Clinical trials: Renin Hypertension
Diabetes Mellitus, Type 2, Arterial Hypertension
Antidiuretic Function Before and During Treatment With SGLT2 Inhibitors
Subjects treated with Canagliflozin, Dapagliflozin and Empagliflozin obtained improvement on blood pressure values, body weight and cardiovascular mortality but pathophysiological explanations of these effects are not yet known.
- Conditions
- Diabetes Mellitus, Type 2, Arterial Hypertension, Body Weight Changes
- Trial name
- GliRACo1 (NCT03917758)
- Testing
- SGLT2 inhibitor
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- University of Turin, Italy
Hypertension
Phase IIa Safety and Efficacy Study of SPP635 in Mild to Moderate Hypertension
This study is conducted to investigate the effect of the oral renin inhibitor SPP635 on blood pressure in patients with mild to moderate hypertension.
- Trial name
- NCT00376636
- Testing
- SPP635 (drug)
- Where
- Germany
- Volunteers
- 35 people
- Sponsor
- Speedel Pharma Ltd.
Hypertension
A Long Term Study of SPP100 in Patients With Essential Hypertension (Trial is Not Recruiting in the US)
This study will evaluate the safety and efficacy of long term treatment of SPP100 in patients with essential hypertension. (Trial is not recruiting in the US)
- Trial name
- NCT00246584
- Testing
- SPP100
- Where
- Switzerland
- Volunteers
- 300 people
- Sponsor
- Novartis
Obesity, Cardiovascular Diseases
PRECISION-BP: Precision Chronopharamacotherapy Targeting NP-RAAS-BP Rhythm Axis
Obese individuals have a higher prevalence of nocturnal hypertension and non-dipping blood pressure (BP). These conditions are associated with an increased risk of cardiovascular (CV) events and death.
- Conditions
- Obesity, Cardiovascular Diseases, Hypertension, Nocturnal Blood Pressure
- Trial name
- PRECISION-BP (NCT04971720)
- Testing
- Sacubitril-Valsartan 49 Mg-51 Mg Oral Tablet, Valsartan 80 mg Oral Tablet
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham