Clinical trials: SCI - Spinal Cord Injury
SCI - Spinal Cord Injury
Double Dose 4-AP on Functional Recovery After Spinal Cord Injury
The purpose of this study is to test a strategy to potentiate functional recovery of lower limb motor function in individuals with spinal cord injury (SCI). The FDA approved drug, Dalfampridine (4-AP).
- Trial name
- NCT06853015
- Testing
- Dalfampridine, STDP stimulation, Exercise training
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Shirley Ryan AbilityLab
Acute Spinal Cord Injury
Early FES Cycling in Acute Spinal Cord Injury for Neuromuscular Preservation and Neurorecovery
Spinal cord injury (SCI) is a devastating condition that often leads to paralysis and multiple health problems such as muscle wasting, bone loss and spasticity.
- Trial name
- NCT05255679
- Testing
- Early FES, Delayed FES
- Where
- Canada
- Volunteers
- 35 people
- Sponsor
- University of Alberta
Tetraplegia, Spinal Cord Injuries
Nerve Transfer After Spinal Cord Injury- Multi-center
Current treatment strategies of acute cervical spinal cord injuries remain limited. Treatment options that provide meaningful improvements in patient quality of like and long-term functional independence will provide a…
- Conditions
- Tetraplegia, Spinal Cord Injuries, Quadriplegia Flaccid
- Trial name
- NCT04023591
- Testing
- Surgery/Occupational Therapy
- Where
- 9 sites in United States, Canada
- Volunteers
- 70 people
- Sponsor
- Washington University School of Medicine
Spinal Cord Injuries, Neuropathic Pain
Evaluation of Initiation Time on the Efficacy of Gabapentin in Treating Neuropathic Pain in SCI
Neuropathic pain is a common complaint in those with spinal cord injury (SCI) that has a significant negative effect on quality of life. Efficacy of various treatments, however, remains controversial.
- Trial name
- NCT04256603
- Testing
- Gabapentin, No gabapentin
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- MetroHealth Medical Center
Spinal Cord Injury, Respiratory Muscle Weakness
Albuterol to Improve Respiratory Strength in SCI
Spinal cord injury (SCI), especially involving the cervical and upper thoracic segments, can significantly compromise respiratory muscle function.
- Trial name
- NCT02508311
- Testing
- Oral Albuterol Extended Release
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- VA Office of Research and Development
Spinal Cord Injury, Chronic Pressure Ulcers
Subcutaneous Injection and Ultrasonic Dispersion of Cefazolin Into Chronic Pelvic-Region Pressure Ulcers in Persons With Spinal Cord Injury
Pressure ulcers (PU) are skin breakdowns that often form after blood flow in the skin is reduced from prolonged and repeated exposure to externally applied forces.
- Trial name
- NCT02584426
- Testing
- Ultrasonic Distribution of Cefazolin
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Incomplete Spinal Cord Injury
Neurofeedback to Improve Spasticity After Incomplete Spinal Cord Injury
After incomplete spinal cord injury (iSCI), many people still have control over their upper and/or lower limbs, but secondary conditions such as spasticity impair the function they have left.
- Trial name
- NCT04849676
- Testing
- visual neurofeedback
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- NHS Greater Glasgow and Clyde
Spinal Cord Injury, Orthostatic Hypotension
Prevention of Orthostatic Hypotension With Electric Stimulation in Persons With Acute SCI
Background: The presence of orthostatic hypotension (OH) as a consequence of blood volume redistribution during verticalisation in persons with spinal cord injury (SCI) is a common condition.
- Trial name
- NCT01891110
- Testing
- ES of the abdominal muscles, ES of the limb muscles, ES of limbs & abdomen
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Swiss Paraplegic Research, Nottwil
Cervical Myelopathy
Timing of Rehabilitation Following Cervical Spinal Surgery in Degenerative Myelopathy
The goal of this clinical trial is to learn whether starting rehabilitation earlier after surgery can improve recovery and is feasible and acceptable for adults with degenerative cervical myelopathy (DCM) undergoing cervical…
- Trial name
- NCT07636135
- Testing
- Physical Therapy
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of Alberta
Wheelchair Users, Caregivers
New Rear Anti-tip Device for Manual Wheelchairs: Subjective Input (RAD-SI)
The objective of this study is to obtain subjective input from wheelchair service providers and end-users about their experiences with conventional rear anti-tip devices (C-RADs) of manual wheelchairs and the potential usefulness…
- Conditions
- Wheelchair Users, Caregivers, Wheelchair Service Providers, Amputation
- Trial name
- RAD-SI (NCT06831240)
- Testing
- Local wheelchair service provider questionnaires, Global wheelchair service provider questionnaires, End-users questionnaires
- Where
- Canada
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Nova Scotia Health Authority
Spinal Cord Injuries
TENS Trial to Prevent Neuropathic Pain in SCI
The purpose of this research study is to: 1) test whether transcutaneous electrical nerve stimulation (TENS) after spinal cord injury can reduce the onset of post-injury neuropathic pain; and 2) to learn more about this kind of…
- Trial name
- TENS (NCT03267810)
- Testing
- TENS
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Miami
Spinal Cord Injuries
Clinical Trial Using Bone Marrow-derived Mononuclear Cells for Spinal Cord Injury
The purpose of study is to determine whether autologous mononuclear cells deriving from the bone marrow are effective in the treatment of spinal cord injury.
- Trial name
- DNH (NCT02923817)
- Testing
- Transplantation of autologous bone marrow-derived mononuclear cells by lumbar injection
- Where
- Vietnam
- Volunteers
- 30 people
- Sponsor
- Da Nang Hospital
Spinal Cord Injury
Paraplegic Cycling: Improving Health After Spinal Cord Injury
Surface electrical stimulation has for many years been widely used to retrain paralysed muscle and achieve the functions of standing and stepping.
- Trial name
- NCT00204100
- Testing
- Surface Functional Electrical Stimulation
- Where
- 2 sites in United Kingdom
- Volunteers
- 5 people
- Sponsor
- University of Glasgow
Spinal Cord Injuries
Randomized Controlled Trial on Robotic Exoskeleton in Spinal Cord Injury: Clinical Outcomes and Cortical Plasticity
The recent introduction of robotics for locomotor training in paraplegic patients, and in particular the use of anthropomorphic exoskeletons, has opened new frontiers in rehabilitation.
- Trial name
- NCT03443700
- Testing
- EKSO-GT, Standard neurorehabilitation locomotor training
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Azienda Usl di Bologna
SCI - Spinal Cord Injury
The Efficacy of Upper Extremity Wearable Robotic Orthosis on Improving Upper Extremity Motor Function and Activities of Daily Living in Persons With Spinal Cord Injury
To evaluate the usefulness of an upper extremity (UE) assistive device, called (MyoPro) in improving upper extremity activities in people with incomplete spinal cord injury (iSCI)
- Trial name
- MyoMo in SCI (NCT04855812)
- Testing
- MyoMo, Myo-SB, Control
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Kessler Foundation
Spinal Cord Injury
The Effect of Probiotic and Prebiotic Supplementation on Gastrointestinal Health in Individuals With Chronic Spinal Cord Injury
The goal of this clinical trial is to evaluate the effect of probiotic and prebiotic supplementation in individuals with chronic spinal cord injury experiencing gastrointestinal complaints.
- Trial name
- PRO-GIDSCI (NCT06870331)
- Testing
- Probiotic, Prebiotic
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- Swiss Paraplegic Research, Nottwil
Spinal Cord Injuries
Efficacy and Safety of hUC-MSCs and hUCB-MSCs in the Treatment of Chronic Spinal Cord Injury
There is evidence that human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) can differentiate into oligodendrocytes and neurons, and improve the recovery of nerve function, which strongly suggests the feasibility…
- Trial name
- NCT04213131
- Testing
- Stem cell transplantation
- Where
- China
- Volunteers
- 42 people
- Sponsor
- The First Affiliated Hospital of Dalian Medical University
Incomplete Spinal Cord Injury
Device-induced Intermittent Hypoxia in Persons With Incomplete Spinal Cord Injury
Spinal cord injury (SCI) is a devastating disability with physical, social and vocational consequences. Owing to its overwhelming complications, the cost of treatment and rehabilitation increases constantly.
- Trial name
- NCT05491837
- Testing
- Device induce acute intermittent hypoxia 9 % of Oxygen, Normoxia 21% of oxygen
- Where
- Pakistan
- Volunteers
- 68 people
- Sponsor
- Riphah International University
Spinal Cord Injuries, Muscle Spasticity
Cyproheptadine and Chlorpromazine Effects on Spasticity
The main goal of this research is to understand the neuronal mechanisms that mediate the development of spasticity and motor dysfunction after spinal cord injury.
- Trial name
- NCT01509885
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Spinal Cord Injury
Enhancing Quality of Life Through Exercise: A Tele-Rehabilitation Approach
Pilot randomized controlled trial evaluating a Self-Determination Theory (SDT) video-based tele-rehabilitation physical activity intervention aimed to enhance basic psychological needs, motivation, physical activity (PA), and…
- Trial name
- NCT02833935
- Testing
- Physical Activity Intervention
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- The Craig H. Neilsen Foundation
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