Clinical trials: Risk Factors Cardiovascular Disease
Primary Hypercholesterolemia
A Study of SCH 58235 (Ezetimibe) When Added to Ongoing Therapy With a Statin in Participants With Primary Hypercholesterolemia, Known Coronary Heart Disease, or Multiple Cardiovascular Risk Factors (P02173)
This is a study to evaluate the lipid-altering efficacy, safety, and tolerability of ezetimibe when added to ongoing therapy with an 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase inhibitor (statin) in participants…
- Trial name
- NCT03882905
- Testing
- Ezetimibe, Simivastatin, Statin
- Volunteers
- 769 people
- Sponsor
- Organon and Co
Atrial Fibrillation (AF)
Alcohol as a Modifiable Risk Factor for Atrial Fibrillation
Atrial fibrillation (AF) is the most common arrhythmia, diagnosed in approximately 50 million people worldwide. Its prevalence is expected to increase, eventually affecting every third person, which will result in significant…
- Trial name
- AFFAIR (NCT07528729)
- Testing
- alcohol abstinence
- Volunteers
- 414 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Cardiovascular Risk Factors
Cardiovascular Patients With no Standard Modifiable Risk Factors
A growing number of patients develop atherosclerotic cardiovascular disease (ASCVD) despite the absence of standard modifiable risk factors (SMuRF-less).
- Trial name
- SMuRF-less-ME1 (NCT06199869)
- Testing
- Evaluation of risk factors by direct interview with subjects who have atherosclerotic cardiovascular patients
- Where
- 2 sites in Jordan
- Volunteers
- 5,540 people
- Sponsor
- Jordan Collaborating Cardiology Group
Diabetes, Cardiovascular Risk Factor
Diabetes Prevention Translation: the Healthy Lifestyle Project
The Diabetes Prevention Program (DPP), a large research study conducted in the United States, found that lifestyle intervention was effective in lowering risk for development of type 2 diabetes.
- Trial name
- NCT01050205
- Testing
- Current Intervention, Delayed Intervention
- Where
- United States
- Volunteers
- 223 people
- Sponsor
- University of Pittsburgh
Diabetes, Heart Disease
Miami Healthy Heart Initiative a Behavioral Study on Cardiovascular Risk Factors
A study to examine the effectiveness of a multilevel Community Health Workers intervention as an adjunct to routine primary care in reducing CVD risk factors among diabetic Latinos in Miami.
- Conditions
- Diabetes, Heart Disease, Hypertension
- Trial name
- MHHI (NCT01152957)
- Testing
- CARIÑO Project, Enhanced Usual Care
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Miami
Cardiovascular Disease
Study on Nutrition and Cardiovascular Risk in Spain.
The purpose of this study is to assess the distribution, awareness and control of main cardiovascular risk factors in the Spanish population.
- Trial name
- ENRICA (NCT01133093)
- Where
- Spain
- Volunteers
- 11,991 people
- Sponsor
- Universidad Autonoma de Madrid
Cardiovascular Diseases, Surgery
Pressure Recording Analytical Method Parameters and Their Relationship With Hypotension in Hypertensive Patients
Perioperative anesthesiologists can benefit from easily obtainable hemodynamic variables detecting or quantifying the lack of an adequate compensatory capacity of the cardiovascular system in order to optimize patient management…
- Conditions
- Cardiovascular Diseases, Surgery, Hypotension, Hypotension on Induction
- Trial name
- PRAM-in-HYPO (NCT05960604)
- Testing
- Passive leg raising
- Where
- 5 sites in Turkey (Türkiye)
- Volunteers
- 660 people
- Sponsor
- Recep Tayyip Erdogan University
Cardiovascular Risk Factors, Hypertension
Cardiovascular Health And Risk Modification in Family Health Teams
Cardiovascular diseases remain the main cause of mortality in Canada. While effective interventions are available for reducing the risk of cardiovascular disease,there continue to be gaps between the potential reduction in risk…
- Conditions
- Cardiovascular Risk Factors, Hypertension, Hyperlipidemia, Diabetes
- Trial name
- Multi-CHARM (NCT00787306)
- Testing
- Active risk factor surveillance
- Where
- Canada
- Volunteers
- 229 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Cardiac Risk Factors, Cardiovascular Diseases
Dance Therapy as an Alternative for Cardiac Rehabilitation in Women Population
This research project aims to investigate the acute effects of a dance-based cardiac rehabilitation session in the cardiovascular system and autonomic modulation of women with cardiac risk factors.
- Trial name
- NCT04967235
- Testing
- Conventional Exercise-based Cardiac Rehabilitation Session, Dance-based Cardiac Rehabilitation Session
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Universidade Estadual Paulista Júlio de Mesquita Filho
Obesity and Cardiovascular Risk
A Phase 2 Study to Evaluate the Pharmacodynamics, Safety and Tolerability of BGE-102 in Participants With Obesity and Cardiovascular Risk Factors
The purpose of this study is to learn about the effects of BGE-102 on blood biomarkers including hsCRP, which is a lab value used to measure inflammation.
- Trial name
- QUELL-CV (NCT07656727)
- Testing
- Oral BGE-102
- Where
- 17 sites in United States, Puerto Rico
- Volunteers
- 160 people
- Sponsor
- BioAge Labs, Inc.
Cardiovascular Risk Factor, Pre Diabetes
Effects of a Workplace Exercise Intervention on Cardio-Metabolic Health
Background: The rising levels of physical inactivity in the Eastern Mediterranean region (43.2%) and in the United Arab Emirates (38%) compared with the global levels of physical inactivity (31.2%) is alarming (6,15).
- Conditions
- Cardiovascular Risk Factor, Pre Diabetes, High Blood Pressure, Elevated LDL Cholesterol
- Trial name
- NCT04403789
- Testing
- Exercise Time, Supervised Group Exercise
- Where
- United Arab Emirates
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- United Arab Emirates University
Rheumatoid Arthritis, Stiffness, Aortic
Methotrexate, Blood Pressure and Arterial Function in Rheumatoid Arthritis
The investigators will study the effects of methotrexate on blood pressure, arterial stiffness and endothelial function in patients with rheumatoid arthritis.
- Conditions
- Rheumatoid Arthritis, Stiffness, Aortic, Endothelial Dysfunction, Cardiovascular Risk Factor
- Trial name
- NCT03254589
- Testing
- Methotrexate, Sulfasalazine, Other DMARDs
- Where
- Australia
- Volunteers
- 124 people
- Sponsor
- Flinders University
Cardiovascular Diseases, Diabetes Mellitus, Type 2
The Japan Diabetes Optimal Integrated Treatment Study for 3 Major Risk Factors of Cardiovascular Diseases
(Intervention study) The objective of the study is to confirm the superiority of the intensive therapy to the conventional therapy concerning the prevention of the incidence or exacerbation of vascular complications caused by…
- Trial name
- J-DOIT3 (NCT00300976)
- Testing
- Lifestyle consultation: weight control, diet, exercise
- Where
- Japan
- Volunteers
- 2,542 people
- Sponsor
- Japan Foundation for the Promotion of International Medical Research Cooperation
Atherosclerotic Cardiovascular Disease (ASCVD), Chronic Kidney Disease (CKD)
The Effect of Retatrutide Once Weekly on Cardiovascular Outcomes and Kidney Outcomes in Adults Living With Obesity (TRIUMPH-Outcomes)
The main purpose of this study is to determine if retatrutide can significantly lower the incidence of serious heart-related complications or prevent the worsening of kidney function.
- Trial name
- NCT06383390
- Testing
- Retatrutide
- Where
- 742 sites in United States, Argentina and 25 more
- Volunteers
- 10,000 people
- Sponsor
- Eli Lilly and Company
Cardiovascular Risk Factors, Insulin Resistance
Pilot Validation of the STELA Preventive Medicine Platform to Reduce Modifiable Health Risk Factors in Adults (CPM-STELA)
This study evaluates a comprehensive digital health platform called STELA, developed at the Center for Preventive Medicine (CPM) of AGEL Hospital Trinec-Podlesi in Czechia.
- Conditions
- Cardiovascular Risk Factors, Insulin Resistance, Obesity, Dyslipidemias
- Trial name
- CPM-STELA (NCT07551960)
- Testing
- STELA Digital Preventive Medicine Platform, Comprehensive Preventive Health Assessment
- Where
- Czechia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Nemocnice AGEL Trinec-Podlesi a.s.
Cardiovascular Disease, Metabolic Syndrome
Canola Oil Multi-center Intervention Trial II
Building on the findings from the investigators previous study, COMIT I, the purpose of the COMIT II study is to supplement the DEXA measurement of body composition with a supplementary DEXA measurement of visceral adipose tissue…
- Trial name
- COMITII (NCT03054779)
- Testing
- Canola Oil, High oleic acid canola oil, Western diet oil combination
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Penn State University
Type 2 Diabetes, Overweight
Effects of Caloric Restriction on Fetuin-A and Cardiovascular Risk Factors
The aim of this randomized controlled study was to evaluate the effects of CR on circulating fetuin-A levels in obese humans with type 2 diabetes based on monitoring energy intake and energy expenditure by daily activity.
- Trial name
- NCT01329822
- Testing
- Caloric restriction
- Where
- South Korea
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Korea University
Preeclampsia, Hypertension
Cardiac and Immune Cell Function in Preeclampsia
Preeclampsia is a multi-system vascular disease which affects 2-5% of pregnancies. It is also a risk factor for the development of cardiovascular disease later in life and a number of functional and structural cardiac changes…
- Conditions
- Preeclampsia, Hypertension, Pregnancy Induced Hypertension, Pregnancy Related
- Trial name
- NCT04508582
- Testing
- Cardiovascular magnetic resonance, Echocardiography, Blood test
- Where
- United Kingdom
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Queen Mary University of London
Cystic Fibrosis, Venous Thrombosis
Cystic Fibrosis and Totally Implantable Vascular Access Devices
The purpose of this study is to evaluate the incidence of venous thrombosis occurring on totally implantable vascular access devices in cystic fibrosis patients who need a new device (it can be the first one or a subsequent one)…
- Trial name
- RITHM (NCT00244270)
- Testing
- totally implantable vascular access device
- Volunteers
- 97 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Testicular Cancer, Seminoma
Cardiac Function and Cardiovascular Risk Profile in Testicular Cancer Patients
For many years, researchers and doctors have studied different kinds of treatments to improve the survival of men with testicular cancer.
- Conditions
- Testicular Cancer, Seminoma, Non-seminomatous
- Trial name
- NCT00705094
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- AHS Cancer Control Alberta
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