Clinical trials: Retinal Vascular, open to volunteers
Coronary Heart Disease (CHD)
Using Retinal Photograph Based AI to Predict Incident Coronary Heart Disease
To determine whether an integrated retinal AI decision support can improve predictive accuracy of coronary heart disease (CHD), the investigators are conducting a randomized controlled study of AI guided prediction of CHD…
- Trial name
- DeepCHD Plus (NCT06695273)
- Testing
- AI-derived probability of coronary heart disease., PCEs derived ASCVD risk
- Volunteers
- 1,570 people, healthy volunteers welcome
- Sponsor
- Tsinghua University
Retinal Disease, Age-Related Macular Degeneration
Stem Cell Ophthalmology Treatment Study II
This study will evaluate the use of autologous bone marrow derived stem cells (BMSC) for the treatment of retinal and optic nerve damage or disease.
- Conditions
- Retinal Disease, Age-Related Macular Degeneration, Retinitis Pigmentosa, Stargardt Disease
- Trial name
- SCOTS2 (NCT03011541)
- Testing
- Arm 1
- Where
- 4 sites in United States, Austria and 1 more
- Volunteers
- 500 people
- Sponsor
- MD Stem Cells
Diabetes Mellitus, Diabetic Retinopathy
Sleep, Diabetic Retinopathy and Melatonin
This study explores the use of melatonin in patients with diabetic retinopathy
- Trial name
- NCT04547439
- Testing
- Melatonin
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- University of Illinois Chicago
Ischemic Stroke, Transient Ischemic Attack (TIA)
Ambulatory Stroke Unit Treatment for Elderly Patients
ARTIFICE is a prospective, multicenter, randomized, controlled, exploratory non-inferiority trial evaluating whether an ambulatory stroke unit model (aSU) is non-inferior to conventional inpatient stroke unit care (SU) in…
- Conditions
- Ischemic Stroke, Transient Ischemic Attack (TIA), Retinal Ischemia
- Trial name
- ARTIFICE (NCT07420374)
- Testing
- Ambulatory Stroke Unit Care, Conventional Stroke Unit Care
- Where
- Germany
- Volunteers
- 400 people
- Sponsor
- University Hospital Heidelberg
Diabetic Retinopathy (DR), Diabetic Retinopathy Associated With Type 2 Diabetes Mellitus
Investigating the Metabolic and Lipidomic Profiles That Are Associated With Varying Grades of Diabetic Maculopathy and Retinopathy in South Wales
Diabetes mellitus is a disorder of sugar and fat metabolism which results in damage to the small blood vessels in various organs, this includes the retina - the part of the eye that processes light into a nerve impulse.
- Conditions
- Diabetic Retinopathy (DR), Diabetic Retinopathy Associated With Type 2 Diabetes Mellitus, Diabetic Macular Edema (DME)
- Trial name
- IMLADRIS (NCT06914778)
- Testing
- Blood draw for the laboratory assessment, Urine sample
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- Hywel Dda Health Board
Diabetic Kidney Disease, Diabetic Retinopathy
Clinical Trial of Keluoxin Capsules in the Treatment of Diabetic Kidney Disease with Diabetic Retinopathy
The purpose of the study is to evaluate the efficacy of Keluoxin Capsules for the treatment of diabetic kidney disease (DKD) and diabetic retinopathy (DR) compared to placebo on a conventional treatment basis.
- Trial name
- NCT06660940
- Testing
- Keluoxin Capsules, Keluoxin Capsule Simulants, Irbesartan
- Volunteers
- 460 people
- Sponsor
- Chinese PLA General Hospital
Diabetic Retinopathy, Retinal Vein Occlusion
Optical Coherence Tomography Angiography in Subjects With Retinal Vascular Disease
This study will perform a prospective, longitudinal analysis of clinical and imaging findings from normal controls and subjects with retinal vascular disease to better define the diagnostic imaging criteria that signify change in…
- Conditions
- Diabetic Retinopathy, Retinal Vein Occlusion, Hypertension,Essential, Retinal Vascular Disorder
- Trial name
- OCTA-RVD (NCT04505618)
- Testing
- Swept-Source (SS) OCT Angiography, Spectral-Domain (SD) OCT Angiography, Fundus Imaging
- Where
- United States
- Volunteers
- 1,050 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Diabetic Macular Edema, Neovascular Age-Related Macular Degeneration
Changes in Intraocular Pressure After Intravitreal Injection
Intravitreal anti-vascular endothelial growth factor (anti-VEGF) injections introduce additional fluid volume into the eye, which can cause an acute, transient elevation in intraocular pressure (IOP).
- Conditions
- Diabetic Macular Edema, Neovascular Age-Related Macular Degeneration, Retinal Vein Occlusion, Ocular Hypertension
- Trial name
- NCT07826286
- Volunteers
- 50 people
- Sponsor
- Assiut University
Diabetic Retinopathy
Biomarker of Diabetic Retinopathy
Diabetic retinopathy (DR) is a complication of diabetes in which blood vessels supplying blood to the back of the eye (retina) are dysfunctional.
- Trial name
- NCT05079399
- Testing
- Blood draw
- Where
- 3 sites in United States
- Volunteers
- 192 people
- Sponsor
- Indiana University
Macular Holes, Epiretinal Membrane
Intraoperative OCT Guidance of Intraocular Surgery II
The overall five-year goals of the project are to develop novel technology to provide actionable new information through provision of live volumetric imaging during surgery, improving surgical practice and outcomes.
- Conditions
- Macular Holes, Epiretinal Membrane, Diabetic Retinopathy, Retinal Detachment
- Trial name
- MIOCT (NCT03713268)
- Testing
- Microscope integrated optical coherence tomography
- Where
- United States
- Volunteers
- 262 people, healthy volunteers welcome
- Sponsor
- Duke University
Susac Syndrome
Phenotypic and Etiological Characterization of Susac Syndrome
SUSAC's Syndrome (SS) is characterized by the clinical triad of encephalopathy, hearing loss, and retinal artery branch occlusions.
- Trial name
- CARESS Cohorte (NCT06881368)
- Where
- France
- Volunteers
- 180 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Retinitis Pigmentosa (RP), Diabetic Retinopathy (DR)
Functional Assessments in Vision Impairment
The aim of the research project is to validate the use of a novel functional assessment tool designed to document how participants with a vision impairment complete activities of daily living in a real world environment.
- Conditions
- Retinitis Pigmentosa (RP), Diabetic Retinopathy (DR), Age Related Macular Degeneration (AMD), Glaucoma
- Trial name
- NCT06908161
- Where
- Australia
- Volunteers
- 45 people
- Sponsor
- Center for Eye Research Australia
Cataract, Refractive Error
Community-Based Eye Screening With Structured Referral Tracking for Preventing Avoidable Blindness in Adults in Rawalpindi, Pakistan
This cluster randomized controlled trial aims to evaluate the effectiveness of a Structured Referral Tracking (SRT) intervention in improving referral completion among adults identified with avoidable blindness during…
- Conditions
- Cataract, Refractive Error, Diabetic Retinopathy
- Trial name
- SIGHT (NCT07611682)
- Testing
- Structured Referral Tracking (SRT)
- Where
- Pakistan
- Volunteers
- 500 people
- Sponsor
- Health Services Academy, Islamabad, Pakistan
Diabetic Retinopathy
Validation of the Artificial Intelligence Subsystem of the DDART Medical Device for the Automated Detection of Lesions Compatible With Diabetic Retinopathy in a Random Sample of Retinal Fundus Photographs
To validate the artificial intelligence subsystem of the DDART medical device for the automated detection of lesions compatible with diabetic retinopathy in a random sample of retinal fundus photographs.
- Trial name
- NCT07758582
- Testing
- Color retinal fundus photograph
- Where
- Greece
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Democritus University of Thrace
Diabetic Macular Edema (DME)
Phase 3 Study of Intravitreal OLN324 in Adults With Diabetic Macular Edema (DME) (OLN324-CP-02)
This is a Phase 3 study of an investigational drug called OLN324, which is being developed by Ollin Biosciences as a treatment for patients with diabetic macular edema (DME).
- Trial name
- ATACAMA (NCT07841899)
- Testing
- OLN324, Aflibercept
- Volunteers
- 450 people
- Sponsor
- Ollin Biosciences, Inc.
Diabetic Retinopathy (DR)
Using Implementation Science to Adapt a Targeted Transportation Intervention for Patients With Diabetic Retinopathy (PRONTO-EYE)
This is a a type 3 hybrid effectiveness-implementation pilot study to evaluate the PRONTO-EYE intervention, a rideshare transportation program, in patients with diabetic retinopathy with Medicaid insurance on adherence to…
- Trial name
- PRONTO-EYE (NCT07296952)
- Testing
- PRONTO-EYE
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Illinois Chicago
Multiple Sclerosis, Dry Eye Syndromes
Clinical Applications of Advanced Ophthalmic Imaging
The purpose of this study is to determine the clinical application of advanced ophthalmic imaging devices such as optical coherence tomography (OCT), retinal function imager (RFI), slit-lamp biomicroscopy (SLB), PERG in diseased…
- Conditions
- Multiple Sclerosis, Dry Eye Syndromes, Diabetic Retinopathy, Presbyopia
- Trial name
- NCT03135327
- Testing
- Ocufolin
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- University of Miami
Prediabetes, Chronic Coronary Syndrome
Reversal to Normoglycemia by Treating Prediabetes
Prediabetes is a precursor to diabetes, but compared with diabetes, much less is known about prediabetes. Prediabetes is defined based on a blood sample measuring long-term average glucose levels.
- Trial name
- NCT07392151
- Testing
- Intensified medical follow-up and glucose-lowering drugs, No intervention
- Where
- Denmark
- Volunteers
- 158 people
- Sponsor
- Michael Mæng
Von Hippel Lindau, Von Hippel Lindau Disease
Real-World Effectiveness and Pharmacogenetics of Belzutifan in VHL Syndrome: The BELIEVE-VHL Trial
The BELIEVE-VHL Trial is a prospective real-life study designed to evaluate the therapeutic effects, benefits, and adverse effects of belzutifan, as well as the timing of treatment response and disease progression in patients…
- Conditions
- Von Hippel Lindau, Von Hippel Lindau Disease, Von Hippel Lindau-Deficient Clear Cell Renal Cell Carcinoma, Hemangioblastoma (HB) of the Central Nervous System (CNS)
- Trial name
- BELIEVE-VHL (NCT07167329)
- Testing
- Belzutifan
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- José Claudio Casali da Rocha
Diabetic Macular Edema, Diabetic Retinopathy
A Study Intravitreal THN391 in Diabetic Macular Oedema Secondary to Non-Proliferative Diabetic Retinopathy.
THN391-OPT-101 is a study assessing safety and preliminary efficacy of THN391 in patients with diabetic macular edema (DME) given as monotherapy.
- Trial name
- NCT06701721
- Testing
- THN391
- Where
- 10 sites in Australia, Georgia
- Volunteers
- 21 people
- Sponsor
- Therini Bio Pty Ltd