Clinical trials: Renal Denervation
Diastolic Heart Failure, Hypertension
Denervation of the renAl sympathetIc nerveS in hearT Failure With nOrmal Lv Ejection Fraction
Increasing evidence suggests an important role of activation of the sympathetic nervous system (SNS) in the clinical phenomena of heart failure with normal left ventricular ejection fraction and hypertension.
- Trial name
- DIASTOLE (NCT01583881)
- Testing
- renal denervation
- Where
- 2 sites in Netherlands
- Volunteers
- 60 people
- Sponsor
- UMC Utrecht
Metabolic Syndrome
Renal Sympathetic Denervation in Metabolic Syndrome (Metabolic Syndrome Study)
The purpose of this clinical investigation is to determine the effects of renal sympathetic denervation on insulin resistance and muscle sympathetic nerve activity in patients with metabolic syndrome.
- Trial name
- NCT01911078
- Testing
- Renal Denervation, EnligHTN™ Renal Denervation System.
- Where
- Greece
- Volunteers
- 20 people
- Sponsor
- Abbott Medical Devices
Hypertension
Renal Denervation for Uncontrolled Hypertension
This is a study investigating the safety and usefulness of the Renal Denervation Procedure in reducing high blood pressure in people whose blood pressure is not adequately controlled despite already being treated with 2 blood…
- Trial name
- RDNP-2012-02 (NCT02016573)
- Testing
- Renal Denervation
- Sponsor
- Baker Heart and Diabetes Institute
Treatment Resistant Essential Hypertension, Insulin Resistance
The Effects of Renal Denervation on Insulin Sensitivity
Renal sympathetic nerves contribute to development of hypertension. Sympathetic overactivity also induces insulin resistance and it could therefore be assumed that a renal denervation might improve insulin sensitivity.
- Trial name
- NCT01631370
- Testing
- Renal denervation
- Where
- Denmark
- Volunteers
- 8 people
- Sponsor
- University of Aarhus
Hypertension, Resistant to Conventional Therapy
Distal Renal Denervation
Objective of this study is to evaluate whether a distal mode of endovascular renal denervation with the treatment performed primarily in segmental branches of renal artery is more effective than conventional mode of the…
- Trial name
- NCT02667912
- Testing
- Distal renal denervation, Conventional renal denervation
- Where
- Russia
- Volunteers
- 55 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Multivessel Coronary Artery Disease, Hypertension Resistant to Conventional Therapy
Expand Management of Blood Pressure With Renal Denervation in Patients Undergoing Staged PCI for Advanced Coronary Artery diseasE
EMBRACE is a randomized, controlled, multicenter clinical study evaluating the effect of renal denervation on clinical adverse events in hypertensive patients undergoing staged percutaneous coronary intervention (PCI) for…
- Trial name
- EMBRACE (NCT07602790)
- Testing
- Renal denervation
- Volunteers
- 1,000 people
- Sponsor
- Ceric Sàrl
Resistant Hypertension
The RESPLASH Study
To assess the safety and effectiveness of renal artery denervation with subsequent splanchnic nerves denervation via catheter-based radiofrequency ablation in improving blood pressure and glycemic control in patients with…
- Trial name
- NCT06880562
- Testing
- Splanchnic Nerve Denervation, Renal Denervation Only
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Tulane University
Heart Failure
Renal Denervation in Patients With Chronic Heart Failure & Renal Impairment Clinical Trial
This is a feasibility study enrolling up to 40 patients in Australia and Europe. The primary aim of the study is to demonstrate the renal denervation with the Symplicity Catheter is safe and determine the evidence of a response…
- Trial name
- SymplicityHF (NCT01392196)
- Testing
- Renal Denervation
- Where
- Australia
- Volunteers
- 39 people
- Sponsor
- Medtronic Vascular
Therapy Resistant Hypertension
Randomized Comparison of Ultrasound Versus Radiofrequency Denervation in Patients With Therapy Resistant Hypertension
Prospective, randomized trial to assess the effectiveness of different renal sympathetic denervation methods (radiofrequency main vs. branches + main vs.
- Trial name
- RADIOSOUND (NCT02920034)
- Testing
- Radiofrequency denervation of the main renal arteries, Radiofrequency denervation of renal arteries and branches, Ultrasound denervation of the main renal arteries
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- Heart Center Leipzig - University Hospital
Hypertension, Uncontrolled, Hypertension, Resistant
INtraprocedural Feedback-Optimized Renal Denervation Based on Measurements Obtained Through Renal Artery Stimulation: a Randomized Controlled Trial (INFORM)
Our previous study (Huang HC, Pan HY, Wang TD, Circ Cardiovasc Interv 2023;16:e012779) demonstrated that when renal artery stimulation continues to trigger systolic blood pressure increases (>=20 mmHg increase compared to…
- Conditions
- Hypertension, Uncontrolled, Hypertension, Resistant, Hypertension
- Trial name
- INFORM (NCT06676553)
- Testing
- Radiofrequency ablation alone, re-denervation to main and/or branch renal artery, Radiofrequency ablation alone, no further renal denervation
- Where
- Taiwan
- Volunteers
- 32 people
- Sponsor
- National Taiwan University Hospital
Hypertension, Resistant to Conventional Therapy
How to Test Success of a Renal Denervation
The study aimed to assess the success of a clinically indicated renal denervation by different tests and correlate the results of the tests with the clinical outcome.
- Trial name
- NCT02559882
- Where
- Switzerland
- Volunteers
- 11 people
- Sponsor
- University of Zurich
Hypertension
Sympathetic Activity and Renal Denervation
Primary hypothesis: Catheter-based renal denervation reduces central sympathetic activation in patients with refractory hypertension. Secondary hypotheses: 1.
- Trial name
- ReD (NCT01355055)
- Where
- Germany
- Volunteers
- 26 people
- Sponsor
- Hannover Medical School
Resistant Hypertension
A First-in-human Study of HyperQureTM", Laparoscopic Renal Denervation Therapy in Patient With Resistant Hypertension
HQ-HTN-K01-02 is a prospective, multicenter, single arm, open label, first-in-human study to evaluate the safety and initial efficacy of HyperQureTM, laparoscopic denervation therapy, in patients with resistant hypertension on 3…
- Trial name
- NCT06216808
- Testing
- HyperQure Renal Denervation System
- Where
- 7 sites in South Korea
- Volunteers
- 10 people
- Sponsor
- DeepQure Inc.
Insulin Resistance, Blood Pressure
Denervation of the REnal Artery in Metabolic Syndrome
The current prevalence of hypertension as part of the metabolic syndrome is substantial and is increasing with the rise of obesity worldwide.
- Trial name
- DREAMS (NCT01465724)
- Testing
- Renal denervation
- Where
- Netherlands
- Volunteers
- 29 people
- Sponsor
- UMC Utrecht
Paroxysmal Atrial Fibrillation, Persistent Atrial Fibrillation
Treatment of Atrial Fibrillation in Patients by Pulmonary Vein Isolation in Combination With Renal Denervation or Pulmonary Vein Isolation Only
Prospective, randomized, controlled, multicenter, international clinical trial. The study population consist of patients with paroxysmal or persistent atrial fibrillation with out range hypertension or signs of sympathetic…
- Conditions
- Paroxysmal Atrial Fibrillation, Persistent Atrial Fibrillation, Out of Range Hypertension, Signs of Sympathetic Overdrive
- Trial name
- ASAF (NCT02115100)
- Testing
- procedure
- Where
- 8 sites in Netherlands, Spain
- Volunteers
- 145 people
- Sponsor
- Diagram B.V.
Hypertension
The Dutch National Renal Denervation Registry
This study is a national registry of patients treated with renal denervation (RD) in the Netherlands. The aim of the study is to collect data on safety of the procedure, predictors of the blood pressure lowering effect…
- Trial name
- NL_RDN_REG (NCT02482103)
- Testing
- Renal denervation
- Where
- Netherlands
- Volunteers
- 1,000 people
- Sponsor
- UMC Utrecht
Arrhythmia Burden in Patients With Recurrent, Paroxysmal Atrial Fibrillation Despite Durable Pulmonary Vein Isolation
Renal Denervation in Patients With Recurrent Atrial Fibrillation After Successful Pulmonary Vein Isolation
The aim of this study is to investigate whether renal denervation can reduce arrhythmia burden in patients with recurrent, paroxysmal atrial fibrillation despite durable pulmonary vein isolation.
- Trial name
- REDE-AF (NCT05817318)
- Testing
- Renal Denervation
- Where
- 2 sites in Switzerland
- Volunteers
- 6 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Hypertension, Metabolic Syndrome
Evaluation of the Integrated Radio Frequency Denervation System for the Treatment of Hypertension
The objective of the study is to evaluate the safety of renal denervation using the iRF System and to understand any potential improvement in hypertension.
- Trial name
- RADAR (NCT04740723)
- Testing
- iRF System Renal Denervation
- Where
- 2 sites in Georgia
- Volunteers
- 30 people
- Sponsor
- Metavention
Chronic Heart Failure
Clinical Study of an Ultrasound Renal Denervation System in Patients With Heart Failure
The purpose is to evaluate the renal denervation system (PRDS-001) for controlling sympathetic nerve over-activation in patients with heart failure, and for its safety in such patients.
- Trial name
- NCT04719637
- Testing
- PRDS-001 Renal Denervation Ultrasound System
- Where
- Japan
- Volunteers
- 6 people
- Sponsor
- Otsuka Medical Devices Co., Ltd. Japan
Hypertension, Resistant, Diabetes Mellitus
Renal Denervation Therapy for Resistant Hypertension in Type 2 Diabetes Mellitus
To demonstrate the efficacy of renal denervation therapy in treating resistant hypertension and its effect on glucose metabolism in patients with type 2 diabetes mellitus
- Conditions
- Hypertension, Resistant, Diabetes Mellitus, Renal Denervation Therapy
- Trial name
- HTN2DM (NCT01887067)
- Testing
- Renal denervation therapy
- Where
- Hong Kong
- Volunteers
- 7 people
- Sponsor
- Pamela Youde Nethersole Eastern Hospital