Clinical trials: Scaffolding
Coronary In-stent Restenosis
Restenosis Intrastent: Bioresorbable Vascular Scaffolds Treatment (RIBS VI)
Treatment of patients with in-stent restenosis (ISR) remains a challenge. This study will assess the efficacy of Bioresorbable Vascular Scaffolds (BVS) (Abbott Vascular) in the treatment of patients suffering from ISR.
- Trial name
- RIBS VI (NCT02672878)
- Testing
- Bioresorbable vascular scaffold
- Where
- 19 sites in Spain
- Volunteers
- 130 people
- Sponsor
- Spanish Society of Cardiology
Inguinal Hernia
Laparoscopic Hernia Defect Obliteration With ProFlor-E
This feasibility study highlights the features of the 3D dynamic responsive prosthesis ProFlor-E® for fixation free obliteration of inguinal hernia defect
- Trial name
- NCT04718298
- Testing
- ProFlor laparoscopic technique
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- University of Cagliari
Aortic Dissection Type B
Safety and Efficacy of TEVAR Combined With Long Bare-metal Stents in the Intervention of ATBAD
The primary objective of this study is to evaluate the safety and efficacy of the TEVAR combined with extended bare-metal stenting (distal landing zone ≥2 cm below renal arteries) in patients with acute complicated type B aortic…
- Trial name
- SAFE-COVER (NCT06892730)
- Testing
- Hybrid TEVAR combined with long bare-metal stent intervention
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Yan'an Affiliated Hospital of Kunming Medical University
Extracting Own Teeth, Bone Substitutes
Study of Alveolar Bone Preservation Using Photobiomodulation Combined With Grafting With Scaffold Biomaterial
Bone graft added to the dental socket immediately after tooth extraction prevents atrophy and deformity of the bone at the site of element loss, enabling rehabilitation with implants.
- Trial name
- NCT06150456
- Testing
- extraction, low level laser therapy, Plenum® OSShp and Plenum® Guide
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Nove de Julho
Percutaneous Transluminal Coronary Angioplasty
Everolimus-Eluting Bioresorbable Scaffolds Versus Everolimus-Eluting Metallic Stents for Diffuse Long Coronary Artery Disease
The purpose of this study is to determine whether ABSORB bioresorbable vascular scaffold is non-inferior to XIENCE everolimus-eluting cobalt-chromium stent with respect to target-lesion failure (TLF) at 1 year.
- Trial name
- ABSORB-LONG (NCT02831205)
- Testing
- everolimus-eluting bioresorbable vascular (Absorb) scaffold, everolimus-eluting cobalt-chromium (Xience) stent
- Where
- South Korea
- Volunteers
- 800 people
- Sponsor
- Duk-Woo Park, MD
Child Development Disorder, Child Development
Investigation of the Usability of the Dynamic Scaffolding System
The aim of the present study was to compare the duration of use of the Dynamic Scaffolding System (DSS) in children with different levels of motor impairment, to report adverse events during use, and to examine parental…
- Conditions
- Child Development Disorder, Child Development, Assistive Technology
- Trial name
- NCT05727046
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Karadeniz Technical University
Coronary Artery Disease, Angina, Unstable
Optimal Lesion Preparation With Non-compliant Balloons Before Implantation Of Bioresorbable Scaffolds
Study aim : To compare a novel strategy of lesion preparation with noncompliant balloons before implantation of BVS. Hypothesis: Predilatation with non-compliant balloons could facilitate optimal deployment of BVS.
- Conditions
- Coronary Artery Disease, Angina, Unstable, Angina, Stable
- Trial name
- OPreNBiS (NCT03518645)
- Testing
- OPN strategy, standard strategy
- Where
- Switzerland
- Volunteers
- 43 people
- Sponsor
- KCRI
Microtia, Outcome Assessment
Safety and Efficacy of Connecting the Residual Ear to the Cartilage Scaffold in First- vs. Second-Stage Surgery
Eligible patients will be admitted from the outpatient clinic to complete the relevant examinations after admission（Preoperative routine examination and chest CT）.
- Conditions
- Microtia, Outcome Assessment, RCT, Surgery Related Complications Rate
- Trial name
- NCT06763991
- Testing
- Two-stage connection, One-stage connection
- Where
- China
- Volunteers
- 78 people
- Sponsor
- Sichuan Provincial People's Hospital
Esophageal Adenocarcinoma
Evaluate Esophageal Reinforcement With ACell MatriStem Surgical Matrix: A Degradable Biologic Scaffold Material
The purpose of this study is to see if implanting MatriStem will lower the risk of one of the more common complications after stomach or esophagus surgery.
- Trial name
- NCT01970306
- Testing
- MatriStem PSM
- Where
- 4 sites in United States
- Volunteers
- 78 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Burns, Ulcers
Clinical Application of Autologous Three-Cellular Cultured Skin Substitutes (CSS)
The aim of this work was to present the investigators experience in the use of autologous three-cellular cultured skin substitutes (CSS) consisting of cultured keratinocytes, melanocytes and fibroblasts attached to a scaffold of…
- Conditions
- Burns, Ulcers, Giant Nevi
- Trial name
- NCT00718978
- Testing
- CSS grafting
- Where
- Italy
- Volunteers
- 11 people
- Sponsor
- University of Roma La Sapienza
Mastopexy
Circumferential Periareolar Mastopexy Using SERI Surgical Scaffold
The purpose of this study is to evaluate the clinical performance of SERI® Surgical Scaffold to maintain the size of the areola by providing additional soft tissue support after circumferential periareolar mastopexy.
- Trial name
- NCT02293798
- Testing
- silk surgical scaffold
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Mark Mofid MD
Peripheral Nerve Injuries
Preliminary Evaluation of the Clinical Safety and Effectiveness of the Bionic Nerve Scaffold
The objective of the study is to preliminarily evaluate the clinical safety and effectiveness of the bionic nerve scaffold with longitudinally oriented microchannels.
- Trial name
- NCT03780855
- Testing
- nerve scaffold
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Xijing Hospital
Surgical Incision
Silk Scaffold Surgical Incision Dressing
Interventional Study of the novel clinical application of SERI surgical silk scaffold affixed with dermaFLEX medical adhesive as a wound dressing, compared to two separate current standard of care for surgical incision closure…
- Trial name
- SSSID (NCT05508945)
- Testing
- Dermabond Prineo Skin Closure System, silk, 3M Steri-Strip
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Mehrdad Mark Mofid
Regeneration
Regenerative Ability of Immature Necrotic Permanent Teeth Using Different Scaffolds
The goal of this clinical trial is to compare effect of different scaffolds on the regenerative potential of young permanent immature teeth with necrotic pulp.
- Trial name
- regeneration (NCT06693739)
- Testing
- Platelet rich fibrin, hyaluronic acid, no scaffold
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Knee Injuries
Trial Comparing BST-CarGel and Microfracture in Repair of Articular Cartilage Lesions in the Knee
This study will investigate whether the treatment of damaged cartilage in the knee with BST-CarGel will increase the amount and quality of cartilage repair tissue when compared with microfracture alone.
- Trial name
- NCT00314236
- Testing
- BST-CarGel with Microfracture, Microfracture without BST-CarGel
- Where
- 18 sites in Canada, South Korea and 1 more
- Volunteers
- 80 people
- Sponsor
- Piramal Healthcare Canada Ltd
Wound of Skin, Non-melanoma Skin Cancer
Efficacy and Safety of a Nanofat-seeded Biological Scaffold in Healing Lower Limb Surgical Defects
Large full-thickness skin defects, such as those resulting from trauma, large and giant congenital nevi, disfiguring scars, or tumor resection remain major clinical problems to patients and physicians.
- Conditions
- Wound of Skin, Non-melanoma Skin Cancer, Skin Graft Complications, Wound of Lower Leg
- Trial name
- NCT03548610
- Testing
- Nanofat-seeded biological scaffold on surgical defect
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Diabetic Foot Ulcers (DFUs), Chronic Wound of the Lower Limb (Leg Ulcer or Foot Ulcer)
Miro3D Wound Matrix Study for Diabetic Foot Ulcers and Wound Healing
This study is a prospective, randomized controlled trial designed to evaluate the effectiveness of Miro3D Wound Matrix plus Standard of Care (SOC) compared to SOC alone in treating Wagner Grade 1 diabetic foot ulcers (DFUs) and…
- Trial name
- STRIDDDE (NCT06939686)
- Testing
- Miro3D Wound Matrix, Standard of Care (SOC)
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- Reprise Biomedical, Inc.
Coronary In-stnent Restenosis
Restenosis Intrastent: Treatment of Bioresorbable Vascular Scaffolds Restenosis
The treatment of patients with intra-stent restenosis (ISR) of Bioresorbable Vascular Scaffolds (Abbott Vascular) remains a challenge.
- Trial name
- RIBS VII (NCT03167424)
- Testing
- Treatment of restenosis
- Where
- 10 sites in Spain
- Volunteers
- 100 people
- Sponsor
- Spanish Society of Cardiology
Coronary Artery Disease, Atherosclerosis of Coronary Artery
Safety and Clinical Performance of the Freesolve Resorbable Magnesium Scaffold System in the Treatment of Subjects With Long de Novo Lesions
The study objective is the assessment of safety and clinical performance of Freesolve 35- and 40-mm in de novo coronary artery lesions up to 38 mm length.
- Conditions
- Coronary Artery Disease, Atherosclerosis of Coronary Artery, Myocardial Ischemia, Ischemic Heart Disease
- Trial name
- BIOMAG-LL (NCT07091682)
- Testing
- Implantation of a Sirolimus-Eluting Resorbable Coronary Magnesium Scaffold
- Where
- 14 sites in Germany, Hungary and 5 more
- Volunteers
- 100 people
- Sponsor
- Biotronik AG
Breast Reconstruction, Breast Cancer
Safety Study of 3D Printing Personalized Biodegradable Implant for Breast Reconstruction
Scope of tumor resection was simulated according to the MR imaging data. After meticulous design, the investigators created the personalized porous biodegradable scaffold and printed by 3D printer, using porous PCL biomaterials.
- Trial name
- NCT03348293
- Testing
- 3D printing
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Xijing Hospital