Clinical trials: Retroperitoneal Sarcoma
Primary Retroperitoneal Sarcoma
Survival and Prognostic Factors of Primary Retroperitoneal Sarcomas After Surgery: a Single-center Experience
he percentage of retroperitoneal sarcomas (RPS) among all soft tissue sarcomas ranges from 10%-15%. Surgery remains the gold standard for RPS.
- Trial name
- NCT06396962
- Testing
- WANG DAORONG
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Northern Jiangsu People's Hospital
Adult Soft Tissue Sarcoma, Bone Sarcoma
Real-Time Contrast-Enhanced Ultrasonography and Shear Wave Elastography in Predicting Treatment Response in Patients With Soft Tissue Sarcoma
This pilot clinical trial studies real-time contrast-enhanced ultrasonography and shear wave elastography in predicting treatment response in patients with soft tissue sarcomas.
- Conditions
- Adult Soft Tissue Sarcoma, Bone Sarcoma, Retroperitoneal Sarcoma
- Trial name
- NCT02384473
- Testing
- Real-Time CEUS, SWE, Definity Suspension for Injection
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Southern California
Retroperitoneal Sarcoma
Radical Resection and HIPEC for Recurrent Retroperitoneal Sarcoma
Retroperitoneal sarcoma is a rare cancer that accounts for 15% of soft tissue sarcomas and affects many young people. In approximately 50% of patients, the tumour will reappear in the same area regardless of therapy.
- Trial name
- NCT03792867
- Testing
- Doxorubicin
- Where
- Singapore
- Volunteers
- 5 people
- Sponsor
- National Cancer Centre, Singapore
Locally Advanced Leiomyosarcoma, Metastatic Leiomyosarcoma
Niraparib for the Treatment of Leiomyosarcoma
This phase II trial tests whether niraparib works to shrink tumor in patients with leiomyosarcoma. Niraparib is an inhibitor of PARP, an enzyme that helps repair deoxyribonucleic acid (DNA) when it becomes damaged.
- Conditions
- Locally Advanced Leiomyosarcoma, Metastatic Leiomyosarcoma, Stage III Retroperitoneal Sarcoma AJCC v8, Stage IIIA Retroperitoneal Sarcoma AJCC v8
- Trial name
- NCT05174455
- Testing
- Niraparib Tosylate Monohydrate
- Sponsor
- David Liebner, MD
Retroperitoneal Sarcoma
Neoadjuvant Chemotherapy Combined With Targeted Treatment in High-risk Retroperitoneal Sarcoma
The goal of this clinical trial is to explore the potential survival benefits of neoadjuvant chemotherapy combined with target treatments followed by radical surgery in patients with primary high-risk/grade retroperitoneal…
- Trial name
- NATARS (NCT05844813)
- Testing
- Doxorubicin+Ifosfamide+Anlotinib(AI+A), Radical Surgery
- Where
- 6 sites in China
- Volunteers
- 102 people
- Sponsor
- Peking University International Hospital
Retroperitoneal Sarcoma
Neoadjuvant Short-course Hypofractionated PBT for Non-metastatic RPS
The investigators' study titled "PROTONS-RPS: a Phase II non-Randomized Open-label single-arm Trial Of Neoadjuvant Short-course hypofractionated proton beam therapy for non-metastatic RetroPeritoneal Sarcoma" is a phase II trial…
- Trial name
- PROTONS-RPS (NCT05302570)
- Testing
- Hypofractionated Proton Beam Therapy
- Where
- 2 sites in United States
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Adrenal; Functional Disturbance, Retroperitoneal Sarcoma
Perioperative Residual Adrenal Function After Extended Resection for Retroperitoneal Soft Tissue Sarcomas
Early recognition of adrenal function deficit in patients undergoing multivisceral surgery including adrenalectomy for primitive retroperitoneal sarcomas
- Conditions
- Adrenal; Functional Disturbance, Retroperitoneal Sarcoma, Intraoperative Hypotension
- Trial name
- RAF (NCT04225494)
- Where
- Italy
- Volunteers
- 52 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Retroperitoneal Sarcoma, Margin, Tumor-Free
Retroperıtoneal Soft-Tıssue Sarcomas
: Soft Tissue Sarcomas are rare mesenchymal tumors with many subtypes. Clean margin-wide resection is recommended for treatment. The guidelines recommend that sarcoma treatments be carried out in sarcoma centers.
- Trial name
- NCT05044624
- Testing
- retroperitoneal mass excision
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Istanbul Medeniyet University
Retroperitoneal Soft Tissue Sarcoma
Trial of Neoadjuvant Intensity-Modulated Radiation Therapy Followed by Surgery and Intraoperative Radiation Therapy in Resectable Retroperitoneal Soft Tissue Sarcoma (RETRO-WTS)
Local control rates in patients with retroperitoneal soft tissue sarcoma (RSTS) remain disappointing even after gross total resection, mainly because wide margins are not achievable in the majority of patients.
- Trial name
- NCT01566123
- Testing
- Neoadjuvant intensity-modulated radiation therapy (IMRT), intraoperative radiation therapy (IORT)
- Where
- Germany
- Volunteers
- 37 people
- Sponsor
- University Hospital Heidelberg
Sarcoma, Soft Tissue, Retroperitoneal Neoplasms
Long Term Morbidity and Quality of Life in Retroperitoneal Sarcomas
No prospective data exist about long term morbidity and quality of life after multivisceral surgical resection for retroperitoneal soft tissue sarcoma (RSTS).
- Conditions
- Sarcoma, Soft Tissue, Retroperitoneal Neoplasms, Surgery, Quality of Life
- Trial name
- LTM (NCT03480399)
- Volunteers
- 60 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Retroperitoneal Sarcoma, Malnutrition
Nutritional Status in Retroperitoneal Sarcoma.
Prospective feasibility study of perioperative nutrition in patients affected by primary retroperitoneal sarcoma
- Trial name
- NOVA (NCT03877588)
- Testing
- Oral Nutritional Support
- Volunteers
- 35 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Retroperitoneal Sarcoma
REtroperitoneal SArcoma Registry: an International Prospective Initiative
Surgery is currently the only potentially curative treatment modality for localized retroperitoneal sarcoma (RPS). Available studies regarding oncologic outcomes are mainly retrospective in nature, and RPS are recognized as a…
- Trial name
- RESAR (NCT03838718)
- Where
- 22 sites in United States, Australia and 9 more
- Volunteers
- 2,000 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Retroperitoneal Sarcoma
Preoperative Proton Radiotherapy for Retroperitoneal Sarcoma
The goal of this study is to evaluate radiation treatment intended to increase the chance of curing your sarcoma and decrease the side effects of proton therapy.
- Trial name
- SA03 (NCT00901836)
- Testing
- Preoperative proton therapy, Surgery
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Florida
Peritoneal Neoplasms, Retroperitoneal Neoplasms
Continuous Hyperthermic Peritoneal Perfusion (CHPP) With Cisplatin for Children With Peritoneal Cancer
There has been no successful treatment of diffuse peritoneal metastasis or carcinomatosis, in childhood tumors. Once this advanced stage of disease is evident, survival is measured in weeks.
- Conditions
- Peritoneal Neoplasms, Retroperitoneal Neoplasms, Gastrointestinal Neoplasms, Adenocarcinoma
- Trial name
- NCT00436657
- Testing
- CHPP of Cisplatin, Abdominal Surgery
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- M.D. Anderson Cancer Center