Clinical trials: Retinopathy
Wet Age-related Macular Degeneration, Neovascular Age-related Macular Degeneration
A Study to Comparing SCD411 and Eylea® in Subjects With Wet Age-related Macular Degeneration (AMD)
Age-related macular degeneration (AMD) is a leading cause of vision loss in adults. Abnormal blood vessels grow under the macula at the back of the eye, and also leak blood and fluid, which damages and scars the macula, affecting…
- Trial name
- NCT04480463
- Testing
- SCD411, Aflibercept
- Where
- 130 sites in United States, Australia and 12 more
- Volunteers
- 576 people
- Sponsor
- Sam Chun Dang Pharm. Co. Ltd.
Macular Degeneration
Visudyne® in Occult (VIO)
The purpose of this study is to demonstrate that Visudyne therapy in patients who have occult with no classic subfoveal choroidal neovascularization (CNV) lesions will, with an acceptable safety profile, significantly reduce the…
- Trial name
- NCT00121407
- Testing
- Visudyne for injection
- Volunteers
- 364 people
- Sponsor
- QLT Inc.
Macular Degeneration
Vascular Endothelial Growth Factor VEGF Trap-Eye:Investigation of Efficacy and Safety in Wet Age-Related Macular Degeneration(AMD)
This study is a phase 3, double-masked, randomized, study of the efficacy and safety of VEGF Trap-Eye in patients with neovascular age-related macular degeneration.
- Trial name
- VIEW1 (NCT00509795)
- Testing
- ranibizumab, aflibercept injection (VEGF Trap-Eye, BAY86-5321)
- Where
- 188 sites in United States, Canada
- Volunteers
- 1,217 people
- Sponsor
- Regeneron Pharmaceuticals
Gestational Diabetes, Eye Diseases
Fundus Findings and Thiol-Disulfide Homeostais
Gestational diabetes mellitus is associated with abnormal blood sugar levels throughout pregnancy in women without prior diabetes. Many studies have been conducted on the relationship between diabetes and oxidative stress.
- Conditions
- Gestational Diabetes, Eye Diseases, Retinal Disease, Oxidative Stress
- Trial name
- NCT05958927
- Testing
- tear test and eye measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Suzan Dogruya
Diabetic Retinopathy, Cataract
Cataract Surgery with Near Normal Eye Pressure in Patients with Diabetic Retinopathy
Diabetes mellitus is a chronic metabolic disease that can lead to visual impairment and eye complications such as diabetic retinopathy and diabetic macular edema.
- Trial name
- NNIOP-PHACO (NCT06617273)
- Testing
- Ophthalmosurgical handpiece with active anterior chamber pressure sensing and regulation
- Where
- Austria
- Volunteers
- 72 people
- Sponsor
- Medical University Innsbruck
Proliferative Vitreoretinopathy
Triamcinolone Acetonide in Silicone-Filled Eyes as Adjunctive Treatment for Proliferative Vitreoretinopathy
To evaluate the effect of triamcinolone acetonide in silicone-filled eyes on the outcome of surgery for PVR.
- Trial name
- NCT00373282
- Testing
- Triamcinolone acetonide
- Where
- Iran
- Sponsor
- Shahid Beheshti University of Medical Sciences
Retinal Detachment
Proof of Concept - Digital Electro-optical Surgical Platform as Replacement for Operational Microscopes
Evaluate the use of Elbit's digital electro-optical systems for generating detailed high quality video imaging during surgery, and thus improving the surgeon's visualization, performance and outcome.
- Trial name
- NCT02715388
- Testing
- GlasScope Surgical Microscope
- Where
- Israel
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Elbit Systems LTD
Ischemic Optic Neuropathy, Branch Retinal Artery Occlusion
New Non-invasive Modalities for Assessing Retinal Structure and Function
This study investigates a new technology to assess the structure and function inside the eye. Retinal imaging of subjects with inner and outer retinal defects to detect areas of abnormal structure and function compared to other…
- Conditions
- Ischemic Optic Neuropathy, Branch Retinal Artery Occlusion, Hemianopia, Leber Hereditary Optic Neuropathy
- Trial name
- NCT03475173
- Testing
- LSFG-NAVI
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Randy Kardon
Retinal Artery Occlusion
Optical Coherence Tomography Angiography Examinations in Chronic Retinal Artery Occlusion
Purpose of the study is to examine the retinal blood flow in chronic cases of retinal artery occlusion with non-invasive, non-contact optical coherence tomography angiography.
- Trial name
- RAO-OCTA (NCT03357146)
- Testing
- Optical coherence tomography angiography
- Where
- Hungary
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Semmelweis University
Maculopathy, High Myopia
Surgical Outcome of Vitrectomy for Myopic Traction Maculopathy in Highly Myopic Eyes
Surgical outcome of vitrectomy for myopic traction maculopathy in highly myopic eyes was evaluated in each stage. Efficacy of internal limiting membrane was also evaluated whether it may improve visual outcome.
- Conditions
- Maculopathy, High Myopia, Surgery
- Trial name
- NCT01658761
- Testing
- vitrectomy
- Where
- Japan
- Volunteers
- 64 people
- Sponsor
- Kyorin University
Proliferative Diabetic Retinopathy - High Risk
Ultra-Widefield Fluorescein Angiography-Based Targeted Retinal Photocoagulation Versus Conventional Panretinal Photocoagulation in the Preservation of Visual Function and Regression of Proliferative Diabetic Retinopathy
Proliferative diabetic retinopathy is a vision-threatening disease that can lead to irreversible visual loss. The treatment options for proliferative diabetic retinopathy are anti-VEGF injection and retinal photocoagulation.
- Trial name
- NCT06653361
- Testing
- Green laser
- Where
- Pakistan
- Volunteers
- 120 people
- Sponsor
- Hayatabad Medical Complex
Macular Holes, Epiretinal Membrane
Intraoperative OCT Guidance of Intraocular Surgery II
The overall five-year goals of the project are to develop novel technology to provide actionable new information through provision of live volumetric imaging during surgery, improving surgical practice and outcomes.
- Conditions
- Macular Holes, Epiretinal Membrane, Diabetic Retinopathy, Retinal Detachment
- Trial name
- MIOCT (NCT03713268)
- Testing
- Microscope integrated optical coherence tomography
- Where
- United States
- Volunteers
- 262 people, healthy volunteers welcome
- Sponsor
- Duke University
Neovascular Age-Related Macular Degeneration
Safety and Pharmacokinetics of RTH258 in Subjects With Age-Related Macular Degeneration
The purpose of this study is to assess the systemic pharmacokinetics (PK) and safety of 2 different doses of brolucizumab (3 milligrams (mg)/50 microliters (μL) and 6 mg/50 μL) when administered at 4-week intervals for a total of…
- Trial name
- NCT02507388
- Testing
- Brolucizumab 3 mg/50 μL, Brolucizumab 6 mg/50 μL
- Volunteers
- 51 people
- Sponsor
- Alcon Research
Age Related Macular Degeneration
A Snapshot Adaptive Optics and Hyperspectral Autofluorescence Fundus Camera for Age-Related Macular Degeneration (AMD)
This study proposes to use a new instrument (AO-OCT/AF: adaptive optics - optical coherence tomography/autofluorescence) combined with a data processing method to image the retinal pigment epithelium (RPE) of the eye in normal…
- Trial name
- NCT03963817
- Testing
- adaptive optics AO-OCT/AF instrument
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Premature Infant Disease, Retinopathy of Prematurity
Pain of Premature Babies and RetCam (DOLICAM)
It is a single-center prospective observational descriptive study. studied population is premature infants, hospitalized in the neonatology department of the University Hospital of Grenoble and for whom the RetCam examination is…
- Trial name
- DOLICAM (NCT04092127)
- Testing
- Video Record
- Where
- France
- Volunteers
- 31 people
- Sponsor
- University Hospital, Grenoble
Diabetic Retinopathy
Comparison of Diabetes Retinopathy Among Type 2 Diabetic Patients Treated With Different Regimens
Diabetic retinopathy (DR) is an important cause of blindness.
- Trial name
- CORRECT (NCT02587741)
- Testing
- Metformin, Lantus, Novomix30
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Proliferative Diabetic Retinopathy
Safety and Efficacy of Low-Fluence PRP for PDR
To determine the safety and efficacy of a single session of low-fluence panretinal photocoagulation when compared to full-fluence PRP.
- Trial name
- NCT01737957
- Testing
- Low-fluence PRP with 532nm green LASER, Full-Fluence PRP with 532nm LASER
- Where
- Mexico
- Volunteers
- 60 people
- Sponsor
- Asociación para Evitar la Ceguera en México
Epiretinal Membrane, Macular Holes
Surgical Outcome of Macular Membrane Peeling Associated With Significant Macular Drusen
Surgical outcome of patients with macular drusen and co-existing abnormalities of the vitreoretinal interface, who routinely undergo pars plana vitrectomy with membrane peeling, is evaluated.
- Conditions
- Epiretinal Membrane, Macular Holes, Age Related Macular Degeneration
- Trial name
- NCT03927430
- Testing
- pars plana vitrectomy with membrane peeling
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Klinikum Chemnitz gGmbH
Age-Related Macular Degeneration
Y402H Comlement Factor H Polymorphism and Age-Related Macular Degeneration in the Austrian Population
The aim of the study is to show a higher expression of the Y402H polymorphism in the complement factor H in patients with AMD compared to healthy individuals.
- Trial name
- NCT00533754
- Testing
- drawing blood
- Where
- Austria
- Sponsor
- Rudolf Foundation Clinic
Diabetic Macular Edema
Intravitreal Triamcinolone Acetonide Versus Intravitreal Bevacizumab for Refractory Diabetic Macular Edema (IBEME Study)
Intravitreal triamcinolone has been effective for central macular thickness reduction and concomitant visual acuity improvement in patients with diabetic macular edema (DME).
- Trial name
- IBEME (NCT00468351)
- Testing
- Intravitreal Injection of 1,5 mg of bevacizumab, Intravitreal injection of 4 mg of Triamcinolone acetonide
- Where
- Brazil
- Sponsor
- University of Sao Paulo