Clinical trials: Renin Hypertension
Genetics in Hypertension
Beta-2 Adrenergic Receptor Polymorphic Variants: An Endotype of Salt Sensitive Hypertension (Beta2AR).
All living things are made of building blocks called cells. Genes are the part of cells that contain the instructions which determine important things about you, like your height or hair color, and affect your health.
- Trial name
- Beta2AR (NCT07832942)
- Testing
- low sodium diet, high sodium diet, renal plasma flow
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Brigham and Women's Hospital
Hypertension
A Study to Evaluate the Safety/Tolerability and Pharmacokinetics of Aliskiren in Hypertensive Pediatric and Adolescent Patients 6-17 Years of Age
This first open-label study in a pediatric population was designed to evaluate aliskiren safety and pharmacokinetics after single and multiple dosing in 6-17 year old children with hypertension.
- Trial name
- NCT00834041
- Testing
- Aliskiren 3.125 mini-tablets
- Where
- 5 sites in United States, Belgium and 3 more
- Volunteers
- 39 people
- Sponsor
- Novartis
Hypertension, Insulin Resistance
Accomplices of Insulin Resistance in Prehypertension: Aldosterone?
The purposes of the study are to evaluate the relative contributions of insulin resistance and renin-angiotensin-aldosterone system to blood pressure (BP) in subjects with prehypertension. This is a cross-sectional study.
- Trial name
- NCT01112007
- Where
- Taiwan
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Chronic Kidney Diseases, Hyperkalemia
Potassium Correction for RAAS Optimization in Chronic Kidney Disease
The goal of this placebo-controlled, double-blinded cross-over trial is to test whether patiromer, compared with placebo, better enables up-titration of RAAS-blocker treatment in patients with chronic kidney disease stage 3b/4.
- Conditions
- Chronic Kidney Diseases, Hyperkalemia, Hypertension
- Trial name
- PROMISE (NCT06256991)
- Testing
- Patiromer 8400 MG [Veltassa]
- Where
- Netherlands
- Volunteers
- 44 people
- Sponsor
- University Medical Center Groningen
Hypertension
Study of Preoperative Management of Angiotensin Converting Enzyme Inhibitor (ACEi) and Angiotensin Receptor Blocker (ARB) Medications
Patients on a stable dose of ACE inhibitor or ARB medication who are scheduled for elective surgery will be randomized to take their ACE inhibitor or ARB up to and including the morning of surgery, or to hold them a day prior to…
- Trial name
- PASS (NCT01091961)
- Testing
- Preoperative ACEi/ARB management
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Low-Renin Hypertension
Double Blind Crossover Comparison of Diuretics in the Young
The principle objective of the study is to determine whether low-renin (i.e. salt sensitive) hypertension at a young age is caused by the kidneys hanging onto too much salt as a result of an over active salt pump in the kidney.
- Trial name
- NCT00429897
- Testing
- Bendroflumethiazide 2.5mg - 5mg, Amiloride 20-40mg, Spironolactone 50-100mg
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Cambridge
Obesity, Vitamin D Deficiency
Vitamin D Supplementation Reduces Renin-Angiotensin System Activity in Obesity
Hypothesis: Vitamin D supplementation lower renin-angiotensin system activity in obesity. Specific Aim: To investigate whether Vitamin D supplementation in obesity improves the vascular sensitivity to angiotensin II.
- Conditions
- Obesity, Vitamin D Deficiency, Hypertension
- Trial name
- NCT01068418
- Testing
- Vitamin D (cholecalciferol)
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Brigham and Women's Hospital
Hypertension, Vitamin D Deficiency
Effects of Vitamin D on Renin Expression in Hypertensive Patients
The cardiovascular effects of vitamin D therapy (in humans) have been documented only in patients with known vitamin D deficiency or hyperparathyroidism (a surrogate marker of inadequate vitamin D activity).
- Trial name
- NCT00585442
- Testing
- calcitriol
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Utah
Cardiovascular Diseases, Heart Diseases
Renin and Prorenin in Pregnancy
To determine the role of the prorenin-renin-angiotensin-aldosterone system (RAAS) in normal and hypertensive pregnancy.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Hypertension, Pregnancy Toxemias
- Trial name
- NCT00005207
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Diabetes, Hypertensive Disease
Effect of Renin-angiotensin System Blockers on Glomerular Filtration Rate in Patients With Hypertension, Type 2 Diabetes With Normoalbuminuria
Diabetes is the leading cause of chronic kidney disease in developed countries. About 30-40% of patients with type 1 and type 2 diabetes mellitus will develop diabetic nephropathy.
- Trial name
- eGFR (NCT01500590)
- Testing
- Renin-angiotensin system blockers, non-renin angiotensin system blockers
- Where
- China
- Volunteers
- 1,400 people
- Sponsor
- Hospital Authority, Hong Kong
Vitamin D Deficiency, Hypertension
Vitamin D Deficiency in Patients With Hypertension
This study will evaluate the effects of Vitamin D replacement and the effects of an approved medication for hypertension, aliskiren (Tekturna), in patients with high blood pressure who have low levels of vitamin D in their blood.
- Trial name
- NCT00974922
- Testing
- Aliskiren, Cholecalciferol
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- UConn Health
Hypertension, Stress, Psychological
Effectiveness of Prazosin on the Urinary Sodium Excretion Response to Mental Stress
High blood pressure, or hypertension, is a serious problem in the African-American (AA) population which affects nearly 7 of every 10 AAs in our area.
- Conditions
- Hypertension, Stress, Psychological, Blood Pressure
- Trial name
- NCT02431936
- Testing
- Prazosin
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Augusta University
Hypertension
Pharmacodynamic Influences of Candesartan, Atenolol, Hydrochlorothiazide and Drug Combinations in Hypertensive Patients.
Angiotensin receptor antagonists (ARA), beta-blockers and diuretics do not seem to confer equivalent cardiovascular protection in hard outcomes clinical trials (beta blockers inferior).
- Trial name
- NCT00232882
- Testing
- Candesartan Thiazide, Atenolol Thiazide, Thiazide Candesartan
- Where
- Canada
- Volunteers
- 86 people
- Sponsor
- Institut de Recherches Cliniques de Montreal
Hypertension, Diabetes
Renin and Aldosterone Levels in the Preterm Neonate At Risk for Hypertension
The purpose of this study is to find out if mothers with high blood pressure (Hypertension) and/or diabetes have babies with high levels of different substances (that help to regulate blood pressure, called Renin and Aldosterone)…
- Conditions
- Hypertension, Diabetes, Infants Small for Gestational Age
- Trial name
- NCT01549444
- Testing
- presence of maternal risk factor for hypertension
- Where
- 2 sites in Canada
- Volunteers
- 76 people
- Sponsor
- Ottawa Hospital Research Institute
Hypertension
Comparison of Single and Combination Diuretics in Low-Renin Hypertension
The purpose of this study is to determine whether the routine combination of optimal thiazide and K+-sparing diuretic will both increase efficacy of BP reduction and reduce risk of glucose intolerance; and whether K+-sparing…
- Trial name
- PATHWAY3 (NCT02351973)
- Testing
- Hydrochlorthiazide, Amiloride, Hydrochlorthiazide and Amiloride
- Where
- United Kingdom
- Volunteers
- 423 people
- Sponsor
- University of Cambridge
Preeclampsia, Type 1 Diabetes
Urine-plasminogen as a Predictor for Development Of Preeclampsia in Pregnant Women With Type 1 Diabetes Mellitus
A tonic active epithelial Na+ channel (ENaC) in pre-eclampsia (PE) escaped normal hormonal control may offer an attractive explanatory model for the pathophysiology of established PE. The channel is activated by plasmin.
- Trial name
- NCT01821053
- Where
- Denmark
- Volunteers
- 85 people
- Sponsor
- Odense University Hospital
Salt Sensitivity of Blood Pressure, High Blood Pressure
Effect of an Isolevuglandin Scavenger on Salt Sensitivity of Blood Pressure and Immune Cell Activation in Humans
Hypertension is the leading cause of preventable deaths globally, driven by complications such as myocardial infarction, stroke, heart failure, and kidney disease.
- Conditions
- Salt Sensitivity of Blood Pressure, High Blood Pressure, Inflammation, Renin-Angiotensin-Aldosterone System
- Trial name
- NCT07602166
- Testing
- 2-hydroxybenzylamine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Vanderbilt University Medical Center
Hypertension
Is There an Adverse Drug Reaction Between Renin-Angiotensin System Blockade and Inhaled Anesthetics
It is controversial whether or not patients whose Renin Angiotensin System is blocked for the treatment of hypertension suffer increased risk when undergoing surgery and anaesthesia.
- Trial name
- NCT01715584
- Testing
- Sevoflurane/oxygen/air/nitrous oxide
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Obstructive Sleep Apnea
Vitamin D and SGLT-2 Inhibitor in CPAP-naive Obstructive Sleep Apnea
The purpose of this study is to determine if vitamin D supplement and SGLT-2 inhibitor treatment combination can improve cardiovascular risks in patients with OSA and hypertension, on top of lifestyle modification, before…
- Trial name
- D3DOSA (NCT06690723)
- Testing
- Dapagliflozin (Forxiga), Vitamin D3 ( Colecalciferol), Vitamin D3 plus Dapagliflozin
- Where
- Malaysia
- Volunteers
- 160 people
- Sponsor
- University Malaysia Sarawak
Type 2 Diabetes, Hypertension
Pilot Study of Aprepitant Effect on Aldosterone Secretion in Diabetic Patient (Diabetes Mellitus) With Hypertension Associated With Low Renin
Aldosterone regulation is mediated by hormonal control, and nervous control. Autonomic nervous system action could be mediated by neuropeptides in the adrenal gland.
- Trial name
- APHOS-02 (NCT02811055)
- Testing
- Blood sampling, Blood Pressure Measurement, electrocardiogram
- Where
- France
- Volunteers
- 5 people
- Sponsor
- University Hospital, Rouen