Clinical trials: Respiratory Exacerbation
Chronic Obstructive Pulmonary Disease, Exacerbation Copd
15-year Mortality After Hospitalization for Exacerbation of Chronic Obstructive Pulmonary Disease
The investigators examine the 15-year mortality after an admission for an exacerbation of Chronic Obstructive Pulmonary disease (COPD).
- Conditions
- Chronic Obstructive Pulmonary Disease, Exacerbation Copd, Mortality
- Trial name
- MORTCOP (NCT02972775)
- Testing
- no interventions. observational study
- Where
- Netherlands
- Volunteers
- 845 people
- Sponsor
- Zuyderland Medisch Centrum
Pulmonary Disease, Chronic Obstructive
Zileuton to Treat Adults With Chronic Obstructive Pulmonary Disease (The LEUKO Study)
Chronic obstructive pulmonary disease (COPD) is a long-term lung disease that is caused by cigarette smoking or by breathing in other lung irritants, including pollution, dust, or chemicals.
- Trial name
- LEUKO (NCT00493974)
- Testing
- Zileuton
- Where
- 18 sites in United States
- Volunteers
- 119 people
- Sponsor
- University of Minnesota
COPD
The Changes in End Expiratory Lung Impedence Measured by EIT and End Expiratory Lung Volume Measured by Passive Expiratory in Controlled Mechanical Ventilated Exacerbation COPD Patients
The pathophysiological characteristics of respiratory failure on exacerbation of chronic pulmonary obstructive disease are the rapid deteriorate of respiratory symptoms, combined with aggravated flow limitation, gas trapping…
- Trial name
- NCT05585060
- Testing
- the changes of end expiratory lung impedence, the changes of end expiratory lung volume
- Where
- China
- Volunteers
- 10 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
COPD
A Study Comparing Doxycycline and Levofloxacin for Treating COPD Exacerbations
This study will include patients with chronic obstructive pulmonary disease (COPD) who present with an acute exacerbation. Participants will be randomly assigned to receive either doxycycline or levofloxacin for 5 days.
- Trial name
- DOLE-COPD (NCT06915688)
- Testing
- Doxycycline, Levofloxacin
- Where
- Pakistan
- Volunteers
- 188 people, healthy volunteers welcome
- Sponsor
- Amina Aslam
Asthma
A Trial of Mepolizumab Adjunctive Therapy for the Prevention of Asthma Exacerbations in Urban Children
The purpose of this study is to see if treatment with a medication called Nucala® (mepolizumab), given along with standard asthma care, makes children less likely to have asthma attacks.
- Trial name
- MUPPITS-2 (NCT03292588)
- Testing
- Mepolizumab
- Where
- 9 sites in United States
- Volunteers
- 335 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
COPD Exacerbation, Hypercapnia
DUET Versus Standard Interface for Hypercapnic COPD Patients
The goal of this clinical trial is to compare the new asymmetric nasal high flow interface with the conventional high flow nasal cannula in patients with COPD exacerbation.
- Conditions
- COPD Exacerbation, Hypercapnia, COPD
- Trial name
- NCT05829083
- Testing
- Asymmetric nasal cannula - DUET, Conventional nasal high flow cannula
- Where
- 2 sites in Greece
- Volunteers
- 50 people
- Sponsor
- Larissa University Hospital
Cystic Fibrosis
Outpatient Antibiotic Treatment for a Cystic Fibrosis Pulmonary Exacerbation
This study plans to learn more about the effect of oral antibiotics for an outpatient pulmonary exacerbation (respiratory illness) on sputum (mucus) bacterial infections, lung function, airway inflammation and quality of life.
- Trial name
- NCT02480270
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Colorado, Denver
Chronic Obstructive Pulmonary Disease, Sepsis
Antibiotic/COPD in Acute Exacerbation of Chronic Obstructive Pulmonary Disease (COPD) Requiring Mechanical Ventilation
Although the use of antibiotics in the treatment of acute exacerbation of chronic obstructive pulmonary disease (COPD) is largely accepted, controversy remains regarding whether the choice of antibiotic has any impact on outcome.
- Conditions
- Chronic Obstructive Pulmonary Disease, Sepsis, Antibiotics
- Trial name
- NCT00791505
- Testing
- ciprofloxacin, trimethoprim-sulfamethoxazole
- Volunteers
- 170 people
- Sponsor
- University of Monastir
Respiratory Decompensation, Multiple Disabilities
Long-term Use of Intrapulmonary Percussive Ventilation for Preventing Hospitalizations Due to Respiratory Decompensation in Children With Multiple Disabilities
Chronic respiratory failure is the leading cause of morbidity and mortality in children with multiple disabilities. Musculoskeletal disorders, swallowing disorders and ventilatory control abnormalities lead to progressive…
- Trial name
- PERKINE (NCT07473856)
- Testing
- Intrapulmonary Percussive Ventilation IPV
- Where
- France
- Volunteers
- 146 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pulmonary Disease, Chronic Obstructive
SERETIDE 50/500mcg Versus Tiotropium Bromide On Exacerbation Rates In Severe Chronic Obstructive Pulmonary Disease
This is a comparator study to assess the relative efficacy of the combination product fluticasone propionate/salmeterol 50/500 and tiotropium bromide on the rate of exacerbations of chronic obstructive pulmonary disease (COPD)…
- Trial name
- NCT00361959
- Testing
- Tiotropium bromide 18mcg, Fluticasone propionate/ salmeterol combination 50/500mcg
- Where
- 166 sites in Austria, Belgium and 18 more
- Volunteers
- 1,270 people
- Sponsor
- GlaxoSmithKline
COPD Exacerbation, Hypoxia
Oxygen Control and Weaning by O2matic to Patients Admitted With an Exacerbation of COPD
The aim of the study is to examine if automated oxygen delivery with O2matic allows for faster weaning from oxygen and better oxygen control than manually controlled oxygen therapy for patients admitted with an exacerbation of…
- Conditions
- COPD Exacerbation, Hypoxia, Hypoxemia, Hyperoxia
- Trial name
- O2MATIC-WEAN (NCT03661086)
- Testing
- O2matic
- Where
- 5 sites in Denmark
- Volunteers
- 157 people
- Sponsor
- Hvidovre University Hospital
Asthma
Adequacy of Management of Patients With Asthma Exacerbation in Martinique
Asthma is a chronic respiratory disease whose goal of therapeutic, educational and preventive care is to prevent the onset of acute crisis, the most serious of which are life threatening.
- Trial name
- APEXA (NCT05253391)
- Testing
- Routine care
- Where
- 7 sites in Martinique
- Volunteers
- 339 people
- Sponsor
- University Hospital Center of Martinique
Chronic Obstructive Pulmonary Disease, Invasive Mechanical Ventilation
Trial to Study Intubation Rates of Non-invasive Ventilation Using Pressure Support Ventilation (PSV) Versus Adaptive Support Ventilation (ASV) Mode in Patients With Acute Exacerbation of Chronic Obstructive Pulmonary Disease
The clinical course of chronic obstructive pulmonary disease (COPD) is associated with recurrent episodes of exacerbation that results in respiratory failure.
- Conditions
- Chronic Obstructive Pulmonary Disease, Invasive Mechanical Ventilation, Adaptive Support Ventilation
- Trial name
- PSV vs ASV for (NCT02877524)
- Testing
- Adaptive support ventilation, Pressure support ventilation
- Where
- India
- Volunteers
- 74 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Asthma-COPD Overlap
Efficiency of Budesonide Combined With Formoterol and Tiotropium in the Treatment of Acute Exacerbation of ACO
This study evaluates the efficiency of ICS(budesonide) combined with LABA (formoterol) and LAMA(tiotropium) in the treatment of acute exacerbation of asthma-chronic obstructive pulmonary overlap.
- Trial name
- NCT03504527
- Testing
- triple combinations, double combinations
- Volunteers
- 120 people
- Sponsor
- Huashan Hospital
Asthma Acute, Asthma Attack
Nebulized Ketamine Plus Standard Care vs. Standard Care Alone in Moderate to Severe Asthma Exacerbations
The goal of this clinical trial is to learn if nebulized ketamine helps treat moderate to severe asthma attacks in adults in the emergency department.
- Conditions
- Asthma Acute, Asthma Attack, Asthma Exacerbations
- Trial name
- KET-AIR (NCT07112456)
- Testing
- Nebulized ketamine (0.5 mg/kg in normal saline to a total volume of 5ml) plus standard asthma excaerbationcare
- Where
- Oman
- Volunteers
- 100 people
- Sponsor
- Oman Medical Speciality Board
Cystic Fibrosis
Mucin in Sputum of CF During Pulmonary Exacerbation
The purpose of this study is to determine whether mucin is increased during pulmonay exacerbations in adult patients with cystic fibrosis (CF).
- Trial name
- NCT00202072
- Where
- 2 sites in Germany
- Volunteers
- 25 people
- Sponsor
- Philipps University Marburg
Asthma
Asthma Exacerbation Study
Asthma is a clinical syndrome that is well recognized by health care practitioners, yet asthma pathogenesis still remains poorly understood.
- Trial name
- NCT00853411
- Testing
- prednisone
- Sponsor
- University of Pittsburgh
COPD Exacerbation
Biomarker of Acute Exacerbation of COPD
Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is the main factor that leads to the deterioration of the disease.
- Trial name
- NCT04963244
- Where
- China
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Pulmonary Disease, Chronic Obstructive
Calprotectin I Serum as a Diagnostic Marker
Lower respiratory tract infection is the most common cause of acute exacerbations of chronic obstructive pulmonary disease (AECOPD).
- Trial name
- NCT03474484
- Where
- Norway
- Volunteers
- 113 people
- Sponsor
- St. Olavs Hospital
Chronic Obstructive Pulmonary Disease (COPD), Exacerbation Copd
Determinants of Lower Limb Muscle Atrophy Induced During an Hospitalization for Exacerbation of COPD
Chronic Obstructive Pulmonary Disease (COPD) is characterized by persistent airway obstruction and inflammatory response of the lungs and bronchi.
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Exacerbation Copd, Muscle Atrophy
- Trial name
- AMI-EX-BPCO (NCT03153826)
- Testing
- Comparison of clinical and biological characteristics of patients
- Where
- France
- Volunteers
- 9 people
- Sponsor
- University Hospital, Montpellier