Clinical trials: Renal Dysfunction
Chronic Kidney Disease
Whole Blood Platelet Aggregation in Chronic Kidney Disease Patients on Aspirin Study
Higher coronary in-stent thromboses and bleeding complications on anti-platelet agents are more common in Chronic Kidney Disease vs. non-Chronic Kidney Disease patients.
- Trial name
- WiCKDonASA (NCT01768637)
- Testing
- Aspirin, Clopidogrel
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Chronic Kidney Disease
Registry to Evaluate Maintenance Treatment With Venofer in Pediatric Patients With Chronic Kidney Disease
The current registry is being undertaken to assess the long-term (12 month) safety and tolerability of Venofer in the pediatric population with chronic kidney disease that requires intravenous iron maintenance therapy.
- Trial name
- NCT02492672
- Where
- 9 sites in United States
- Volunteers
- 50 people
- Sponsor
- American Regent, Inc.
Kidney Failure, Acute, Contrast Media
Bicarbonate v Saline to Prevent Contrast Nephropathy
Slowing of kidney function occurs in a minority of people given dye during angiography. The purpose of this study is to compare two different types of fluid given into a vein to reduce the risk of kidney injury: salt in water or…
- Trial name
- NCT00384995
- Testing
- 0.9% (154 mEq/L) IV Sodium Chloride, 1/6 M (166 mEq/L) IV Sodium Bicarbonate
- Where
- 5 sites in Italy
- Volunteers
- 61 people
- Sponsor
- Italian Society of Nephrology
Renal Insufficiency
Pharmacokinetics (PK) and Metabolism of FTY720 in Patients With Severe Renal Impairment and Healthy Matched Subjects.
The purpose of this study is to compare the pharmacokinetics of FTY720 and its metabolites in patients with severe renal insufficiency and in matched, healthy volunteers.
- Trial name
- NCT00731523
- Testing
- fingolimod (FTY720)
- Where
- Russia
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Novartis
Kidney Neoplasm
Impact of Chronic Renal Failure on Plasma Exposure of Kinase Inhibitors in Patients Treated for Metastatic Kidney Cancer
The study of the blood concentration of ITK what are pazopanib and cabozantinib at 1 month and 3 months from the start of treatment will allow to evaluate the impact of renal failure on their efficacy and toxicity in patients…
- Trial name
- IREKI (NCT04823923)
- Testing
- blood sampling for ITK dosage
- Where
- 5 sites in France
- Volunteers
- 60 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Chronic Kidney Disease
Safety and Pharmacokinetics of HRS-1780 in Healthy Subjects and Subjects With Impaired Renal Function
This is a multicenter, non-randomized, open-label, parallel-controlled study. The main objective is to evaluate the safety and pharmacokinetics of HRS-1780 in subjects with mild and moderate renal impairment versus healthy…
- Trial name
- NCT06039254
- Testing
- HRS-1780
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Shandong Suncadia Medicine Co., Ltd.
ESRD, Hepatitis C
Live Kidney Donors With Positive Anti-HCV Antibody, But Negative HCV PCR
It is well recognized that a subset of patients who contracts Hepatitis C virus (HCV) spontaneously clears the virus. Such individuals are anti-HCV antibody positive, yet HCV RNA PCR negative in the blood.
- Trial name
- NCT02669966
- Testing
- Kidney transplantation
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Florida
Acute Kidney Injury
Effect of Cholesterol Level on Postoperative Acute Kidney Injury of Non-cardiac Surgeries
Preoperative serum cholesterol level may influence occurrence of postoperative acute kidney injury of cardiac surgeries. However, the effect of Preoperative serum cholesterol level for non cardiac surgery remains unknown.
- Trial name
- NCT03954353
- Where
- China
- Volunteers
- 78,888 people
- Sponsor
- Peking University First Hospital
Acute Kidney Injury, Critical Illness
Predicting Adverse Kidney Events of Cardiac Surgery-Associated Acute Kidney Injury Using Novel Biomarkers
The aim of this study was to identify and validate novel biomarkers for predict acute kidney injury (AKI) subphenotype, major adverse kidney events and other poor outcomes.
- Conditions
- Acute Kidney Injury, Critical Illness, Kidney Failure
- Trial name
- NCT06351813
- Where
- China
- Volunteers
- 358 people
- Sponsor
- Shanghai Zhongshan Hospital
Kidney Failure, Chronic
Renal Toxicity of Iodixanol and Iopromide in Patients With Renal Dysfunction
The purpose of this study is to compare renal toxicity of Iodixanol and Iopromide in patients with renal dysfunction.
- Trial name
- RIPE (NCT01580046)
- Testing
- iodixanol, iopromide
- Where
- 19 sites in China
- Volunteers
- 200 people
- Sponsor
- Yong Huo
Acute Kidney Injury
Ibuprofen and Biomarkers of Acute Kidney Injury After Running in the Heat
The goal of this study is to determine if ibuprofen prior to exercise in the heat worsens biomarkers of acute kidney injury. Participants were given 600mg of ibuprofen or placebo (corn starch) 12- and 1-hour prior to running for…
- Trial name
- NCT06247462
- Testing
- Ibuprofen 600 mg
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
Acute Kidney Injury
The Use of Renal Guard System in Patients Undergoing CRT Implantation
The purpose of this study is to determine whether the use of RenalGuard system which creates high urine output with fluid balancing may prevent contrast induced nephropathy in patient undergoing cardiac resynchronization therapy…
- Trial name
- NCT01936142
- Testing
- Use of RenalGuard
- Where
- Israel
- Sponsor
- Tel-Aviv Sourasky Medical Center
Acute Kidney Injury
A Study of Acute Kidney Injury in Care Transitions
This research is being done to develop materials and processes that will help facilitate education and kidney care coordination for AKI survivors.
- Trial name
- NCT05184894
- Testing
- AKI in Care Transitions (ACT) program
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Mayo Clinic
Chronic Kidney Disease (Stages 3b-5)
Monitoring Hyperkalemia Using Point-of-care AI-enabled ECG Device Among Patients With Chronic Kidney Disease Stages 3b-5
The clinical trial will be conducted in a real-world outpatients setting with the goal of learning if monitoring serum potassium frequently among patients with moderate-to-advanced stages of chronic kidney disease leading to…
- Trial name
- POCKET (NCT06901960)
- Testing
- A mobile artificial intelligence-enhanced electrocardiogram device estimating plasma potassium categories (<5 mmol/L, 5 - <5.5 mmol/L, 5.5 - <6.0 mmol/L and ≥ 6.0 mmol/L)
- Where
- 3 sites in China
- Volunteers
- 1,066 people
- Sponsor
- Peking University First Hospital
Cardiovascular Abnormalities, Chronic Kidney Diseases
Characteristics, Treatment, and Economic Burden of Patients With CVD,CKD or at High Cardiovascular Risk
The heavy disease burden is mainly due to diabetic complications. Diabetes is a major risk factor for cardiovascular disease (CVD) and chronic kidney disease (CKD).China has been the largest absolute disease burden of diabetes in…
- Conditions
- Cardiovascular Abnormalities, Chronic Kidney Diseases, Diabetes
- Trial name
- NCT03958760
- Where
- China
- Volunteers
- 200,000 people
- Sponsor
- West China Hospital
Acute Kidney Injury
Incidence of Acute Kidney Injury and Mortality in Critically Ill Patients: Urinary Chloride as a Prognostic Marker
Acute kidney injury (AKI) is characterized by a rapid decrease in renal function. It is frequent in hospitalized patients and its incidence is higher in critically ill patients.
- Trial name
- NCT05542927
- Testing
- urine chloride
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Ain Shams University
Reperfusion Injury
Myocardial and Renal Dysfunction by Oxidative Stress Caused by Cardiac Surgery
Assessment of the severity of oxidative stress caused by the on-pump and off-pump cardiac surgery using mtDNA, nDNA, carbonilated proteins, nitrotyrosine, oxy-LDL, S100b-protein.
- Trial name
- NCT02394405
- Where
- Russia
- Volunteers
- 21 people
- Sponsor
- Moscow Regional Research and Clinical Institute (MONIKI)
Acute Kidney Failure
Essential Nutrients in Critically Ill Patients With Severe AKI Treated With and Without CRRT
The aim of this study is to measure plasma levels of essential vitamins, trace elements and amino acids in critically ill patients with severe AKI.
- Trial name
- NCT02470520
- Testing
- CRRT
- Volunteers
- 40 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Chronic Kidney Disease
The Effects of Dietary Fiber in CKD: A Systematic Review and Meta-analysis
Chronic kidney disease (CKD) is a debilitating condition in which there is a gradual decline of renal function associated with increased overall mortality.
- Trial name
- NCT01844882
- Volunteers
- 1 people
- Sponsor
- Unity Health Toronto
Covid19, Chronic Kidney Diseases
Physical Activity Level in Patients with Chronic Kidney Disease During COVID-19 Pandemic
In the literature, there are no studies evaluating fear of COVID-19, anxiety, depression, physical activity, fear of movement and quality of life in patients with chronic kidney disease during COVID-19 pandemic.
- Trial name
- NCT04745923
- Where
- Turkey (Türkiye)
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Hacettepe University