Clinical trials: Root Canal Infection
Root Canal Infection
Evaluation of Post Operative Pain Following Reciprocating and Rotary Heat-treated NiTi Instrumentation of Root Canals: a Randomized Controlled Clinical Trial
The present clinical evaluation was planned for comparing the post-operative pain incidence in maxillary premolar teeth with acute irreversible pulpitis treated by recently introduced heat treated TruNatomy TM and other widely…
- Trial name
- NCT04655105
- Testing
- root canal rotary files
- Where
- India
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Tamil Nadu Dr.M.G.R.Medical University
Root Canal Infection, Periapical; Infection
Bacteria Elimination in Retreatment Cases Using Different Disinfection Techniques
Nonsurgical root canal retreatment may become essential when the initial endodontic treatment fails because of the persistent intracanal or extracanal infections.It has been stated that the one of the main cause of posttreatment…
- Trial name
- NCT03750162
- Testing
- VDW Ultra, AMD picasso, ProtaperNext X3 gutta-percha
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Bulent Ecevit University
Apical Periodontitis, Root Canal Infection
Clinical Investigation of Chemomechanical Parameters for an Efficient Disinfection of the Root Canal
The aim of the study is first, to evaluate the clinical antibacterial efficacy of two different NaOCl concentrations (2,5% and 5%) under a predefined irrigant flow rate in teeth with pulp necrosis and apical periodontitis by…
- Trial name
- ENDOA (NCT06949176)
- Testing
- Root canal tratment using mecchanical and chemical preparation., Sodium Hypochlorite., Hydrogen peroxide.
- Where
- Greece
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- National and Kapodistrian University of Athens
Root Canal Infection
One-visit Root Canal Treatment Using Chlorhexidine as a Final Irrigant
A hundred asymptomatic molar teeth with periapical lesions were treated in single versus multiple visit root canal treatment. Half of the teeth were randomly assigned to the one-visit (OV) group and received an additional final…
- Trial name
- NCT05006209
- Testing
- One visit root canal treatment, Two visit root canal treatment
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ege University
High Grade Anal Canal Squamous Intraepithelial Neoplasia, Human Immunodeficiency Virus
Development of a Health-Related Symptom Index for Participants With and Either Treated or Monitored for Anal High-Grade Squamous Intraepithelial Lesions
This trial develops a health-related symptom index for participants with and either treated or monitored for anal high-grade squamous intraepithelial lesions.
- Trial name
- NCT04276935
- Testing
- Interview, Quality-of-Life Assessment, Questionnaire Administration
- Where
- 4 sites in United States
- Volunteers
- 20 people
- Sponsor
- AIDS Malignancy Consortium
Root Canal Infection, Periapical Periodontitis
Sealer-Based Obturation With AH Plus Bioceramic Sealer vs. Warm Vertical Compaction With AH Plus
The goal of this clinical trial is to assess the efficacy and outcome of sealer-based obturation (SBO) using a new calcium silicate sealer in comparison with warm vertical compaction (WVC) using a resin-based sealer, which is the…
- Conditions
- Root Canal Infection, Periapical Periodontitis, Periapical Diseases
- Trial name
- NCT05763420
- Testing
- AH Plus Bioceramic Sealer, AH Plus Sealer (resin-based)
- Where
- Kuwait
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Ministry of Health, Kuwait
Periapical Lesion, Periapical Periodontitis
Comparing Two Medicines for Healing Jaw Bone Infections After Root Canal Treatment
This study compares two commonly used intracanal medicaments-Triple Antibiotic Paste and Calcium Hydroxide-in patients with infected single-rooted teeth.
- Trial name
- NCT07239739
- Testing
- Triple Antibiotic Paste, Calcium Hydroxide (Ca(OH)2)
- Volunteers
- 62 people
- Sponsor
- Faiz ur rahman
Root Canal Infection, Periapical Diseases
Microbial Load After Apical Enlargement in Asymptomatic Teeth With Periapical Lesion
The goal of this observational study is to define the role of apical shaping and irrigation activation on root canal cleanliness.
- Conditions
- Root Canal Infection, Periapical Diseases, Periapical; Infection, Endodontic Disease
- Trial name
- NCT06035185
- Testing
- apical shaping size
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Root Canal Infection, Periapical Abscess
Comparing Different Single and Combination Chelating Agents on Sealer Penetration and Dentin Erosion.
The basic aim of root canal treatment is to reduce the microbial content and prevent further recontamination in the canal. Every tooth has a variable, complex canal anatomy consisting of ramifications, accessory and lateral…
- Conditions
- Root Canal Infection, Periapical Abscess, Irreversible Pulpitis, Apical Periodontitis
- Trial name
- NCT05778227
- Testing
- Ethylene Diamine Tetra Acetic acid, smearOFF, Etidronic acid /sodium hypochlorite
- Where
- Pakistan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Dow University of Health Sciences
Postoperative Pain
Effect of Root Canal Treatment (Versus no Treatment) for Patients With Tooth Infections and Toothaches
The purpose of this study is to evaluate patients with emergency pain and a sore (infected) tooth to determine if immediate root canal therapy is better at reducing pain, when compared to initial treatment with antibiotic and…
- Trial name
- NCT01870973
- Testing
- root canal treatment, anesthesia, pain medications, and antibiotic, no root canal treatment, anesthesia, pain medications, and antibiotic
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- Ohio State University
Escherichia Coli Infections
Detection of Biofilm Among Uropathogenic Escherichia Coli Clinical Isolates in Suez Canal University Hospitals
This descriptive cross-sectional study will beconducted in Suez Canal University Hospitals (SCUHs) in Ismailia, Egypt. The study aims to detect Escherichia coli biofilm producers to improve prognosis and treatment and reduce…
- Trial name
- NCT06252428
- Where
- Egypt
- Volunteers
- 47 people
- Sponsor
- Suez Canal University
Apical Periodontitis, Dental Pulp Necrosis
Chitosan Irrigation in Premolar Root Canal Therapy (Randomized Trial)
The goal of this clinical trial is to learn which of three common root-canal rinsing (irrigation) methods removes bacteria most effectively in adult patients who need root-canal treatment.
- Conditions
- Apical Periodontitis, Dental Pulp Necrosis, Root Canal Infection
- Trial name
- CHITO-PRE RCT (NCT07048028)
- Testing
- Chitosan Low Molecular Weight (20-200 Mpa.S), Sodium Hypochlorite, EDTA chelating agents
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- ESRA DAĞCI
Pulpitis - Irreversible, Pulp Necroses
Lesion Sterilization Tissue Repair and Conventional Pulpectomy in Primary Molars
The aim of this study was to compare the clinical and radiographic success of conventional root canal treatment and lesion sterilisation tissue repair methods in deciduous molars with necrotic or irreversible pulpitis.
- Conditions
- Pulpitis - Irreversible, Pulp Necroses, Root Canal Infection
- Trial name
- NCT06811636
- Testing
- Lesion sterilization and tissue repair, Conventional pulpectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Çanakkale Onsekiz Mart University
Root Canal Infection, Bisphosphonate-Associated Osteonecrosis
Root Canal Treatment Outcome in Patients Under Bisphosphonate Therapy
The aim of this study was to evaluate the survival rate and healing time of compromised teeth and seriously compromised teeth that were endodontically treated in patients which received bisphosphonate therapy .
- Conditions
- Root Canal Infection, Bisphosphonate-Associated Osteonecrosis, Periapical Abscess, Endodontically Treated Teeth
- Trial name
- NCT04399720
- Testing
- Root canal treatment
- Volunteers
- 111 people
- Sponsor
- University of Bologna
Root Canal Infection
Effect of Apical Negative Pressure Irrigation System at Cleaning Lateral Canals and Reduction of Periapical Lesions After Endodontic Therapy
The aim of the present study is to assess with PA x-rays and CBCT scans the volumetric changes in periapical radiolucencies in endodontically treated teeth 1 year after endodontic treatment and evaluate how well the lateral…
- Trial name
- NCT03384004
- Testing
- Irrigation Technique 1, Irrigation Technique 2
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- KaVo Kerr
Pulp Necrosis, Root Canal Infection
Comparison of Ultrasonic vs 980-nm Diode Laser Irrigant Activation for Reducing Residual Bacterial DNA in Necrotic Teeth
This randomized clinical trial aimed to compare residual oral bacterial DNA detection after ultrasonic irrigant activation and 980-nm diode laser irrigant activation during root canal treatment of necrotic single-rooted teeth.
- Trial name
- NCT07607028
- Testing
- Ultrasonic Activation, 980-nm Diode Laser Activation
- Where
- Indonesia
- Volunteers
- 16 people
- Sponsor
- Hasanuddin University
HSIL, High Grade Squamous Intraepithelial Lesions, Anal Cancer
A Safety and Efficacy Trial of Circumferential Anal Canal Radiofrequency Ablation for High-Grade Anal Intraepithelial Neoplasia Using the BARRX™ Anorectal Wand
The purpose of this research is to assess the safety and effectiveness of circumferential radiofrequency ablation (RFA) to the anal canal using the BarrxTM Ablation System to destroy anal high-grade squamous intraepithelial…
- Conditions
- HSIL, High Grade Squamous Intraepithelial Lesions, Anal Cancer, HPV-Related Squamous Cell Carcinoma, Human Papilloma Virus
- Trial name
- NCT03302858
- Testing
- BARRX™ Anorectal Wand
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Stephen E. Goldstone
Periapical Periodontitis, Root Canal Infection
Antibacterial Efficacy of Bioceramic and Calcium Hydroxide Intracanal Medicaments
This study evaluates the antibacterial effectiveness of two different intracanal medicaments, Bio-C Temp and UltraCal XS , in mandibular molar teeth with chronic apical periodontitis.
- Conditions
- Periapical Periodontitis, Root Canal Infection, Intracanal Medicaments
- Trial name
- NCT07671326
- Testing
- Root canal treatment with Bio-C Temp, a calcium silicate-based bioceramic intracanal medicament, Root canal treatment with UltraCal XS, a calcium hydroxide-based intracanal medicament
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Medipol University
Dental Caries, Pulp Necrosis
Moringa Oleifera vs Sodium Hypochlorite for Root Canal Irrigation in Nonvital Primary Molars
This randomized clinical trial aims to evaluate and compare the antimicrobial efficacy of Moringa Oleifera leaf extract versus sodium hypochlorite as root canal irrigants in pulpectomy of nonvital primary molars in pediatric…
- Conditions
- Dental Caries, Pulp Necrosis, Primary Tooth Pulpectomy, Pediatric Dentistry
- Trial name
- MORvNAOCL (NCT06971055)
- Testing
- Sodium hypochlorite, Moringa Oleifera Leaf Extract
- Where
- Egypt
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Cairo University
Endodontic Disease, Endodontically Treated Teeth
Outcome of Endodontic Retreatment in One or Two Visits
This study is a prospective randomized controlled study of patients who come to the University and non-surgical root canal retreatment is considered as the election of choice in presence of periapical disease.
- Conditions
- Endodontic Disease, Endodontically Treated Teeth, Root Canal Infection
- Trial name
- NCT04527705
- Testing
- Non-surgical root canal retreatment
- Where
- Spain
- Volunteers
- 110 people
- Sponsor
- Universitat Internacional de Catalunya