Clinical trials: Renin Hypertension
Prehypertension, Hypertension
Combined Dietary Education of Low Sodium and High Potassium Consumption
Reduction in sodium consumption is important approach in public health care. In general population, reduction of sodium intake can reduce the future development of hypertension and cardiovascular event.
- Trial name
- NCT01914224
- Testing
- dietary education of low sodium and high potassium consumption, dietary education of low sodium consumption only
- Where
- South Korea
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- DongGuk University
Blood Pressure, Hypertension
Blood Pressure Regulation - Role of Potassium
Project titel: Oral potassium supplementation in healthy men - interactions with the renin-angiotensin-aldosterone system and the sympathetic nervous system Protocol number: KARAASS-1 EudraCT number: 2013-004460-66 Introduction…
- Trial name
- NCT02380157
- Testing
- Kaleorid, 750mg (trade name), Potassium chloride (active substance)
- Where
- Denmark
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Glostrup University Hospital, Copenhagen
Hypertension, Insulin Resistance
Accomplices of Insulin Resistance in Prehypertension: Aldosterone?
The purposes of the study are to evaluate the relative contributions of insulin resistance and renin-angiotensin-aldosterone system to blood pressure (BP) in subjects with prehypertension. This is a cross-sectional study.
- Trial name
- NCT01112007
- Where
- Taiwan
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Hypertension
Effect of Salt Restriction on Renin Activation
The present prospective, randomized, crossover study is designed to investigate the effect of salt consumption on blood pressure in hypertensive subjects.
- Trial name
- NCT01628302
- Testing
- Lowering salt in diet
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Turkish Society of Hypertension and Renal Diseases
Hypertension, Left Ventricular Hypertrophy
Pediatric Hypertension and the Renin-Angiotensin SystEm (PHRASE)
Studying the causal roles of components of the renin-angiotensin-aldosterone system (including angiotensin-(1-7) (Ang-(1-7)), angiotensin-converting enzyme 2 (ACE2), Ang II, and ACE), uric acid, and klotho in pediatric…
- Conditions
- Hypertension, Left Ventricular Hypertrophy, Left Ventricular Dysfunction, Left Atrial Dilatation
- Trial name
- PHRASE (NCT04752293)
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Hypertension, Metabolic Syndrome
The Study of Novel Dual Renin Angiotensin Aldosterone System (RAAS) Blockade; Valsartan/Aliskiren in African American Patients With Hypertension and the Metabolic Syndrome
Study purpose: African Americans with hypertension and markers of metabolic syndrome (small elevations in blood glucose, triglycerides and or weight) are at a high risk of cardiovascular (heart and blood vessel) problems.
- Trial name
- SAAVE (NCT01432106)
- Testing
- Aliskerin/Valsartan and Rampiril
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Michigan
Obesity, Prehypertension
Vascular Dysfunction in Human Obesity Hypertension
The purpose of the study is to test the effects of blocking sympathetic nerve activity with a drug called clonidine on blood vessel function and muscle nerve activity in adults who are obese and have high blood pressure.
- Conditions
- Obesity, Prehypertension, Hypertension
- Trial name
- VANISH (NCT01983462)
- Testing
- Clonidine, Hydrochlorothiazide
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Gary L. Pierce
Pediatric Disorder, Pediatric Obesity
Pediatric Primary Hypertension and the Renin-Angiotensin System (PHRAS)
Pediatric primary hypertension is increasingly common, occurring in 5-10% of normal-weight children and up to 25% of children with obesity. It is a risk factor for adult cardiovascular and renal disease.
- Conditions
- Pediatric Disorder, Pediatric Obesity, Primary Hypertension
- Trial name
- PHRAS (NCT03310684)
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Uncontrolled Hypertension
Uncontrolled Hypertension Management (TEAM-HTN)
Current guideline directed medical therapies (GDMT) for hypertension (HTN) endorse a trial and error approach based on drug class.
- Trial name
- TEAM-HTN (NCT03281772)
- Testing
- Clinical Decision Software - provider portal, Clinical Decision Software - patient portal
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Madigan Army Medical Center
Cardiovascular Diseases, Hypertension
The African-PREDICT Study
The African-PREDICT study aims to (i) generate new knowledge on the early pathophysiology accompanying hypertension development in black South Africans; and (ii) to identify early novel markers or predictors for the development…
- Conditions
- Cardiovascular Diseases, Hypertension, Health Risk Behaviors, Arterial Stiffness
- Trial name
- PREDICT (NCT03292094)
- Where
- South Africa
- Volunteers
- 1,202 people, healthy volunteers welcome
- Sponsor
- North-West University, South Africa
Hypertension
Acute Effect of Agiotensin-(1-7) in Healthy and Hypertensive Subjects
In the modern concept of Renin-angiotensin System, Angiotensin-(1-7) plays a key role and demonstrates promising therapeutic potential due to it is generally opposite effects to Angiotensin II.
- Trial name
- Ang-(1-7) (NCT03001271)
- Testing
- Angiotensin 1-7
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Instituto de Cardiologia do Rio Grande do Sul
Hypertension
Hemodynamic Effects of Aliskiren Compared to Captopril on the Kidney in Healthy Volunteers on a Low- and High- Sodium Diet
This study will measure the effects of different doses of aliskiren on kidney blood flow and function in healthy adults and determine how salt intake affects the response to aliskiren.
- Trial name
- NCT00518765
- Testing
- Aliskiren
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Novartis
Salt-sensitive Hypertension
Intervention Study to Compare the Natriuretic Effects of Enalapril on Low and High Salt Diet
The kidney plays a crucial role in maintaining salt balance by two opposing physiological mechanisms: the renal dopaminergic system which enhances salt excretion and the renin-angiotensin system (RAS) which causes salt retention.
- Trial name
- Salt (NCT01324245)
- Testing
- Fenoldopam
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Georgetown University
Hyperaldosteronism, Hypertension
Water and Electrolytes Content in HYpertension (WHYSKI) in the SKIn
WHYSKI is a prospective within-patient observational clinical study designed to test the hypothesis that alterations of Na+, K+, water, and the lympho-angiogenetic transcription factor Tonicity Enhancing Binding Protein (TonEBP)…
- Conditions
- Hyperaldosteronism, Hypertension, Aldosterone-producing Adenoma, Aldosteronism
- Trial name
- WHYSKI (NCT06090617)
- Testing
- Skin Biopsy, Video-laparoscopic adrenalectomy
- Where
- Italy
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University Hospital Padova
Healthy Participants, Hypertension
Human Intestinal Amino Acid Absorption and the Role of a Local (Renin)-Angiotensin System (RAS)
Aim of this trial is to investigate the expression and localisation of different amino acid transporters and their regulatory proteins derived from the regulatory proteins of the local renin angiotensin system (RAS) in the…
- Trial name
- NCT01252368
- Testing
- hypertension
- Where
- Switzerland
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Preeclampsia, Hypertension
Hypertension and Urine Protease Activity in Preeclampsia
Preeclampsia (PE) is a common disorder of pregnancy that complicates 4-7% of all pregnancies. It is a serious condition with acute proteinuria and hypertension and varying degrees of edema after 20 weeks of gestation.
- Conditions
- Preeclampsia, Hypertension, Proteinuria, Pregnancy
- Trial name
- HUPP (NCT01828138)
- Testing
- Sodium
- Where
- Denmark
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Hypertension
Renin-Guided Therapeutics in the Management of Untreated, Uncontrolled, or Complicated Hypertension
Plasma renin values determine whether volume or vasoconstrictor (renin) factors predominate in elevating blood pressure and are useful in selecting effective antihypertensive therapy.2,3 The researchers hypothesize that: 1.
- Trial name
- Renin (NCT00684489)
- Testing
- clinical hypertension specialist-no specific med. Any anti-hypertension meds., renin guided therapeutics-no specific med. Any anti-hypertensive med.
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Hypertension, Stress, Psychological
Effectiveness of Prazosin on the Urinary Sodium Excretion Response to Mental Stress
High blood pressure, or hypertension, is a serious problem in the African-American (AA) population which affects nearly 7 of every 10 AAs in our area.
- Conditions
- Hypertension, Stress, Psychological, Blood Pressure
- Trial name
- NCT02431936
- Testing
- Prazosin
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Augusta University
Psychological Stress, Hypertension, Renal
Effects of an Immunosuppressant Mycophenolate Mofetil or MMF on the Urinary Sodium Excretion Response to Mental Stress
The purpose of this study is to determine if stopping the stress induced increase in inflammation will prevent sodium retention which in turn increases blood pressure. Each subject will test two separate times.
- Trial name
- MMF (NCT02432339)
- Testing
- mycophenolate mofetil (MMF)
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Augusta University
Atrial Fibrillation, Hypertension
Irbesartan for the Prevention of Atrial Arrhythmias and Cardiac Electrical Remodeling in Patients With Hypertension and Permanent Pacemakers
The purpose of this study is to determine whether irbesartan will reduce the rate of recurrent atrial high rate episodes and the development of clinical sustained atrial fibrillation in patients with hypertension and permanent…
- Trial name
- NCT00225667
- Testing
- Irbesartan
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Connolly, Stuart, M.D.