Clinical trials: Rhythm Control
Rumination, Chronic Pain
Modulation of Cortical Brain Activity During Attentional Control
The goal of this study is to determine whether an open-loop sham neurofeedback system can effectively modulate EEG alpha rhythms, which are associated with attentional control.
- Conditions
- Rumination, Chronic Pain, Fibromyalgia
- Trial name
- NCT06748976
- Testing
- Control
- Where
- Argentina
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- National Council of Scientific and Technical Research, Argentina
Blood Pressure, Heart Rate and Rhythm Disorders
Acute Maternal and Fetal Effects of Exercise in Pregnancy
This will be an open randomized clinical trial involving pregnant women between 35 and 37 weeks randomized to two modalities of exercise: treadmill or stationary bike.
- Conditions
- Blood Pressure, Heart Rate and Rhythm Disorders, Hypoglycemia, Lactate
- Trial name
- EXPREG (NCT01383889)
- Testing
- Physical exercise
- Where
- Brazil
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Instituto Materno Infantil Prof. Fernando Figueira
Jet Lag Disorder, Jet Lag
A Study on the Effectiveness of a Dietary Supplement FitoAvia for Jet Lag
Purpose of the study: Evaluation of the effects of dietary supplement Fitoavia in people with dyssynchrony Objectives of the study: 1. Assessment of the condition of patients with jet lag of 4 hours or more 2.
- Conditions
- Jet Lag Disorder, Jet Lag, Jet Lag Type Insomnia, Cognition Improvement
- Trial name
- NCT07695870
- Testing
- Fitoavia, Questionnaire and Physical Exam, cognition tests
- Where
- Russia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- MiraxBioPharma
Paroxysmal Supraventricular Tachycardia (PSVT)
Efficacy and Safety of Intranasal MSP-2017 (Etripamil) for the Conversion of PSVT to Sinus Rhythm
The primary objective of this study is to demonstrate the superiority of at least 1 dose of intranasal (IN) MSP-2017 (Etripamil) over placebo in terminating PSVT induced in an electrophysiology (EP) laboratory.
- Trial name
- NODE-1 (NCT02296190)
- Testing
- Etripamil
- Where
- 30 sites in United States, Canada
- Volunteers
- 199 people
- Sponsor
- Milestone Pharmaceuticals Inc.
Circadian Rhythm Sleep Disorder, Delayed Sleep Phase, Sleep
The Effects of a Blue Monochromatic Light Intervention on Evening-type Individuals' Sleep and Circadian Rhythms
The present project is aimed to contribute with new knowledge concerning how light conditions in the physical environment can be manipulated to alter the sleep and circadian rhythms of individuals with an evening-type circadian…
- Trial name
- NCT03758768
- Testing
- Blue light exposure, Full spectrum light exposure
- Where
- Norway
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Bergen
Glucose, Circadian Rhythm
Interaction of Melatonin With MTNR1B Genotype on Glucose Control - Study 2
This project aims to test the impact of melatonin and MTNR1B variation on regulation glucose regulation in a highly controlled in-laboratory setting and ex vivo in pancreatic islets.
- Conditions
- Glucose, Circadian Rhythm, Melatonin, Genes
- Trial name
- NCT03464084
- Testing
- melatonin, bright light, dim light
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Electrical Alternation of Heart, Blood Pressure
Impact of Energy Drink Brands on Heart Rhythm
To assess the cardiac effects of energy drink brands in healthy volunteers
- Trial name
- NCT03196908
- Testing
- Energy Drink Brand 1, Energy Drink Brand 2
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of the Pacific
Seasonal Affective Disorder
Low Intensity 'Blue Light' Treatment of Seasonal Affective Disorder
One of the most frequently investigated hypothesis of the pathophysiology underlying Seasonal Affective Disorder(SAD) or so called winter depression is a disturbance of circadian rhythms.
- Trial name
- NCT01149135
- Testing
- Blue enriched light with a low intensity, standard light treatment
- Volunteers
- 22 people
- Sponsor
- University Medical Center Groningen
Atrial Fibrillation, Atrial Flutter
Intravenous Tedisamil in the Rapid Conversion of Atrial Fibrillation or Flutter to Normal Sinus Rhythm in Female Subjects
The purpose of this study is to demonstrate the ability of tedisamil to convert atrial fibrillation or flutter into normal sinus rhythm (NSR) in female patients.
- Trial name
- NCT00126074
- Testing
- Tedisamil sesquifumarate
- Where
- 26 sites in United States, Bulgaria and 4 more
- Sponsor
- Solvay Pharmaceuticals
Circadian Misalignment, Sex Differences
Does Circadian Misalignment Have Sex-Specific Effects on Metabolism?
This study will test whether biological sex influences how the body responds to circadian misalignment-a mismatch between the internal body clock and the timing of sleep and eating (as can occur with shift work or jet lag).
- Trial name
- NCT07441265
- Testing
- Day shift, Night shift
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Heart Rhythm Disorder
Role of Ivabradine for Heart Rate Control in Management of Patients With Sepsis and Septic Shock
Tachycardia is associated with excess mortality during septic shock. This may be related to the increase in cardiac metabolic demand, impaired cardiac diastolic function and less effect of administered exogenous catecholamines.
- Trial name
- NCT06742164
- Testing
- Ivabradine 5mg Tab, control
- Volunteers
- 76 people
- Sponsor
- Ain Shams University
Surgical Stress Response, Stress Physiological
Feasibility of Breathwork Intervention With Older Adults After Knee Surgery
Postoperative complications after surgical procedures, including following total knee arthroplasty (TKA), have a negative impact on the health and well-being of surgical patients.
- Conditions
- Surgical Stress Response, Stress Physiological, Stress Physiology, Stress Psychological
- Trial name
- NCT07464860
- Testing
- A 5-minute Asynchronous Breathwork Intervention, A 5-minute Asynchronous Card Game Video
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Aging, Postural Balance
Tai Chi Intervention for Balance Function in Older Adults: Predictive and Modifying Roles of Circadian Age
This study investigates the effects of a 12-week Tai Chi intervention on balance function in community-dwelling older adults. Participants are randomly assigned to either a Tai Chi exercise group or a health education control…
- Conditions
- Aging, Postural Balance, Accidental Falls
- Trial name
- NCT07567976
- Testing
- Tai Chi Exercise, Health Education
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Zhide Liang
Atrial Fibrillation
Multimodality Prediction of Success of Atrial Fibrillation Rhythm Control Strategy
In this study the investigators aim to build a model to predict the maintenance of sinus rhythm (SR) after successful direct current cardioversion (DCC) incorporating standard predictors such as echocardiographic parameters…
- Trial name
- MULTI-AF (NCT02009683)
- Where
- Netherlands
- Volunteers
- 220 people
- Sponsor
- Maastricht University Medical Center
Non-24-Hour Sleep-Wake Disorder
Efficacy and Safety of Tasimelteon Compared With Placebo in Totally Blind Subjects With Non-24-Hour Sleep-Wake Disorder
The purpose of this study is to evaluate the efficacy and safety of a six month double-mask treatment of tasimelteon or placebo in male and female subjects with Non-24-Hour Sleep-Wake Disorder
- Trial name
- NCT01163032
- Testing
- tasimelteon
- Where
- 28 sites in United States, Germany
- Volunteers
- 136 people
- Sponsor
- Vanda Pharmaceuticals
Atrial Fibrillation, Heart Failure
Randomized Ablation-based AF Rhythm-control Versus Rate-control in Patients With HF and High-burden AF Extend
This is an extended follow up study of the original RAFT-AF Study. The RAFT-AF study was a multi-centre randomized controlled trial with a prospective randomized open blinded endpoint trial (PROBE) design.
- Trial name
- RAFT-AF Extend (NCT05118893)
- Where
- 11 sites in Canada
- Volunteers
- 324 people
- Sponsor
- Anthony Tang
Healthy Volunteers
A Study Evaluating the Effect of a Single-dose Oral Administration of Nemonoxacin Capsule on QTc Intervals and Heart Rhythms of Healthy Subjects and the Influence of Food Intake on QTc Intervals and Pharmacokinetic Characteristics
A randomized, single-center, placebo and positive control, 4-period and 4-crossover clinical study with the following main purposes: (1) To evaluate the effect of a single-dose oral administration of nemonoxacin malate capsule on…
- Trial name
- NCT03362853
- Testing
- Nemonoxacin 500Mg Capsule, Moxifloxacin 400Mg Tablet, Nemonoxacin 750Mg Capsule
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- TaiGen Biotechnology Co., Ltd.
Seasonal Affective Disorder
Ramelteon in the Treatment of Sleep and Mood in Patients With Seasonal Affective Disorder
The purpose of this study is to determine whether treating sleep difficulties in patients with seasonal affective disorder also improves their depressive symptoms.
- Trial name
- SAM-SAD (NCT00502320)
- Testing
- Ramelteon
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Lehigh Valley Hospital
Atrial Fibrillation, Atrial Flutter
Intravenous Tedisamil in the Rapid Conversion of Atrial Fibrillation or Flutter to Normal Sinus Rhythm in Female Subjects
The purpose of this study is to demonstrate the ability of tedisamil to convert atrial fibrillation or flutter into normal sinus rhythm (NSR) in female patients.
- Trial name
- NCT00126022
- Testing
- Tedisamil sesquifumarate
- Where
- 81 sites in United States, Argentina and 11 more
- Sponsor
- Solvay Pharmaceuticals
Obesity & Overweight, Circadian Rhythm Disorders
Effects of Akkermansia Muciniphila and Berberine Supplementation on Insulin Sensitivity in Night-shift Workers
Night shift work is associated with an increased risk of obesity, insulin resistance, and cardiometabolic disorders, largely due to circadian misalignment, disrupted sleep, and altered eating patterns.
- Conditions
- Obesity & Overweight, Circadian Rhythm Disorders, Gut Microbiota Modulation, Prediabetes (Insulin Resistance, Impaired Glucose Tolerance)
- Trial name
- Shift2Health (NCT07440147)
- Testing
- Verum (A)
- Where
- Austria
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- FH Joanneum Gesellschaft mbH