Clinical trials: Rhinosinusitis Acute
Acute Rhinitis, Nasal Obstruction
Performance and Safety Assessment of the Mechanical Decongestant Seawater Spray Enriched With Essential Oils From Laboratoires Gilbert in Patient With Acute Rhinitis Associated With Nasal Obstruction
The purpose of this post-market clinical investigation is to assess the performance and the safety of the mechanical decongestant seawater spray enriched with essential oils from Laboratoires Gilbert.
- Conditions
- Acute Rhinitis, Nasal Obstruction, Rhinosinusitis, Rhinopharyngitis
- Trial name
- DEMECA (NCT06580210)
- Where
- 3 sites in France
- Volunteers
- 114 people
- Sponsor
- Laboratoires Gilbert
Rhinosinusitis Acute
The Effect of Facial Effleurage on Acute Rhinosinusitis
Rhinosinusitis accounts for 12% of the total antibiotic prescriptions filled in the United States annually; however, the majority of rhinosinusitis cases have been proposed to have a viral etiology, or are capable of…
- Trial name
- NCT04642989
- Testing
- Facial Effleurage, Antibiotics
- Where
- United States
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Edward Via Virginia College of Osteopathic Medicine
Recurrent Acute Rhinosinusitis
Evaluation of Nitric Oxide Nasal Spray (NONS) for Treatment of Recurrent Acute Rhinosinusitis
A two-week therapy of nitric oxide nasal spray (NONS) vs Placebo (saline nasal spray) initiated immediately after the onset of a new Recurrent Acute Rhinosinusitis (RARS) episode to assess the acceleration to clinical success…
- Trial name
- NONS-RARS-01 (NCT06264141)
- Testing
- Nitric Oxide Releasing Solution, Nasal spray with isotonic saline
- Where
- 7 sites in Canada
- Volunteers
- 162 people
- Sponsor
- Sanotize Research and Development corp.
Sinusitis, Sinusitis, Acute
Efficacy and Safety of Modified Release Cefpodoxime Formulation in the Treatment of Acute Sinusitis.
The aim of this study is to compare the efficacy and safety of cefpodoxime 200 mg immediate (b.i.d) and cefpodoxime 400 mg modified release (q.d) tablet formulations in the treatment of acute bacterial rhinosinusitis.
- Conditions
- Sinusitis, Sinusitis, Acute, Rhinosinusitis, Rhinosinusitis Acute
- Trial name
- NCT03729258
- Testing
- Infex 400 MR, Infex 200 IR
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Neutec Ar-Ge San ve Tic A.Ş
Sinusitis
Application of Ectoin® Rhinitis Nasal Spray in Patients With Acute Rhinosinusitis
This is a comparative, open label, parallel group, non interventional study to further demonstrate the effectiveness and tolerability of Ectoin® Rhinitis Nasal Spray.
- Trial name
- SNS01 (NCT01684540)
- Testing
- Medical Device, Drug-like, Sinupret forte
- Where
- 6 sites in Germany
- Volunteers
- 66 people
- Sponsor
- Bitop AG
Acute Rhinitis, Nasal Obstruction
Safety and Performance Assessment of the Decongestant Seawater Spray Pocket Valve Enriched With Essential Oils in Patients With Acute Rhinitis Associated With Nasal Obstruction: "DEVALPO"
The purpose of this pre-market clinical investigation is to assess the safety and the performance of decongestant seawater spray pocket valve enriched with essential oils by Gilbert Laboratories.
- Conditions
- Acute Rhinitis, Nasal Obstruction, Rhinosinusitis, Rhinopharyngitis
- Trial name
- DEVALPO (NCT05494346)
- Testing
- Measurement of peak nasal flow.
- Where
- 5 sites in France
- Volunteers
- 101 people
- Sponsor
- Laboratoires Gilbert
Chronic Rhinosinusitis (CRS) With and Without Nasal Polyps
Safety and Efficacy of BHV-3000 (Rimegepant) Orally Disintegrating Tablet for the Acute Treatment of Chronic Rhinosinusitis
The purpose of this study is to compare the efficacy and safety of rimegepant versus placebo in the acute treatment of chronic rhinosinusitis (CRS) with and without nasal polyps.
- Trial name
- NCT05248997
- Testing
- rimegepant 75 mg ODT
- Where
- 33 sites in United States
- Volunteers
- 261 people
- Sponsor
- Pfizer
Acute Rhinosinusitis, Recurrent Acute Rhinosinusitis
NAC Inhalation in the Treatment Of Symptomatic acuTe rhinosinUSitis
N-acetylcysteine (NAC), known to have mucolytic and antioxidant effects, is widely used to treat respiratory diseases and manage post-surgery pulmonary complications.
- Conditions
- Acute Rhinosinusitis, Recurrent Acute Rhinosinusitis, Chronic Rhinosinusitis
- Trial name
- NOTUS (NCT04131686)
- Where
- South Korea
- Volunteers
- 294 people
- Sponsor
- Boryung Pharmaceutical Co., Ltd
Acute Rhinosinusitis
Effectiveness and Safety of Once or Twice Daily Mometasone Nasal Spray Versus Amoxicillin Versus Placebo for Treatment of Acute Rhinosinusitis (Study P02683)
This study was conducted to compare the effectiveness and safety of mometasone nasal spray once daily or twice daily with amoxicillin or with placebo in treating the signs and symptoms of acute rhinosinusitis.
- Trial name
- NCT00750750
- Testing
- mometasone furoate nasal spray (MFNS), MFNS, Amoxicillin
- Volunteers
- 981 people
- Sponsor
- Organon and Co
Acute Upper Respiratory Tract Infection and Acute Bacterial Rhinosinusitis
Acute Upper Respiratory Tract Infection - When is Bacteria Involved?
The purpose of this study is to find out if we can predict the progress of acute upper respiratory tract infection to acute bacterial rhinosinusitis in Finnish conscripts by symptoms, clinical, endoscopic or radiological…
- Trial name
- NCT01580137
- Where
- Finland
- Volunteers
- 48 people
- Sponsor
- Oulu University Hospital
Sinusitis Chronic
GLS-1200 Topical Nasal Spray to Prevent Sinusitis After Endoscopic Sinus Surgery
This clinical trial will evaluate the safety, tolerability and effectiveness of GLS-1200 nasal spray in addition to the standard of care after endoscopic sinus surgery in people with chronic sinusitis.
- Trial name
- NCT04060316
- Testing
- GLS-1200
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- GeneOne Life Science, Inc.
Recurrent Acute Rhinosinusitis
Comparison of Balloon Sinuplasty In-Office Versus Medical Management for Recurrent Acute Sinusitis Patients (CABERNET)
This post-market study aims to compare health outcomes for Recurrent Acute Rhinosinusitis (RARS) patients treated with balloon sinus dilation (BSD) versus medical management alone.
- Trial name
- CABERNET (NCT01714687)
- Testing
- balloon sinus dilation, medical therapy
- Where
- 5 sites in United States
- Volunteers
- 59 people
- Sponsor
- Integra LifeSciences Corporation
Acute Rhinosinusitis, Allergic Rhinitis
An Observational Study to Evaluate The Relationship of Nasal Mucus Properties and Symptoms
This is a study to learn more about the common cold from studying the nasal secretions produced during a cold or episode of allergic rhinitis.
- Trial name
- NCT01553110
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Virginia Commonwealth University
Rhino-Sinusitis
Treatment of Acute Rhino-Sinusitis With Essential Oils of Aromatic Plants
This randomized, double blind, parallel group study, compared the efficacy of spray containing aromatic essential oils of some herbal plants, against placebo in the treatment of patients with acute Rhino-sinusitis.
- Trial name
- NCT00610779
- Testing
- mixture of aromatic essential oils.
- Where
- Israel
- Volunteers
- 14 people
- Sponsor
- HaEmek Medical Center, Israel
Rhinosinusitis Acute, Rhinosinusitis Chronic
Sinolpan® Pharmacy Non-interventional Study - Quality of Live
This non-interventional study investigates the Quality of Life of patients suffering from rhinosinusitis. Patients who seek advice in a pharmacy and choose to intake Sinolpan® or Sinolpan® forte or to use nasally applied…
- Conditions
- Rhinosinusitis Acute, Rhinosinusitis Chronic, Bronchitis
- Trial name
- NCT04703673
- Testing
- Cineole, Nasal Decongestant
- Where
- Germany
- Volunteers
- 350 people
- Sponsor
- Engelhard Arzneimittel GmbH & Co.KG
Infections, Bacterial
A Pharmacokinetics and Safety Study of Augmentin ES-600 in Children With CAP and ABRS
The purpose of this study is to evaluate the pharmacokinetics, safety or tolerability through treatment emergent adverse event (TEAE) and to explore primary and secondary clinical response of treatment with Augmentin ES in…
- Trial name
- NCT05340257
- Testing
- Augmentin ES
- Where
- 2 sites in Brazil
- Sponsor
- GlaxoSmithKline
Persian Gulf Syndrome, Chronic Sinusitis
Gulf War Illness Nasal Irrigation Study
The purpose of this study is to determine whether nasal irrigation with Xylitol or saline are effective in the treatment of chronic rhinosinusitis and fatigue symptoms associated with Gulf War Illness.
- Conditions
- Persian Gulf Syndrome, Chronic Sinusitis, Fatigue, Acute Sinusitis
- Trial name
- GWINIS (NCT01700725)
- Testing
- Nasal Irrigation - Saline, Nasal Irrigation - Xylitol
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Wisconsin, Madison
Acute Respiratory Infection, Sinusitis
Middle Meatal Bacteriology During Acute Respiratory Infection in Children
The purpose of this study is to find out whether the children with respiratory infection and the presence of pathogenic bacteria (S. pneumoniae, H. influenzae or M.
- Trial name
- NCT00545961
- Testing
- amoxicillin clavulanate acid
- Where
- 3 sites in Finland
- Volunteers
- 120 people
- Sponsor
- Oulu University Hospital
Rhino Sinusitis
Safety Evaluation of Intranasal Use of DSM 32444 Postbiotic in Humans
Rhinitis is a type of upper respiratory infection with a common nasal pathology especially in Southeast Asia, which is characterized by the presence of one or more of the following symptoms: itchy nose, sneezing, runny nose, and…
- Trial name
- NCT05984004
- Testing
- 0.9% NaCl isotonic saline solution, Bacillus subtilis DSM32444, inactivated
- Where
- Vietnam
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Huro Biotech Joint Stock Company
Rhinitis, Sinusitis
Topical Irrigation Therapy for CRS
The purpose of the study is to evaluate the physiologic response of quinine-saline irrigations for acute exacerbation of uncomplicated chronic rhinosinusitis following endoscopic sinus surgery.
- Trial name
- QSIND (NCT02630472)
- Testing
- Quinine Sulfate
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Pennsylvania