester medical…
- Trial name
- NCT02013960
- Testing
- Cytotec
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Abortion, Induced
Mifepristone Plus Misoprostol Versus Misoprostol Alone for 2nd Trimester Abortion (14 - 21 Weeks Last Menstrual Period (LMP))
The primary goal of this study is to determine the clinical advantage of pre-treatment with mifepristone in second trimester misoprostol induction abortion.
- Trial name
- NCT00969982
- Testing
- mifepristone+misoprostol
- Where
- 2 sites in Moldova, Tunisia
- Volunteers
- 238 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Pregnancy
Techniques to Improve Efficacy of Second Trimester Medical Termination
Interruption of a pregnancy after 14 weeks gestation may be required when the fetus is dead, severely malformed or in cases of maternal illness.
- Trial name
- NCT00864799
- Testing
- Misoprostol
- Where
- Australia
- Volunteers
- 302 people
- Sponsor
- King Edward Memorial Hospital