Clinical trials: SARS-CoV2
COVID-19
Treatments for COVID-19: Canadian Arm of the SOLIDARITY Trial
This study is an adaptive, randomized, open-label, controlled clinical trial, in collaboration with countries around the world through the World Health Organization.
- Trial name
- CATCO (NCT04330690)
- Testing
- Artesunate, Imatinib, Infliximab
- Where
- 53 sites in Canada
- Volunteers
- 2,900 people
- Sponsor
- Sunnybrook Health Sciences Centre
Mental Disorder, COVID
Psychotherapy Strategies for the Treatment of Professionals and Students From Essential Services With High Levels of Emotional Distress in the Context of COVID-19
The study consists in a pragmatic superiority randomized controlled trial comparing different strategies of psychotherapy for professionals and students from essential services with high levels of emotional distress during the…
- Conditions
- Mental Disorder, COVID, Emotional Distress, Depression
- Trial name
- NCT04635618
- Testing
- Cognitive Behavioral Brief-Telepsychotherapy, Brief Interpersonal Telepsychotherapy, Telepsychoeducation
- Where
- Brazil
- Volunteers
- 999 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Post COVID-19 Condition, Long COVID
Study to Evaluate the Efficacy and Safety of Ampligen in Patients With Post-COVID Conditions
The purpose of this study is to assess the efficacy and safety of Ampligen® administered twice weekly by intravenous (IV) infusions in subjects experiencing the Post-COVID Condition of fatigue.
- Trial name
- NCT05592418
- Testing
- Rintatolimod
- Where
- 5 sites in United States
- Volunteers
- 80 people
- Sponsor
- AIM ImmunoTech Inc.
COVID, Corona Virus Infection
Study Assessing Vagus Nerve Stimulation in CoViD-19 Respiratory Symptoms
The study is a prospective, randomized, controlled investigation designed for comparison of two groups for the reduction of respiratory distress in a CoViD-19 population, using gammaCore Sapphire (nVNS) plus standard of care…
- Conditions
- COVID, Corona Virus Infection, Respiratory Failure, Respiratory Distress Syndrome, Adult
- Trial name
- SAVIORII (NCT04382391)
- Testing
- gammaCore® Sapphire (non-invasive vagus nerve stimulator), Standard of care therapies
- Where
- 2 sites in United States
- Volunteers
- 21 people
- Sponsor
- Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
Respiratory Tract Infections
Comparison of Nasopharyngeal Swab v. Nasopharyngeal Saline Wash or Saliva Collection in Testing for Respiratory Viruses
Respiratory tract infections (RTIs) are prevalence community diseases and is the third leading cause of death worldwide. Rapid diagnosis of RTIs is essential as it drives decision points such as treatment, disposition, and…
- Trial name
- NCT05864118
- Testing
- Respiratory pathogen panel PCR test, COVID-19 antibody test
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- University of Nebraska
SARS (Disease)
Cyclosporine For The Treatment Of COVID-19(+)
Phase IIa clinical trial in which 75 non-ICU hospital inpatients will be randomized 2:1 to 7 days of an oral formulation of cyclosporine, Neoral (2.5mg/kg PO BID) + standard of care (SOC) or no Neoral + SOC.
- Trial name
- NCT04492891
- Testing
- Cyclosporine, Standard of Care Treatment
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Bryan Burt, MD
COVID-19
A Clinical Trial on Booster Immunization of Two COVID-19 Vaccines Constructed From Different Technical Routes
This is an open-label, randomized, parallel-controlled clinical trial conducted in people aged 18 years and older to evaluate the immunogenicity and safety of two SARS-CoV-2 bivalent vaccines constructed by adenovirus type…
- Trial name
- NCT05886790
- Testing
- Prototype and Omicron BA.4/5 Bivalent Recombinant COVID-19 Vaccine(Adenovirus Type 5 Vector) For Inhalation, Bivalent COVID-19 mRNA Vaccine, Recombinant COVID-19 Vaccine (Adenovirus Type 5 Vector) For Inhalation
- Where
- China
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Zhongnan Hospital
COVID-19
Randomized Proof-of-Concept Trial to Evaluate the Safety and Explore the Effectiveness of Resveratrol, a Plant Polyphenol, for COVID-19
Resveratrol is a plant polyphenol (that is sold commercially as a supplement) that might help fight coronavirus as well as help protect the body from the effects of disease (COVID-19) caused by the infection.
- Trial name
- NCT04400890
- Testing
- Resveratrol, Vitamin D3
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- Marvin McCreary, MD
Kidney Transplant, Pancreatic Transplat
SARS-CoV2 (COVID-19) Seroepidemiological Transplanted Subjects (Kidney, Kidney-pancreas, Pancreas, Langerhans Islets)
Evaluate SARS-CoV2 infection and the degree of immunity possibly developed in transplanted population using the Luciferase Immuno Precipitation System (LIPS) test.
- Conditions
- Kidney Transplant, Pancreatic Transplat, Pancreatic Islets Langerhans
- Trial name
- NCT04487197
- Testing
- blood sample for seroepidemiological investigation
- Where
- Italy
- Volunteers
- 282 people
- Sponsor
- Antonio Secchi
Covid19, Sars-CoV-2 Infection
Management of Cytokine Storms in Severe COVID-19 Patients With Autologous Activated Platelet-rich Plasma Therapy
The positive cases of coronavirus disease-2019 (COVID-19) in Indonesia has been increasing rapidly since the first case found in March 2020 to date.
- Conditions
- Covid19, Sars-CoV-2 Infection, ARDS, Human, Severe covid19
- Trial name
- NCT04715360
- Testing
- autologous activated platelet-rich plasma, Avigan
- Where
- Indonesia
- Volunteers
- 30 people
- Sponsor
- Hayandra Peduli Foundation
COVID-19
Recombinant Bacterial ACE2 Receptors -Like Enzyme of B38-CAP Could be Promising Treatment for COVID-19 Infection- and Its Inflammatory Complications Better Than Recombinant Human ACE2
Recombinant Bacterial ACE2 receptors -like enzyme of B38-CAP could be promising treatment for COVID-19 infection- and Its inflammatory complications better than recombinant human ACE2 Mahmoud ELkazzaz(1),Tamer Haydara(2),Yousry…
- Trial name
- Bacterial ACE2 (NCT04375046)
- Testing
- Recombinant Bacterial ACE2 receptors -like enzyme of B38-CAP (rbACE2)
- Volunteers
- 24 people
- Sponsor
- Kafrelsheikh University
Long Covid19, Exercise Intolerance
Restoring Energy With Sub-symptom Threshold Optimized Rehabilitation Exercise for Long COVID
The overall goal of this study is to find out if rehabilitation exercise can help people who have long COVID. Participants will be randomized by chance to receive either aerobic exercise or breathing exercise (combined with…
- Conditions
- Long Covid19, Exercise Intolerance, Riboflavin-Responsive
- Trial name
- RESToRE (NCT06172803)
- Testing
- Restoring Energy with Sub-symptom Threshold Aerobic Rehabilitation Exercise, Light Stretching/Breathing Exercises
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Columbia University
Covid19, SARS CoV-2
Capturing Infectious COVID-19 Asymptomatic Cases in Singapore
This study is being conducted to assess the performance of the BD Veritor™ Plus System for Rapid Detection of SARS-CoV-2, used in serial testing, in identification of infectious, asymptomatic individuals.
- Trial name
- NCT04812327
- Testing
- BD Veritor Plus System for Rapid Detection of SARS CoV-2, rt-PCR, viral culture
- Where
- Singapore
- Sponsor
- Becton, Dickinson and Company
Post-COVID Condition
Nutritional Intervention and Rehabilitation Treatment in Patients With Post-COVID Condition
SARS-CoV-2 is the coronavirus responsible for developing the disease known as COVID-19. Once the acute phase of the disease has passed, about 40% of the people who discharged continue to have symptoms, and of these, between 50…
- Trial name
- ARACOV-02 (NCT06063031)
- Testing
- Active
- Where
- Spain
- Volunteers
- 146 people
- Sponsor
- Instituto de Investigación Sanitaria Aragón
COVID-19, Pneumonia, Viral
SOLIRIS® (Eculizumab) Treatment of Participants With COVID-19
This protocol provides access to eculizumab treatment for participants with severe COVID-19.
- Conditions
- COVID-19, Pneumonia, Viral, Acute Lung Injury/Acute Respiratory Distress Syndrome (ARDS)
- Trial name
- NCT04355494
- Testing
- eculizumab
- Where
- 12 sites in United States, France
- Sponsor
- Alexion Pharmaceuticals, Inc.
COVID-19, SARS-CoV 2
Trial to Promote Recovery From COVID-19 With Endocrine Therapy
Patients with COVID-19 requiring inpatient hospitalization will be randomized to treatment with standard of care or standard of care + bicalutamide.
- Trial name
- RECOVER (NCT04374279)
- Testing
- Bicalutamide 150 Mg Oral Tablet
- Where
- United States
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
COVID-19, SARS-CoV 2
Tannin Specific Natural Extract for COVID-19 Infection
There is an urgent need to evaluate interventions that could be effective against the infection with SARS-CoV 2. Tannins based wood extracts are an inexpensive and safe product with protective effect in both bacterial and viral…
- Conditions
- COVID-19, SARS-CoV 2, Coronavirus Infection
- Trial name
- TanCOVID (NCT04403646)
- Testing
- ARBOX
- Where
- Argentina
- Volunteers
- 124 people
- Sponsor
- Hospital de Clinicas José de San Martín
COVID19
Clinical Trial to Evaluate the Efficacy of Food Supplement Manremyc® Against SARS- COV-2 Infection (COVID-19) in Healthcare Workers
The purpose of this study is to assess the efficacy of Manremyc® food supplement for reduce the incidence of SARS-CoV-2 infection in a high risk population, as healthcare workers.
- Trial name
- NCT04452773
- Testing
- Manremyc
- Where
- 5 sites in Spain
- Volunteers
- 315 people, healthy volunteers welcome
- Sponsor
- Reig Jofre Group
SARS-CoV-2 Infection
Cross-sectional Study of COVID-19 Infection in Hospital Health Personnel
The objective of the study is to determine the percentage of past SARS-CoV-2 infections in hospital health personnel involved in the care of people with COVID-19 in HUGTiP and in Badalona Serveis Assistencials de Badalona.
- Trial name
- NCT04466462
- Where
- 2 sites in Spain
- Volunteers
- 1,000 people
- Sponsor
- Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia
Coronavirus, SARS-CoV-2 Infection
Next Generation T-cell Vaccine Against Coronavirus Disease (COVID-19)
The study aims to investigate the safety and immunogenicity of one dose vs two doses of a T-cell priming next-generation vaccine against Coronavirus disease.
- Conditions
- Coronavirus, SARS-CoV-2 Infection, COVID-19
- Trial name
- NCT05633446
- Testing
- PepGNP-COVID19 (One vaccination), Water for injection (One vaccination), PepGNP-COVID19 (Two vaccinations)
- Where
- 2 sites in Philippines
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Gylden Pharma Ltd