Clinical trials: Rhinosinusitis With Polyps
Chronic Rhinosinusitis, Nasal Polyps
Influence of Oral Doxycycline on Wound Healing After Endonasal Endoscopic Sinus Surgery for Chronic Rhinosinusitis With and Without Nasal Polyposis: a Double-blind Randomized Placebo-controlled Trial
This is a randomized, double blind, placebo controlled, parallel group, study in patients with chronic rhinosinusitis with or without nasal polyps.
- Trial name
- DOXYPOSTOP (NCT01198912)
- Testing
- doxycycline 100 mg
- Where
- 2 sites in Belgium, Germany
- Volunteers
- 33 people
- Sponsor
- University Hospital, Ghent
Chronic Rhinosinusitis (CRS), Chronic Rhinosinusitis (CRS) With and Without Nasal Polyps
Evaluation of the Safety and Performance of a Bioresorbable Nasal Dressing Containing Mometasone Furoate (MF)
The primary objective of the study is to evaluate the safety and effectiveness of OCEAN as an adjunct aid in wound healing after nasal/sinus surgery and to demonstrate that OCEAN is non-inferior compared to a steroid-eluting…
- Trial name
- ENHANCE II (NCT07286201)
- Testing
- OCEAN, Steroid-eluting sinus stent
- Where
- 9 sites in United States
- Volunteers
- 110 people
- Sponsor
- Polyganics BV
Chronic Rhinosinusitis (Diagnosis), Nasal Polyposis
Mometasone vs Budesonide in CRS With Polyposis
The principal objective is to compare the use of mometasone nasal spray to budesonide irrigations in patients suffering from CRSwNP who have never been operated.
- Trial name
- NCT03323866
- Testing
- Budesonide 0.5 MG/ML, Mometasone nasal spray
- Where
- Canada
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Chronic Rhinosinusitis
Itraconazole for Fungal Sensitive Chronic Rhinosinusitis With Nasal Polyps
The purpose of this randomized controlled double-blinded trial is to determine if the addition of an oral antifungal to typical post-operative medical therapy can prevent or reduce the incidence of recurrence of nasal polyps in…
- Trial name
- NCT02285283
- Testing
- Itraconazole
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- The University of Texas Health Science Center, Houston
Sinusitis, Chronic
Effect of Postoperative Additive Systemic Steroids in CRSwNP
This study investigate the additive effect of systemic postoperative steroids in patients with chronic rhinosinusitis (CRSwNP). All patients receive a functional endoscopic sinus surgery (FESS) followed by topical steroid spray…
- Trial name
- NCT04915456
- Testing
- Systemic Steroid (Prednisolone)
- Volunteers
- 106 people
- Sponsor
- Friedrich-Alexander-Universität Erlangen-Nürnberg
Chronic Rhinosinusitis With Nasal Polyps
Efficacy of Long-Term Low Dose Macrolide Therapy in Preventing Early Recurrence of Nasal Polyps After Endoscopic Sinus Surgery
This randomized controlled trial evaluated the effectiveness of long-term, low-dose clarithromycin (250 mg/day) in reducing symptoms, improving endoscopic and radiologic scores, and preventing early recurrence of nasal polyps…
- Trial name
- NCT07316959
- Testing
- clarithromycin 250 mg
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- Fatima Jinnah Medical University
Nasal Polyps, Aspirin-exacerbated Respiratory Disease
Role of IL-5R Signaling in Non-eosinophil Upper Airway Cells in CRSwNP
The overarching hypothesis of this proposal is that IL-5 acts on multiple sinus tissue cell types, including plasma cells and epithelial cells, to promote immune dysregulation, and that inhibition of IL-5 affects several relevant…
- Trial name
- RECAP-5 (NCT05672030)
- Testing
- Non-Interventional
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Chronic Rhinosinusitis Without Nasal Polyps
Efficacy and Safety of 186 mcg of OPN-375 Nasal Spray Twice a Day (BID) in Adolescents With Chronic Rhinosinusitis Without Nasal Polyps
This is a 12-Week randomized, double-blind, placebo-controlled, parallel-group, multicenter study evaluating the efficacy and safety of intranasal administration of 186 µg of OPN-375 twice a day (BID) in adolescent subjects with…
- Trial name
- Re-Open 3 (NCT06850805)
- Testing
- OPN-375
- Where
- 24 sites in United States
- Volunteers
- 84 people
- Sponsor
- Optinose US Inc.
Chronic Rhinosinusitis, Polyps
QOL Outcomes in CRS With Polyps
Chronic rhinosinusits (CRS) is common disease with reports of prevalence ranging from 4-16% in the western population. The main outcome measure for chronic disease treatment, such as CRS, is quality of life.
- Trial name
- NCT03144375
- Testing
- Medical optimization and education, Standard of Care sinus surgery
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Miami
Chronic Sinusitis With Nasal Polyps and Eosinophilia
Study of Dexpramipexole Chronic Sinusitis With Nasal Polyps and Eosinophilia
Phase 2, open-label, multi-center study to evaluate the clinical effects of oral administration of dexpramipexole for 6 months in subjects with chronic sinusitis with nasal polyps and eosinophilia.
- Trial name
- CS201 (NCT02217332)
- Testing
- dexpramipexole
- Where
- 7 sites in United States
- Volunteers
- 20 people
- Sponsor
- Knopp Biosciences
Chronic Sinusitis, Nasal Polyps
Biologics in Chronic Rhinosinusitis With Nasal Polyposis
The prevalence of Chronic Sinusitis with Nasal Polyps (CRSwNP) in the United States is estimated at roughly 4%, which equates to over 13 million Americans.
- Trial name
- CRSwNP (NCT06824649)
- Testing
- Biologic Agents
- Where
- 3 sites in United States
- Volunteers
- 504 people
- Sponsor
- Medical University of South Carolina
Nasal Polyps
Efficacy and Safety of Depemokimab (GSK3511294) in Participants With Chronic Rhinosinusitis With Nasal Polyps
This study will evaluate the efficacy and safety of depemokimab (GSK3511294) in participants with Chronic rhinosinusitis with nasal polyps (CRSwNP).
- Trial name
- ANCHOR-1 (NCT05274750)
- Testing
- Depemokimab (GSK3511294)
- Where
- 105 sites in United States, Argentina and 9 more
- Volunteers
- 276 people
- Sponsor
- GlaxoSmithKline
Severe Eosinophilic Asthma w/wo CRSwNP
Role of Epithelial Barrier Integrity in Biologic Treatment Response of Severe Asthmatics With/Out Chronic Rhinosinusitis With Nasal Polyps (CRSwNP).
Advances in understanding the pathophysiology of asthma development and severity have pointed towards a prominent role of the bronchial epithelium, especially in more chronic and severe disease.
- Trial name
- NCT05365841
- Testing
- Mepolizumab 100 MG
- Where
- 2 sites in Greece
- Volunteers
- 85 people
- Sponsor
- University of Crete
Postoperative Agitation: Impaired Awareness, Abnormal Cognitive Function, Confusion, and Verbal and Physical Agitation During Recovery From General Anesthesia, Deviated Nasal Septum
Anterior Ethmoidal Nerve Block in Prevention of Postoperative Agitation
Postoperative agitation is an important complication of general anesthesia, moreover, it has been found with high incidence in ear, nose, throat (ENT) surgeries.
- Conditions
- Postoperative Agitation: Impaired Awareness, Abnormal Cognitive Function, Confusion, and Verbal and Physical Agitation During Recovery From General Anesthesia, Deviated Nasal Septum, Chronic Rhinosinusitis (Diagnosis), Nasal Polyps
- Trial name
- NCT03427502
- Testing
- Bupivacaine-epinephrine, normal saline
- Where
- Nepal
- Volunteers
- 100 people
- Sponsor
- Lumbini Medical College
AERD - Aspirin Exacerbated Respiratory Disease
Effect of Dupilumab on Aspirin Intolerance
To test the efficacy of dupilumab in patients with AERD regarding the intolerance to salicylic acid after 6 months. This will be evaluated by oral drug provocation testing with low dose salicylic acid after 6 months of dupilumab…
- Trial name
- NCT04442256
- Testing
- Dupilumab
- Where
- Austria
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Hyperactivity, Allergic Rhinitis Due to House Dust Mite
Mediators in Nasal Hyperreactivity in Allergic Rhinitis and Chronic Rhinosinusitis
Rhinitis, or inflammation of the nasal mucosa, can present with nasal obstruction, nasal discharge, itch or sneezing. If the sinusal mucosa is involved as well, it is called rhinosinusitis and facial pain or loss of smell is…
- Conditions
- Hyperactivity, Allergic Rhinitis Due to House Dust Mite, Chronic Rhinosinusitis With Nasal Polyps
- Trial name
- NCT04286542
- Testing
- Cold, dry air
- Where
- Belgium
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)
Upper Airway Inflammation and Olfaction: Mechanisms of Loss and Recovery
The goal of this clinical trial is to understand the mechanisms leading to olfactory dysfunction (OD) in chronic rhinosinusitis (CRS).
- Trial name
- IMMUNODOR (NCT06776042)
- Testing
- Nasal brushing of the olfactory cleft, Smell testing
- Where
- Belgium
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Chronic Rhinosinusitis With Nasal Polyps, Asthma; Eosinophilic
A Real-world, Head-to-head Comparison of Dupilumab Versus Mepolizumab in Danish Patients With Chronic Rhinosinusitis With Nasal Polyps
The goal of this randomized clinical trial is to compare the effects of two newly available biological drugs for the treatment of severe chronic rhinosinusitis with nasal polyps in Danish patients.
- Conditions
- Chronic Rhinosinusitis With Nasal Polyps, Asthma; Eosinophilic, Eosinophilia
- Trial name
- TORNADO (NCT05942222)
- Testing
- dupilumab, mepolizumab
- Where
- 9 sites in Denmark
- Volunteers
- 220 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Chronic Rhinosinusitis With Nasal Polyps
Real Life Study of Biologicals in Patients With Severe CRSwNP
This study is a pragmatic, real-life, observational study recruiting adult patients with chronic rhinosinusitis with nasal polyposis who are eligible to start biologicals as standard treatment.
- Trial name
- NASUMAB (NCT05938972)
- Testing
- Mepolizumab
- Where
- Belgium
- Volunteers
- 180 people
- Sponsor
- University Hospital, Ghent
Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)
A Study to Evaluate the Efficacy and Safety of AK139 in Participants With Chronic Rhinosinusitis With Nasal Polyps
This is a multicenter, randomized, double-blind, placebo-controlled study designed to evaluate the efficacy, safety, pharmacokinetics (PK), pharmacodynamics (PD), and immunogenicity of AK139 injection compared with placebo in…
- Trial name
- NCT07755371
- Testing
- AK139
- Where
- China
- Volunteers
- 75 people
- Sponsor
- Akeso