Clinical trials: Risk for Colorectal Cancer
Anxiety Disorder, Cognitive/Functional Effects
Health Education Materials With/Out a Physical Activity Program for Patients Who Have Undergone Treatment for High-Risk Stage II or Stage III Colon Cancer
RATIONALE: Participating in a physical activity program designed to increase free time physical activity and receiving written health education materials may influence the chance of cancer recurring as well as impact on physical…
- Conditions
- Anxiety Disorder, Cognitive/Functional Effects, Colorectal Cancer, Depression
- Trial name
- CHALLENGE (NCT00819208)
- Testing
- exercise intervention, counseling intervention, educational intervention
- Where
- 47 sites in United States, Australia and 4 more
- Volunteers
- 889 people
- Sponsor
- Canadian Cancer Trials Group
Colo-rectal Cancer, Shared Decision Making
Shared Decision-Making for Colorectal Cancer Screening in High-Risk First-Degree Relatives Aged 40-49
The primary objective of this study was to evaluate the impact of a constructed shared decision (SDM) intervention (offering an option between colonoscopy and immunochemical collapsible occult blood testing (fecal immunochemical…
- Conditions
- Colo-rectal Cancer, Shared Decision Making, Patient Decision Aid
- Trial name
- NCT07503847
- Testing
- Colonoscopy, Shared Decision-Making
- Where
- Taiwan
- Volunteers
- 2,286 people
- Sponsor
- National Taiwan University Hospital
Colorectal Cancer
Community Based Screening for Colorectal Cancer in an Underserved High Risk Population in Nigeria
Patient age 45 year old and above who presented with rectal bleeding at three tertiary hospitals in South West Nigeria were invited for colonoscopy. The clinical information of the patients and the colonoscopy data were analyzed
- Trial name
- NCT03032874
- Testing
- Colonoscopy
- Where
- Nigeria
- Volunteers
- 100 people
- Sponsor
- Obafemi Awolowo University Teaching Hospital
Breast Cancer, Prostate Cancer
Physical Activities by Technology Help (PATH)
PATH is a research study for cancer survivors to help participants to become more active. Studies suggested an association between inactivity and cancer.
- Conditions
- Breast Cancer, Prostate Cancer, Lung Cancer, Colorectal Cancer
- Trial name
- PATH (NCT03212079)
- Testing
- Mycoach Smart Text, MyCoach on Amazon Alexa
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Johns Hopkins University
Colon Cancer
Combined Colon and Endometrial Cancer Screening in Women With HNPCC
Primary Objectives: To test the feasibility of combined colon and endometrial cancer screening in women with increased risk for colon and endometrial cancer. To measure patient satisfaction for the combined procedure.
- Trial name
- NCT00510796
- Testing
- Interview
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- M.D. Anderson Cancer Center
Febrile Neutropenia, Stage 0 Breast Cancer
S1415CD, Trial Assessing CSF Prescribing Effectiveness and Risk (TrACER)
This randomized clinical trial studies prophylactic colony stimulating factor management in patients with breast, colorectal or non-small cell lung cancer receiving chemotherapy and with risk of developing febrile neutropenia.
- Conditions
- Febrile Neutropenia, Stage 0 Breast Cancer, Stage 0 Colorectal Cancer, Stage 0 Non-Small Cell Lung Cancer
- Trial name
- TrACER (NCT02728596)
- Testing
- Preventive Intervention, Quality-of-Life Assessment, Questionnaire Administration
- Where
- 160 sites in United States, Puerto Rico
- Volunteers
- 3,665 people
- Sponsor
- SWOG Cancer Research Network
Pancreatic Cancer, Gastrointestinal Neoplasms
Permission to Collect Blood Over Time for Research
To determine whether biomarkers assessed in blood samples can be used to detect individuals at risk for developing blood clots or worsening of their underlying disease.
- Conditions
- Pancreatic Cancer, Gastrointestinal Neoplasms, Colon Rectal Cancer Adenocarcinoma, Esophageal Cancer
- Trial name
- NCT00767234
- Testing
- Observation
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- Stanford University
Colorectal Neoplasms Malignant, Colonoscopy
Sensitivity of Fecal Immunochemical Test (FIT) for Colorectal Cancer (CRC) Screening
Fecal immunochemical test (FIT) was introduced in France late 2015, FIT has better diagnostic accuracy for colorectal cancers (CRCs) than previous screening tests.
- Conditions
- Colorectal Neoplasms Malignant, Colonoscopy, Early Detection of Cancer, Female
- Trial name
- FITBACK (NCT05163236)
- Testing
- Positive fecal immunochemical test (FIT), Negative fecal immunochemical test (FIT), Fecal immunochemical test (FIT) not performed
- Where
- France
- Volunteers
- 1,149 people
- Sponsor
- University Hospital, Brest
Rectal Adenocarcinoma, High-Risk Cancer
SCRT+mFOLFOX6+PD-1 Antibody and Targeted Therapy for High-Risk pMMR/MSS Rectal Cancer
To explore the efficacy and safety of short-course radiotherapy combined with mFOLFOX6, PD-1 monoclonal antibody and cetuximab (for RAS/BRAF Wild-Type)/bevacizumab (for RAS/BRAF Mutant) in High-Risk pMMR/MSS Rectal Adenocarcinoma…
- Conditions
- Rectal Adenocarcinoma, High-Risk Cancer, MSS
- Trial name
- CRIT (NCT06908031)
- Testing
- Short-Course Radiotherapy, PD-1 monoclonal antibody, mFOLFOX6 regimen
- Where
- China
- Volunteers
- 49 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Risk of Breast Cancer, Risk of Gynaecological Cancer
Cohort Evaluation of Body Fluids Early Detection of Cancer in High-risk Individuals
LEAH is a prospective, observational, single-centre, non-randomised, open-label study of people at increased risk of cancer or malignant disease.
- Conditions
- Risk of Breast Cancer, Risk of Gynaecological Cancer, Risk of Colorectal Cancer, Risk of Upper Gastrointestinal Cancers
- Trial name
- LEAH (NCT06907095)
- Testing
- biological samples
- Where
- France
- Volunteers
- 5,909 people
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Screening Colonoscopy for Low Risk Subjects
First in Man Aer-O-Scope
A single center study intended to evaluate the Aer-O-Scope Colonoscope System.
- Trial name
- NCT02102412
- Testing
- screening colonoscopy
- Where
- Croatia
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- GI View Ltd.
Anal Dysplasia, Human Papillomavirus
The HPV-SAVE Study Team: HPV Screening and Vaccine Evaluation in Men Who Have Sex With Men
Human papillomavirus (HPV) is the most common sexually transmitted infection worldwide. Infection by certain high-risk oncogenic types of HPV (HR-HPV) is the major cause of several cancers in men, notably squamous cell carcinoma…
- Conditions
- Anal Dysplasia, Human Papillomavirus, Anal Cancer
- Trial name
- HPV-SAVE (NCT02503111)
- Testing
- The Hyfrecator ® 2000 Electrosurgical System, Observation Alone
- Where
- 4 sites in Canada
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Colorectal Cancer, Early Onset Colorectal Cancer
Exogenous and Endogenous Risk Factors for Early-onset Colorectal Cancer
An increase in early-onset colorectal cancers (eoCRC), defined as a CRC before 50 years, is confirmed globally. CRC pathogenesis has been associated with several risk factors (family history, germline pathogenic variants…
- Conditions
- Colorectal Cancer, Early Onset Colorectal Cancer, Diet Habit, Risk Reduction
- Trial name
- DEMETRA (NCT05732623)
- Testing
- Semi Quantitative Food Frequency Questionnaire (SQFFQ)
- Where
- 8 sites in United States, Finland and 4 more
- Volunteers
- 2,300 people, healthy volunteers welcome
- Sponsor
- San Raffaele University
Colo-rectal Cancer
Blood Collection Sub-Study for CRC Screening in Individuals 45-49 at Average Risk for CRC.
The primary objective of this sub-study, 2018-10B, is to collect blood specimens to assess new biomarkers for the detection of Colorectal Cancer (CRC).
- Trial name
- NCT03741166
- Testing
- Blood Sample Collection
- Where
- 37 sites in United States
- Volunteers
- 871 people, healthy volunteers welcome
- Sponsor
- Exact Sciences Corporation
Peritoneal Carcinomatosis, Peritoneal Metastases
Diagnostic Value of Diffusion-weighted Magnetic Resonance in High-risk Colorectal and Appendiceal Neoplasms
Diffusion-weighted magnetic resonance imaging (DWI/MRI) has been described in recent literature as a highly sensitive and specific modality for the detection of peritoneal metastases PM.
- Conditions
- Peritoneal Carcinomatosis, Peritoneal Metastases, Appendix Cancer, Appendix Neoplasm
- Trial name
- DWI-HighRisk (NCT05623787)
- Testing
- Whole-body diffusion-weighted magnetic resonance imaging
- Where
- 2 sites in Canada
- Volunteers
- 30 people
- Sponsor
- Laval University
Glucose Metabolism Disorders, Colon Cancer
COLONIC RESECTION FOR CANCER AS DIABETOGENIC RISK FACTOR
Colon cancer (CC) survivors have an increased risk of developing T2D. A recent study revealed that the surgical procedures per se may be causally involved. Hence, left-sided colon resections increased the risk of developing T2D.
- Conditions
- Glucose Metabolism Disorders, Colon Cancer, Surgery, Chemotherapy Effect
- Trial name
- COLECDIAB (NCT04649567)
- Where
- 2 sites in Denmark
- Volunteers
- 60 people
- Sponsor
- Hvidovre University Hospital
Colorectal Cancer, Surgical Resection of the Colorectal Tumor
The Immunoscore as a Prognostic Marker for Patients With a Colorectal Cancer
Medical and Scientific Background: Colorectal cancers (CRC) are the leading cancers in both genders. This cancer is of prognostic severity. The prognosis of this cancer has not been significantly improved.
- Trial name
- IMMUCOL (NCT01688232)
- Where
- 6 sites in France
- Volunteers
- 459 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Colorectal Cancer, Peritoneal Metastases
Prophylactic HIPEC for Colorectal Cancers at High Risk of Developing Peritoneal Metastases
The study investigators hypothesize that prophylactic HIPEC is feasible and well tolerated in patients with colorectal cancers with high-risk of developing peritoneal recurrence.
- Trial name
- NCT03422432
- Testing
- HIPEC
- Where
- Singapore
- Volunteers
- 17 people
- Sponsor
- National Cancer Centre, Singapore
Colon Cancer Stage II, Colon Cancer Stage III
Neoadjuvant FOLFOXIRI Versus Immediate Surgery for Stage II and III Colon Cancers
BACKGROUND: In patients with high risk stage II and stage III colon cancer (CC), curative surgery followed by adjuvant chemotherapy with FOLFOX or CAPOX regimens has become a standard treatment.
- Trial name
- NCT05194878
- Testing
- neoadjuvant chemotherapyI, Colectomy, adjuvant chemotherapy
- Where
- China
- Volunteers
- 840 people
- Sponsor
- Sun Yat-sen University
Colorectal Cancer
ASPirin Intervention for the REDuction of Colorectal Cancer Risk
This research study is investigating the use of aspirin as a potential chemopreventive agent to reduce risk of colorectal cancer
- Trial name
- ASPIRED (NCT02394769)
- Testing
- Aspirin
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Massachusetts General Hospital