Clinical trials: Refractory Ascites
Malignant Ascites
PD-1 Inhibitor Intraperitoneal Perfusion Combined With PRaG Therapy for Malignant Ascites
The effect and safety of intraperitoneal infusion of PD-1 inhibitor is unclear for patients with peritoneal metastasis of advanced malignant tumors and malignant ascites.
- Trial name
- NCT05501340
- Testing
- Serplulimab, Molgramostim, Hypofractionated radiotherapy/Sterotactic body radiotherapy
- Volunteers
- 40 people
- Sponsor
- Second Affiliated Hospital of Soochow University
Liver Cirrhoses, Malignant Ascites
International Alfapump Cohort Study
This Registry is designed to follow patients who have been implanted with an alfapump system, which is a newly marketed product from Sequana Medical AG, a Swiss Medical Device company.
- Trial name
- TOPMOST (NCT04326946)
- Testing
- Alfapump
- Where
- 2 sites in Germany, Switzerland
- Volunteers
- 400 people
- Sponsor
- Sequana Medical N.V.
Liver Cirrhosis, Ascites
Peritoneal Dialysis Catheters for the Treatment of Refractory Ascites
One complication of liver disease is the buildup of fluid within the belly. This is known as ascites. Patients who have ascites have a decreased appetite, pain, nausea and shortness of breath.
- Trial name
- NCT02975726
- Testing
- Peritoneal Dialysis Catheter, Large Volume Paracentesis, 25% Human Serum Albumin injection
- Where
- Canada
- Volunteers
- 2 people
- Sponsor
- University of Manitoba
Refractory Malignant Ascites
Phase I Trial of Intraperitoneal Bevacizumab in Refractory Malignant Ascites
Malignant ascites often has a profound impact on the quality of life of cancer patients. Current treatments,including dietary, medical, and procedural are often temporary and unsatisfactory options in patients approaching the end…
- Trial name
- NCT01852409
- Testing
- bevacizumab
- Where
- 2 sites in China
- Volunteers
- 18 people
- Sponsor
- Peking University
Ascites
Trial of Sunitinib for Refractory Malignant Ascites
The study is to see whether treatment with Sunitinib decreases the accumulation of ascites in patients with refractory malignant ascites.
- Trial name
- NCT00796861
- Testing
- Sunitinib
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Milton S. Hershey Medical Center
Refractory Ascites, Hepatic Hydrothorax
Glutamine Challenge as Predictor of Hepatic Encephalopathy After Transjugular Intrahepatic Portosystemic Shunt (TIPS)
Transjugular intrahepatic portosystemic shunt (TIPS) is the first-line therapy for patients with cirrhosis and refractory ascites. However, mental changes known as hepatic encephalopathy (HE) frequently occur after TIPS.
- Conditions
- Refractory Ascites, Hepatic Hydrothorax, Hepatic Encephalopathy, Cirrhosis
- Trial name
- NCT02026609
- Testing
- Oral glutamine challenge, Psychometric Tests
- Where
- 3 sites in United States, Canada and 1 more
- Volunteers
- 3 people
- Sponsor
- University of Arkansas
Cirrhosis
Terlipressin in Cirrhotic Patients With Recidivation Ascites Treated With Paracentesis and Albumin
Ascites is a common complication of cirrhosis. Sodium restriction and diuretics are the first step treatment. Refractory ascites (not responding to first step treatment) is treated with repeated large volume paracentesis followed…
- Trial name
- TERAS (NCT00986817)
- Testing
- Terlipressin
- Where
- France
- Volunteers
- 82 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pleural Effusion, Malignant
IFN-γ Combined With T Cells in the Treatment of Refractory Malignant Pleural Effusion and Ascites
The purpose of this study was to evaluate the efficacy of IFN- Y combined with T cells in the treatment of refractory malignant pleural effusion and acties, using a multicenter, single-arm, open design.
- Trial name
- NCT05268172
- Testing
- IFN-γ and CIK cells, Tcm cells or CAR T cells
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Affiliated Hospital of Jiangnan University
Ascites, Cirrhosis
Metabolic Effects of Furosemide +HSS in Refractory Ascites
Introduction: Patients with chronic liver diseases are usually thin as a result of hypermetabolism and malnutrition expressed by reduced levels of leptin and impairment of other adyponectins such as visfatin.
- Trial name
- NCT02821377
- Testing
- intravenous furosemide, Hypertonic saline solutions, Seriated paracentesis
- Where
- 3 sites in Italy
- Volunteers
- 40 people
- Sponsor
- University of Palermo
Refractory Ascites in Children With Cirrhosis
Efficacy and Safety of Midodrine in Refractory or Recurrent Ascites in Children With Cirrhosis.
Refractory ascites is seen in 17% of cirrhotic patients with the 1year mortality rate being high, upto 20-50% [1]. The pathogenesis of cirrhotic ascites includes release of vasodilatory molecules like nitric oxide, damage…
- Trial name
- NCT05084534
- Testing
- Midodrine, Standard medical treatment
- Where
- India
- Sponsor
- Institute of Liver and Biliary Sciences, India
Decompensated Liver Cirrhosis
TIPS in Patients With Decompensated Liver Cirrhosis
This is a single center patient registry of patients receiving a transjugular intrahepatic portosystemic shunt (TIPS) at Hannover Medical School.
- Trial name
- NCT04801290
- Testing
- TIPS insertion
- Where
- Germany
- Volunteers
- 250 people
- Sponsor
- Hannover Medical School
Ascites, Paracentesis
Medical-economic Evaluation of the Care of Refractory Ascites by Implantation of Alfapump® Device in Cirrhotic Patients
The hypothesis is that the Alfapump® strategy would be more effective in terms of QALYs generated , and that the cost of Alfapump® device and its implantation will be totally or partially offset by the reduction in the number of…
- Conditions
- Ascites, Paracentesis, Cirrhosis
- Trial name
- ARIAPUMP (NCT03506893)
- Testing
- Alphapump, Ascites puncture
- Where
- 10 sites in France
- Volunteers
- 90 people
- Sponsor
- University Hospital, Grenoble
Liver Cirrhosis
Comparing a Direct Versus an Indirect Approach to Measuring the Portalsytemic Pressure Gradients
The objective of this study is to evaluate the correlation of the calculated portosystemic pressure gradient (PPG) obtained by direct portal and hepatic pressure measurements with the EchoTip® Insight™ and indirect portal vein…
- Trial name
- NCT04987034
- Testing
- EchoTip® Insight™
- Where
- 3 sites in Belgium, Netherlands and 1 more
- Volunteers
- 35 people
- Sponsor
- Cook Research Incorporated
Hepatic Cirrhosis
Effect of Beta-adrenergic Blockers on Cardiac Function, Systemic and Splanchnic Haemodynamic and Kidney Function in Cirrhotic Patiets With Refractory Ascites
Multicentric, observational and prospective study with two groups of treatment: Refractory ascites and non-refractory ascites. All patients should be prescribed beta-adrenergic blockers as primary or secondary profilaxis for…
- Trial name
- ALB-BET (NCT02163512)
- Where
- 2 sites in Spain
- Volunteers
- 46 people
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
Ascites
Alfapump® System in the Treatment of Refractory or Recurrent Ascites (POSEIDON Study)
The POSEIDON study is a multi-center, prospective, single arm, crossover pivotal study enrolling up to 70 pivotal cohort patients and up to 45 additional Roll-in patients with refractory or recurrent ascites at up to 20 sites.
- Trial name
- POSEIDON (NCT03973866)
- Testing
- Alfapump
- Where
- 15 sites in United States, Canada
- Volunteers
- 110 people
- Sponsor
- Sequana Medical N.V.
Liver Cirrhosis, Cirrhosis
Empagliflozin in Diuretic Refractory Ascites
Ascites is the most frequent complication of liver cirrhosis and results in increased morbidity and mortality but current medical management options are limited.
- Conditions
- Liver Cirrhosis, Cirrhosis, Ascites, Ascites Hepatic
- Trial name
- DRAin-Em 01 (NCT05013502)
- Testing
- Empagliflozin 10 MG
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Stanford University
Decompensated Cirrhosis, Portal Hypertension
The Effectiveness of L-ornithine-L-aspartate (LOLA) on Plasma Ammonia in Cirrhotic Patients After TIPS
The aim of this study is to evaluate the effectiveness of L-ornithine-L-aspartate (LOLA) on plasma ammonia in cirrhotic patients after Transjugular Intrahepatic Portosystemic Shunt (TIPS) procedure.
- Conditions
- Decompensated Cirrhosis, Portal Hypertension, Bleeding Varices, Refractory Ascites
- Trial name
- NCT01440829
- Testing
- L-ornithine-L-aspartate
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Air Force Military Medical University, China
Refractory Ascites
Evaluation of Hemodynamic Parameters Following Transjugular Intrahepatic Portosystemic Shunt (TIPS)
During a TIPS procedure, a shunt or stent (mesh tube) is passed down the jugular vein (the vein above the collarbone in the neck) using fluoroscopy (real time x-rays) guidance.
- Trial name
- NCT04050683
- Testing
- Study - Transjugular Intrahepatic Portosystemic Shunt (TIPS), Control - Transjugular Intrahepatic Portosystemic Shunt (TIPS)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Medical College of Wisconsin
Liver Cirrhosis, Refractory Ascites in Patients With Cirrhosis
Role of Nutritional Intervention for the Treatment of Sarcopenia in Cirrhotic Patients With Refractory Ascites Candidate to Transjugular Intrahepatic Portosystemic Shunt Placement and Identification of Prognostic Factors Related to Clinical Outcome
The hypothesis is that in patients with cirrhosis and refractory ascites candidate to TIPS, and sarcopenia (identified by a PMA ≤16 cm² at the level of L3), who are at high-risk of 6-month mortality after TIPS placement, a…
- Conditions
- Liver Cirrhosis, Refractory Ascites in Patients With Cirrhosis, Sarcopenia in Liver Cirrhosis
- Trial name
- NS-TIPS (NCT06814626)
- Testing
- 12-week nutritional intervention with Friliver dispensing, 12-week nutritional intervention with personalized diet, 12-week nutritional intervention with diet diary to report foods eaten.
- Where
- 2 sites in Italy, Switzerland
- Volunteers
- 72 people
- Sponsor
- The Mediterranean Institute for Transplantation and Advanced Specialized Therapies
Malignant Ascites
EUS-Guided Drainage of Refractory Malignant Ascites
This study evaluates the efficacy and safety of drainage of refractory malignant ascites by endoscopic ultrasound-guided (EUS-Guided) implantation of plastic prostheses.
- Trial name
- NCT03550560
- Testing
- EUS-Guided drainage
- Volunteers
- 100 people
- Sponsor
- Hospital Universitario Virgen Macarena