Clinical trials: Retinal Vascular
Diabetes Complications, Diabetic Retinopathy
Human iPSC for Repair of Vasodegenerative Vessels in Diabetic Retinopathy
This study proposes to carefully examine the hypothesis that human inducible pluripotent stem cells (iPSCs) can be effectively employed as a future therapeutic option for individuals with diabetic retinopathy and macular…
- Trial name
- iPSC (NCT03403699)
- Testing
- Generation of inducible pluripotent stem cells
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Cardiovascular Diseases, Childhood Obesity
Sportcheck Follow-Up
The study resembles a four-year follow-up on the influence of physical activity and fitness, blood pressure, BMI and stress on vascular health in primary schoolchildren.
- Conditions
- Cardiovascular Diseases, Childhood Obesity, Hypertension
- Trial name
- NCT03085498
- Testing
- No intervention
- Where
- Switzerland
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- University of Basel
Retinal Vein Occlusion
Fluocinolone Acetonide Implant for Retinal Vein Occlusion (RVO)
Purpose: To determine whether a fluocinolone acetonide sustained drug delivery implant is effective in the treatment of retinal vein occlusion that has caused persistent macular edema and decreased visual acuity.
- Trial name
- NCT00636493
- Testing
- fluocinolone acetonide (Retisert Implant)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Glenn Jaffe
Diabetes Mellitus, Diabetic Retinopathy
A Study to Evaluate THR-149 Treatment for Diabetic Macular Oedema
Part A of the study is conducted to select the THR-149 dose level. Part B of the study is conducted to assess the efficacy and safety of the selected dose level compared to aflibercept, up to Month 3.
- Conditions
- Diabetes Mellitus, Diabetic Retinopathy, Diabetic Macular Edema
- Trial name
- KALAHARI (NCT04527107)
- Testing
- THR-149 dose level 1, THR-149 dose level 2, THR-149 dose level 3
- Where
- 78 sites in United States, Czechia and 6 more
- Volunteers
- 135 people
- Sponsor
- Oxurion
Diabetic Retinopathy
Retinal Thickness Analysis Using Optical Coherence Tomography
The main objective of this study is to characterize and correlate diabetic macular edema (DME), i.e. increased retinal thickness, measured by Optical Coherence Tomograph (OCT), and retinal visual function.
- Trial name
- NCT00797134
- Where
- Portugal
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Association for Innovation and Biomedical Research on Light and Image
Irvine-Gass Syndrome
Treatment of Macular Edema After Cataract Surgery with Subconjunctival Aflibercept
This research study is being conducted to determine the safety and tolerability of subconjunctival injections of aflibercept in the treatment of pseudophakic cystoid macular edema that has not responded well to first-line…
- Trial name
- ACME (NCT03396861)
- Testing
- Aflibercept
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Tufts Medical Center
Diabetic Macular Edema, Macular Edema
Influence of Systemic Parameters in Diabetic Macular Edema - LIPSIA Study
This study aims to evaluate the influence and prognostic value of systemic factors (such as the cardiovascular and metabolic status) on the treatment response to anti-VEGF therapy in macular edema due to diabetes or retinal vein…
- Conditions
- Diabetic Macular Edema, Macular Edema, Retinal Vein Occlusion
- Trial name
- NCT03762226
- Testing
- Anti-VEGF
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- University of Leipzig
Sexual Desire
Effects of Glucagon-like-Peptide-1 Analogues on Sexuality
This study is to investigate the effects of GLP-1 analogues (combined with lifestyle interventions in comparison to lifestyle interventions only) on sexual desire, mood, quality of life, the reproductive axis, retinal vessel…
- Trial name
- Desire PLUS (NCT05598008)
- Where
- Switzerland
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Chronic Coronary Syndrome, Heart Failure
COVID-19 Related Lockdown Effects On Chronic Diseases
The containment associated with the VIDOC-19 pandemic creates an unprecedented societal situation of physical and social isolation.
- Conditions
- Chronic Coronary Syndrome, Heart Failure, AMD and Macular Edema, Chronic Respiratory Failure
- Trial name
- CLEO-CD (NCT04390126)
- Testing
- life questionnaires, questionnaire
- Where
- France
- Volunteers
- 1,343 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Macular Edema (ME)
To Assess the Efficacy and Safety of Intravitreal Ranibizumab in People With Vision Loss Due to Macular Edema
To evaluate the efficacy and safety of 0.5 mg Ranibizumab intravitreal injections in adult patients with visual impairment due to macular edema (ME).
- Trial name
- NCT01846299
- Testing
- Ranibizumab
- Where
- 61 sites in Australia, Belgium and 17 more
- Volunteers
- 181 people
- Sponsor
- Novartis Pharmaceuticals
Retinal Blood Vessels, Age-Related Macular Degeneration
Multimodal Imaging of Retinal Vessels
Retinal blood flow measurement is of scientific and clinical value. For this purpose retinal vessel morphology (such as diameter, vessel wall thickness, etc) determination is crucial.
- Trial name
- MIR (NCT02717026)
- Testing
- Optical coherence tomography, Fluorescein angiography, Fundus photography
- Where
- Austria
- Volunteers
- 50 people
- Sponsor
- Medical University of Graz
Diabetic Retinopathy, Macular Degeneration
Diabetic Retinopathy and Visual Function Study
The purpose of this study is to evaluate possible mechanisms of central visual loss in patients with diabetes mellitus. The visual loss of interest to be investigated is that associated with macular edema (prior to and following…
- Conditions
- Diabetic Retinopathy, Macular Degeneration, Vision, Subnormal
- Trial name
- NCT00001346
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- National Eye Institute (NEI)
Retinal Disease, Diabetic Retinopathy
Pain During Pars Plana Vitrectomy With Sub-tenon Anesthesia
Vitreoretinal surgery has evolved to less invasive procedures, and it is used to treat a wide range of diseases. So anesthesia for vitreoretinal procedures has evolved, promoting adequate analgesia while reducing risks to the…
- Conditions
- Retinal Disease, Diabetic Retinopathy, Maculopathy
- Trial name
- NCT03902925
- Testing
- Topical lidocaine 2% jelly plus sub-tenon ropivacaine 10% injection, Peribulbar injection
- Where
- Brazil
- Volunteers
- 56 people
- Sponsor
- University of Sao Paulo
Diabetes Mellitus, Type 1, Hypertension
Correlation of Flicker Induced and Flow Mediated Vasodilatation in Patients With Endothelial Dysfunction and Healthy Volunteers.
A couple of studies have shown that illuminating the eye with diffuse flickering light is accompanied by an increase of retinal vessel diameters, optic nerve head blood flow and retinal blood flow.
- Conditions
- Diabetes Mellitus, Type 1, Hypertension, Hypercholesterolemia, Regional Blood Flow
- Trial name
- NCT00432029
- Testing
- Forearm blood flow measurement, Flow mediated dilation (FMD), Zeiss Retinal Vessel Analyzer (RVA), Stimulation with Flicker-light
- Where
- Austria
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Macular Edema, Retinal Vein Occlusion
A Safety and Efficacy Study of OZURDEX® in Macular Edema Associated With Branch Retinal Vein Occlusion
This study will evaluate the safety and efficacy of OZURDEX® (700 µg dexamethasone implant) in patients with macular edema associated with branch retinal vein occlusion.
- Trial name
- COBALT (NCT01903720)
- Testing
- dexamethasone implant
- Where
- South Korea
- Volunteers
- 71 people
- Sponsor
- Allergan
Macular Degeneration, Choroidal Neovascularization
Safety and Preliminary Efficacy Study of WST11 (Stakel®)-Mediated VTP Therapy in Subjects With CNV Associated With AMD
The objectives of this study are to evaluate the safety(first objective) and efficacy(second objective)of an experimental drug product,Stakel®, in the treatment of neovascular Age related Macular Degeneration (AMD).
- Trial name
- NCT01021956
- Testing
- STAKEL
- Where
- 4 sites in United States, France
- Volunteers
- 10 people
- Sponsor
- Steba Biotech S.A.
Diabetic Retinopathy
The Santa Cruz Diabetic Retinopathy Utilizing Artificial Intelligence Study
In this clinical trial, we plan to evaluate the usefulness of artificial intelligence (AI) software paired with a handheld retinal camera to compare diabetic retinopathy status in Bolivian patients as read by retina specialists…
- Trial name
- SC-DRAI (NCT03912961)
- Testing
- Picture of the retina with a handheld retinal camera
- Where
- 3 sites in Bolivia
- Volunteers
- 1,034 people
- Sponsor
- Retina Global
Retinal Vein Occlusion
Safety and Proof of Concept Study of ANXV (Annexin A5) in Patients With Retinal Vein Occlusion
Open-label, dose ascending safety, tolerability, and proof of concept study to evaluate the use of ANXV (human recombinant Annexin A5) in the treatment of subjects with recently diagnosed Retinal Vein Occlusion.
- Trial name
- NCT05532735
- Testing
- ANXV
- Where
- 7 sites in United States
- Volunteers
- 16 people
- Sponsor
- Annexin Pharmaceuticals AB
Cataract, Refractive Error
Community-Based Eye Screening With Structured Referral Tracking for Preventing Avoidable Blindness in Adults in Rawalpindi, Pakistan
This cluster randomized controlled trial aims to evaluate the effectiveness of a Structured Referral Tracking (SRT) intervention in improving referral completion among adults identified with avoidable blindness during…
- Conditions
- Cataract, Refractive Error, Diabetic Retinopathy
- Trial name
- SIGHT (NCT07611682)
- Testing
- Structured Referral Tracking (SRT)
- Where
- Pakistan
- Volunteers
- 500 people
- Sponsor
- Health Services Academy, Islamabad, Pakistan
Retinal Vascular Disorder, Sport Injury
Analysis of the Variation of the Retinal Vascularization After a Prolonged Effort
The cardiovascular parameters of prolonged physical exercice have been studied, but very little data is available about the retinal vascularization.
- Trial name
- MARETINE (NCT03864380)
- Testing
- Color retinography, OCT-A, Blood pressure measurement
- Where
- France
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild