Clinical trials: Risk Stratification
Crohn Disease (CD), Ulcerative Colitis (UC)
IBD Biomarker Discovery and Validation Platform
The goal of this observational study is to establish a multicenter prospective clinical and biospecimen platform for biomarker discovery and validation in inflammatory bowel disease, including Crohn's disease and ulcerative…
- Conditions
- Crohn Disease (CD), Ulcerative Colitis (UC), Inflammatory Bowel Diseases (IBD)
- Trial name
- IBD-BIOP (NCT07686406)
- Where
- 2 sites in China
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Sepsis, Septic Shock
Molecular Diagnosis and Risk Stratification of Sepsis in India
Background: Globally, sepsis is common with an estimated population incidence of 437 cases per 100, 000 person-years and acute mortality of 26%, one of the few major medical conditions whose incidence and resulting mortality…
- Conditions
- Sepsis, Septic Shock, Sepsis Syndrome
- Trial name
- MARS-India (NCT03727243)
- Where
- India
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Cardiovascular Diseases
Precision Medicine Study on Cardiovascular Disease (PRECISE)
Cardiovascular diseases are the leading cause of death in China and have become a financial burden on society under the traditional medical model.
- Trial name
- PRECISE (NCT04434911)
- Where
- China
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- China National Center for Cardiovascular Diseases
Postoperative Complications
Derivation and Validation of the Extended Care (Ex-Care) Model II
The goal of this study is to develop a novel surgical risk stratification tool designed to adults operated in Brazil. The main question it aims to answer is: •Is the Extended Care (Ex-Care) II model a good tool to assess the risk…
- Trial name
- Ex-CareII (NCT05796024)
- Where
- Brazil
- Volunteers
- 107,372 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
Gastrointestinal Hemorrhage
Artificial Intelligent Clinical Decision Support System Simulation Center Study for Technology Acceptance
The purpose of this research study is to measure the effect on of a large language model interface on the usability, attitudes, and provider trust when using a machine learning algorithm-based clinical decision support system in…
- Trial name
- NCT05816473
- Testing
- LLM
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Yale University
Prostate Cancer, Polygenic Risk Score
Polygenic Risk Stratification Combined With mpMRI to Identify Clinically Relevant Prostate Cancer
The goal of this clinical trial is to evaluate a screening method to detect clinically relevant prostate cancer. This clinical trial is using genetic data to determine a man's risk of cancer, together with multiparametric…
- Trial name
- PRS (NCT06398639)
- Testing
- Polygenic Risk Score (PRS)
- Where
- 5 sites in United States
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Adam S. Kibel, MD
Anti-Tumor Drug-Associated Interstitial Pneumonia
Research on Early Diagnosis and Risk Stratification Biomarkers of Anti-Tumor Drug-Associated Interstitial Pneumonia Driven by Multi-Omics Integration
This study aims to construct an early diagnostic biomarker panel and risk stratification model for anti-tumor drug-related ILD through integrative analysis of multi-omics data including genomics, transcriptomics, proteomics, and…
- Trial name
- NCT07190703
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Fuzhou University Affiliated Provincial Hospital
Hypertension
Emerging Biomarkers in Hypertension
First of all to evaluate the relationship between non-conventional biomarkers and essential hypertension; then to evaluate the effects of various anti-hypertensive drugs on blood pressure control and non-conventional biomarkers…
- Trial name
- NCT02064218
- Testing
- Anti-hypertensive drugs
- Where
- Italy
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Pavia
Vasomotor Symptoms, Urinary Incontinence
Nurse-led Primary Healthcare Intervention Model in Women's Health Management in Hong Kong
The goal of this randomized clinical trial is to learn if a nurse-led primary healthcare intervention can help improve health management in women adults aged 45 to 64, and to develop an evidence-based primary healthcare model for…
- Conditions
- Vasomotor Symptoms, Urinary Incontinence, Anxiety, Depression - Major Depressive Disorder
- Trial name
- JCDATAZONEWH (NCT06628388)
- Testing
- Nurse-Led Risk-Based 5As Primary Healthcare Model, Minimal Intervention
- Where
- 3 sites in Hong Kong
- Volunteers
- 1,728 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Cervix Cancer, HPV Testing
Screening Triage and Risk Stratification
To investigate the performance of cytology, extended genotyping, p16/Ki67 dual stain cytology, DNA methylation and viral load as triage markers in post-menopausal HPV-screen-positive women aged 50-64 years in the organized…
- Conditions
- Cervix Cancer, HPV Testing, Postmenopausal Women
- Trial name
- I-share (NCT05727228)
- Testing
- cytology, p16/ki67 dual stain cytology (DS), extended genotyping, DNA methylation, viral load,
- Where
- Denmark
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Long QT Syndrome, Sudden Cardiac Death
Electromechanical Profiling of the Long-QT Syndrome (LQTS)
High-resolution, non-invasive electromechanical mapping in genotyped long-QT syndrome patients and healthy controls at baseline and during smart provocation.
- Conditions
- Long QT Syndrome, Sudden Cardiac Death, Ventricular Tachycardia
- Trial name
- EMLoQ (NCT04074122)
- Testing
- Adenosine and epinephrine, isoprenaline provocation
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Heart Failure, Diastolic, Multicenter Study
Diagnosis and OutcoMes evaluAtIoN of Multicenter Patients With HFpEF Using Multimodality Imaging
The incidence of Heart failure with preserved ejection fraction (HFpEF) in Heart failure patients increases rapidly. However, the current clinical awareness is insufficient, and the cardiac structural and functional injury are…
- Trial name
- NCT04602338
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Gestational Diabetes Mellitus
Stratification of Risk of Diabetes in Early Pregnancy
Hyperglycaemia in Pregnancy or Gestational Diabetes Mellitus (GDM) is one of the most common obstetric medical conditions which when undetected can cause significant adverse outcomes for the mother and the offspring.
- Trial name
- STRiDE (NCT03005600)
- Where
- 2 sites in India, Kenya
- Volunteers
- 7,400 people, healthy volunteers welcome
- Sponsor
- University of Warwick
Chronic Pancreatitis, Pancreatic Cancer
Blood Biomarkers and Gut Microbiota for Pancreatic Cancer Risk in Chronic Pancreatitis
The goal of this observational study is to learn more about pancreatic cancer risk in people with chronic pancreatitis. Researchers will study blood markers and gut microorganisms, which are bacteria and other microbes living in…
- Trial name
- NCT07762950
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Latent Tuberculosis
Determining Risk in Latent Tuberculosis
Background: Tuberculosis (TB) is a leading cause of death worldwide. Those who are exposed to the TB bacteria but have not become sick are said to have latent TB.
- Trial name
- NCT01571739
- Where
- South Korea
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Pregnancy-Associated Heart Disease, Fetal Congenital Heart Disease
Maternal-Fetal Heart Sound/Electrocardiogram Monitoring and Cardiac Risk Early Warning
This is a prospective observational cohort study conducted at Beijing Anzhen Hospital. The study aims to establish reference ranges of heart sound and electrocardiogram (ECG) parameters for both mothers and fetuses.
- Conditions
- Pregnancy-Associated Heart Disease, Fetal Congenital Heart Disease, Autoimmune-Related Fetal Heart Block, Perinatal Adverse Events
- Trial name
- NCT07526662
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Yihua He,MD
Clinical High Risk for Psychosis (CHR), Clinical High Risk for Psychosis
Stratification and Treatment in Early Psychosis Study - PROMOTE
The purpose of this trial is: To investigate whether cannabidiol (CBD), compared to placebo, can reduce the severity of attenuated psychotic symptoms in individuals at clinical high risk for psychosis.
- Conditions
- Clinical High Risk for Psychosis (CHR), Clinical High Risk for Psychosis, Clinical High Risk for Developing Psychosis
- Trial name
- STEP-PROMOTE (NCT07434973)
- Testing
- Cannabidiol (CBD)
- Where
- 19 sites in Austria, Canada and 8 more
- Volunteers
- 586 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Valvular Heart Disease Stenosis and Regurgitation
Natriuretic Peptides as a Prognostic and Risk Stratification Tool in Assessment of Valvular Heart Disease
NPs can be used To detect subset of asymptomatic with subtle LV dysfunction for further evaluation and earlier referral for intervention and its correlation with echocardiographic finding.
- Trial name
- NCT05439369
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Assiut University
Cardiovascular Diseases (CVD), Coronary Artery Disease
wCAR-Austria: A Women-Specific Score to Assess Cardiovascular Risk in Women Aged 40 to 65
The wCAR-Austria Study is a multicentre, prospective, interventional study evaluating a novel women-specific cardiovascular risk score (wCAR) in 800 women aged 40-65 years across Austria.
- Conditions
- Cardiovascular Diseases (CVD), Coronary Artery Disease, Atheroscleroses
- Trial name
- wCAR-Austria (NCT07849127)
- Testing
- Arm 1: wCAR-CARE - Precision Prevention (Arm A), Guideline-directed standard of care
- Where
- Austria
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Women's Heart Austria
Risk Stratification
QRS Microfragmentation in ECG as Predictor of Mortality and Morbidity - a Retrospective Analysis
Over the past decades, several ECG-based parameters have been identified as independent predictors of worsened prognosis in affected patients.
- Trial name
- NCT06011590
- Testing
- No intervention.
- Volunteers
- 150,000 people, healthy volunteers welcome
- Sponsor
- Medical University Innsbruck