Clinical trials: Rheumatic Joint Disease
Osteoarthritis, Rheumatoid Arthritis
Maxim® Knee Pop-Top® Tibia vs. Regular Maxim® Knee Tibia
The purpose of this prospective clinical data collection is to compare the outcomes of two different tibial bearings: the Maxim® Pop-Top® Tibia and Maxim® Modular Tibia.
- Conditions
- Osteoarthritis, Rheumatoid Arthritis, Traumatic Arthritis
- Trial name
- NCT00579059
- Testing
- Maxim® Knee System with Removable Molded Polyethylene Tibia, Regular Maxim® Knee System
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Biomet Orthopedics, LLC
Osteoarthritis of the Knee
A Study of Duloxetine (LY248686) in Participants With Chronic Osteoarthritis and Knee Pain in Japan
The main purpose of this study is to evaluate the efficacy of the study drug known as duloxetine in participants with chronic osteoarthritis (OA) and knee pain in Japan.
- Trial name
- NCT02248480
- Testing
- Duloxetine
- Where
- Japan
- Volunteers
- 354 people
- Sponsor
- Eli Lilly and Company
Rheumatoid Arthritis
An Observational Study of RoActemra/Actemra (Tocilizumab) in Smoking Versus Non-Smoking Patients With Rheumatoid Arthritis
This observational study will assess the efficacy and safety of RoActemra/Actemra (Tocilizumab) in smoking versus non-smoking patients with rheumatoid arthritis.
- Trial name
- NCT01337388
- Where
- 29 sites in Norway, Sweden
- Volunteers
- 197 people
- Sponsor
- Hoffmann-La Roche
Rheumatoid Arthritis
BG9924 in Combination With Methotrexate for Participants With Active Rheumatoid Arthritis
This Phase 2b study is designed to evaluate the efficacy and safety of BG9924 given subcutaneously (SC) versus placebo in participants with active rheumatoid arthritis (RA) who have previously had an inadequate response to…
- Trial name
- NCT00458861
- Testing
- BG9924
- Where
- United States
- Volunteers
- 115 people
- Sponsor
- Biogen
Rheumatoid Arthritis, Pharmacokinetics of ASP2409
A Dose Escalation Study to Assess Safety, Tolerability and Pharmacokinetics of ASP2409 Following a Single Intravenous Dose in Patients With Rheumatoid Arthritis on Methotrexate
The purpose of this study is to assess the safety, tolerability and pharmacokinetics (PK) of single, ascending, intravenous (IV) doses of ASP2409 in patients with Rheumatoid Arthritis (RA) on methotrexate (MTX) and to evaluate…
- Trial name
- NCT02171143
- Testing
- ASP2409
- Where
- 10 sites in United States
- Volunteers
- 58 people
- Sponsor
- Astellas Pharma Global Development, Inc.
Osteoarthritis Arthritis, Rheumatoid Arthritis
G7 Acetabular System vs. Exceed ABT Acetabular System in THA
Evaluate the safety and effectiveness of patients who received G7 Acetabular system in conjunction with Ceramic on Ceramic articulation and Taperloc Complete Microplasty stem compared to patients who received the Exceed ABT…
- Trial name
- G7 (NCT02340390)
- Testing
- G7, Exceed ABT
- Where
- 3 sites in South Korea
- Volunteers
- 160 people
- Sponsor
- Zimmer Biomet
Neurodegenerative Diseases, Osteoarthritis
Safety and Clinical Outcomes Study: SVF Deployment for Orthopedic, Neurologic, Urologic, and Cardio-pulmonary Conditions
To evaluate for any adverse effects that may be related to the administration and reception of autologous adipose derived stromal vascular fraction (SVF).
- Conditions
- Neurodegenerative Diseases, Osteoarthritis, Erectile Dysfunction, Autoimmune Diseases
- Trial name
- NCT01953523
- Testing
- Administration of autologous adipose derived SVF
- Where
- United States
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Elliot Lander
Inflammation, Rheumatoid Arthritis
A Trial of NNC0109-0012, an Anti-IL-20 Biologic, in Patients With Active Rheumatoid Arthritis Who Are Inadequate Responders to Methotrexate
This trial is conducted in Europe, North America and South America. The aim of this trial is to investigate the clinical efficacy of NNC0109-0012, a human monoclonal antibody, compared to placebo when administered as weekly…
- Trial name
- NCT01636843
- Testing
- NNC0109-0012
- Where
- 139 sites in United States, Argentina and 12 more
- Volunteers
- 298 people
- Sponsor
- Novo Nordisk A/S
Osteoarthritis, Rheumatoid Arthritis
Etoricoxib Prescribing Patterns and Adverse Events of Interest in Primary Care in the United Kingdom (MK-0663-162 AM1)
This postmarketing study was conducted to describe prescribing patterns for etoricoxib (ARCOXIA®) in General Practice and describe the incidence of selected adverse events recorded in the United Kingdom (UK) Medicines and Health…
- Conditions
- Osteoarthritis, Rheumatoid Arthritis, Ankylosing Spondylitis, Gout
- Trial name
- NCT01685424
- Testing
- Etoricoxib
- Volunteers
- 79,189 people
- Sponsor
- Organon and Co
Sjogren's Syndrome
Study of Safety and Tolerability of CFZ533 in Patients With Sjögren's Syndrome
This study will evaluate the safety and tolerability of iscalimab at two dose levels in patients with Sjögren's Syndrome, who participated in the TWINSS core study, CCFZ533B2201 (NCT03905525).
- Trial name
- TWINSS Extn (NCT04541589)
- Testing
- Iscalimab
- Where
- 62 sites in United States, Argentina and 21 more
- Volunteers
- 206 people
- Sponsor
- Novartis Pharmaceuticals
Rheumatoid Arthritis
Study of Enbrel in Rheumatoid Arthritis (RA) Subjects With Comorbid Disorders
The objective of this study was to evaluate the safety of Enbrel (etanercept) in rheumatoid arthritis (RA) subjects with greater than or equal to 1 documented comorbid disease (diabetes mellitus; chronic pulmonary disease…
- Trial name
- NCT00132418
- Testing
- Enbrel
- Volunteers
- 564 people
- Sponsor
- Amgen
Joint Disease
Comprehensive Shoulder System Nano IDE
The purpose of this clinical study is to determine the safety and efficacy of the Comprehensive® Shoulder System with Nano Humeral Component in Total Shoulder Arthroplasty (TSA).
- Trial name
- Nano (NCT01936259)
- Testing
- Mini Stem, Nano
- Where
- 12 sites in United States
- Volunteers
- 258 people
- Sponsor
- Zimmer Biomet
Rheumatoid Arthritis
Long Term Extension Study to Assess the Safety and Efficacy of Filgotinib in Adults With Rheumatoid Arthritis
The primary objective of this study is to evaluate the long-term safety and tolerability of filgotinib in participants who have completed one of the parent studies of filgotinib in rheumatoid arthritis (RA).
- Trial name
- FINCH 4 (NCT03025308)
- Testing
- Filgotinib
- Where
- 345 sites in United States, Argentina and 30 more
- Volunteers
- 2,731 people
- Sponsor
- Alfasigma S.p.A.
Rheumatoid Arthritis
A Study to Evaluate Efficacy of Tocilizumab Administered as Monotherapy or in Combination With Methotrexate and/or Other Disease Modifying Antirheumatic Drugs (DMARDs) in Rheumatoid Arthritis (RA) Participants
This open-label, single arm, Phase 3b study will evaluate the efficacy of tocilizumab (RoActemra), administered as monotherapy or in combination with methotrexate and/or other DMARDs, in participants with moderate to severe…
- Trial name
- NCT01941940
- Testing
- Tocilizumab, DMARDs
- Where
- 49 sites in Italy
- Volunteers
- 227 people
- Sponsor
- Hoffmann-La Roche
Rheumatoid Arthritis
An Efficacy and Safety Study of Golimumab in Patients With Active Rheumatoid Arthritis Despite Methotrexate Therapy
The purpose of this study is to evaluate the efficacy and safety of golimumab, alone or in combination with methotrexate (MTX), as compared to methotrexate alone in rheumatoid arthritis (RA) patients who have active rheumatoid…
- Trial name
- GO-FORWARD (NCT00264550)
- Testing
- Golimumab 100 mg, Golimumab 50 mg, Methotrexate
- Where
- 50 sites in United States, Argentina and 10 more
- Volunteers
- 444 people
- Sponsor
- Centocor, Inc.
Rheumatoid Arthritis
Study of NI-071 in Comparison With Remicade in Patients With Rheumatoid Arthritis
The purpose of this study is to compare the safety of NI-071 with Remicade® (infliximab) in patients with Rheumatoid Arthritis inadequately treated with Methotrexate.
- Trial name
- NCT01567358
- Testing
- Infliximab
- Where
- Japan
- Volunteers
- 14 people
- Sponsor
- Nichi-Iko Pharmaceutical Co., Ltd.
Rheumatoid Arthritis
Impact and Use of Abatacept IV for Rheumatoid Arthritis in Real Life Setting
The purpose of this study is to assess Abatacept Intravenous (IV) effectiveness in patients with inadequate response to one or more conventional Disease Modifying Against Rheumatism (DMARDs) including Methotrexate in France…
- Trial name
- ReACTION (NCT02037737)
- Testing
- Abatacept
- Volunteers
- 153 people
- Sponsor
- Bristol-Myers Squibb
Rheumatoid Arthritis
A Phase 1b Open-label Study to Evaluate Safety of Plamotamab in Participants With Rheumatoid Arthritis
The purpose of this study is to determine the safety and tolerability of plamotamab in patients with rheumatoid arthritis. Participants will be given XmAb13676 subcutaneously (SC) by injection under the skin.
- Trial name
- NCT07230353
- Testing
- Plamotamab
- Where
- 3 sites in Georgia, Moldova and 1 more
- Volunteers
- 68 people
- Sponsor
- Xencor, Inc.
Arthritis, Gouty
Efficacy and Safety of a Single Dose of Canakinumab (ACZ885) in Hospitalized Patients With Acute Gout
This is an exploratory proof-of-concept study to evaluate the safety and efficacy of canakinumab (ACZ885) for inflammation and pain associated with acute gouty arthritis.
- Trial name
- NCT00663169
- Testing
- canakinumab, dexamethasone
- Where
- 4 sites in United States, Switzerland and 1 more
- Volunteers
- 6 people
- Sponsor
- Novartis
Rheumatoid Arthritis
A Randomized, Placebo-Controlled, Double-Blind, Single Ascending Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of BMS-986104 in Healthy Male Subjects
The primary objective in this study is to assess if single doses of BMS-986104 that are safe, tolerable, and result in sufficient lymphopenia (50% to 70% reduction in absolute lymphocyte count) can be achieved without bradycardia…
- Trial name
- NCT02211469
- Testing
- BMS-986104
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
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