Clinical trials: Resection
Early-stage Non-squamous Non-small Cell Lung Cancer (NSCLC)
Pharmacokinetic Similarity Between ABP 234 and Keytruda® (Pembrolizumab)
The primary objective of this study is to demonstrate pharmacokinetic (PK) similarity ABP 234 with pembrolizumab.
- Trial name
- Eucalyptus (NCT06430866)
- Testing
- ABP 234, Pembrolizumab
- Where
- 128 sites in Argentina, Bulgaria and 16 more
- Volunteers
- 163 people
- Sponsor
- Amgen
Non-small Cell Lung Cancer
A Study to Evaluate the Efficacy and Safety of Divarasib Compared With Investigator's Choice of Immunotherapy or Observation in Participants With Resected Stage II-III KRAS G12C-Positive Non-Small Cell Lung Cancer (NSCLC)
The main purpose of this study is to evaluate the efficacy of divarasib compared with investigator's choice of immunotherapy (pembrolizumab or nivolumab) or observation in participants with resected Kirsten rat sarcoma viral…
- Trial name
- KRASCENDO 3 (NCT07541170)
- Testing
- Divarasib, Pembrolizumab, Nivolumab
- Where
- 46 sites in United States, Argentina and 12 more
- Volunteers
- 400 people
- Sponsor
- Hoffmann-La Roche
Healthy Volunteer
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of MRG-110 Following Intradermal Injection in Healthy Volunteers
MRG-110 is intended to promote the growth of new blood vessels by inhibiting a molecule called miR-92a. MRG-110 is being studied to determine if it can accelerate healing of wounds by improving blood flow into the wound area.
- Trial name
- NCT03603431
- Testing
- MRG-110
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- miRagen Therapeutics, Inc.
Tattoo Removal
Study of Picosecond and Nanosecond Q-switched Lasers for Tattoo Removal
The purpose of this study is to compare the investigational medical grade laser device to a marketed medical grade laser device for effectiveness in lightening or clearing unwanted tattoos.
- Trial name
- NCT01973166
- Testing
- Picosecond Q-switched Laser Treatment, Nanosecond Q-switched Laser Treatment
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Cutera Inc.
BCC - Basal Cell Carcinoma, BCC
CellFX Treat & Resect Low-Risk BCC Feasibility Study
This prospective, multicenter, study is designed to evaluate the safety and effectiveness of the CellFX System in adults subjects with low-risk basal cell carcinoma (superficial and nodular) for complete histological clearance of…
- Conditions
- BCC - Basal Cell Carcinoma, BCC, Excision Margin
- Trial name
- NCT04918381
- Testing
- CellFX System
- Where
- 5 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Pulse Biosciences, Inc.
Arteriovenous Graft Thrombosis
AVATR - Arteriovenous Access Thrombosis Removal With CAPERE Thrombectomy System
A prospective, single-arm, non-blinded study, intending to treat and collect and evaluate data in up to ten (10) human subjects who are currently being treated with hemodialysis and who present with acute thrombosis in their…
- Trial name
- AVATR (NCT04494035)
- Testing
- CAPERE Thrombectomy System
- Where
- Canada
- Volunteers
- 7 people
- Sponsor
- Medtronic Endovascular
Postoperative Pain
A Study of Two Approved Drugs in the Treatment of Postoperative Dental Pain (0966-182)
The purpose of this study is to compare the safety and effectiveness of two approved drugs in the treatment of pain following dental surgery.
- Trial name
- NCT00092313
- Testing
- MK0966, rofecoxib, Comparator: oxycodone and acetaminophen
- Volunteers
- 271 people
- Sponsor
- Merck Sharp & Dohme LLC
Parenchymous Tissue Surgical Bleeding
Safety and Efficacy of Fibrin Sealant Grifols (FS Grifols) During Parenchymous Tissue Open Surgeries
This study is designed to assess the safety and efficacy of Fibrin Sealant Grifols in patients undergoing open surgical procedures where bleeding may be present on parenchymous tissue (e.g., solid abdominal organs such as the…
- Trial name
- NCT01754480
- Testing
- Fibrin Sealant Grifols, Surgicel®
- Where
- 33 sites in United States, Hungary and 2 more
- Volunteers
- 325 people
- Sponsor
- Instituto Grifols, S.A.
Kidney Failure
Non Invasive External Monitoring in Dialysis Patients
This is a single center, non randomized study to gather data to correlate physiological signals with the patient's fluid status during fluid removal in hemodialysis.
- Trial name
- FARM (NCT00919438)
- Testing
- AVIVO™ Mobile Patient Management System
- Volunteers
- 25 people
- Sponsor
- Corventis, Inc.
Skin Laxity, Lipodystrophy
CONFORM: Rotational Fractional Resection for Submental Contouring
This study will evaluate the safety and efficacy of rotational fractional resection (RFR) to improve neck contouring. RFR is used to remove loose skin and fat.
- Trial name
- NCT03407313
- Testing
- Rotational fractional resection (1.5mm diameter device)
- Where
- 6 sites in United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Recros Medica, Inc.
Lung Cancer, Lung Tumor
NeoMend ProGEL™ Pleural Air Leak Sealant Post-Approval Study
The purpose of this post approval study is to further characterize the safety profile of the ProGEL™ Pleural Air Leak Sealant in commercial use, with specific reference to long-term safety over 90 days of follow-up.
- Trial name
- NCT01394978
- Testing
- Control, ProGEL Pleural Air Leak Sealant with standard surgical closure, ProGEL Pleural Air Leak Sealant without standard surgical closure
- Where
- 18 sites in United States
- Volunteers
- 444 people
- Sponsor
- C. R. Bard
Frequency and Type of Medical Adhesive-Related Skin Injury, NPWT Drape Seal Effectiveness Rate (or Leak Incidence Rate)
Evaluation of a Switchable Acrylic Adhesive Drape for Safer Removal in Negative Pressure Wound Therapy Applications.
Negative pressure wound therapy (NPWT) is widely used for chronic and acute wounds, severe burns, and post-operative care. Despite its benefits, the strong adhesive required to maintain an airtight seal increases the risk of…
- Conditions
- Frequency and Type of Medical Adhesive-Related Skin Injury, NPWT Drape Seal Effectiveness Rate (or Leak Incidence Rate), Clinician Acceptability of New NPWT Drape, Patient Drop-out Rate From Prescribed NPWT Treatment
- Trial name
- NCT06717308
- Testing
- Comfort Release® NPWT drape
- Where
- 7 sites in United States
- Volunteers
- 300 people
- Sponsor
- Global Biomedical Technologies, LLC
Gastroenterology, LARS - Low Anterior Resection Syndrome
A Randomised Clinical Investigation to Assess Efficacy of Low Volume Transanal Irrigation by Qufora® IrriSedo MiniGo Versus Conservative Treatment for Low Anterior Resection Syndrome Patients
The purpose of this post-market clinical follow up study is to assess the efficacy on clinical symptoms of LARS of low volume Transanal Irrigation by MiniGo in conjunction with conservative treatment versus conservative treatment…
- Conditions
- Gastroenterology, LARS - Low Anterior Resection Syndrome, Rectal Cancer
- Trial name
- MINIGO (NCT06923150)
- Where
- 9 sites in France
- Volunteers
- 78 people
- Sponsor
- Qufora A/S
Craniotomy for Epilepsy and Malignant Tumor Removal
Brain-Shift Monitoring Using 3D Scanning
A prospective non-invasive data/image collection for evaluation of the performance of the Advanced Scanners 3D scanner during brain surgery.
- Trial name
- NCT05018338
- Testing
- Brain shift monitoring
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Advanced Scanners Inc.
Non-Small Cell Lung Cancer (NSCLC)
A Study In Patients Who Will Undergo Surgical Removal Of Non-Small Cell Lung Cancer To Evaluate Molecular Changes That Occur In Tumor Tissue After Short Term Exposure To PF-00299804
This study will enroll patients who are planned to undergo surgical removal of their tumor. The goal of the study is to evaluate the changes that occur in the tumor after brief (about 8 days) exposure to the study drug.
- Trial name
- NCT00971191
- Testing
- PF-00299804
- Where
- 3 sites in United States
- Volunteers
- 22 people
- Sponsor
- Pfizer
Dry Eye Syndromes
A Study to Determine the Prevalence of Inflammatory Dry Eye Disease in Patients Prior to Cataract Removal
This study will evaluate the prevalence of inflammatory dry eye disease in patients prior to cataract surgery. No treatment is administered in this study.
- Trial name
- REVEAL (NCT01882413)
- Testing
- No intervention
- Where
- 6 sites in Canada
- Volunteers
- 204 people
- Sponsor
- Allergan
Malignant Glioma
Study of NPC-07 for Fluorescence-guided Resection of Malignant Gliomas
The aim of the present Phase III study is to assess the positive predictive value of NPC-07 (5-aminolevulinic acid hydrochloride) induced tissue fluorescence, safety and pharmacokinetics following a single dose of NPC-07 orally…
- Trial name
- NCT01167322
- Testing
- NPC-07 for oral administration
- Where
- 3 sites in Japan
- Volunteers
- 45 people
- Sponsor
- Nobelpharma
Dental Pain
Study of Diclofenac Capsules to Treat Dental Pain
The purpose of this study is to determine whether Diclofenac Test Formulation Capsules are safe and effective for the treatment of dental pain.
- Trial name
- NCT00985439
- Testing
- Diclofenac Test (lower dose), Diclofenac Test (upper dose), Celecoxib 400 mg
- Where
- United States
- Volunteers
- 202 people
- Sponsor
- Iroko Pharmaceuticals, LLC
Melanoma
Effectiveness and Safety of Dabrafenib in Combination With Trametinib as Adjuvant Treatment for Chinese Patients With Stage III BRAF V600 Mutation-positive Melanoma After Complete Resection
This is a prospective, open label, single-arm, multicenter, non-interventional study of dabrafenib in combination with trametinib as adjuvant treatment for Chinese patients with stage III BRAF V600 mutation positive melanoma…
- Trial name
- NCT04666272
- Testing
- dabrafenib, trametinib
- Where
- 8 sites in China
- Volunteers
- 78 people
- Sponsor
- Novartis Pharmaceuticals
Hair Remval
Clinical Evaluation of Splendor X for Hair Removal
At least 40 healthy male or female subjects that wish to remove their hair will be enrolled to this study. Each subject will receive five treatments at 6-8 weeks intervals.
- Trial name
- NCT04152707
- Testing
- Splendor X
- Where
- 2 sites in United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Lumenis Be Ltd.