Clinical trials: Rheumatic Diseases
Knee Osteoarthritis
Physical Therapy Versus Internet-Based Exercise Training for Patients With Knee Osteoarthritis
The purpose of this study is to examine the effectiveness of standard physical therapy and an internet-based exercise program for people with knee osteoarthritis (OA).
- Trial name
- PATH-IN (NCT02312713)
- Testing
- Internet Based Exercise Training, Physical Therapy
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- University of North Carolina, Chapel Hill
Juvenile Idiopathic Arthritis
A Study of Decreased Dose Frequency in Participants With Systemic Juvenile Arthritis Who Experience Laboratory Abnormalities During Treatment With RoActemra/Actemra (Tocilizumab)
PART1 Participants in Part 1 (Run-in-Phase) of study will receive tocilizumab (TCZ) (RoActemra/Actemra) 12 milligrams per kilogram (mg/kg) or 8 mg/kg intravenously (IV) every 2 weeks (Q2W) for up to 24 weeks.
- Trial name
- NCT01734382
- Testing
- Tocilizumab
- Where
- 19 sites in United States, Argentina and 8 more
- Volunteers
- 35 people
- Sponsor
- Hoffmann-La Roche
Knee Osteoarthritis, Knee Arthritis
Comparison of Two Robotic-Assisted Total Knee Arthroplasty Systems
The goal of this prospective study is to compare two different knee replacement robots. This study will look at patient reported outcome measures and data collected during the operation.
- Conditions
- Knee Osteoarthritis, Knee Arthritis, Knee Disease
- Trial name
- NCT06284824
- Testing
- Stryker Triathlon with MAKO Robotic-Arm, DePuy Attune with VELYS Robotic-Assistance
- Volunteers
- 120 people
- Sponsor
- Southeast Orthopedic Specialists
Early Inflammatory Arthritis
Peer to Peer Mentoring For Individuals With Early Inflammatory Arthritis: An Effectiveness Study (Pilot RCT)- Peer Mentoring Program
Peer support (including informational, emotional, appraisal support) has been shown to help persons with chronic conditions. The goal of this research is to examine the impact of early peer support on the health and quality of…
- Trial name
- P2P EIA RCT (NCT01347359)
- Testing
- One-on-one peer support, Standard of care
- Where
- 2 sites in Canada
- Volunteers
- 40 people
- Sponsor
- Sunnybrook Health Sciences Centre
Chemical Injuries, Unspecified Complication of Corneal Transplant
Use of Cross-linked Donor Corneas as Carriers for the Boston Keratoprosthesis
The purpose of the pilot study is to test the efficacy and safety of riboflavin/Ultraviolet A (UVA) cross-linked human donor corneas as carriers for the Boston Keratoprosthesis (Boston KPro) in patients with higher risk for…
- Conditions
- Chemical Injuries, Unspecified Complication of Corneal Transplant, Autoimmune Diseases, Ocular Cicatricial Pemphigoid
- Trial name
- NCT01582880
- Testing
- Riboflavin
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Joseph B. Ciolino, MD
Rheumatoid Arthritis
A Study on Safety and Efficacy of Tocilizumab (RoActemra/Actemra) Alone or in Combination With Non-Biologic Antirheumatics in Participants With Rheumatoid Arthritis
This multi-center, open-label single arm Phase IIIb study will evaluate the safety and efficacy of subcutaneous (SC) tocilizumab administered as monotherapy and/or in combination with methotrexate or other non-biologic disease…
- Trial name
- OSCAR (NCT01987479)
- Testing
- Non-Biologic DMARDs, Tocilizumab, Methotrexate
- Where
- 20 sites in Netherlands
- Volunteers
- 150 people
- Sponsor
- Hoffmann-La Roche
Knee Osteoarthritis
Laser Cell Therapy for Knee Cartilage Repair
Laser pulsed energy will be delivered over an optical fiber to create channels into damaged cartilage of the knee or knees. The channels have a diameter of approximately 100 microns or less and an approximate depth of 1…
- Trial name
- NCT04001361
- Testing
- Laser Cell Therapy
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Endocellutions
Rheumatoid Arthritis
Renal Resistive Index as a Predictor of Renal Involvement in Rheumatoid Arthritis
Evaluation of resistive index on the renal artery as early predictor factor of renal affection in patients with rheumatoid arthritis.
- Trial name
- NCT06227442
- Testing
- KDIGO criteria of 2010
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Assiut University
Osteoarthritis, Knee
Synovitis in Patients With Osteoarthritis
To study synovial membrane (SM) inflammation in suprapatellar fossa in advanced knee osteoarthritis (OA), and to correlate the pathological features with clinical findings.
- Trial name
- NCT05617573
- Testing
- Total knee arthroplasty due to advanced osteoarthritis.
- Where
- China
- Volunteers
- 272 people
- Sponsor
- The Affiliated Hospital of Qingdao University
Knee Osteoarthritis
Dry Needling Treatment for Knee Osteoarthritis
The population affected by degenerative knee arthritis is very large. The investigator performed dry needle (DN) treatments with acupuncture needles.
- Trial name
- NCT03639441
- Testing
- dry needling, Transcutaneous electrical nerve stimulation
- Where
- Taiwan
- Volunteers
- 33 people
- Sponsor
- China Medical University Hospital
Osteoarthritis
Effectiveness of Manual Therapy and Exercise in Shoulder OA
Approximately 60 subjects from a sample of convenience diagnosed with shoulder arthritis will be randomized into a two groups. The control group will receive usual medical advice and the experimental group will be referred to…
- Trial name
- NCT02587559
- Testing
- physical therapy
- Where
- United States
- Sponsor
- University of Texas Southwestern Medical Center
Osteoarthritis
Trabecular Metal Mesh Tibial Monoblock RSA
Trabecular Metal(TM) is a relatively new technology and its use in knee replacement is quite different from the more conventional total knee replacement (arthroplastie).
- Trial name
- NCT00405379
- Testing
- Trabecular Metal Mesh Tibial Monoblock Knee Arthroplasty
- Volunteers
- 67 people
- Sponsor
- Dalhousie University
Rheumatoid Arthritis
Non-Interventional Study of Tocilizumab Subcutaneous (SC) Monotherapy in Participants With Rheumatoid Arthritis (RA)
The aim of this non-interventional study in Hungarian participants is to gather real life data about the efficacy and safety of tocilizumab SC monotherapy in RA, to assess data about pattern of usage of tocilizumab monotherapy in…
- Trial name
- SIMPACT (NCT02402686)
- Testing
- Tocilizumab
- Where
- 18 sites in Hungary
- Volunteers
- 353 people
- Sponsor
- Hoffmann-La Roche
Rheumatoid Arthritis
Clinical Pharmacology Study of MRA in Patient With Rheumatoid Arthritis (RA) With Renal Impairment
This is an open-label, clinical pharmacology study to evaluate the safety and PK of MRA in patients with RA with Renal Impairment.
- Trial name
- NCT00144573
- Testing
- MRA(Tocilizumab)
- Volunteers
- 14 people
- Sponsor
- Chugai Pharmaceutical
Knee Osteoarthritis, Degenerative Joint Disease of Knee
Genicular Artery Embolization for the Treatment of Knee Osteoarthritis
The purpose of this clinical research study is to examine whether Embozene treatment of the genicular artery is a safe and effective way to treat arthritic knee pain.
- Trial name
- GAE-OA (NCT03491397)
- Testing
- Embozene MicroSpheres
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Siddharth Padia, MD
Osteoarthritis, Knee
Acupuncture Safety/Efficacy in Knee Osteoarthritis
The goal of this research is to determine the efficacy and safety of Traditional Chinese Acupuncture (TCA) in patients with osteoarthritis of the knee.
- Trial name
- NCT00010946
- Testing
- Acupuncture
- Where
- 3 sites in United States
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Musculoskeletal Pain, Chronic Pain
The PROACTIVE Study for Black Elders
Chronic musculoskeletal pain (CMP), while a leading cause of physical disablement, is a neglected national health disparity issue in Black communities.
- Conditions
- Musculoskeletal Pain, Chronic Pain, Osteoarthritis, Pain, Chronic
- Trial name
- PROACTIVE (NCT06512727)
- Testing
- PROACTIVE Intervention
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Florida
Systemic Lupus Erthematosus, Systemic Sclerosis (SSc)
Safety and Efficacy of Universal CD19-targeting CAR-γδT Cells in Refractory Autoimmune Diseases
Autoimmune diseases refer to a common category of diseases caused by the immune system reacting to self-antigens, leading to tissue damage.
- Conditions
- Systemic Lupus Erthematosus, Systemic Sclerosis (SSc), Sjogren Syndrome, ANCA Associated Vasculitis (AAV)
- Trial name
- NCT06828042
- Testing
- anti-CD19 CAR T cell therapy
- Where
- China
- Volunteers
- 9 people
- Sponsor
- Peking University Third Hospital
Arthritis, Rheumatoid, Atherosclerosis
Does Sildenafil Improve Endothelial Dysfunction in Rheumatoid Arthritis?
The purpose of this study is to determine whether sildenafil improves parameters of vascular function and blood markers involved in development of heart disease in patients with rheumatoid arthritis.
- Trial name
- NCT02908490
- Testing
- Sildenafil
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Kimberly Liang
HIP AND KNEE OSTEOARTHRITIS
Prepare II - Predictive Model Training and External Validation
The general aim of the project is training and testing a predictive model of inpatient rehabilitation stay after hip and knee replacement for osteoarthritis.
- Trial name
- NCT07304323
- Testing
- Functional rehabilitation
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio