Clinical trials: Safety Study
Clinical Efficacy, Safety
Hodgkin Lymphoma Treatment With Adcetris and Levact in the Old Patient
Treatment outcome with ABVD in elderly patients remains inferior to adults. Moreover, Bleomycin-induced lung toxicity in the elderly has been reported as high as 46%.
- Trial name
- HALO (NCT02467946)
- Testing
- Adcetris-Levact
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Centre Antoine Lacassagne
Feasibility, Safety and Tolerability of Device
A 6-month Study on the Feasibility, Safety, and Tolerability of a Silicone Myofunctional Infant Pacifier
The goal of this interventional feasibility study is to learn about the feasibility, acceptability, and safety of a novel myofunctional pacifier in infants from birth to 6 months of age.
- Trial name
- NCT07793058
- Testing
- BREATHE myofunctional pacifier
- Where
- 2 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Keystone OrthotropiX
Safety, Tolerability
Phase 1/2 Clinical Study of HY07121 for Injection (Subcutaneous) in Patients With Advanced Solid Tumors
This is a multi-center, open-label, phase 1/2 study to evaluate the safety, efficacy, and pharmacokinetic (PK)/pharmacodynamic (PD) characteristics of HY07121 for Injection (Subcutaneous) in participants with advanced solid…
- Conditions
- Safety, Tolerability, Efficacy
- Trial name
- NCT07789327
- Testing
- Test Product HY07121 for Injection (Subcutaneous)
- Volunteers
- 254 people
- Sponsor
- Sichuan Huiyu Pharmaceutical Co., Ltd
Arrhythmia Recognition, Patient Safety Attitudes
Case-Based Collaborative Learning for Arrhythmia Recognition in Novice Intensive Care Nurses
This randomized controlled trial evaluates the effectiveness of case-based collaborative learning (CBCL) in improving arrhythmia recognition and patient safety attitudes among novice intensive care nurses.
- Conditions
- Arrhythmia Recognition, Patient Safety Attitudes, Arrhythmia
- Trial name
- NCT07780448
- Testing
- Case-Based Collaborative Learning-Based Arrhythmia Education
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Naile ALANKAYA
Suicide Prevention, Suicide Safety Planning
Suicide Safety Planning
The goal of this clinical trial is to learn the best way to provide suicide prevention care to adults receiving outpatient mental health care.
- Conditions
- Suicide Prevention, Suicide Safety Planning, Suicidal Ideation, Suicide Attempt
- Trial name
- STAY (NCT07783490)
- Testing
- Local Care Continuity, Centralized Care Navigation
- Where
- United States
- Volunteers
- 176,000 people
- Sponsor
- Kaiser Permanente
Rotator Cuff Tears, Muscle Atrophy or Weakness
E-CEL UVEC Cells as an Adjunct Cell Therapy for the Arthroscopic Rotator Cuff Repair in Adults
This is a phase 1b investigator-initiated clinical trial that will evaluate the safety and feasibility of E-CEL UVEC® cells with the aim of improving outcomes for patients with full-thickness rotator cuff tears who undergo…
- Conditions
- Rotator Cuff Tears, Muscle Atrophy or Weakness, Tendon Rupture - Shoulder, Safety Issues
- Trial name
- NCT04057833
- Testing
- E-CEL UVEC
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Hospital for Special Surgery, New York
Infant Sleep Safety
Animation-Supported Infant Sleep Safety Education
The aim of this research is to evaluate the effect of animation-supported sleep safety training on the knowledge and attitudes of pediatric nurses.
- Trial name
- NCT07771348
- Testing
- Animation-Supported Infant Sleep Safety Education
- Where
- Turkey (Türkiye)
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Marmara University
Efficacy and Safety
Clinical Study of Fospropofol Disodium for Injection in the Painless Endoscopic Diagnosis and Treatment
This is a study on the efficacy and safety of fospropofol disodium for injection in painless endoscopic diagnosis and treatment, project No.2024-YCRF-M1021, which will take more than 2 years to complete.
- Trial name
- NCT06732427
- Testing
- fospropofol Disodium for injection, Propofol
- Where
- 5 sites in China
- Volunteers
- 426 people
- Sponsor
- Affiliated Hospital of Nantong University
Tolerability, Safety, Immunogenicity and Pharmacokinetic of JS005
Phase I Study of Comparing Single Dose JS005 (Recombinant Humanized Monoclonal Antibody Against IL-17A) With Placebo in Tolerability, Safety, Immunogenicity and Pharmacokinetic in Healthy Volunteers
JS005-001 is one randomized, double-blind, placebo-controlled study to evaluate the tolerability, safety, immunogenicity and pharmacokinetic profile of single dose of JS005 injection in healthy volunteers.
- Trial name
- NCT04220073
- Testing
- JS005 (recombinant humanized monoclonal antibody against IL-17A)
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Shanghai Junshi Bioscience Co., Ltd.
Healthy Participants Study, Overweight and Obese Adults
A Single and Multiple Ascending Dose Trial Assessing Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ZP6590 in Participants With Normal Weight, Overweight and Obesity
The goal of this clinical trial is to learn about the safety and tolerability of drug ZP6590 and to learn how the body processes the drug ZP6590 in adults.
- Conditions
- Healthy Participants Study, Overweight and Obese Adults, First in Man Study to Evaluate Initial Safety
- Trial name
- NCT07721597
- Testing
- ZP6590, solution for injection
- Where
- Germany
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Zealand Pharma
Lethal Means Safety
Leveraging Video Vignettes and Social Media to Promote Safe Firearm Storage Among Veterans
Family and friends are trusted by Veterans, and can play a vital role in supporting Veteran suicide prevention. Veterans are more likely to adopt secure firearm storage if their loved ones discuss firearm safety with them and if…
- Trial name
- WAV (NCT07756697)
- Testing
- WAV videos, VA News videos, VA LMS brochure
- Where
- United States
- Volunteers
- 654 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Cultural Safety, Medical Education
Evaluating in Person Curriculum for Educating Obstetrical Residents on Better Caring for 2 Spirit Metis Patients Using and AI Assisted OSCE.
Two-Spirit (2S) Métis individuals often encounter significant barriers and discrimination in healthcare settings. This multisite randomized controlled feasibility trial evaluates a novel artificial intelligence (AI)-assisted…
- Conditions
- Cultural Safety, Medical Education, Cultural Competency
- Trial name
- NCT07760675
- Testing
- 2S Métis Cultural Safety Academic Half Day &AI-OSCE, Standard Institutional Cultural Safety Training&AI-OSCE
- Where
- 3 sites in Canada
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
NAD+ Bioavailability, NAD+ Safety
A Clinical Trial to Assess the Absorption, Safety, and Efficacy of an Oral Nicotinamide Adenine Dinucleotide (NAD+) Supplement in Healthy Adults
The goal of this clinical trial is to assess the absorption, safety, and efficacy of an NAD+ supplement in healthy adults. The main question it aims to answer is: What is the change in NAD+ levels in whole blood from baseline to…
- Conditions
- NAD+ Bioavailability, NAD+ Safety, NAD+ Efficacy
- Trial name
- NCT07692633
- Testing
- NAD+
- Where
- Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Reus Research
Safety and Tolerability in Healthy Volunteers
Phase 1 Trial to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of TRT-448 in Healthy Adult Subjects
Phase 1, Randomized, Double-blind, Placebo-controlled, Single Ascending and Multiple Ascending Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of TRT-448 in Healthy Adult Subjects
- Trial name
- TRT-448-101 (NCT07745751)
- Testing
- TRT-448
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Trotana, Inc.
Safety Issues, Pain
Role of a CCK Receptor Antagonist Proglumide in Management of Chronic Pancreatitis
Chronic pancreatitis is a rare but debilitating condition associated with chronic abdominal pain, diarrhea, diabetes, and an 8-fold increased risk for the development of pancreatic cancer.
- Conditions
- Safety Issues, Pain, Pancreas Fibrosis
- Trial name
- ProCP (NCT05551858)
- Testing
- Proglumide
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Georgetown University
Safety Issues, Tolerance
Phase I Study to Evaluate KP405 in Healthy and Parkinson's Disease Patients
This study will explore the safety, pharmacokinetics (PK) and pharmacodynamics (PD) of KP405 as a potential new treatment for Parkinson's disease.
- Trial name
- NCT06189170
- Testing
- KP405
- Where
- United Kingdom
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Kariya Pharmaceuticals
Efficacy and Safety of Short-course Radiotherapy in Total Neoadjuvant Therapy Combined With Enlonstobart for pMMR Locally Advanced Rectal Cancer
Short-course Radiotherapy in TNT Combined With Enlonstobart for pMMR LARC
Efficacy and safety of short-course radiotherapy in total neoadjuvant therapy combined with enlonstobart for pMMR locally advanced rectal cancer
- Trial name
- NCT07448077
- Testing
- Experimental: short-course radiotherapy and immunotherapy, Chemoradiotherapy
- Where
- China
- Volunteers
- 128 people
- Sponsor
- Hebei Medical University Fourth Hospital
Safety, Tolerability
A First-in-Human SAD and MAD Study in Healthy Participants to Evaluate Oral YR011 Tablet
This is a Phase I clinical trial (protocol number: YR-011-B01) sponsored by Hangzhou Yirui Pharmaceutical Technology Co., Ltd., focusing on the novel oral small-molecule drug YR011 (active ingredient: PA032, a Kv1.3 channel…
- Conditions
- Safety, Tolerability, Pharmacokinetics
- Trial name
- NCT07285967
- Testing
- Kv1.3 potassium channel blocker (PA032, investigational oral small-molecule drug)
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Hangzhou Yirui Pharmaceutical Technology Co., Ltd
Patient Safety Education
Blended Learning for Patient Safety Education in Nursing and Midwifery Students
Patient safety education is important for preparing nursing and midwifery students to recognize risks, prevent avoidable harm, and provide safe care.
- Trial name
- NCT07736755
- Testing
- Blended Patient Safety Education, Face-to-Face Patient Safety Education
- Where
- Turkey (Türkiye)
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Mardin Artuklu University
Hospital Fire Safety Preparedness
Augmented Reality for Hospital Fire Safety
This study evaluated the effectiveness of augmented reality-based hospital fire-safety education among hospitalized patients and accompanying caregivers.
- Trial name
- NCT07732959
- Testing
- Augmented Reality Fire-Safety Education, Traditional Fire-Safety Education
- Where
- Taiwan
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- Chou Yun Jyuan