Clinical trials: Respiratory Insufficiency, open to volunteers
Congenital Heart Disease, Advanced Heart Failure
TORCH-LATAM-003: Regional Advanced-Therapy Pathways for Congenital Heart Disease
TORCH-LATAM-003 is a pragmatic stepped-wedge cluster randomized trial evaluating a regional pathway for children and adults with congenital heart disease and advanced cardiac and/or respiratory failure who may require heart…
- Conditions
- Congenital Heart Disease, Advanced Heart Failure, Respiratory Failure, Heart Transplantation
- Trial name
- TORCH-003 (NCT07837024)
- Testing
- TORCH Congenital Advanced Therapies Pathway (TORCH-CATP)
- Volunteers
- 360 people
- Sponsor
- CardioVision International Tech, S.A.S. de C.V.
Acute Hypoxemic Respiratory Failure
Interleukin-6 Guided Treatment With Dexamethasone or Tocilizumab in Patients Hospitalized With Acute Respiratory Symptoms - a Feasibility Study
Acute hypoxemic respiratory failure (AHRF) happens when the lungs are unable to absorb enough oxygen. The bloodstream is deprived of oxygen which can eventually lead to more severe conditions like multi-organ failure (MOF) and…
- Trial name
- IDENTIFY (NCT07334379)
- Testing
- Tocilizumab (Actemra®), Dexamethasone
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Lorenzo delSorbo
Acute Respiratory Failure, Electrical Impedance Tomography (EIT)
Predicting High-Flow Nasal Oxygen Failure Within 72 Hours Using a Physiology-Informed Dual-Domain Model at 30 Minutes
This is a single-center, ambispective observational cohort study of adults with acute hypoxemic respiratory failure (AHRF) receiving high-flow nasal oxygen (HFNO) as initial respiratory support. The study includes three stages.
- Conditions
- Acute Respiratory Failure, Electrical Impedance Tomography (EIT), High-Flow Nasal Oxygen Therapy
- Trial name
- EFI-HFNO (NCT07366541)
- Testing
- High-Flow Nasal Oxygen Therapy, Electrical Impedance Tomography Monitoring
- Where
- China
- Volunteers
- 115 people
- Sponsor
- Ruijin Hospital
Hernia, Ventral, Hernia Incisional
Compliance-Guided Abdominal Wall Closure Strategy in Large Ventral Hernia Repair
People undergoing repair of large ventral hernias can develop breathing problems after surgery, especially around the time when the abdominal wall is closed.
- Conditions
- Hernia, Ventral, Hernia Incisional, Postoperative Complications, Respiratory Insufficiency
- Trial name
- CLOSE-STAT (NCT07422441)
- Testing
- Compliance-Guided Abdominal Wall Closure Decision Strategy
- Where
- Poland
- Volunteers
- 50 people
- Sponsor
- Swissmed Hospital
Acute Hypoxemic Respiratory Failure
Physiological Effects of Continuous Negative External Pressure for Acute Hypoxemic Respiratory Failure
This study is being conducted to evaluate if wearing a non-invasive breathing support device over the chest/abdomen improves markers of breathing in patients with lung injury requiring high-flow oxygen.
- Trial name
- NCT05675345
- Testing
- HFNC only, HFNC + CNEP10, HFNC + CNEP20
- Where
- 4 sites in United States
- Volunteers
- 20 people
- Sponsor
- NYU Langone Health
Weaning From Mechanical Ventilation, Tracheostomy Weaning
Physiological Effect High-flow Tracheal Oxygen on Viscosity of Airway Mucus and Respiratory Effort in Patients Weaning From Invasive Mechanical Ventilation
Rationale: Tracheostomized patients weaning from mechanical ventilation are at risk for dryness of airway mucosa and sputum accumulation during disconnection from mechanical ventilation.
- Conditions
- Weaning From Mechanical Ventilation, Tracheostomy Weaning, Respiratory Failure
- Trial name
- PIONEER (NCT06776939)
- Testing
- Oxygen therapy
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Henrik Endeman
Amyotrophic Lateral Sclerosis (ALS)
Developing New Ways to Detect Respiratory Impairment Early in ALS
The goal of this observational study is to develop new ways to detect early changes associated with amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease.
- Trial name
- NCT07844590
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Acute Hypoxemic Respiratory Failure, High-Flow Nasal Cannula Therapy
Protocolized Weaning of High-Flow Nasal Cannula in Adult Patients
High-flow nasal cannula (HFNC) is a type of oxygen therapy commonly used in adults with breathing problems. While HFNC can help patients avoid breathing tubes and improve oxygen levels, there is no standard method for deciding…
- Trial name
- PRO-WEAN HFNC (NCT07452406)
- Testing
- Protocolized HFNC Weaning Strategy, Usual Care HFNC Weaning
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- Rush University Medical Center
Ventilatory Depression, Postoperative Respiratory Failure
The Effect of Hyperoxia on Ventilation During Recovery From General Anesthesia
In this randomized-controlled trial the investigators will examine the effect of oxygen supplementation on the recovery of breathing for 90 minutes in the immediate post-anesthesia period starting from extubation of the trachea.
- Trial name
- NCT05379673
- Testing
- Oxygen Gas for Inhalation
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Stanford University
Respiratory Mechanics, Monitoring, Physiologic
Dynamic Non-invasive Monitoring of Inspiratory Effort
This prospective, observational cohort study aims to evaluate whether the dynamic monitoring of a patient's breathing effort can predict successful liberation from invasive mechanical ventilation.
- Conditions
- Respiratory Mechanics, Monitoring, Physiologic, Respiratory Insufficiency Requiring Mechanical Ventilation, Critical Illness
- Trial name
- NCT07839949
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Fundació d'investigació Sanitària de les Illes Balears
Respiratory Failure Without Hypercapnia, Respiratory Failure With Hypercapnia
Management of Post-operative Respiratory Failure by Using NIV and High Velocity Nasal Insufflation (HVNI)
Postoperative respiratory failure (PORF) remains a critical driver of morbidity, mortality, and incremental care costs in surgical populations.
- Conditions
- Respiratory Failure Without Hypercapnia, Respiratory Failure With Hypercapnia, Postoperative Respiratory Complication
- Trial name
- NCT06988111
- Testing
- BIPAP, Vapotherm
- Where
- Egypt
- Volunteers
- 180 people
- Sponsor
- Assiut University
Premature Birth, Respiration Failure
Predictors of Prolonged Mechanical Ventilation in Preterm Infants
This prospective cohort study aims to identify the independent predictors of prolonged mechanical ventilation in preterm infants admitted to the Neonatal Intensive Care Unit of Assiut University Children Hospital.
- Conditions
- Premature Birth, Respiration Failure, Bronchopulmonary Dysplasia
- Trial name
- NCT07821632
- Volunteers
- 100 people
- Sponsor
- Assiut University
Acute Hypoxemic Respiratory Failure, Acute Respiratory Distress Syndrome
EndotyPIng PreHospitAl de Novo Acute hYpoxemic Respiratory Failure
We attempt to perform dynamic endotyping of critically ill patients presenting in the emergency department with de novo acute hypoxemic respiratory failure (AHRF).
- Trial name
- EPIPHANY (NCT05150483)
- Where
- Greece
- Volunteers
- 350 people
- Sponsor
- Evangelismos Hospital
Diaphragm Issues, Mechanical Ventilation Complication
Diaphragm Atrophy and Dysfunction in Mechanical Ventilation
The gold standard of twitch transdiaphragmatic pressure recordings would ultimately clear the fog around the rate of development of Ventilator induced Diaphragm Dysfunction (VIDD) in mechanically ventilated patients over time.
- Conditions
- Diaphragm Issues, Mechanical Ventilation Complication, Respiratory Failure, Intensive Care (ICU) Myopathy
- Trial name
- DAM (NCT05211661)
- Testing
- Respiratory Muscle Testing
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- RWTH Aachen University
Diaphragm Dysfunction, Weaning Invasive Mechanical Ventilation
Diaphragm Hibernation and Its Driving Factors in Mechanically Ventilated ICU Patients
Rationale: Patients with invasive mechanical ventilation (IMV) frequently develop diaphragm dysfunction and experience difficult weaning.
- Conditions
- Diaphragm Dysfunction, Weaning Invasive Mechanical Ventilation, Respiratory Failure, ICU
- Trial name
- DISSECT (NCT07819864)
- Where
- Netherlands
- Volunteers
- 112 people
- Sponsor
- Radboud University Medical Center
Respiration Failure, Diaphragmatic Dysfunction
Dynamic POCUS of Diaphragm Function to Predict Respiratory Failure in Septic Shock
This prospective observational cohort study aims to evaluate the prognostic value of serial bedside ultrasound assessment of diaphragmatic function in adult patients with septic shock.
- Conditions
- Respiration Failure, Diaphragmatic Dysfunction, Mechanical Ventilation, Septic Shock
- Trial name
- POCUS in RF (NCT07820267)
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Assiut University
Breathing, Lung Function Decreased
Phase Resolved Functional Lung MRI and Oscillometry for the Observation of Healthy Lung Function
This study will examine the relationship of airways resistance measured by oscillometry with ventilation defects measured by Phase Resolved Functional Lung (PREFUL) MRI in healthy human subjects.
- Conditions
- Breathing, Lung Function Decreased, MRI Imaging, Healthy
- Trial name
- PROOF (NCT07614685)
- Testing
- Airway Oscillometer, Phase Resolved Functional Lung MRI
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Blunt Chest Trauma, Respiratory Failure
Combined Lung and Diaphragmatic Ultrasound to Predict Respiratory Failure in Blunt Chest Trauma
Blunt chest trauma is a leading cause of emergency hospital visits and can result in severe breathing complications such as hypoxemic respiratory failure.
- Conditions
- Blunt Chest Trauma, Respiratory Failure, Thoracic Injuries, Hypoxemic Respiratory Failure
- Trial name
- NCT07807566
- Volunteers
- 130 people
- Sponsor
- Assiut University
Spinal Cord Injury Cervical, Respiratory Failure
Epidural Spinal Cord Stimulation for Respiratory Recovery in Cervical SCI
This multicenter, single-arm exploratory IIT evaluates epidural spinal cord electrical stimulation (ESCES) in 20 adults with C1-C5 SCI and respiratory failure.
- Trial name
- NCT07722130
- Testing
- Epidural spinal cord stimulation
- Where
- 2 sites in China
- Volunteers
- 20 people
- Sponsor
- Zhongda Hospital
Acute Respiratory Failure, Respiratory Insufficiency
HERMES: Quality and Safety of Advanced Respiratory Support During Patient Transport
The HERMES Phase III study is an international, multicenter, prospective observational investigation designed to characterize the quality and safety of patient transport during advanced respiratory support.
- Conditions
- Acute Respiratory Failure, Respiratory Insufficiency, Respiratory Distress, Critical Illness
- Trial name
- HERMES (NCT07805603)
- Testing
- Advanced Respiratory Support During Patient Transport
- Where
- 4 sites in Colombia, Egypt and 2 more
- Volunteers
- 565 people
- Sponsor
- Medipol University