Clinical trials: Refractory Schizophrenia
Treatment Resistant Schizophrenia, Clozapine Adverse Reaction
Effect of Atenolol Versus Ivabradine on HRV in TRS Patients on Clozapine With Tachycardia: A Randomised Control Trial.
Clozapine is the only drug approved for Treatment Resistant Schizophrenia. However, it has been associated with many adverse drug reactions including agranulocytosis, myocarditis, sialorrhea, constipation, orthostasis…
- Conditions
- Treatment Resistant Schizophrenia, Clozapine Adverse Reaction, Heart Rate Variability, Tachycardia
- Trial name
- NCT06505668
- Testing
- Atenolol 25 mg, Ivabradine 10mg
- Where
- India
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- All India Institute of Medical Sciences, Bhubaneswar
Schizophrenia, Psychosis
The Music Study in Refractory Psychosis
The perception of music requires coordinated neural activities in distributed multi-functional centers across both hemispheres. The association between musical abilities and other general cognitive functions have been studied in…
- Trial name
- MARS (NCT02431949)
- Testing
- Admission to BCPP
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Anti-Psychotic, Management of Manifestations of Psychotic Disorders
Assessment of Intra-subject Variability in the Bioavailability of Chlorpromazine Hydrochloride
Cycle Pharmaceuticals Ltd. (Cycle) is developing an oral tablet formulation of Chlorpromazine Hydrochloride and intends to conduct bioequivalence trials to demonstrate its similarity to the RLD.
- Conditions
- Anti-Psychotic, Management of Manifestations of Psychotic Disorders, Treatment of Schizophrenia, Control Nausea and Vomiting
- Trial name
- NCT02943213
- Testing
- Chlorpromazine Hydrochloride
- Where
- South Africa
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cycle Pharmaceuticals Ltd.
Schizophrenia, Schizoaffective Disorder
Efficacy and Safety Study of Escitalopram Augmentation in Treatment Resistant Schizophrenia
A primary hypothesis to be explored here is that, given its pharmacodynamic profile and hypothesized mechanisms associated with schizophrenia, escitalopram will, in comparison to placebo, be effective when added to risperidone or…
- Trial name
- NCT00231335
- Testing
- escitalopram
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Emory University
Schizophrenia
Response to Clozapine in Treatment Resistant Schizophrenia: A Longitudinal Magnetic Resonance Spectroscopy Study
The purpose of this study is to investigate the relationship between glutamate and related brain chemicals and treatment response to clozapine in patients with treatment-resistant schizophrenia.
- Trial name
- NCT02714894
- Testing
- Clozapine
- Where
- Canada
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Treatment-resistant Schizophrenia, Treatment-responsive Schizophrenia
The Role of Glutamatergic Function in the Pathophysiology of Treatment-resistant Schizophrenia
The goal of this basic science study is to to explore the responsivity of glutamate in the brain of treatment-resistant schizophrenia patients to the drug riluzole.
- Conditions
- Treatment-resistant Schizophrenia, Treatment-responsive Schizophrenia, Healthy Controls
- Trial name
- RESTORE (NCT06270108)
- Testing
- Riluzole
- Where
- United Kingdom
- Volunteers
- 288 people, healthy volunteers welcome
- Sponsor
- King's College London