Clinical trials: Right Heart Failure
Pulmonary Arterial Hypertension, Right Heart Failure
Repurposing a Histamine Antagonist to Benefit Patients With Pulmonary Hypertension
This is a Phase 2, single-center, randomized placebo controlled trial of famotidine (an H2 receptor antagonist) in adults with pulmonary arterial hypertension.
- Trial name
- REHAB-PH (NCT03554291)
- Testing
- Famotidine 20 MG
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Washington
Right Heart Failure, Unspecified, Critical Illness
Echocardiographic Evaluation of RV Injury in the ICU
The adequate characterization of RV injury is currently unknown. The hypothesis is that the best characterization of RV injury is the one with the most significant impact on the response to fluids and on the outcome.
- Conditions
- Right Heart Failure, Unspecified, Critical Illness, ARDS, Human, Septic Shock
- Trial name
- RECHOicu (NCT05525936)
- Testing
- Echocardiography and central venous pressure
- Volunteers
- 440 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Right Bundle-Branch Block, Heart Failure
Right Ventricular Septal Pacing in Patients With Right Bundle Branch Block and Heart Failure (The SPARK Trial)
This clinical study has been designed to test whether a new pacing therapy would lead to improvement in heart function, symptoms and quality of life in a specific group of heart failure patients.
- Trial name
- SPARK (NCT02441101)
- Testing
- RV DDD(R)-60 with AV optimization, RV DDD(R)-60
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Barry London
Left-Sided Heart Failure, Right-Sided Heart Failure
Echocardiography as Risk-Assessment for Major Adverse Cardiac Events in Major Vascular Surgery Patients
Patient with coronary artery disease (CAD), heart failure and abnormal heart function undergoing major vascular surgery have a high associated high morbidity and mortality with myocardial infarction accounting for 33-50% of…
- Conditions
- Left-Sided Heart Failure, Right-Sided Heart Failure, Heart Valve Diseases
- Trial name
- NCT04836702
- Volunteers
- 813 people
- Sponsor
- University of Virginia
Extracorporeal Circulation; Complications, Extracorporeal Membrane Oxygenation Complication
Definition and Management of Right Ventricular Injury in Adult Patients Receiving Extracorporeal Membrane Oxygenation
The aim of this study is to identify existing definitions and therapeutic approaches for acute right ventricular injury (RVI) in patients receiving extracorporeal membrane oxygenation (ECMO) for respiratory support.
- Conditions
- Extracorporeal Circulation; Complications, Extracorporeal Membrane Oxygenation Complication, Right Heart Failure, Right Ventricular Dysfunction
- Trial name
- NCT05948332
- Testing
- Delphi Rounds to generate consensus opinions among Experts
- Where
- United Arab Emirates
- Volunteers
- 52 people
- Sponsor
- Prashant Nasa
Right Ventricular Dysfunction, Right Heart Failure
Right Ventricular Pressure Waveform Monitoring in Cardiac Surgery
RV dysfunction has been associated with increased mortality in the ICU and cardiac surgical patients. Thus, early identification of RV dysfunction at less severe stages will allow for earlier intervention and potentially better…
- Conditions
- Right Ventricular Dysfunction, Right Heart Failure, Congestive Heart Failure
- Trial name
- PACEPORT (NCT04092855)
- Where
- Canada
- Volunteers
- 112 people
- Sponsor
- Montreal Heart Institute
Heart; Dysfunction Postoperative, Cardiac Surgery, Right Heart Failure
Femoral Venous Pulsatility and Right Heart Dysfunction in Heart Surgery: An Observational Study
Right heart failure during cardiac surgery is associated with increased perioperative morbidity and mortality. In this context, it is imperative to develop simple diagnostic tools to detect right heart failure.
- Conditions
- Heart; Dysfunction Postoperative, Cardiac Surgery, Right Heart Failure, Right Ventricular Dysfunction
- Trial name
- FemousTechno6 (NCT05038267)
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- Montreal Heart Institute
Systemic Right Ventricle, Heart Failure
ARNI Versus plAcebo in Patients With Congenital sYStemic Right Ventricle Heart Failure
This study is a prospective monocentric, randomized, double-blind, placebo-controlled, crossover clinical trial to assess the efficacy of Sacubitril/Valsartan over placebo in improving exercise capacity and neurohormonal…
- Trial name
- PARACYS-RV (NCT05117736)
- Testing
- Sacubitril / Valsartan Oral Tablet
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- Montreal Heart Institute
Cardiovascular Diseases, Right Heart Failure
Repository of Phase Signals for Pulmonary Hypertension Algorithm Development
This study is designed as a repository study to collect resting cardiac phase signals and subject meta data from eligible subjects using the Phase Signal Recorder (PSR) prior to Right Heart Cath (RHC).
- Conditions
- Cardiovascular Diseases, Right Heart Failure, Cardiac Disease
- Trial name
- IDENTIFY - PH (NCT04031989)
- Testing
- CorVista Capture
- Where
- 17 sites in United States
- Volunteers
- 2,500 people
- Sponsor
- Analytics For Life
Tricuspid Valve Regurgitation, Nonrheumatic, Cardiac Catheterization
Evaluating Edge-to-edge Transcatheter Tricuspid Valve Repair in Patients With Severe Symptomatic Tricuspid Regurgitation
This is a national multicenter, open-label, randomized controlled trial to show superiority of edge-to-edge Transcatheter Tricuspid Valve repair (TTVr) on top of the Standard Of Care (SOC; heart failure medication) over the SOC…
- Conditions
- Tricuspid Valve Regurgitation, Nonrheumatic, Cardiac Catheterization, Heart Failure, Right Sided, Valve Regurgitation, Tricuspid
- Trial name
- TRACE-NL (NCT05628779)
- Testing
- TriClip TTVr system (Abbott Vascular), PASCAL TTVr system (Edwards Lifesciences)
- Where
- 6 sites in Netherlands
- Volunteers
- 150 people
- Sponsor
- St. Antonius Hospital
Transposition of the Great Arteries, Systemic Right Ventricle
Systemic Right Ventricle Long-term Outcome
Patients with the transposition of great arteries (TGA) who undergo atrial switch operation and congenitally corrected TGA (ccTGA) patients have the right ventricle as their systemic ventricle.
- Trial name
- SINCERE (NCT06258083)
- Where
- 9 sites in Belgium, Netherlands
- Volunteers
- 542 people
- Sponsor
- University Medical Center Groningen
Ventricular Dysfunction, Right, Lung Diseases
Evaluation of the Right Ventricular Systolic Function Using Real-time Three-dimensional Echocardiography in Intensive Care Unit Patients
Right ventricular failure (RVF) is an independent factor of mortality for many pulmonary diseases. Currently, RVF is defined as the incapacity of the RV to maintain the flow without dilating to use the Frank-Starling law (i.e.…
- Conditions
- Ventricular Dysfunction, Right, Lung Diseases, Intensive Care Units
- Trial name
- REA-3D-VD (NCT04222764)
- Testing
- Real-time three-dimensional echocardiography
- Where
- 2 sites in France
- Volunteers
- 341 people
- Sponsor
- University Hospital, Limoges
COVID-19, ARDS, Human
Cardiac Dysfunction in Critically Ill Covid-19 Patients
We conducted an observation sub-study of the prospective randomized controlled trial "High Dose Inhaled Nitric Oxide in Acute Hypoxemic Respiratory Failure", in which we analysed the echocardiographic data collected both at…
- Conditions
- COVID-19, ARDS, Human, Cardiac Failure, Right Ventricular Dysfunction
- Trial name
- NCT06197256
- Where
- Sweden
- Volunteers
- 39 people
- Sponsor
- Region Stockholm
Pulmonary; Hypertension, Steatosis
Reversal of Right Ventricular Steatosis in Pulmonary Hypertension
The goal of this study is to elucidate the relationship between myocardial right ventricular triglyceride content (steatosis) and right ventricular dysfunction in participants with pulmonary hypertension, and investigate…
- Conditions
- Pulmonary; Hypertension, Steatosis, Right Ventricular Failure
- Trial name
- NCT02966899
- Testing
- Omega-3 fatty acids
- Where
- United States
- Sponsor
- Wen-Chih Wu
Heart Failure With Reduced Ejection Fraction, Left Ventricular Assist Device
Influence of Right Ventricular Function on Changes in Exercise Capacity After LVAD
This is an exploratory project with the purpose to describe the responses of the right ventricle (RV) and gas exchange during exercise in patients scheduled to undergo left ventricular assist device (LVAD) implant.
- Trial name
- NCT05916612
- Sponsor
- Henry Ford Health System
Tricuspid Regurgitation, Right Heart Failure
Pforzheim Tricuspid Valve Registry - Outcomes of Percutaneous Tricuspid Valve Repair
The Pforzheim Tricuspid Valve Registry study is designed to confirm the safety and performance of the TriClip™ device in a contemporary real-world setting in critically ill patients.
- Conditions
- Tricuspid Regurgitation, Right Heart Failure, Cardiac Remodeling, Ventricular, Cardiac Remodeling, Atrial
- Trial name
- NCT05179616
- Testing
- Transcatheter edge-to-edge tricuspid valve repair
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Helios Klinikum Pforzheim
Chronic Heart Failure, Right Ventricular Dysfunction
Right Ventricular Dysfunction in Chronic Heart Failure
The goal of this multi center observational prospective study is to analyze the concordance between the signs and symptoms of RHF and echocardiographic features of RVD in patient with heart failure.
- Conditions
- Chronic Heart Failure, Right Ventricular Dysfunction, Right Heart Failure
- Trial name
- RIVED-CHF (NCT06002321)
- Testing
- Echocardiography, Laboratory Test
- Where
- 14 sites in Italy
- Volunteers
- 1,000 people
- Sponsor
- University of Siena
Heart Failure, Cardiac Resynchronization Therapy
LVSP Based CRT vs. RVAP Based CRT
To find out whether left ventricular septal pacing (LVSP)-based cardiac resynchronization therapy (CRT) is superior to right ventricular apical pacing (RVAP)-based CRT in patients with failed left bundle branch pacing at the…
- Conditions
- Heart Failure, Cardiac Resynchronization Therapy, Left Ventricular Septal Pacing, Right Ventricular Septal Pacing
- Trial name
- NCT05985408
- Testing
- left ventricular septal pacing, right ventricular apical pacing
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Fu Wai Hospital, Beijing, China
Coronary Artery Bypass Surgery, Right-Sided Heart Failure
The SWEDEGRAFT Right-Heart-Substudy
BACKGROUND Right ventricular dysfunction is a common echocardiographic finding after cardiac surgery. Pericardial disruption has been suggested as the most probable cause as the phenomenon occurs within minutes after pericardial…
- Trial name
- NCT05049421
- Testing
- Echocardiography
- Where
- Denmark
- Volunteers
- 207 people
- Sponsor
- Aarhus University Hospital Skejby
Tricuspid Valve Insufficiency, Right Heart Failure
Treatment of Tricuspid Valve Regurgitation in Patients Undergoing Left Ventricular Assist Device Implantation Study
The purpose of this study is to determine the utility of tricuspid valve repair at the time of LVAD implantation for patients presenting with moderate or severe tricuspid regurgitation.
- Conditions
- Tricuspid Valve Insufficiency, Right Heart Failure, Heart Failure
- Trial name
- TVVAD (NCT03775759)
- Testing
- Tricuspid valve repair or replacement, Medical management of tricuspid regurgitation
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- Duke University