Clinical trials: Renal Function
Transplant Recipient (Kidney), Primary Kidney Transplantation
Posttranslationally Modified Fetuin-A in Urine as a Marker for Renal Dysfunction (Patients With Chronic Kidney Disease - With or Without Kidney Transplantation).
Kidney transplantation is the preferred treatment method for patients with chronic kidney disease. Standard parameters (estimated glomerular filtration, albuminuria) of renal function detection are limited by many factors…
- Trial name
- (uPTM-FetA) (NCT06950931)
- Testing
- uPTM-FeA
- Where
- Slovakia
- Volunteers
- 86 people
- Sponsor
- University Hospital, Martin
Intracranial Pressure Increase, Abdominal Compartment Syndrome
Vasopressin in Intraabdominal Pressure Elevation
The aim of this study is to investigate any direct correlation between increased intrathoracic pressure, intraabdominal pressure and intracranial pressure, following a controlled elevation in intraabdominal pressure and…
- Trial name
- NCT03707054
- Testing
- Study Arm
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Non-Valvular Atrial Fibrillation
Study to Gather Information on the Kidney Function of Patients With Non-valvular Atrial Fibrillation (Irregularly Heart Beats Which is Not Caused by a Heart Valve Problem) Treated With Rivaroxaban or Vitamin K Antagonists
By evaluating routine clinical practice data from the UK primary care database, researchers in this study want to gather information on the kidney function of patients with non-valvular atrial fibrillation (NVAF, irregularly…
- Trial name
- ANTENNA (NCT04297072)
- Testing
- Rivaroxaban (Xarelto, BAY-597939), VKAs
- Where
- United Kingdom
- Volunteers
- 25,000 people
- Sponsor
- Bayer
Chronic Kidney Diseases
Propolis Effects in Patients With Chronic Kidney Disease
The aim of this study is to determine the impact of Propolis on proteinuria reduction and protection of the glomerular filtration rate in chronic renal failure patients.
- Trial name
- NCT02766036
- Testing
- Propolis
- Where
- Brazil
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Cirrhosis, Hepatorenal Syndrome
Treatment of Hepatorenal Syndrome With Terlipressin Plus Albumin vs Albumin
Hepatorenal syndrome is a common complication of cirrhotic patients. The prognosis of patients with HRS is very poor. It have been demonstrated that vasoconstrictors agents (Terlipressin) plus albumin are effective in the…
- Trial name
- NCT00287664
- Testing
- terlipressin
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Hospital Clinic of Barcelona
Type 2 Diabetes Mellitus
TRENDY Follow-up: Study on Endothelial Function in Subjects With Type 2 Diabetes Mellitus
Basal nitric oxide (NO) activity plays a pivotal role in the regulation of glomerular hemodynamics, and in animal experiments its alteration has been associated with morphological changes characteristic of diabetic nephropathy.
- Trial name
- NCT00905528
- Testing
- Telmisartan 80 mg/d, Ramipril 10 mg/d
- Where
- Germany
- Volunteers
- 69 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Type 2 Diabetes Mellitus
Renal Impairment Study With ASP1941
A study to investigate if the pharmacokinetics of ASP1941 is different in Type 2 Diabetes Mellitus (T2DM) patients with different grades of renal failure compared with T2DM patients with normal renal function and healthy…
- Trial name
- NCT01302028
- Testing
- ASP1941
- Where
- 5 sites in Czechia, Hungary and 2 more
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Astellas Pharma Inc
Sepsis, Severe, Sepsis
Multiple Biomarkers in ICU Sepsis Patients
Acute kidney injury (AKI) is a common condition among sepsis patients in the intensive care unit (ICU) and is associated with high morbidity and mortality.
- Conditions
- Sepsis, Severe, Sepsis, Septic Shock, AKI
- Trial name
- NCT03802136
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Zhongnan Hospital
Kidney Transplant
A Study of Factors That Affect Long-Term Kidney Transplant Function
The causes of deterioration of transplanted kidney function are poorly understood. The purpose of this study is to determine the disease processes that cause transplanted kidney dysfunction and loss in patients who received a…
- Trial name
- DeKAF (NCT00270712)
- Where
- 7 sites in United States, Canada
- Volunteers
- 3,175 people
- Sponsor
- University of Minnesota
Chronic Kidney Disease
Vitamin D Supplementation and Cardiac Hypertrophy in Chronic Kidney Disease (CKD)
Patients with Chronic Kidney Disease (CKD) are upto 3.5 times more likely to die from diseases of heart and blood vessels (Cardiovascular Disease-CVD). Vitamin D insufficiency is very common in CKD and associated with CVD.
- Trial name
- 5C (NCT01323712)
- Testing
- Vitamin D Cholecalciferol
- Where
- 2 sites in United Kingdom
- Volunteers
- 50 people
- Sponsor
- St George's, University of London
Postoperative Renal Function
Intraoperative Laser Speckle Imaging Predicts Early Renal Function After Kidney Transplantation
This observational study aims to explore the predictive value of intraoperative laser speckle contrast imaging for early postoperative renal function in kidney transplant recipients.
- Trial name
- NCT07753434
- Testing
- laser speckle contrast imaging (LSCI)
- Where
- China
- Volunteers
- 80 people
- Sponsor
- The Second Affiliated Hospital of Chongqing Medical University
Infected Total Hip or Knee Arthroplasty
Assessing Renal Function in Patients With an Antibiotic Laden Spacer
The purpose of this study is to monitor the renal function of patients who have an antibiotic laden spacer in place to treat an infected hip or knee arthroplasty.
- Trial name
- NCT01683734
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Central DuPage Hospital
CKD Stage 4, CKD Stage 5
Frailty, Cognitive Function and Health-related Quality of Life in Older Adults With Advanced Chronic Kidney Disease.
This observational study explores the impact of cognitive impairment and frailty in older adults with advanced chronic kidney disease ].
- Conditions
- CKD Stage 4, CKD Stage 5, Frailty, Cognitive Impairment
- Trial name
- NCT05705011
- Where
- Romania
- Volunteers
- 240 people
- Sponsor
- Grigore T. Popa University of Medicine and Pharmacy
Gait, Drop Foot, Chemotherapy-induced Peripheral Neuropathy
Impact of an Orthotic Intervention in Children With Peripheral Neuropathy
This research study will investigate the effect of two orthotic (brace) devices for the ankle and foot on walking and ankle flexibility in children with cancer not involving the brain or spinal cord.
- Conditions
- Gait, Drop Foot, Chemotherapy-induced Peripheral Neuropathy, Acute Lymphocytic Leukemia, Pediatric, Rhabdomyosarcoma
- Trial name
- IOPN (NCT03655587)
- Testing
- Solid ankle foot orthotic, Resting night splint
- Where
- 2 sites in United States
- Volunteers
- 27 people
- Sponsor
- Children's Hospitals and Clinics of Minnesota
Cirrhosis, Hepatorenal Syndrome
Interest of the Echocardiography in the Management of Cirrhotic Patients With Acute Kidney Injury
This prospective study focuses on the interest of the echocardiography for cirrhotic patients, who present acute kidney injury corresponding to the criteria of hepatorenal syndrome.
- Conditions
- Cirrhosis, Hepatorenal Syndrome, Acute Kidney Injury, Diastolic Function
- Trial name
- CIRREN (NCT02097784)
- Testing
- Echocardiography
- Where
- France
- Volunteers
- 28 people
- Sponsor
- Hospices Civils de Lyon
Chronic Kidney Disease
Nortriptyline and the Risk of Serious Adverse Events
This is a population-based retrospective, new-user, active comparator cohort study assessing whether initiating a new outpatient prescription of high-dose nortriptyline (>10-150 mg/day), compared with low-dose (10 mg/day), is…
- Trial name
- NCT07527481
- Testing
- Nortriptyline Hydrochloride
- Volunteers
- 5,000 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Nephrotoxicity
0,9% NaCl Effect on Kidney Function and Glycocalyx in Patients Operated on for Primary Hiparthrosis
The purpose of this study is to determine if chloride is nephrotoxic using 0,9% saline versus Plasma-Lytein in patients having primary hip replacement surgery.
- Trial name
- KIPA (NCT02528448)
- Testing
- Plasma-lyte, 0,9% saline
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- Regional Hospital Holstebro
Renal Impairment
A Study of Inclisiran in Participants With Renal Impairment Compared to Participants With Normal Renal Function (ORION-7)
This study is a Phase I, single-dose, open-label trial to evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics of a single dose of inclisiran subcutaneous (SC) injection in participants with mild…
- Trial name
- NCT03159416
- Testing
- Inclisiran
- Where
- 2 sites in New Zealand
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- The Medicines Company
Delayed Graft Function, Renal Outcome After Kidney Transplantation
Volatile Anesthetic Protection Of Renal Transplants 2
To compare the effect of a sevoflurane based anesthesia versus a propofol based anesthesia on the incidence of DGF in recipients of kidneys of donation after circulatory death (DCD) and donation after brain death (DBD) donors
- Conditions
- Delayed Graft Function, Renal Outcome After Kidney Transplantation, Acute Rejection (AR) of Transplanted Kidney, Graft Survival
- Trial name
- VAPOR-2 (NCT02727296)
- Testing
- sevoflurane, propofol
- Where
- 5 sites in Denmark, Netherlands and 2 more
- Volunteers
- 488 people
- Sponsor
- University Medical Center Groningen
Renal Diseases
A Study to Evaluate the Pharmacokinetics and Safety of Levofloxacin in Patients With Varying Degrees of Renal Function.
The primary objective was to evaluate the pharmacokinetics and safety of two dosing regimens of levofloxacin in patients with varying degrees of renal function.
- Trial name
- NCT00645437
- Testing
- Levofloxacin
- Volunteers
- 59 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.