Clinical trials: Sciatica
Piriformis Syndrome
Interfascial Hydrodissection Added to Ultrasound-Guided Piriformis Injection for Piriformis Syndrome
The gluteus maximus overlies the piriformis muscle and forms a broad fascial interface with it. Restricted movement, increased tension, or adhesions between these tissue layers may contribute to persistent buttock pain in…
- Trial name
- NCT07813455
- Testing
- Ultrasound-Guided Piriformis Injection, Ultrasound-Guided Interfascial Hydrodissection, Standardized Home-Based Piriformis Stretching Program
- Where
- Turkey (Türkiye)
- Volunteers
- 110 people
- Sponsor
- Haydarpasa Numune Training and Research Hospital
Sciatica
Effectiveness of Oral Prednisone in Improving Physical Functioning and Decreasing Pain in People With Sciatica
Sciatica is a condition that causes a sharp, burning pain in the back, buttock, and leg. The condition is caused by injury to or compression of the sciatic nerve, which is located in the back of the leg.
- Trial name
- ACT FAST (NCT00668434)
- Testing
- Prednisone
- Where
- 3 sites in United States
- Volunteers
- 269 people
- Sponsor
- Kaiser Permanente
Discal Sciatica
Comparison of a Cortivazol (ALTIM®) Infiltration of Posterior Epidural Space at L3-L4 Stage Versus an Epidural Infiltration of Cortivazol (ALTIM®) on Contact With Disco Radicular Conflict in Discal Sciatica
In discal sciatica, after failure of medical treatment, the investigators propose frequently a spinal infiltration of corticoids the most closer of disco-radicular conflict.
- Trial name
- EPI-AMELIE (NCT02151045)
- Testing
- Non target epidural infiltration done at L3-L4 stage, Epidural infiltration on contact of disco radicular conflict
- Where
- 2 sites in France
- Volunteers
- 112 people
- Sponsor
- University Hospital, Montpellier
Low Back Pain, Disc Disease
Fibrin for Chronic Multi-level Discogenic Low Back Pain
Intra-annular injections of non-autologous fibrin for moderate to severe chronic low back pain (LBP).
- Conditions
- Low Back Pain, Disc Disease, Disc Degeneration, Radiculopathy
- Trial name
- NCT04621799
- Testing
- Fibrin sealant
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Pauza, Kevin, MD
Cyclists, Sciatica
Comparative Effects of Sciatic Nerve Flossing and Active Release Technique in Cyclists With Sciatica
Thus the aim of my study is to determine the comparative effects of sciatic nerve flossing and active release technique on pain, flexibility, and functionality in lower limbs of cyclists with sciatica.
- Trial name
- NCT06827574
- Testing
- Sciatic nerve flossing technique, Active Release Technique
- Where
- Pakistan
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Sciatica
Comparison of Intravenous Ibuprofen and Paracetamol in Patients With Sciatica Presented to the Emergency Department
Currently, Paracetamol and Ibuprofen are widely used by emergency physicians in Turkey for the pain treatments. The objective of the study was to assess whether intravenous Paracetamol has superior Sciatica pain reduction will…
- Trial name
- NCT02777320
- Testing
- paracetamol, Ibuprofen
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Pamukkale University
Lumbar Radiculopathy, Sciatica
Dose Dependent Steroid Injections
This study aims to evaluate the efficacy of interlaminar steroid injections at treating pain in lumbar radiculopathy at varying doses, to evaluate the efficacy of interlaminar steroid injections at improving quality of life and…
- Conditions
- Lumbar Radiculopathy, Sciatica, Back Pain With Radiation
- Trial name
- NCT07494136
- Testing
- Triamcinolone 10 Mg/mL Injectable Suspension, Triamcinolone 40 Mg/mL Injectable Suspension, Triamcinolone 80 Mg/mL Injectable Suspension
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Miami
Neck Pain, Back Pain
Metabolic and Endocrine Effects of Repeated Epidural and Sacroiliac Joint Corticosteroid Injections
Corticosteroid injections into the epidural space or sacroiliac joint are increasingly used for the treatment of chronic neck, low back, and leg pain.
- Trial name
- NCT01717430
- Where
- Canada
- Volunteers
- 126 people
- Sponsor
- University of Manitoba
Herniated Disc, Sciatica Due to Intervertebral Disc Disorder
Effects of Neural Mobilization Combined With Manual Therapy on Infrared Thermography, Inflammatory Markers and Clinical Outcomes in Patients With Lumbar Disc Herniation: A Randomized Controlled Clinical Trial
The objective of this randomized controlled clinical trial is to evaluate whether manual therapy combined with neural mobilization can improve pain, functional impairment, quality of life, inflammatory markers, and infrared…
- Trial name
- NCT07752199
- Testing
- Neural Mobilization, Manual Therapy
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Longhua Hospital
Sciatica
Effects of Control Scan for Presumed Difficult Epidural Infiltrations (ECHORACHIS)
The aim of this care protocol is to study the effects of scan to help epidural infiltration realization, in presumed difficult patients suffering from sciatica.
- Trial name
- ECHORACHIS (NCT01832844)
- Testing
- Group " with scan prior to infiltration ", Group " without scan "
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Nantes University Hospital
Sciatica
Comparing the Efficacy of Steroid, Acupuncture and Platelet Rich Plasma Injection in Patients With Sciatica
Disc herniation, stenosis of the spine and spondylolisthesis are the common causes of radiculitis in medical practice today, and can cause symptoms of sciatica.
- Trial name
- NCT03801512
- Testing
- Steroid, Acupuncture, Platelet Rich Plasma
- Where
- Taiwan
- Volunteers
- 90 people
- Sponsor
- Taipei Medical University Hospital
Lumbar Disc Degeneration, Lumbar Disc Disease
Total Lumbar Disc Prosthesis and Subsequent Work Activity at at Least Five Years After Total Lumbar Disc Replacement
Lumbosciatica is a very prevalent pathology. When conservative treatments fail, surgery should be considered. The traditional surgical treatment is lumbar arthrodesis.
- Conditions
- Lumbar Disc Degeneration, Lumbar Disc Disease, Sciatica, Lumbar Disc Herniation
- Trial name
- NCT06989632
- Testing
- Total lumbar disc prosthesis (Baguera®L, Spineart, Switzerland)
- Where
- Spain
- Volunteers
- 130 people
- Sponsor
- University of Valencia
Sciatica Pain, Sciatica
Effects of SSMC With and Without Myofascial Release in Patients With Sciatica
Sciatica involves a radiating pain along the sciatic nerve, extending from the lower back through the hips and buttocks to each leg.
- Trial name
- Sciatica (NCT06696898)
- Testing
- Somatosensory Motor Control Exercises, Myofascial Release Technique, Sensorymotor training
- Where
- Pakistan
- Volunteers
- 74 people
- Sponsor
- Riphah International University
Lumbar Disc Herniation, Lumbar Spinal Stenosis
Long-term Outcomes of Surgical and Nonsurgical Management of Sciatica Secondary to a Lumbar Disc Herniation or Spinal Stenosis
The rate of success 12 months after surgery is reported to be 60-65% in patients with lumbar disc herniation and 60-70% in patients with spinal stenosis.
- Trial name
- NCT02836730
- Testing
- Low back pain surgery
- Where
- Denmark
- Volunteers
- 425 people
- Sponsor
- Back and Rehabilitation Center, Copenhagen
Sciatica, Lumbar Radiculopathy
Brain Mechanisms Supporting Cannabis-induced Pain Relief
Chronic low back pain is a common and disabling condition that affects millions of people in the United States. Many people with chronic low back pain do not get enough relief from current treatments.
- Conditions
- Sciatica, Lumbar Radiculopathy, Lower Back Pain, Degenerative Disc Disease
- Trial name
- NCT04982965
- Testing
- Active Cannabis
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Painful Lumbar Radiculopathy, Healthy
Phase 1 Subcutaneous Single and Multiple Ascending Dose Study of BG00010 (Neublastin)
The primary objective of the study is to evaluate the safety and tolerability of a range of single intravenous (IV) and subcutaneous (SC) doses of BG00010 in healthy volunteers, and a range of multiple SC doses of BG00010 in…
- Trial name
- NCT01842126
- Testing
- BG00010 IV, BG00010 SC
- Where
- Netherlands
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Biogen
Low Back Pain, Sciatica
BOL-DP-o-04 in Patients With Low Back Pain and Sciatica
The study is aimed to evaluate the pain-relieving effect of BOL-DP-o-04, in addition to SOC, on Low Back Pain and Sciatica.
- Trial name
- NCT04145310
- Testing
- BOL-DP-o-04 + SCO
- Where
- Israel
- Volunteers
- 26 people
- Sponsor
- Breath of Life International Pharma Ltd
Lumbosacral Radiculopathy
Does Magnetic Resonance Imaging (MRI) Improve Interventional Outcomes for Lumbosacral Radiculopathy?
Epidural steroid injections (ESI) are the most frequently performed procedures in pain clinics. When performing ESI, there is no consensus about how to best select candidates for this intervention, and which level(s) to inject.
- Trial name
- NCT00826124
- Testing
- Epidural steroid injection, Magnetic Resonance Imaging (MRI)
- Where
- 2 sites in United States
- Volunteers
- 131 people
- Sponsor
- Johns Hopkins University
Pelvic Organ Prolapse
Ischia Spinous Fascia Fixation Procedure Versus Modified Total Pelvic Floor Reconstructive Surgery for Pelvic Organ Prolapse Stage III
Pelvic organ prolapse is a common problem. The primary treatment is surgery. Ischia spinous fascia fixation procedure and modified total pelvic floor reconstructive surgery with mesh are both developed in China for vaginal apex…
- Trial name
- NCT01670682
- Testing
- ischia spinous fascia fixation, Modified Pelvic Floor Reconstruction Surgery with Mesh, polypropylene mesh(Gynemesh)
- Where
- 5 sites in China
- Volunteers
- 80 people
- Sponsor
- Peking Union Medical College Hospital
Sciatica Pain, Physical Therapy Modalities
Effectiveness of a Novel Neural Tissue Management to Improve Short-term Pain and Disability in Patients With Sciatica
Objectives: To analyse the effects of sciatic neural mobilisation, in combination to the treatment of the surrounding structures, on pain and disability.
- Conditions
- Sciatica Pain, Physical Therapy Modalities, Manual Therapies, Disability Evaluation
- Trial name
- NCT03663842
- Testing
- Physical therapy treatment
- Volunteers
- 44 people
- Sponsor
- Centro Universitário Augusto Motta