Clinical trials: Respiratory Distress Syndrome, Adult
Acute Respiratory Distress Syndrome
Dead Space and Inhaled Nitric Oxide in Pediatric Acute Respiratory Distress Syndrome
The goal of this observational study is to determine whether a marker of dead space (the end-tidal to alveolar dead space fraction [AVDSf]) is more strongly associated with mortality risk than markers of oxygenation abnormality…
- Trial name
- DiNO (NCT06690801)
- Where
- 10 sites in United States
- Volunteers
- 1,260 people
- Sponsor
- Children's Hospital Los Angeles
COVID, Sars-CoV2
Using GM-CSF as a Host Directed Therapeutic Against COVID-19
The coronavirus disease 2019 (COVID-19) has rapidly become a pandemic. COVID-19 poses a mortality risk of 3-7%, rising to 20% in older patients with co-morbidities.
- Conditions
- COVID, Sars-CoV2, ARDS, Human
- Trial name
- NCT04400929
- Testing
- Sargramostim, Normal Saline 0.9%
- Where
- Singapore
- Volunteers
- 2 people
- Sponsor
- Singapore General Hospital
Respiratory Distress Syndrome, Adult
Role of Vascular Endothelial Growth Factor (VEGF) in Acute Lung Injury/Adult Respiratory Distress Syndrome (ARDS)
Understanding the role VEGF plays in ARDS consequently provides an ideal opportunity to discover new therapies for ARDS.
- Trial name
- NCT00319631
- Where
- United States
- Sponsor
- Weill Medical College of Cornell University
Respiration, Artificial, Respiratory Distress Syndrome, Adult
Weaning From Mechanical Ventilation Using Permissive Hypercarbia
Some patients receiving mechanical ventilation have difficulty weaning off the ventilator because of physiological factors such as pre-existing lung disease, respiratory distress syndrome, and trauma among others.
- Trial name
- NCT00357929
- Testing
- Permissive hypercarbia
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Milton S. Hershey Medical Center
Fluid Overload, Critical Illness
Role of Active Deresuscitation After Resuscitation:
The RADAR-Canada trial is a pilot RCT undertaken to assess the acceptability of, compliance with, and biologic consequences of a deresuscitation protocol designed to expedite the removal of excess interstitial fluid in patients…
- Conditions
- Fluid Overload, Critical Illness, Sepsis, ARDS
- Trial name
- RADAR-Canada (NCT06326112)
- Testing
- Furosemide Injection, Metolazone Tablets
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- Unity Health Toronto
Acute Respiratory Distress Syndrome (ARDS)
Clinical Features, Treatments, and Outcomes in Acute Respiratory Distress Syndrome (ARDS-CTO)
The goal of this observational prospective cohort study is to explore the clinical characteristics, treatment strategies, and outcomes of adult patients with acute respiratory distress syndrome (ARDS) admitted to the medical…
- Trial name
- ARDS-CTO (NCT07186140)
- Where
- South Korea
- Volunteers
- 800 people
- Sponsor
- Jee Hwan Ahn
SARS-CoV2 Infection, Ventilator Associated Pneumonia
Ventilation Associated Pneumonia and Covid-19
In December 2019, a new pandemic emerged, the COVID-19 disease caused by a SARS-Cov-2 virus. One of the most common symptoms of COVID-19 is mainly respiratory failure and patients requires assistance by mechanical ventilation.
- Conditions
- SARS-CoV2 Infection, Ventilator Associated Pneumonia, Ards, COVID-19
- Trial name
- ECOLCOVID (NCT05089968)
- Where
- France
- Volunteers
- 268 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Prone Positioning, High Flow Nasal Cannula
Early PP With HFNC Versus HFNC in COVID-19 Induced Moderate to Severe ARDS
Coronavirus disease 2019 (COVID-19) is an emerging infectious disease that was first reported in Wuhan, China, and had subsequently spread worldwide. Twenty-nine percent of COVID-19 patients may develop ARDS.
- Conditions
- Prone Positioning, High Flow Nasal Cannula, Acute Respiratory Distress Syndrome, Corona Virus Infection
- Trial name
- NCT04325906
- Testing
- high flow nasal cannula (HFNC), Prone positioning (PP)
- Where
- United States
- Volunteers
- 224 people
- Sponsor
- Rush University Medical Center
Respiratory Infection
Netosis in Determination of Respiratory Infection Severity
The study aims to evaluate the prognostic value of alveolar and blood NETosis in patients under mechanical ventilation and treated for an acute low-respiratory tract infection.
- Trial name
- NETMINDERS (NCT04318691)
- Testing
- Blood sampling, Bronchoalveolar lavage
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Respiratory Distress Syndrome, Conventional Mechanical Ventilation
Invasive Ventilation for Neonates With Acute Respiratory Distress Syndrome(ARDS)
Acute respiratory distress syndrome (ARDS) in neonates has been defined in 2017.The death rate is over 50%. HFOV and CMV are two main invasive ventilation strategies. However, which one is better needing to be further elucidated.
- Conditions
- Acute Respiratory Distress Syndrome, Conventional Mechanical Ventilation, High Frequency Oscillation Ventilation
- Trial name
- NCT03591796
- Testing
- HFOV, CMV
- Where
- China
- Volunteers
- 386 people
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Acute Respiratory Distress Syndrome (ARDS), Extracorporeal Membrane Oxygenation
Personalized Ventilator Settings for Patients on ECMO
While mechanical ventilation can be used to sustain life in those with lung injury, it, can further worsen lung injury or prevent lung healing resulting in high morbidity and mortality as seen in Acute Respiratory Distress…
- Conditions
- Acute Respiratory Distress Syndrome (ARDS), Extracorporeal Membrane Oxygenation, Respiratory Failure Patients Treated With ECMO, Respiratory Failure, ICU
- Trial name
- PEEPECMO (NCT07673250)
- Testing
- Personalized Positive End-Expiratory Pressure (PEEP)
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- University of California, San Diego
Human ARDS, Coronavirus Infection
Post-intensive Care Follow-up of Patients Hospitalized for an Acute Respiratory Distress Syndrome Caused by COVID-19
For the last years, studies have described the " Post-intensive care Syndrome " (PICS), which consists in alteration of quality of life, cognition, autonomy and psychological disorders within the months after intensive-care.
- Trial name
- RE-CoV-ERY (NCT04619368)
- Testing
- Follow up calls
- Where
- France
- Volunteers
- 52 people
- Sponsor
- University Hospital, Toulouse
SARS-CoV-2, Influenza, Human
Study on Safety and Efficacy of Two Doses of PRS CK STORM in the Modulation of the Cytokine Storm in Patients With Acute Respiratory Infection Caused by SARS-Cov-2, Influenza A, Influenza B and Respiratory Syncytial Virus (RSV)
The purpose of this clinical trial is to evaluate the safety, tolerability and efficacy of two doses (dose A and dose B) of Standardized Conditioned Medium Obtained by Coculture of M2-macrophages and fat-derived Mesenchymal…
- Conditions
- SARS-CoV-2, Influenza, Human, Respiratory Syncytial Virus Infections, Respiratory Distress Syndrome
- Trial name
- NCT06684379
- Testing
- PRS CK STORM
- Where
- 3 sites in Spain
- Volunteers
- 50 people
- Sponsor
- PEACHES BIOTECH
Covid-19, Acute Respiratory Failure
Mavrilimumab in Severe COVID-19 Pneumonia and Hyper-inflammation (COMBAT-19)
This study is a prospective, phase II, multi-center, randomized, double-blind, placebo-controlled trial to evaluate the efficacy and safety of mavrilimumab in hospitalized patients with acute respiratory failure requiring oxygen…
- Conditions
- Covid-19, Acute Respiratory Failure, ARDS, Human, Sars-CoV2
- Trial name
- COMBAT-19 (NCT04397497)
- Testing
- Mavrilimumab
- Where
- 3 sites in Italy
- Volunteers
- 50 people
- Sponsor
- Ospedale San Raffaele
ARDS
Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF) Inhalation to Improve Host Defense and Pulmonary Barrier Restoration
This trial evaluates efficacy and safety of inhaled molgramostim (rhGM-CSF) in 45 patients with pneumonia associated acute respiratory distress syndrome (ARDS).
- Trial name
- GI-HOPE (NCT02595060)
- Testing
- inhaled molgramostim (rhGM-CSF)
- Where
- 7 sites in Germany
- Volunteers
- 45 people
- Sponsor
- University of Giessen
Music Therapy, Anxiety
The Effect of Music Therapy in COVID-19 Patients Given Prone Position
Almost half of the patients diagnosed with COVID-19 pneumonia develop ARDS and most of these patients are treated in the intensive care unit.
- Conditions
- Music Therapy, Anxiety, Respiratory Distress Syndrome, Intensive Care Units
- Trial name
- NCT05038514
- Testing
- musıc therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Kutahya Health Sciences University
Acute Respiratory Distress Syndrome (ARDS), Proning
A Trial of Staff Time With Proned Patients in the ICU Using the 'BathMat'
Proning is a way of helping people who are very sick and have trouble breathing. It involves lying patients on their front to get more oxygen into their body.
- Conditions
- Acute Respiratory Distress Syndrome (ARDS), Proning, Intensive Care Medicine
- Trial name
- NCT06844617
- Testing
- BathMat
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Royal United Hospitals Bath NHS Foundation Trust
ARDS (Acute Respiratory Distress Syndrome), Electrical Impedance Tomography (EIT)
Pulse Wave vs. Saline Contrast EIT for Pulmonary Perfusion in ARDS
Monitoring pulmonary perfusion is crucial in critical care, especially for conditions like ARDS. Electrical Impedance Tomography (EIT) is a valuable, non-invasive tool for real-time bedside monitoring.While well-established for…
- Conditions
- ARDS (Acute Respiratory Distress Syndrome), Electrical Impedance Tomography (EIT), Mechanical Ventilation
- Trial name
- NCT07908368
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Acute Respiratory Distress Syndrome
Human Mesenchymal Stem Cells For Acute Respiratory Distress Syndrome
This is a Phase 1, open label, dose escalation, multi-center clinical trial of Allogeneic Bone Marrow-Derived Human Mesenchymal Stem Cells (hMSCs) for the treatment of Acute Respiratory Distress Syndrome (ARDS).
- Trial name
- START (NCT01775774)
- Testing
- Allogeneic Bone Marrow-Derived Human Mesenchymal Stem Cells
- Where
- 4 sites in United States
- Volunteers
- 9 people
- Sponsor
- Michael A. Matthay
Acute Lung Injury, Decidual Stromal Cells
A Pilot Study Using Placenta Derived Decidual Stromal Cells for Toxicity and Inflammation With Special Focus to the Allogeneic Hematopoietic Cell Transplantation Setting
To evaluate safety and efficacy using decidual stromal cell therapy for toxicity and inflammation, with special focus on allogeneic hematopoietic cell transplantation patients.
- Conditions
- Acute Lung Injury, Decidual Stromal Cells, Stem Cell Transplantation, Inflammation
- Trial name
- NCT02175303
- Testing
- Decidual stromal cell therapy
- Where
- Sweden
- Volunteers
- 25 people
- Sponsor
- Karolinska Institutet
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