Clinical trials: Reward Learning
Placebo Effect on Mood Improvement
The Role of Dopamine, Reward Learning and Prefrontal Activity in Expectation-induced Mood Enhancement
Although placebo effects on depressive symptoms are well documented, the underlying mechanisms and moderating factors of expectation effects on mood and depression are poorly understood.
- Trial name
- CRC289A07 (NCT05208294)
- Testing
- Sulpiride 400 MG, High expectation manipulation, Low expectation manipulation
- Where
- Germany
- Volunteers
- 297 people, healthy volunteers welcome
- Sponsor
- Philipps University Marburg
Healthy, Parkinson
Optimistic and Pessimistic Dopamine Signals in the Human Brain: a Mapping and Modelling Study in Health and Parkinson's Disease
The goal of this observational study is to investigate whether the healthy human brain shows a diversity of optimistic and pessimistic reward signals and whether changes in this distribution in Parkinson's disease (PD) can…
- Conditions
- Healthy, Parkinson, Medication Administration
- Trial name
- OPD (NCT07402928)
- Where
- Denmark
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Danish Research Centre for Magnetic Resonance
Social Anhedonia, Social Function Impairment
Clinical and Neurocomputational Effects of Behavioral Activation in Veterans With Impaired Social Functioning
Poor psychosocial functioning, including social disconnection, is common and disabling among Veterans, and often fails to improve following the best available evidence-based treatments, particularly if more severe pathology is…
- Trial name
- NCT07697001
- Testing
- Behavioral Activation (BA), Supportive Care Therapy (SCT)
- Where
- United States
- Volunteers
- 136 people
- Sponsor
- VA Office of Research and Development
Healthy
Effect of Reward on Learning in Motor Cortex
Background: Magnetic resonance imaging (MRI) uses a strong magnetic field and radio waves to take pictures of the brain. Some MRI studies suggest that this technique reveals brain differences in patients with a nervous system…
- Trial name
- NCT00885131
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Depression in Adolescence, Antidepressant Activity in Healthy Volunteers
Fluoxetine and Understanding Social Experiences
Adolescence is a critical developmental period marked by significant social, cognitive, and emotional changes. Unfortunately, it is also a time when the risk of depression and anxiety rises dramatically.
- Conditions
- Depression in Adolescence, Antidepressant Activity in Healthy Volunteers, Healthy Adult Participants
- Trial name
- FUSE (NCT07456501)
- Testing
- Fluoxetine
- Where
- United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Anhedonia
Effect of D-amphetamine on Reward Functioning
The purpose of this study is to establish the dose-response curve for therapeutic doses of d-amphetamine on tasks of motivation and reward learning in the same participants and to use d-amphetamine as a dopaminergic probe to test…
- Trial name
- NCT03369015
- Testing
- 10 mg d-amphetamine, 20mg d-amphetamine
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Healthy
The Effects of Losartan on Reward Reinforcement Learning
This study aims to investigate whether a single dose of losartan (50 mg) can affect learning from positive and negative outcomes and its related neural mechanisms.
- Trial name
- NCT04604938
- Testing
- Losartan
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China