Clinical trials: Root Canal
Endodontic Disease
Effect of Music on Young Practitioner's Stress During Endodontic Treatment
According to several studies, patients consider endodontic treatment as one of the most stress-inducing dental procedures. Two studies demonstrated that music enables the patient to be less stressed during RCT.
- Trial name
- MUSIQUENDO (NCT04471558)
- Testing
- Music
- Where
- France
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Anterior Cruciate Ligament Tear, Pain, Postoperative
Evaluation of Exparel Adductor Canal Field Block for Pain Control After ACL Reconstruction
This is a prospective, randomized study for adult patients presenting to the Carilion Clinic Institute of Orthopedics and Neurosurgery. Patients undergoing isolated ACL reconstruction will be eligible for inclusion.
- Conditions
- Anterior Cruciate Ligament Tear, Pain, Postoperative, Opioid Use
- Trial name
- NCT04764916
- Testing
- Liposomal bupivacaine, Bupivacaine Hydrochloride
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Carilion Clinic
Anesthesia, Local
Combined Intravenous Dexamethasone and Dexmedetomidine as Adjuncts to Popliteal and Saphenous Nerve Blocks in Patients Undergoing Orthopaedic Surgery of the Foot and Ankle
The investigators will investigate the beneficial and harmful effects of combining dexamethasone (12 mg) and dexmedetomidine (1mcg/kg) as adjuncts to popliteal and saphenous nerve blocks in patients undergoing surgery of their…
- Trial name
- ADJUNCT2 (NCT04818749)
- Testing
- Saline, Dexamethasone 12 mg, Dexamethasone 12 mg + dexmedetomidine 1 mcg/kg
- Where
- 2 sites in Denmark
- Volunteers
- 120 people
- Sponsor
- Zealand University Hospital
Anterior Cruciate Ligament Injury
Effect of Adding Vastus Medialis Nerve Block to Adductor Canal Block After Anterior Cruciate Ligament Reconstruction
Anterior cruciate ligament (ACL) reconstruction is frequently associated with moderate to severe postoperative pain, which can delay mobilization and rehabilitation.
- Trial name
- VAMA (NCT07683078)
- Testing
- Adductor Canal Block (ACB) Only, Vastus Medialis Nerve Block
- Where
- Turkey (Türkiye)
- Volunteers
- 104 people
- Sponsor
- Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization
Squamous Cell Carcinoma of the Head and Neck, Anal Canal Cancer
Combination of UCPVax Vaccine and Atezolizumab for the Treatment of Human Papillomavirus Positive Cancers (VolATIL)
70% all cases of cervical cancer, 95% of anal cancers and about 70% of oropharyngeal cancers are linked to Human Papillomavirus (HPV) infection. HPV oncogenic proteins are trans-activators of telomerase.
- Conditions
- Squamous Cell Carcinoma of the Head and Neck, Anal Canal Cancer, Cervical Cancer
- Trial name
- VolATIL (NCT03946358)
- Testing
- Blood sample collection, Tumor biopsies, CT scan
- Where
- 4 sites in France
- Volunteers
- 47 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Pain, Postoperative
Ibuprofen Versus Ibuprofen/Acetaminophen Postoperatively in Patients Needing Root Canal Therapy
Aim: The purpose of this study was to compare ibuprofen versus an ibuprofen/acetaminophen combination for postoperative pain control in patients requiring root canal treatment with a tooth that is painful to cold and biting.
- Trial name
- NCT03631433
- Testing
- Ibuprofen 600 mg, ibuprofen 600 mg and acetaminophen 650 mg
- Volunteers
- 102 people
- Sponsor
- Ohio State University
Asymptomatic Apical Periodontitis
Evaluation of Postoperative Pain After Using Resin-Based and Bioceramic Sealers in Mandibular Molars With Asymptomatic Apical Periodontitis
This study aims to evaluate the effect of two different root canal sealers-BioRoot RCS (a bioceramic-based sealer) and AH Plus (a resin-based sealer)-on postoperative pain following single-visit root canal treatment in mandibular…
- Trial name
- NCT07289633
- Testing
- BioRoot RCS, AH Plus
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- AZİZ ŞAHİN ERDOĞAN
Endodontic Treatment
Disinfection Effect of Gaseous Ozone
The current study aimed to investigate the effect of gaseous ozone in disinfection the root canals of primary teeth. Thirty-six primary molars of 36 completely healthy patients (aged 5-10) were included in the study.The included…
- Trial name
- NCT06470126
- Testing
- 2.5% NaOCl group: The interventions performed in the study are root- canal therapies and disinfection procedure of these therapies., 0.9% sterile saline solution combined with 80 seconds: The OzonyTronX® interventions performed in the study are root- canal therapies and disinfection procedure of these therapies., 2.5% NaOCl with 80 seconds OzonyTronX®:The interventions performed in the study are root- canal therapies and disinfection procedure of these therapies.
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Ankara University
Cancer That is Associated With a Chronic Viral Infection, p16 Positive SCCHN
Avelumab With Valproic Acid in Virus-associated Cancer
Up to 20% of all cancers may be associated with a bacterial or viral infection. In some instances, the infection may be one of the reasons why the cancer developed in the first place.
- Conditions
- Cancer That is Associated With a Chronic Viral Infection, p16 Positive SCCHN, Squamous Cell Carcinoma of the Cervix, p16 Positive Squamous Cell Carcinoma of the Vagina or Vulva
- Trial name
- LATENT (NCT03357757)
- Testing
- Valproic Acid, Avelumab
- Where
- Canada
- Volunteers
- 39 people
- Sponsor
- AHS Cancer Control Alberta
Acute Pain, Total Knee Arthroplasty
Adductor Canal Block in Outpatient Clinic for Pain Control After Knee Arthroplasty
Single-shot Adductor Canal Block in the outpatient clinic is safe, significantly decreased pain and analgesic consumption and may enhance the rehabilitation program
- Trial name
- ACB (NCT04883034)
- Testing
- adductor canal block in outpatient clinic, Analgesics, etoricoxibe
- Where
- Indonesia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Gadjah Mada University
Endodontic Disease
Effect of Different Root Canal Instruments on Removal of Endotoxins From Necrotic Root Canals
Grouping: The patients will be randomly assigned into two equal groups Group : OneShape Group: ProtaperNext Endodontics procedure steps: 1.
- Trial name
- NCT03641612
- Testing
- one shape, protaper next
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Heba Elasfouri
Post-endodontic Pain
Comparison Of The Effect Of Final Rinse Of Tramadol and Dexamethasone on Post-Endodontic Pain in Teeth With SIP
Briefly, 105 teeth with symptomatic irreversible pulpitis will be included in the study and randomly allocated to three groups (A, B and C).
- Trial name
- NCT07036237
- Testing
- Tramadol group, Dexamethasone Group
- Where
- Pakistan
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Dow University of Health Sciences
Endodontic Disease, Post Operative Pain
Effect of Post-Operative Anesthetics on Post-Operative Pain in Patients Receiving Endodontic Treatment
This study will assess the efficacy of two local anesthetics (2% lidocaine 1:100,000 epinephrine and 0.5% bupivicaine 1:200,000 epinephrine) in reducing post-operative pain in patients receiving endodontic treatment.
- Conditions
- Endodontic Disease, Post Operative Pain, Symptomatic Irreversible Pulpitis
- Trial name
- NCT05338671
- Testing
- Local anesthetic
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Washington
Squamous Cell Carcinoma of External Auditory Canal, Locally Advanced Tumor
Induction Chemotherapy Combined With Tislelizumab for Locally Advanced Squamous Cell Carcinoma of the External Auditory Canal
To evaluate the efficacy and safety of induction chemotherapy combined with tislelizumab as neoadjuvant therapy in patients with locally advanced squamous cell carcinoma of the external auditory canal; to explore the improvement…
- Trial name
- NCT07370337
- Testing
- Tislelizumab
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Eye & ENT Hospital of Fudan University
Lumbar Spinal Stenosis
Minimal Invasive Surgery Versus Interlaminar Decompression in Lumbar Canal Stenosis
Conventional open surgery has been shown to be an effective procedure for LCS decompression. Minimally invasive surgery (MIS) through tubular retractors is a recently introduced alternative procedure for decompression of LCS.
- Trial name
- NCT05147064
- Testing
- minimally invasive surgery, conventional open surgery
- Volunteers
- 40 people
- Sponsor
- Assiut University
Pulpitis, Periapical Lesions
Success of Endodontic Treatment With Different Obturation Techniques and Sealer Cements
The present study aims to compare the radiographic success of endodontic treatment using Orstavik's criteria between two sealers: AH Plus (Dentsply DeTrey, Konstanz, Germany) and Neosealer Flo (Avalon Biomed, Bradenton, Florida…
- Conditions
- Pulpitis, Periapical Lesions, Periapical Periodontitis, Periapical Pathology
- Trial name
- NCT07019298
- Testing
- AH Plus (Dentsply Sirona, Charlotte, NC, USA), NeoSealer Flo, Continuous Wave Condensation
- Where
- Spain
- Volunteers
- 270 people
- Sponsor
- University of Siena
Inferior Alveolar Approximation, Implants
CBCT-Based Safety Distance for Implant Placement Near the Inferior Alveolar Canal
o evaluate the radiologic proximity of mandibular dental implants placed less than 2 mm from the inferior alveolar canal using cone-beam computed tomography (CBCT), and to determine the relationship between implant-canal distance…
- Trial name
- NCT07363239
- Testing
- nerve approximation group
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Cairo University
Knee Osteoarthritis
Effectiveness of Ultrasound Guided Adductor Canal Block on Chronic Pain in Knee Osteoarthritis
Adductor canal block has become popular as effective mean for pain relief following knee surgery.This block has not been checked in chronic pain patients.The purpose of this study is to assess the efficacy and safety of adductor…
- Trial name
- NCT02695654
- Testing
- Levobupivacaine, Clonidine
- Where
- Slovenia
- Volunteers
- 77 people
- Sponsor
- Mensur Salihovic
Knee Osteoarthritis, Osteoarthritis, Knee
US-Guided Saphenous Block in Knee OA
The purpose of this prospective, randomized, open-label, active-controlled clinical trial is to evaluate the clinical and sonographic effects of ultrasound-guided (US-guided) high-volume saphenous nerve block combined with…
- Conditions
- Knee Osteoarthritis, Osteoarthritis, Knee, Gonarthrosis, Knee Pain
- Trial name
- SAPH-KNEE-OA (NCT07868770)
- Testing
- Intra-articular corticosteroid injection, Ultrasound-Guided High-Volume Saphenous Nerve Block, Home-Based Exercise Program
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Gaziler Physical Medicine and Rehabilitation Education and Research Hospital
Asymptomatic Irreversible Pulpitis
Effect of Apical Third Enlargement to Different Taper and Master Apical Preparation Size on Periapical Healing and Postoperative Pain After Primary Single Sitting Non Surgical Root Canal Treatment
To Determine Effect Of Apical Third enlargement To Different Taper And Master Apical Preparation Size On Periapical Healing And Postoperative Pain After Primary Single Sitting Non Surgical Root Canal Treatment : A Randomized…
- Trial name
- NCT07166679
- Testing
- root canal treatment with 2% taper, root canal treatment with 4% taper, root canal treatment with 6 %taper
- Where
- India
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak