Clinical trials: Risk Reduction
Opioid Use Disorder, Infectious Disease
Addressing Risk Through Community Treatment for Infectious Disease and Opioid Use Disorder Now (ACTION) Among Justice-involved Populations
This is a 5-year Hybrid Type 1 Effectiveness-Implementation Randomized Control Trial (RCT) that compares two models of linking and retaining individuals recently released from justice involvement to the continuum of…
- Conditions
- Opioid Use Disorder, Infectious Disease, Risk Reduction Behavior, Substance Use
- Trial name
- ACTION (NCT05286879)
- Testing
- Patient Navigator, Mobile Health Unit
- Where
- 3 sites in United States
- Volunteers
- 601 people
- Sponsor
- Yale University
Risk Reduction, Environmental Exposure
Monitoring Environmental Exposures and Behavioral Change
The goal of this study is to examine what effect real-time feedback on particulate matter (PM) air pollution levels has on risk recognition and behavior.
- Conditions
- Risk Reduction, Environmental Exposure, Risk Behavior, Health
- Trial name
- NCT05338242
- Testing
- Real-Time Exposure Feedback
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Utah
Risk Reduction
Urine Tenofovir Point-of-care Test to Identify Patients in Need of ART Adherence Support (UTRA Study)
ART is given to people living with HIV in order to suppress the virus, resulting in improved health for the individual and decreased transmission of the virus to others. Success of ART is dependent on adherence.
- Trial name
- NCT05333679
- Testing
- UTRA, UTRA feedback
- Where
- South Africa
- Volunteers
- 200 people
- Sponsor
- University of California, San Francisco
Children, Only, Risk Reduction
Reducing Pesticide Exposures in Child Care Centers
A randomized control study was conducted to reduce the exposure to pesticides in child care centers. A 7-month child care health consultant-led integrated pest management (IPM) intervention was conducted in 85 child care centers…
- Conditions
- Children, Only, Risk Reduction, Environmental Exposure
- Trial name
- HCES (NCT03319927)
- Testing
- Changes in pesticide exposure, IPM Practices, Educational Workshops
- Where
- United States
- Volunteers
- 987 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Risk Reduction
PrEP Point-of-Care Brief-Intervention for Adherence Among Young Men Who Have Sex With Men
Despite advances in HIV prevention, the HIV incidence among young men who have sex with men (YMSM) is increasing, threatening to derail achievement of the United States End the HIV Epidemic goals.
- Trial name
- PrEP2-BAY (NCT05353283)
- Testing
- Motivational Interviewing Counselling, Point-of-care Urine Tenofovir Measurement
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
PreDiabetes, Hyperglycemia
Effectiveness and Cost-Effectiveness of Fully-Automated Digital vs. Human Coach-Based Diabetes Prevention Programs
The purpose of this research study is to compare the effectiveness of a fully automated digital diabetes prevention program to standard of care human coach-based diabetes prevention programs for promoting clinically meaningful…
- Conditions
- PreDiabetes, Hyperglycemia, Glucose, High Blood, Overweight
- Trial name
- NCT05056376
- Testing
- Digital Diabetes Prevention Program (dDPP), Human Coach-based Diabetes Prevention Program (hDPP)
- Where
- 2 sites in United States
- Volunteers
- 368 people
- Sponsor
- Johns Hopkins University
Health Risk Behaviors, Risk Reduction Behavior
Enhancing Quality in Protective Strategies
The most successful young adult alcohol or marijuana interventions involve the provision of accurate, nonjudgmental personalized feedback, but notably the inclusion and effectiveness of protective behavioral strategies (PBS)…
- Trial name
- EQUIP (NCT04978129)
- Testing
- Online and Text Messaging Intervention
- Where
- United States
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- University of North Texas Health Science Center
HIV, Violence, Gender-Based
Supporting Trans Affirmation, Relationships, and Sex, Phase 3
The purpose of this clinical trial is to evaluate and test a newly developed gender-affirming intervention that addresses the dual and interconnected risks of HIV and intimate partner victimization (IPV) among transgender women…
- Conditions
- HIV, Violence, Gender-Based, Violence, Domestic, Risk Reduction Behavior
- Trial name
- STARS (NCT06001307)
- Testing
- Program STARS (Supporting Trans Affirmation, relationships, and Sex), Relaxation and Stress Reduction
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Brown University
Adherence, Medication, Risk Reduction
Prevention and Risk: Treatment With a New Emphasis on Relationships
This research examines the efficacy of an individually-delivered intervention tailored for YMSM in relationships. The intervention - termed PARTNER - utilizes a brief (4 session) motivational interviewing format to target…
- Conditions
- Adherence, Medication, Risk Reduction, Drug Use, Sex, Anal
- Trial name
- PARTNER (NCT03396367)
- Testing
- PARTNER, Education Intervention
- Where
- United States
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- Hunter College of City University of New York
Risk Reduction
Point-of-care Urine Monitoring of Adherence: Testing a Real-Time Urine Assay of Tenofovir in PrEP
Worldwide expansion of pre-exposure prophylaxis (PrEP) with oral tenofovir disoproxil fumarate/emtricitabine (TDF/FTC) will be critical to ending the HIV epidemic.
- Trial name
- PUMA (NCT03935464)
- Testing
- PUMA
- Where
- Kenya
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Cancer, Risk Reduction Behavior
Broadening the Reach, Impact, and Delivery of Genetic Services
The purpose of this study is to compare the uptake of genetic testing among patients randomized with two different models of genetic services delivery (a patient-directed model and an enhanced standard of care model) and examine…
- Trial name
- BRIDGE (NCT03985852)
- Testing
- Patient Directed Standard of Care
- Where
- 2 sites in United States
- Volunteers
- 3,073 people
- Sponsor
- University of Utah
Human Immunodeficiency Virus, Risk Reduction
Building Mobile HIV Prevention and Mental Health Support in Low-resource Settings
The purpose of this research study is to provide help and support for mental health and human immunodeficiency virus (HIV) risk reduction among Romanian gay and bisexual men.
- Conditions
- Human Immunodeficiency Virus, Risk Reduction, Alcohol Abuse, Depression, Anxiety
- Trial name
- NCT03912753
- Testing
- Comunică, Education Attention Control
- Where
- Romania
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Columbia University
Prevention or Reduction of HIV Risk Behavior, Prevention or Reduction of Intimate Partner Violence
Schools Championing Safe South Africa
This study explores the acceptability and feasibility of a school-based intervention called Schools Championing Safe South Africa that engages teachers and students in an integrated approach for preventing risk behavior related…
- Trial name
- NCT05869864
- Testing
- Schools Championing Safe South Africa
- Where
- South Africa
- Volunteers
- 282 people, healthy volunteers welcome
- Sponsor
- Brown University
Risk Reduction, Mammographic Density Reduction
Low Dose Tamoxifen for Mammographic Density Reduction
KARISMA2 is a randomized, double-blinded, six-armed placebo controlled study to identify a low dose of tamoxifen, with less side-effects and a density reduction non-inferior to the standard dose of 20 mg.
- Trial name
- KARISMA2 (NCT03346200)
- Testing
- Tamoxifen Oral Tablet
- Volunteers
- 1,440 people, healthy volunteers welcome
- Sponsor
- Per Hall
Influenza, Vaccination
Using Explainable AI Risk Predictions to Nudge Influenza Vaccine Uptake
The study team previously demonstrated that patients are more likely to receive flu vaccine after learning that they are at high risk for flu complications.
- Conditions
- Influenza, Vaccination, Health Promotion, Health Behavior
- Trial name
- NCT05009251
- Testing
- Reminder, Risk reduction, Medical records-based recommendation
- Where
- United States
- Volunteers
- 45,061 people
- Sponsor
- National Bureau of Economic Research, Inc.
Influenza, Vaccination
Encouraging Flu Vaccination Among High-Risk Patients Identified by ML
The purpose of the current study is to test different interventions to determine the most effective way to promote flu vaccine uptake in a high-risk population identified by an "artificial intelligence" (AI) or machine learning…
- Conditions
- Influenza, Vaccination, Health Promotion, Health Behavior
- Trial name
- NCT04323137
- Testing
- Risk reduction, Medical records-based recommendation, Algorithm-based recommendation
- Where
- United States
- Volunteers
- 117,649 people
- Sponsor
- Geisinger Clinic
HIV Infections, Hepatitis C
Tajik Migrant Health Education Study
This study will test the efficacy of a peer-education prevention intervention to reduce risky drug, alcohol, and sexual behaviors among male Tajik labor migrants who inject drugs (MWID) while working in Moscow.
- Conditions
- HIV Infections, Hepatitis C, Risky Health Behavior, Risk Reduction Behavior
- Trial name
- NCT04853394
- Testing
- MASLIHAT, TANSIHAT
- Where
- Russia
- Volunteers
- 420 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Chicago
Colorectal Adenoma, Risk Reduction
Anthocyanin Extract and Phospholipid Curcumin in Colorectal Adenoma
It has been shown that curcumin and cyanidin-3-glucoside (C3G) have anticancer effects. In this clinical trial we compare the affect of their combination vs placebo in a four weeks intervention before endoscopic polypectomy.
- Trial name
- MIRACOL (NCT01948661)
- Testing
- Mirtoselect® + Meriva®
- Where
- 4 sites in Italy
- Volunteers
- 45 people
- Sponsor
- Ente Ospedaliero Ospedali Galliera
Cardiovascular Risk Reduction
Oophorectomy, Estrogen Therapy and Cardiovascular Disease Risk in Young Women
Researchers are trying to assess the appropriate dose of estrogen for decreasing the risk of cardiovascular disease in women who have removal of their ovaries at a young age, before the age of 46 years.
- Trial name
- NCT03815929
- Testing
- Estradiol 100 Micrograms Patch, Estradiol Patch
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Risk Reduction
Utilizing Text Messaging to Improve Vehicle Safety Among At-Risk Young Adults
The "Safe Vehicle Engagement (SaVE)" trials are 3 parallel randomized clinical trials that aim to determine the impact of text messaging (SMS) vehicle safety interventions vs.
- Trial name
- SaVE (NCT03833713)
- Testing
- SMS Dialogue, SMS Assessments
- Where
- 2 sites in United States
- Volunteers
- 218 people
- Sponsor
- University of Pittsburgh