Clinical trials: Risk Reduction
Child Rearing, Risk Reduction Behavior
Age 6 Test of Home Visits by Nurses vs Paraprofessionals
To examine the impact of prenatal and infancy home visiting by paraprofessionals and by nurses from child age 2 through 6.
- Conditions
- Child Rearing, Risk Reduction Behavior, Reproductive Behavior
- Trial name
- DenverY06 (NCT00438282)
- Testing
- home visitation
- Where
- United States
- Volunteers
- 604 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Cardiovascular Disease Risk Factors
Reducing CVD Risk in African Americans Faith Communities
The ultimate goal of our partnership with local African-American churches is to implement an effective, multi-component intervention to increase awareness of the critical importance of healthy lifestyle in the prevention of…
- Trial name
- FAITH! (NCT02235896)
- Testing
- Education/Behavior Modification
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Cardiovascular Disorder, Chronic Kidney Disease
Cancer and Blood Pressure Management, CARISMA Study
This phase II trial studies how well intensive blood pressure management works in decreasing systolic blood pressure in patients with kidney or thyroid cancer that has spread to other places in the body (metastatic) who are…
- Conditions
- Cardiovascular Disorder, Chronic Kidney Disease, Metastatic Renal Cell Carcinoma, Metastatic Thyroid Gland Medullary Carcinoma
- Trial name
- NCT04467021
- Testing
- Best Practice, Blood Pressure Measurement, Clinical Management
- Where
- 25 sites in United States
- Volunteers
- 61 people
- Sponsor
- ECOG-ACRIN Cancer Research Group
Pregnancy Early, Outcome, Adverse Birth
Generation R Next - Optimaal Opgroeien
The aim of this randomized controlled trial is to improve birth outcomes and long-term outcomes in mother and child by optimizing lifestyle,nutrition and stress experience in the preconception period and early pregnancy in women…
- Conditions
- Pregnancy Early, Outcome, Adverse Birth, Lifestyle Factors, Preconception Care
- Trial name
- NCT05870878
- Testing
- Standard care, Lifestyle program
- Where
- Netherlands
- Volunteers
- 1,750 people, healthy volunteers welcome
- Sponsor
- Erasmus Medical Center
HIV, Alcohol
GLP-1 Receptor Agonists to Decrease Ethanol and CVD Risk in HIV
The goal of this clinical trial is to learn if the drug semaglutide works to reduce alcohol intake among adults living with HIV. The main questions it aims to answer are: 1.
- Conditions
- HIV, Alcohol, Smoking Cigarette, Cardiovascular Disease Prevention
- Trial name
- GL1DER HIV RCT (NCT07221214)
- Testing
- Semaglutide (Rybelsus®)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Vanderbilt University Medical Center
Myocardial Infarction, Risk Reduction
The Perfect-CR Implementation Study
The goal of this open-label cluster-randomized effectiveness-implementation hybrid trial is to study whether a) audit and feedback of cardiac rehabilitation service delivery within a national quality registry and b) structured…
- Trial name
- NCT05889416
- Testing
- Audit and feedback through a quality registry, Implementation support
- Where
- Sweden
- Volunteers
- 75 people
- Sponsor
- Skane University Hospital
Suicidal Ideation, Suicide, Attempted
Stepped Approach to Reducing Risk of Suicide in Primary Care
Suicide is the second leading cause of death among young people aged 12-17 years in the United States, yet many youth at risk for suicide are not identified or go untreated.
- Conditions
- Suicidal Ideation, Suicide, Attempted, Suicide Prevention
- Trial name
- STARRS-PC (NCT06018285)
- Testing
- Stepped Approach to Reducing Risk of Suicide in Primary Care
- Where
- 15 sites in United States
- Volunteers
- 2,572 people
- Sponsor
- Cynthia Fontanella
Decreased Cardovascular Risk, Decreased Risk of Diabetes Mellitus Type II
MoKaRi II Intervention Study
The proposed intervention study addresses the development and validation of nutritional concepts based on menu plans for patients with hypertriglyceridemia (triglycerides > 1.5 mmol/l) and participants with impaired glucose…
- Trial name
- MoKaRi II (NCT05382533)
- Testing
- Menu plans
- Where
- Germany
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Jena
Coronary Heart Disease
Risk Reduction in Coronary Heart Disease
Study hypothesis: Multifactorial risk reduction in coronary heart disease can reduce the risk of new coronary heart disease and death
- Trial name
- SPREK! (NCT00679237)
- Testing
- smoking cessation, betablocker, diuretics, ACEI, ARB,, statins, ezetimibe
- Where
- Norway
- Volunteers
- 1,600 people
- Sponsor
- Sorlandet Hospital HF
Depression, Adolescent Health
Reducing Health Risk Behavior and Improving Health in Adolescents With Depression
This study will determine the effectiveness of a health education intervention in reducing health risk behavior and improving health in adolescents with depression.
- Trial name
- NCT00461539
- Testing
- Treatment as usual, Behavioral health intervention
- Where
- 2 sites in United States
- Volunteers
- 217 people
- Sponsor
- University of California, Los Angeles
Diabetic Polyneuropathy
Differential Air Pressure Technology for Treatment of Diabetic Elderly Patients
Aging can be defined as sequential deterioration that occurs in elderly people including weakness, loss of mobility, decline of physical capabilities, increase susceptibility to disease and many other age-related physiological…
- Trial name
- NCT04620265
- Testing
- Antigravity treadmill training 100% weight bearing, Antigravity treadmill training 75% weight bearing, Antigravity treadmill training 50% weight bearing
- Where
- Saudi Arabia
- Volunteers
- 110 people
- Sponsor
- Umm Al-Qura University
Chronic Pain, Opioid-use Disorder
Validation of the ASI-SR Form in a Population of Chronic Non-cancer Pain Patients
The Swedish version of ASI-SR has shown good feasibility in assessment of addiction patients functioning compare to long and time-consuming ASI, which is upp to date golden standard in Sweden.
- Conditions
- Chronic Pain, Opioid-use Disorder, Quality of Life, Risk Reduction
- Trial name
- ASI-SR (NCT04998734)
- Testing
- ASI-SR
- Where
- Sweden
- Volunteers
- 1 people
- Sponsor
- Uppsala University
Suicide, Suicidal Ideation
Brief Interventions for Short-Term Suicide Risk Reduction in Military Populations
The purpose of the proposed study is to identify the most effective brief interventions for reducing short-term risk for suicide attempts in "real world" military triage settings, and to identify potential mechanisms of change…
- Trial name
- BISSR (NCT02042131)
- Testing
- Treatment As Usual (TAU), Standard Crisis Response Plan (S-CRP), Enhanced Crisis Response Plan (E-CRP)
- Where
- United States
- Volunteers
- 97 people
- Sponsor
- University of Utah
Insomnia, Physical Health Functioning
Efficacy of a Computerized Cognitive Behavioral Treatment for Insomnia: Increasing Access to Insomnia Treatment to Decrease Suicide Risk
Insomnia is major problem among Operation Enduring Freedom (OEF), Operation Iraqi Freedom (OIF), and Operation New Dawn (OND) Veterans.
- Conditions
- Insomnia, Physical Health Functioning, Mental Health Functioning
- Trial name
- Vets Sleep (NCT03366870)
- Testing
- Computerized Cognitive Behavioral Therapy for Insomnia, Sleep Education
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Internal Carotid Artery Stenosis
SONOlysis in Prevention of Brain Infarctions dUring Carotid Stenting and caroTid EndaRterectomy
The aim of the project is to demonstrate a fibrinolytic effect of sonothrombolysis (continual transcranial Doppler monitoring) using 2 MegaHertz (MHz) diagnostic probe on the reduction of risk of brain infarctions due to the…
- Trial name
- SONOBUSTER (NCT01591005)
- Testing
- sonolysis, endarterectomy, carotid stenting
- Where
- Czechia
- Volunteers
- 242 people
- Sponsor
- University Hospital Ostrava
Reduction of Small Intestinal Ulceration Risk
The Effect of a Probiotic Strain on Aspirin-induced GI Damage
The primary objective of this trial is to investigate if a daily dose of minimum 50 billion CFU of Bif195 reduces the risk of small-intestinal tissue damage in an acetylsalicylic acid challenge model as assessed by video capsule…
- Trial name
- PIP-L (NCT03910322)
- Testing
- Bif195
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Chr Hansen
HIV, STDs
Culturally Congruent HIV Risk Reduction App for Young Women, an Acceptability & Pilot Evaluation
Smartphone applications and mobile technologies offer users the potential to access critical information (e.g., proper condom use, directions to testing sites, and other sexual and reproductive health services) when it is needed…
- Trial name
- NCT02733692
- Testing
- Understanding Reproductive Health for Ladeez (GURHL) Code
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- City University of New York, School of Public Health
Adult Hepatocellular Carcinoma, Recurrent Hepatocellular Carcinoma
Oral Thalidomide and Tegafur-uracil to Decrease Hepatocellular Carcinoma Recurrence
This single-centered phase II clinical study is to obtain preliminary information on 1-year recurrence-free survival rate, recurrence-free survival and safety profile of thalidomide in combination with tegafur-uracil in…
- Conditions
- Adult Hepatocellular Carcinoma, Recurrent Hepatocellular Carcinoma, Adverse Reaction to Drug, Vascular Endothelial Growth Factor Overexpression
- Trial name
- NCT02447679
- Testing
- thalidomine, tegafur-uracil
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- Chang Gung Memorial Hospital
Head and Neck Cancer
Haemorrhage Risk Reduction Using Endovascular Embolisation in Place of Vessel Ligation for Patients Undergoing Transoral Robotic Surgery (HELPR)
Transoral robotic surgery (TORS )has been shown to offer excellent oncological and functional outcomes for treating cancer at multiple subsites of the head and neck.
- Trial name
- NCT05477992
- Testing
- Endovascular embolization
- Volunteers
- 10 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Refractory and/or Relapsed Metastatic Solid Tumors
Reduced Intensity Haploidentical BMT for High Risk Solid Tumors
The purpose of this study is to see if giving reduced intensity chemotherapy, haploidentical bone marrow, post-transplant cyclophosphamide and shortened duration tacrolimus is safe and feasible for patients with very high-risk…
- Trial name
- NCT01804634
- Testing
- Cyclophosphamide, Fludarabine, low dose total body irradiation
- Where
- 3 sites in United States
- Volunteers
- 60 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins