Clinical trials: Retinopathy of Prematurity
Infant, Newborn, Infant, Low Birth Weight
Multi-dose Pharmacokinetics and Dose Ranging of Inositol in Premature Infants (INS-2)
This pilot study is a randomized, placebo-controlled, clinical trial to measure changes in blood and urine levels of inositol in premature infants at high risk for retinopathy of prematurity (ROP) following repeated doses of…
- Conditions
- Infant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age, Infant, Premature
- Trial name
- INS-2 (NCT01030575)
- Testing
- Inositol lower volume, Inositol mid-level volume, Inositol high volume
- Where
- 17 sites in United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- NICHD Neonatal Research Network
Retinopathy of Prematurity, Myopia
Prematurity and Ophthalmological Changes
Ophthalmological differences in school-aged children with and without a history of retinopathy of prematurity
- Trial name
- NCT06452524
- Testing
- axial length (AU) and anterior chamber depth (ACD), optical coherence tomography (OCT)
- Where
- Turkey (Türkiye)
- Volunteers
- 211 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Retinopathy of Prematurity, Diabetic Retinopathy
Optical Coherence Tomography Angiography (OCT-A) in Children (≥ 6 <14 Years of Age)
Comparison of OCTA to conventional imaging modalities for the diagnosis of eye diseases in children
- Trial name
- OCTAC (NCT03399825)
- Testing
- OCT-A
- Volunteers
- healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Retinopathy of Prematurity, Retinal Detachment
Efficient Study of ACULAR in Inhibiting Proliferative Retinopathy in Prematurity
The purpose of this study is to test whether ACULAR, a nonsteroidal anti-inflammatory eye drop medication, can prevent the development of retinopathy of prematurity (ROP) and/ or decrease its severity.In this study ACULAR will be…
- Conditions
- Retinopathy of Prematurity, Retinal Detachment, Blindness
- Trial name
- ROP (NCT00634972)
- Testing
- ACULAR, REFRESH TEARS
- Where
- United States
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- University of South Alabama
Early-Onset Sepses, Neonatal, Periventricular Haemorrhage Neonatal
Zinc Supplementation on Very Low Birth Weight Infant
Premature birth is a major cause of neonatal death in addition to neonatal asphyxia and infections. Early in life, premature babies must get aggressive nutrition so that there is no extrauterine growth restriction (EUGR) in the…
- Conditions
- Early-Onset Sepses, Neonatal, Periventricular Haemorrhage Neonatal, Bronchopulmonary Dysplasia, Retinopathy of Prematurity
- Trial name
- NCT04050488
- Testing
- Zinc Sulfate
- Volunteers
- 364 people, healthy volunteers welcome
- Sponsor
- Fakultas Kedokteran Universitas Indonesia
Retinopathy of Prematurity (ROP)
To Assess the Effect of Dexamethasone Eye Drops on the Retinopathy of Prematurity Outcome
The purpose is to compare the treatment frequency of preterm infants who developed severe Retinopathy of Prematurity (ROP) during the years 2015-2018 with 2020-2021 in the country, using the statistical method 'difference in…
- Trial name
- NCT06775353
- Testing
- Dexamethasone eyedrop
- Where
- Sweden
- Volunteers
- 2,017 people, healthy volunteers welcome
- Sponsor
- Region Skane
Retinopathy of Prematurity, Neurodevelopmental Abnormality
Analysis of Ocular and Neurodevelopmental Function for Retinopathy of Prematurity
The goal of this research project is to identify the long-term outcome of neurodevelopment in patients with retinopathy of prematurity(ROP) and the treatment of anti-vascular endothelial growth factor (VEGF) such as intravitreal…
- Trial name
- NCT05186155
- Testing
- Severe ROP
- Where
- Taiwan
- Volunteers
- 510 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Lactation
Dietary Lutein and the Retinopathy of Prematurity
The clinical trial aspect of this study is the provision of a lutein supplement to lactating women and compare the amount of lutein in the milk and blood with lactating women who do not receive the lutein supplement.
- Trial name
- NCT00672230
- Testing
- Lutein supplement
- Where
- United States
- Volunteers
- 212 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Retinopathy of Prematurity, Microbiome
The Analysis of Association of Retinopathy of Prematurity, Gut Microbiome Profile, and Systemic Inflammation
Study Aims 1. Understanding the gut microbiome profile in very low birth weight infants with or without ROP. The onset and aggravation of ROP and their relationship with gut microbiome will be examined. 2.
- Trial name
- NCT05144282
- Testing
- intravitreal injection of anti VEGF, laser photocoagulation
- Where
- Taiwan
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Retinopathy of Prematurity, Genetic Polymorphism
Genetic Polymorphism and Retinopathy of Prematurity: Correlation of Clinical Presentations and Severity
Study Aim and Goals 1. Evaluate the correlation between genetic polymorphism and ROP development 2. To study the possibility if there are any specific genetic polymorphisms that lead to poor outcome or recurrence of ROP after…
- Trial name
- NCT05132257
- Testing
- Severe ROP
- Where
- Taiwan
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Retinopathy of Prematurity
A Study Investigating Whether Low Dose Eyedrops for Pupil Dilation is as Effective and Safe as Standard Dose Eyedrops in Examination for Retinopathy of Prematurity.
A prospective, randomized controlled study was conducted from August, 2022 to March, 2023 in the neonatal intensive care unit in Queen Mary Hospital, Hong Kong.
- Trial name
- NCT06288321
- Testing
- Microdrop Mydrin-P, Standard Mydrin-P
- Where
- Hong Kong
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Premature Retinopathy, Visual Impairment
Evaluation of Visual - Motor Development in Children With Retinopathy of Prematurity
The aim of this study was to investigate the eye structure, visual impairment, visual motor development and motor coordination of children between 2-6 ages that had applied to diod laser photocoagulation and intravitreal anti …
- Conditions
- Premature Retinopathy, Visual Impairment, Motor Delay
- Trial name
- NCT03865134
- Testing
- Snellen Test, Autorefractometer, Titmus Stereo Fly Test
- Where
- Turkey (Türkiye)
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
ROP Examination
The Effect of Music on Pain, Comfort and Physiological Parameters During Prematurity Retinopathy Examination
It is planned to determine the effect of music during Retinopathy of Prematurity (ROP) examination on pain, comfort and physiological parameters in preterm infants.
- Trial name
- NCT05263973
- Testing
- Music
- Where
- Turkey (Türkiye)
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Retinopathy of Prematurity, Neurodevelopmental Disorders
Analyzing Retinal Microanatomy in ROP
Retinopathy of prematurity (ROP) is a disorder of development of the neural retina and its vasculature that may impact vision in vulnerable preterm neonates for a lifetime.
- Conditions
- Retinopathy of Prematurity, Neurodevelopmental Disorders, Macular Edema
- Trial name
- BabySTEPS (NCT02887157)
- Testing
- Swept Source OCT, Magnetic Resonance Imaging, Scavenged blood collection
- Where
- 4 sites in United States
- Volunteers
- 191 people, healthy volunteers welcome
- Sponsor
- Duke University
Retinopathy of Prematurity
Registry for Severe ROP and Treatment on Visual Outcomes
The purpose of this study is to determine what factors influence the visual outcomes of infants with severe retinopathy of prematurity (ROP) and to monitor the outcomes.
- Trial name
- NCT01559571
- Where
- 2 sites in United States
- Volunteers
- 324 people, healthy volunteers welcome
- Sponsor
- Pediatrix
Retinopathy of Prematurity
Oral Propranolol Improve Retinopathy of Prematurity Outcomes in Very Preterm Infants
Retinopathy of prematurity (ROP) is a major cause of blindness and visual impairment in children in both developing and developed countries around the world.
- Trial name
- NCT02977000
- Testing
- Propranolol
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Huiqing Sun
Retinopathy of Prematurity
Effects of Early Vitamin A Supplementation on the Risk for Retinopathy of Prematurity in Extremely Preterm Infants
Retinopathy of prematurity (ROP) is a common retinal neovascular disorder and major cause of vision impairment or blindness, despite current treatment of late stage ROP.
- Trial name
- NCT03154723
- Testing
- Vitamin A
- Where
- China
- Volunteers
- 262 people, healthy volunteers welcome
- Sponsor
- Huiqing Sun
Premature Retinopathy, Pain
The Effect of Ocean Sound In Premature Retinopathy Examination
Purpose: It was planned as a randomized controlled experiment in order to evaluate the effectiveness of the ocean sound on pain, comfort and physiological parameters in the NICU, Retinopathy of Prematurity (ROP) examination.
- Trial name
- NCT05203159
- Testing
- Ocean sound, Routine
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Necmettin Erbakan University
Retinopathy of Prematurity
Role of Cord Blood Cytokines and Perinatal Factors in Prediction of Retinopathy of Prematurity
Cord blood will be taken after birth for evaluation of cytokines level. At age of 4-6 weeks, we will do fundus examination for babies . Retrograde, we will study the perinatal risk factors in subjects found to have retinopathy.
- Trial name
- NCT04769661
- Testing
- Cytokines
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assiut University
Retinopathy of Prematurity
Heredity of Retinal Vessel Tortuosity
The purpose of this study is to asses the relative influence of genetic and environmental influence on the tortuosity of retinal arterioles in eyes of 218 healthy Danish twins aged 20-46 years.
- Trial name
- NCT00427063
- Where
- Denmark
- Volunteers
- 218 people, healthy volunteers welcome
- Sponsor
- Glostrup University Hospital, Copenhagen