Clinical trials: Risk Reduction
Anemia
INTERCEPT Blood System for RBCs Study in Regions at Potential Risk for Zika Virus Transfusion-Transmitted Infections
To evaluate the safety and efficacy of red blood cells (RBCs) prepared with the INTERCEPT Blood System for Red Blood Cells Pathogen Reduction Treatment (PRT) in comparison to conventional RBCs in patients who require RBC…
- Trial name
- RedeS (NCT03037164)
- Testing
- INTERCEPT Blood System for Red Blood Cells, Conventional (Control)
- Where
- 16 sites in United States, Puerto Rico and 1 more
- Volunteers
- 692 people
- Sponsor
- Cerus Corporation
Ovarian Neoplasms, BRCA 1 Gene Mutation
Ovarian Cancer Liquid Biopsy for Early Assessment & Detection in Individuals With BRCA1/2 Pathogenic Variants
The goal of this clinical study is to evaluate the feasibility and acceptability of the Galleri multi-cancer early detection blood test in people with BRCA1 or BRCA2 gene changes who are at high risk for ovarian cancer.
- Conditions
- Ovarian Neoplasms, BRCA 1 Gene Mutation, BRCA 2 Gene Mutation, Serous Tubal Intraepithelial Carcinoma
- Trial name
- OC-LEAD (NCT07764744)
- Testing
- Galleri Multi-Cancer Early Detection (MCED) Blood Test
- Where
- 2 sites in United States
- Volunteers
- 70 people
- Sponsor
- Weill Medical College of Cornell University
Obesity, Bariatric Surgery Candidate
Reducing Fall Risks for Adults With Obesity
The objective of the clinical study was to examine if practice could improve walking patterns associated with fall risks before patients with obesity underwent weight loss surgery.
- Conditions
- Obesity, Bariatric Surgery Candidate, Gait, Unsteady
- Trial name
- ObesityFalls (NCT03558100)
- Testing
- Obstacle crossing intervention for adults with obesity
- Volunteers
- 100 people
- Sponsor
- Boston University Charles River Campus
Health Communication, Smoking
Messages About Reduced Nicotine in Combusted Tobacco Products
The investigators will conduct a message-exposure experiment with nationally representative samples of smokers, dual-users (cigarettes and e-cigarettes), and young adult non-smokers (aged 18-29).
- Conditions
- Health Communication, Smoking, Smoking, Tobacco, Smoking Behaviors
- Trial name
- NCT05506046
- Testing
- Reduced nicotine message exposure, Modified risk message exposure, Combined message exposure (reduced nicotine + modified risk)
- Where
- United States
- Volunteers
- 1,901 people
- Sponsor
- Georgia State University
Thrombocytopenia, Neonatal Alloimmune
A Study of Nipocalimab in Reducing the Risk of Fetal and Neonatal Alloimmune Thrombocytopenia (FNAIT)
The purpose of this study is to evaluate the effectiveness of nipocalimab compared with placebo in reducing the risk of severe fetal and neonatal alloimmune thrombocytopenia (FNAIT).
- Trial name
- FREESIA-1 (NCT06449651)
- Testing
- Nipocalimab
- Where
- 21 sites in Belgium, Brazil and 10 more
- Volunteers
- 39 people
- Sponsor
- Janssen Research & Development, LLC
Risk Reduction Behavior
HIV Prevention in Very High Risk Men Who Have Sex With Men
The purpose of this study is to pilot test an innovative program development project in an open trial format an 8-session, individual, cognitive-behavioral therapy based, intervention on ten (10) HIV-infected men who have sex…
- Trial name
- ENGAGE (NCT01291589)
- Testing
- Cognitive-behavioral therapy
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Fenway Community Health
Spinal Cord Injuries
Health Promotion and Cardiovascular Risk Reduction Among People With Spinal Cord Injury
This study is a controlled pragmatic implementation study in clinical practice, with a primary focus on cardiovascular risk reduction through adherence to behavioral interventions related to physical activity and healthy diet.The…
- Trial name
- NCT03689023
- Testing
- A controlled multimodal intervention
- Where
- Denmark
- Volunteers
- 97 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Diet Modification, Substance Use Disorders
The Impact of a Parenting Intervention on Latino Youth Health Behaviors
The purpose of this study is to test if a parenting program can be used to prevent substance use among Latino youth and at the same time promote healthy eating.
- Conditions
- Diet Modification, Substance Use Disorders, Diabetes Mellitus Risk, Cardiovascular Risk Factor
- Trial name
- FPNG+ (NCT03517111)
- Testing
- Nutrition/substance use prevention, Substance use prevention only, Academic success program
- Where
- United States
- Volunteers
- 844 people, healthy volunteers welcome
- Sponsor
- Arizona State University
Cognitive Impairment, Cognitive Decline
Digitally Supported Lifestyle Programme to Promote Brain Health Among Older Adults
Previous research has shown that a healthy lifestyle, including a balanced diet, physical and social activity, and management of vascular risk factors can support both cardiovascular and brain health.
- Conditions
- Cognitive Impairment, Cognitive Decline, Dementia
- Trial name
- LETHE (NCT05565170)
- Testing
- Structured ICT-assisted multimodal lifestyle intervention, Self-guided multimodal lifestyle intervention
- Where
- 4 sites in Austria, Finland and 2 more
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Finnish Institute for Health and Welfare
Isolated Systolic Hypertension
Blood Pressure and Lipids Reduction in High Risk Elderly Patients With Isolated Systolic Hypertension
1. Study name: Blood Pressure and Lipids Reduction in High Risk Elderly Patients with Isolated Systolic Hypertension. 2. Medicine: amlodipine/atorvastatin tablet (5mg/10mg) and amlodipine (5mg). 3.
- Trial name
- NCT05165251
- Testing
- Amlodipine/Atorvastatin 5 Mg-10 Mg ORAL TABLET, Amlodipine 5mg, Lifestyle intervention
- Where
- China
- Volunteers
- 480 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Reduction in the Initial Length of Stay
An Evaluation of Multisense® to Ensure a Safe Return Home Following High-risk Gastrointestinal Surgery, Compared With Standard Care.
The SENSE-ECO study is a prospective, randomized trial of 490 high-risk patients designed to show that the MultiSense® remote monitoring patch safely reduces hospital stays following major digestive surgery.
- Trial name
- SENSE-ECO (NCT07552805)
- Testing
- Monitoring by MultiSense®
- Where
- 9 sites in France
- Volunteers
- 490 people
- Sponsor
- Rhythm Diagnostic Systems
brca1 Mutation Carrier, brca2 Mutation Carrier
Deslorelin Combined With Low-Dose Add-Back Estradiol and Testosterone in Preventing Breast Cancer in Premenopausal Women Who Are at High Risk for This Disease
RATIONALE: Chemoprevention therapy is the use of certain drugs to try to prevent the development or recurrence of cancer. Deslorelin combined with low-dose add-back estradiol and testosterone (given to replace hormones suppressed…
- Conditions
- brca1 Mutation Carrier, brca2 Mutation Carrier, Breast Cancer
- Trial name
- NCT00080756
- Testing
- therapeutic estradiol, deslorelin, therapeutic testosterone
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- City of Hope Medical Center
Ovarian Cancer, Fallopian Tube Cancer
Risk Reducing Salpingectomy With Delayed Oophorectomy as an Alternative to Risk- Reducing Salpingo-oophorectomy in High Risk-Women to Assess the Safety of Prevention - US Cohort Study
This is a prospective preference study that will evaluate non-inferiority of the innovative treatment (RRS with delayed RRO) as compared to the standard treatment (RRSO) with respect to high grade serous (ovarian) cancer incidence
- Trial name
- NCT05287451
- Testing
- RIsk-Reducing Salpingectomy (RRS), Risk-Reducing Oophorectomy-RRO, Risk-Reducing Salpingo-Oophorectomy-RRSO
- Where
- 11 sites in United States
- Volunteers
- 100 people
- Sponsor
- M.D. Anderson Cancer Center
Hypertension
Improving Blood Pressure Control Through the myBPmyLife mHealth Application
This study is enrolling eligible participants that have high blood pressure. Reducing dietary salt intake and engaging in regular physical activity is known to decrease blood pressure in people with hypertension.
- Trial name
- myBPmyLife (NCT05154929)
- Testing
- Dietary and physical activity JITAI delivered through the myBPmyLife app, Control Group
- Where
- 2 sites in United States
- Volunteers
- 608 people
- Sponsor
- University of Michigan
Prediabetes, Depressive Symptoms Mild to Moderate in Severity
Mindfulness-based Personalized Health Planning for Reducing Risk of Heart Disease and Diabetes
The purpose of this study is to compare the effectiveness of educational and lifestyle intervention programs aimed at reducing fasting blood sugar and emotional distress in adults with prediabetes.
- Trial name
- AWARENESS (NCT01430221)
- Testing
- Mindfulness-based Personalized Health Planning, Structured & Guided Education
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Duke University
Acute Leukaemia, Chronic Disease
Hematopoietic Cell Transplantation for Pediatric Patients With Hematologic Malignancies
This is a phase II trial of reduced intensity conditioning with Bu/Flu/ATG in pediatric patients with hematologic malignancies at high risk for transplant related mortality with standard transplantation.
- Conditions
- Acute Leukaemia, Chronic Disease, Leukemia, Myelodysplasia
- Trial name
- NCT00795132
- Testing
- Busulfan, Anti-Thymocyte Globulin, Fludarabine
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- University of Utah
Ovarian Cancer, Breast Cancer
A Bidirectional Cohort Study on Prophylactic Resection Surgery in Populations at Moderate-to-High Risk for Hereditary Ovarian Cancer
The goal of this multi-center observational study is to learn about the effectiveness and safety of different prophylactic (preventive) surgical options in women at moderate-to-high genetic risk for hereditary ovarian cancer…
- Trial name
- NCT07532434
- Where
- China
- Volunteers
- 480 people
- Sponsor
- Peking University Third Hospital
Risk Reduction, Ovarian Cancer
STOP OVarian CAncer; Implementation of the Opportunistic Salpingectomy in the Netherlands
The aim of this study is to optimize implementation of the opportunistic salpingectomy throughout the Netherlands.
- Trial name
- STOPOVCA (NCT04470921)
- Testing
- Opportunistic Salpingectomy
- Where
- 27 sites in Netherlands
- Volunteers
- 10,000 people
- Sponsor
- Radboud University Medical Center
High Blood Pressure
IMPlementation of gUideLines for the Management of Arterial hypertenSION. The IMPULSION Study
The objective of this protocol is to improve awareness, treatment, and control of arterial hypertension, within primary prevention of target organ damage, by implementing guidelines, after training of the participating physicians.
- Trial name
- IMPULSION (NCT00416611)
- Testing
- Implementation of guidelines
- Where
- Greece
- Volunteers
- 1,000 people
- Sponsor
- Hellenic Atherosclerosis Society
HIV
Females of African American Legacy Empowering Self (FemAALES)
The FemAALES Project is a community collaborative two-arm intervention designed to prevent HIV (human immunodeficiency) and STD (sexually transmitted disease) infection and transmission among African American women and men by…
- Trial name
- FemAALES (NCT02189876)
- Testing
- Standard of Care, FemAALES
- Where
- 2 sites in United States
- Volunteers
- 256 people, healthy volunteers welcome
- Sponsor
- Charles Drew University of Medicine and Science