Clinical trials: Screening, open to volunteers
Sickle Cell Disease
Evaluation of an Information Management and Communication System for Population-wide Point-of-Care Infant Sickle Cell Disease Screening
A cluster randomized trial (CRT) of the novel sickle cell disease (SCD), M-health based SCD Information Management and Communication system SIMCS vs routine new born screening strategy in health care centres in Uganda to evaluate…
- Trial name
- SMICS (NCT07610239)
- Testing
- Sickle Cell Disease screening information management and communication system
- Where
- Uganda
- Volunteers
- 24,000 people, healthy volunteers welcome
- Sponsor
- Makerere University
Tuberculosis Infection, Latent, Tuberculosis Active
SCAF-TB - Saving Children and Their Families From Tuberculosis: Implementation Research to Improve TB Preventive Treatment Initiation and Completion Rates Among Contact Persons in Tajikistan and Tanzania
The SCAF-TB study aims to evaluate how the WHO-endorsed SIILTIBCY skin test can be best implemented to test close contacts for tuberculosis infection (TBI) in Tajikistan and Tanzania, either facility-based or home-based delivered…
- Conditions
- Tuberculosis Infection, Latent, Tuberculosis Active, TPT
- Trial name
- SCAF-TB (NCT07714707)
- Testing
- CY-TB Patch, Audiblehealth DX
- Where
- 2 sites in Tajikistan, Tanzania
- Volunteers
- 880 people, healthy volunteers welcome
- Sponsor
- KNCV Tuberculosis Foundation
Stroke, Hypertension
CEEEC-II: A 12-Week Physical and Cognitive Enrichment Extension Study in Older Stroke Survivors With Multimorbidity
CEEEC-II is a 12-week, community-based, prospective extension study conducted in 32 community health service stations in Kunshan, China.
- Conditions
- Stroke, Hypertension, Type 2 Diabetes Mellitus (T2DM), Multimorbidity
- Trial name
- CEEEC-II (NCT07778771)
- Testing
- Physical Enrichment, Cognitive Enrichment
- Where
- China
- Volunteers
- 365 people
- Sponsor
- Duke Kunshan University
Preventive Practice
Prevention Habits of Medical Doctors
Preventive practices among physicians remain insufficiently studied, particularly in situations for which recommendations are limited or unavailable.
- Trial name
- Prevmed (NCT07829601)
- Testing
- PREVMED questionnaire
- Where
- France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Clermont-Ferrand
Placenta; Implantation
MRI Screening of Placenta Adhesion Abnormalities
Placenta Adhesion Abnormalities (PAA) are the consequence of an excessive invasion of the placenta within the myometrium. PAA are related to severe maternal pregnancy outcomes, especially in case of incidental discovery during…
- Trial name
- DIANE (NCT04328532)
- Testing
- MRI
- Where
- France
- Volunteers
- 71 people
- Sponsor
- Central Hospital, Nancy, France
Glioblastoma, Organoid
Drug Response Testing and Repurposing Using Glioblastoma Organoid
The aim of this observational study, based on a prospectively collected cohort, is to evaluate the prognostic value of patient-derived organoids in predicting responses to conventional and repurposing drugs, including…
- Trial name
- NCT06782984
- Testing
- Organoid-based drug sensitivity test
- Where
- South Korea
- Volunteers
- 150 people
- Sponsor
- Chungnam National University Hospital
Lung Cancer
SingapOre Lung Cancer Screening Through Integrating CT With Other biomarkErs (SOLSTICE)
This is a single arm screening study. All eligible participants will be subjected to low dose CT (LDCT) screening and biomarker testing.
- Trial name
- NCT05724264
- Testing
- Low-dose CT of the Chest (LDCT) + Sampling for Biomarker Assays
- Where
- 6 sites in Singapore
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- National Cancer Centre, Singapore
Lung Cancer in Normal and Malignant Tumors
SERS-Based Serum Molecular Spectral Screening for Benign and Malignant Pulmonary Proliferative Nodules
Pulmonary nodules are often an early indicator of lung cancer. With the widespread adoption of chest CT scans in routine physical examinations, an increasing number of pulmonary nodules are being detected, including a variety of…
- Trial name
- SERS on lung (NCT06775587)
- Testing
- Serum Raman spectroscopy intelligent diagnostic system
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Fuzhou General Hospital
Atrial Fibrillation Paroxysmal, Atrial Fibrillation, Persistent
Value of Screening and Treatment of SAHS in the Management of AF Ablation Candidates
The present prospective cohort study (not randomized) analyses the value of screening and treatment of SAHS in the management of patients with AF refractory to antiarrhythmics drugs, potentially candidates for ablation.
- Conditions
- Atrial Fibrillation Paroxysmal, Atrial Fibrillation, Persistent, Apnea Syndrome, Hypopnea Syndrome
- Trial name
- SLEEP-AF (NCT04606693)
- Testing
- Treatment of SAHS
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Hospital San Carlos, Madrid
Aging, Aortic Aneurysm, Abdominal
The Intersectional Viborg Screening Program: Cost-(Effectiveness) of Screening for Diabetes and Cardiovascular Diseases
This is an intersectional and interdisciplinary screening program in Viborg Municipality, including 67 years old citizens. This observational study will estimate the cost-effectiveness of a combined screening program for the…
- Conditions
- Aging, Aortic Aneurysm, Abdominal, Hypertension, Mass Screening
- Trial name
- VISP (NCT03395509)
- Where
- Denmark
- Volunteers
- 4,500 people, healthy volunteers welcome
- Sponsor
- Central Jutland Regional Hospital
Sudden Cardiac Death, Cardiac Arrhythmias
Cardiovascular Pre-participation Screening in Children and Adolescents
Sports participation is strongly encouraged in children and adolescents, but intense training at early ages may reveal hidden heart conditions that increase the risk of sudden cardiac death.
- Trial name
- NCT07862504
- Testing
- Pre-participation clinical evaluation, Diagnostic Test: Resting 12-lead electrocardiogram, Diagnostic Test: Step test (Harvard step test)
- Where
- Brazil
- Volunteers
- 334 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Colorectal Cancer, Colorectal Neoplasms
Clinical Performance of the Mainz Biomed Colorectal Cancer Screening Test for Colorectal Cancer and Advanced Adenoma
This study is to determine how the Mainz Biomed Colorectal Cancer Screening Test works when used in people aged ≥45 years of age and at an average risk of developing colorectal cancer.
- Conditions
- Colorectal Cancer, Colorectal Neoplasms, Colorectal Polyp, Colorectal Adenoma
- Trial name
- reconAAsense (NCT05636085)
- Testing
- Mainz Biomed Colorectal Cancer Screening Test
- Volunteers
- 15,000 people, healthy volunteers welcome
- Sponsor
- Mainz Biomed
Depression - Major Depressive Disorder, Depression Anxiety Disorder
Evaluating the Effectiveness and Acceptability of a GPT-4o and RAG-Based Voice Chatbot for Depression Screening Using PHQ-9
This study aims to assess the feasibility and acceptability of a voice-based chatbot, powered by GPT-4o and Retrieval-Augmented Generation (RAG), for conducting depression screening using the Patient Health Questionnaire-9…
- Trial name
- GPT4-RAG-PHQ (NCT06801925)
- Testing
- GPT-4o and RAG Voice Chatbot for PHQ-9 Screening
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University College, London
Opioid Use Disorder, Opioid Misuse
Opioid and Pain Treatment in Indigenous Communities (OPTIC) Trial
The present study seeks to examine the implementation process of culturally tailoring screening and brief intervention for both chronic pain and opioid misuse/opioid use disorder in three American Indian and Alaska Native (AI/AN)…
- Conditions
- Opioid Use Disorder, Opioid Misuse, Chronic Pain
- Trial name
- OPTIC (NCT06565416)
- Testing
- Implementation Strategies
- Where
- 3 sites in United States
- Volunteers
- 225 people
- Sponsor
- University of New Mexico
Colorectal Cancer, Screening
Artificial Intelligence-based Screening Models for Prevention and Early Detection of Colorectal Cancer
Colorectal cancer screening is based on the fecal occult blood test (FIT), which has low sensitivity for adenomatous polyps, based on the currently used cut-off.
- Trial name
- NCT06799793
- Testing
- GI Genius, Colonscope Olympus
- Where
- Italy
- Volunteers
- 1,400 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Lung Cancer, EGFR Gene Mutation
EQUAL: EGFR ctDNA QUantative Assessment for Lung Cancer Screening in Asian and Latinx Populations
This research study is studying a new blood test to screen for Epidermal Growth Factor Receptor (EGFR) positive lung cancer in healthy individuals at risk for the disease and who cannot undergo regular lung cancer screening.
- Trial name
- EQUAL (NCT06716580)
- Testing
- Circulating Tumor DNA (ctDNA) Assay
- Where
- 6 sites in United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Dana-Farber Cancer Institute
Hepatocellular Carcinoma (HCC), Cholangiocarcinoma
A Noninvasive and Screening miRNA Signature for Gastrointestinal Cancer
Gastrointestinal (GI) cancers remain a major global health burden, largely due to the lack of effective and accessible early screening strategies.
- Conditions
- Hepatocellular Carcinoma (HCC), Cholangiocarcinoma, Pancreatic Ductal Adenocarcinoma (PDAC), Esophageal Squamous Cell Carcinoma (ESCC)
- Trial name
- MiGIC (NCT07224750)
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Mild Cognitive Impairment, Alzheimer Disease
Screening for Anti-amyloid Treatment Eligibility Using Digital Cognition and Blood-based Biomarkers
This study evaluates a diagnostic screening solution for Alzheimer's disease (AD) using digital cognitive assessments and blood-based biomarkers.
- Conditions
- Mild Cognitive Impairment, Alzheimer Disease, Dementia
- Trial name
- NCT07041450
- Testing
- Digital MoCA, XpressO, MoCA
- Where
- Canada
- Volunteers
- 500 people
- Sponsor
- MoCA Clinic and Institute
Cervical Cancer Screening
A Mobile Web App Intervention to Promote Cervical Cancer Screening
The overarching goal of this study is to increase cervical cancer (CC) screening rates among Indigenous women in the U.S. Specifically, the study aims to develop and evaluate a culturally tailored, multilevel, multimedia mobile…
- Trial name
- wPap (NCT07574190)
- Testing
- wPap Mobile Web App Intervention
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of South Dakota
Breast Neoplasms, Uterine Cervical Neoplasms
Nudging Preventive Screening Via Message Framing and Bundling
This study is a randomized controlled field experiment embedded in the medical institution Early Diagnosis Program in Chile. Participants with two exams pending (a cancer screening test and a chronic disease test for diabetes and…
- Conditions
- Breast Neoplasms, Uterine Cervical Neoplasms, Colorectal Neoplasms, Prostatic Neoplasms
- Trial name
- NCT07644910
- Testing
- Basic cancer screening message, Basic chronic disease test message, Basic combined message
- Volunteers
- 235,000 people
- Sponsor
- University of Chile
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