Clinical trials: Respiration Failure
Hypercapnia, Ventilatory Depression
Effect of Selective Serotonin Reuptake Inhibitors (SSRIs) and an Opioid on Ventilation
This study is designed to evaluate the effects of the coadministration of paroxetine or escitalopram with an opioid on ventilation. Ventilation will be assessed using a rebreathing methodology.
- Trial name
- NCT05470465
- Testing
- Paroxetine and Oxycodone, Escitalopram and Oxycodone
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Food and Drug Administration (FDA)
Heart Failure
Reassure Remote Respiration Monitoring in Heart Failure Patients
This study is designed to descriptively assess improvement in quality of life and test the usability of remotely monitored respiration parameters in the routine management of recently discharged heart failure patients.
- Trial name
- NCT02624739
- Testing
- Reassure Non-Contact Respiration Monitor
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- ResMed
Congestion, Nasal
A Pivotal Study to Assess the Effectiveness of Nasal Dilator (Breathe Right Nasal Strips)
This randomized, double-blind, parallel group, placebo-controlled study assessed subjective measures of nasal airway breathing immediately after application in the morning upon awakening after use of breathe right nasal strips…
- Trial name
- NCT03549130
- Testing
- Breathe Right Tan (small/medium) nasal strips
- Where
- 2 sites in United States
- Volunteers
- 130 people
- Sponsor
- GlaxoSmithKline
Respiratory Failure
The Use of the GlideScope Ranger in Pediatric Critical Care Transport
This study seeks to assess the role of the GlideScope Ranger video laryngoscope in facilitating successful neonatal/pediatric intubation by pediatric critical care transport teams.
- Trial name
- NCT01054183
- Testing
- GlideScope Ranger Intubation, Direct Laryngoscopy
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Akron Children's Hospital
ARDS, Human, Mechanical Ventilation Complication
Awake Prone Positioning to Reduce Invasive VEntilation in COVID-19 Induced Acute Respiratory failurE
Prone positioning (PP) is an effective first-line intervention to treat moderate-severe acute respiratory distress syndrome (ARDS) patients receiving invasive mechanical ventilation, as it improves gas exchanges and lowers…
- Conditions
- ARDS, Human, Mechanical Ventilation Complication, COVID19
- Trial name
- APPROVE-CARE (NCT04347941)
- Testing
- Prone Positioning, Standard of care.
- Where
- Ireland
- Volunteers
- 24 people
- Sponsor
- University College Hospital Galway
Prematurity, Respiratory Insufficiency
Inhaled Prostaglandin E1 (IPGE1) for Hypoxemic Respiratory Failure (NHRF)
This is a randomized controlled trial (RCT) on the use of Inhaled prostaglandin E1 (IPGE1) in Neonatal Hypoxemic Respiratory Failure (NHRF).
- Conditions
- Prematurity, Respiratory Insufficiency, Pulmonary Hypertension, Respiratory Distress Syndrome, Newborn
- Trial name
- NCT01467076
- Testing
- Aerosolized Normal Saline, Inhaled PGE1
- Where
- 11 sites in United States
- Volunteers
- 7 people
- Sponsor
- NICHD Neonatal Research Network
Acute Respiratory Failure, Shock
Impact of Early Enteral vs. Parenteral Nutrition on Mortality in Patients Requiring Mechanical Ventilation and Catecholamines
The purpose of this study is to assess the hypothesis that, as compared to early intravenous feeding, early nutrition via the enteral route is associated with reduced Day 28-mortality in critically ill patients treated with…
- Trial name
- NUTRIREA2 (NCT01802099)
- Testing
- Enteral nutrition, Parenteral nutrition
- Where
- 41 sites in France
- Volunteers
- 2,410 people
- Sponsor
- Centre Hospitalier Departemental Vendee
Sepsis, Delirium
The MENDS2 Study, Maximizing the Efficacy of Sedation and Reducing Neurological Dysfunction and Mortality in Septic Patients With Acute Respiratory Failure
Ventilated ICU patients frequently have sepsis and the majority have delirium, a form of brain dysfunction that is an independent predictor of increased risk of dying, length of stay, costs, and prolonged cognitive impairment in…
- Conditions
- Sepsis, Delirium, Impaired Cognition
- Trial name
- MENDS2 (NCT01739933)
- Testing
- Dexmedetomidine, Propofol
- Where
- 11 sites in United States
- Volunteers
- 438 people
- Sponsor
- Vanderbilt University Medical Center
Postoperative Respiratory Condition
Effect of Neuromuscular Reversal With Sugammadex on Postoperative Recovery Profile
Suboptimal reversal of neuromuscular blockage after surgery is possibly related to unfavorable postoperative respiratory conditions and elevated pain levels.
- Trial name
- Neuropa (NCT02243943)
- Testing
- Sugammadex, Neostigmine
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Leiden University Medical Center