Clinical trials: Reflux
Dysphagia
Impact of Glossopharyngeal Nerve Block on Swallowing Difficulties Caused by Gastroesophageal Reflux Disease
The goal of this clinical trial is to explore Clinical Effect of Glossopharyngeal Nerve Block on Pharyngeal Dysphagia Induced by Gastroesophageal Reflux Disease.
- Trial name
- NCT06328205
- Testing
- Rehabilitation therapy, Glossopharyngeal Nerve Block, Lidocaine Hydrochloride
- Volunteers
- 80 people
- Sponsor
- Copka Sonpashan
GERD
A Comparative Study of Proton-pump Inhibitor Tests for Chinese Reflux Patients in Relation to the CYP2C19 Genotypes
Backgrounds \& Aims: Proton-pump inhibitor (PPI) test has been proposed as a valuable tool in the diagnosis of gastroesophageal reflux disease (GERD) in Western populations.
- Trial name
- NCT00681005
- Testing
- rabeprazole, pantoprazole
- Volunteers
- 178 people
- Sponsor
- National Taiwan University Hospital
Gastroesophageal Reflux Disease
A Study to Evaluate the Improvement Effect on Subjective Symptom of FEXUCLUE Tab
This observation study is a large-scale, prospective, and multi-organ observation study to observe the improvement effect of the self-evaluation results (PRO) of erosive gastroesophageal reflux disease at least 4 to 8 weeks after…
- Trial name
- NCT05660122
- Testing
- Fexuprazan Hydrochloride
- Where
- South Korea
- Volunteers
- 2,852 people
- Sponsor
- Daewoong Pharmaceutical Co. LTD.
Artificial Intelligence, Tongue
Connection Between Tongue Signs and Bile Reflux Analysed With Artificial Intelligence
By introducing artificial intelligence into Chinese medicine tongue diagnosis, we collated and collected tongue images, anxiety and depression scales and gastroscopy reports, mined and analysed the correlation between tongue…
- Conditions
- Artificial Intelligence, Tongue, Bile Reflux
- Trial name
- NCT05369572
- Where
- China
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Shandong University
Microaspiration, Gastro Esophageal Reflux
Transpyloric Feeding for Prevention of Micro-aspiration
To determine the effect of transpyloric (TP) feeding on microaspiration and lung inflammation in ventilated preterm infants.
- Trial name
- NCT03646045
- Testing
- Transpyloric feeding
- Where
- 2 sites in United States
- Volunteers
- 46 people
- Sponsor
- Nemours Children's Clinic
Varicose Veins
Endovenous Radiofrequency Versus Laser Ablation for the Treatment of Great Saphenous Vein Reflux
our aim is to compare early outcomes following EVL 1320 nm and segmental RF in a randomized study.
- Trial name
- NCT02080013
- Testing
- radiofrequency
- Volunteers
- 5 people
- Sponsor
- Ain Shams University
Gastroesophageal Reflux Disease
Feasibility Study for Evaluating the Effect of Electrical Stimulation on Lower Esophageal Sphincter Pressure and Esophageal Acid Exposure in Patients With Gastroesophageal Reflux Disease
The EndoStim Stimulation System is an investigational device intended to improve the lower esophageal sphincter (LES) resting tone and restore LES function in individuals suffering with gastroesophageal reflux disease (GERD).
- Trial name
- NCT01578642
- Testing
- EndoStim LES Stimulation System
- Where
- Chile
- Volunteers
- 24 people
- Sponsor
- EndoStim Inc.
Gastroesophageal Reflux, Dyspepsia
Effects of Diet on Reflux and Dyspepsia
Reflux and dyspeptic symptoms are common affecting 10-20% of the population on a regular basis. Reflux symptoms such as heartburn and regurgitation are caused by the return of acid or non-acid gastric contents into the esophagus.
- Trial name
- NCT02425553
- Testing
- Diet
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of Zurich
GERD
A Study to Compare PK, PD and Safety of CKD-382 in Healthy Subjects
To compare pharmacokinetics, pharmacodynamics and safety after single/multiple administration of CKD-382 and D026 in healthy subjects
- Trial name
- NCT04703374
- Testing
- CKD-382(formulation I), CKD-382(formulation II), D026
- Where
- South Korea
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Chong Kun Dang Pharmaceutical
Gastroesophageal Reflux Disease
Ilaprazole for the Treatment of Gastroesophageal Reflux Disease (GERD) in Chinese Patients
This study is designed to evaluate the efficacy and tolerability of ilaprazole relative to that of esomeprazole in healing erosive esophagitis and resolving accompanying symptoms of GERD.
- Trial name
- NCT02860624
- Testing
- 10 mg ilaprazole, 40mg esomeprazole
- Volunteers
- 550 people
- Sponsor
- Livzon Pharmaceutical Group Inc.
Obesity, Bariatric Surgery Candidate
Crural Repair During Laparoscopic Sleeve Gastrectomy in Patients With a Lax Gastroesophageal Junction
Background: Laparoscopic sleeve gastrectomy (LSG) is one of the commonest bariatric procedures. However, it is associated with postoperative gastroesophageal reflux disease (GERD) and erosive esophagitis (EE).
- Conditions
- Obesity, Bariatric Surgery Candidate, Esophagus Injury, Gastroesophageal Reflux
- Trial name
- REPAIR (NCT05330910)
- Testing
- Laparoscopic sleeve gastrectomy with concomitant hiatal hernia repair arm, Laparoscopic sleeve gastrectomy arm
- Where
- 2 sites in Singapore
- Volunteers
- 96 people
- Sponsor
- Sengkang General Hospital
Gastroesophageal Reflux Disease, Bronchopulmonary Dysplasia
The Role of Anti-Reflux Surgery for Gastroesophageal Reflux Disease in Premature Infants With Bronchopulmonary Dysplasia
The purpose of this study is to evaluate the efficacy of fundoplication in premature infants with GERD and BPD.
- Trial name
- GERD-BPD (NCT00926276)
- Testing
- Fundoplication
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- The University of Texas Health Science Center, Houston
GERD
A Randomized Trial of Medical and Surgical Treatments for Patients With GERD Symptoms That Are Refractory to Proton Pump Inhibitors
Background: Gastroesophageal reflux disease (GERD), which affects at least 20% of adult Americans, may be especially common and severe in Veteran patients.
- Trial name
- NCT01265550
- Testing
- Nissen fundoplication, baclofen, Desipramine
- Where
- 15 sites in United States
- Volunteers
- 366 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
GERD, Hiatal Hernia
Antireflux Surgery Without Preoperative Esophageal Manometry
The goal of this clinical trial is to learn if people can safely skip a test called esophageal manometry before surgery for acid reflux (gastroesophageal reflux disease, or GERD) or a hiatal hernia.
- Conditions
- GERD, Hiatal Hernia, Heartburn, Paraesophageal Hernia
- Trial name
- NOMA (NCT07659080)
- Testing
- Preoperative workup without high-resolution esophageal manometry, Standard preoperative workup with high-resolution esophageal manometry
- Where
- 2 sites in United States, Canada
- Volunteers
- 96 people
- Sponsor
- McMaster University
IPF, Reflux
The Role of Laryngopharyngeal Reflux in IPF
The primary objective of this study is to show that the Supraglottic Index (SGI) is an easily-collected index that accurately identifies the presence and severity of laryngopharyngeal reflux (LPF) in idiopathic pulmonary fibrosis…
- Trial name
- NCT03418350
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- National Jewish Health
Symptomatic Gastroesophageal Reflux Disease (sGERD)
A Multicenter, Randomized, Double-Blind Parallel-Group, Placebo-Controlled Efficacy Study Comparing 4 Weeks of Treatment With Esomeprazole 20 mg Once Daily to Placebo qd for the Resolution of Upper Abdominal Pain in Patients With Symptomatic Gastroesophageal Reflux Disease (sGERD)
This study compares 4 weeks of treatment with Esomeprazole 20 mg once daily to Placebo in the treatment of Upper Abdominal Pain in patients with Symptomatic Gastroesophageal Reflux Disease (sGERD)
- Trial name
- NCT00626535
- Testing
- Esomeprazole
- Volunteers
- 500 people
- Sponsor
- AstraZeneca
Asthma
Lansoprazole to Treat Children With Asthma
Many individuals with asthma also experience gastroesophageal reflux disease (GERD), a condition in which excess stomach acid flows backwards into the esophagus.
- Trial name
- SARCA (NCT00442013)
- Testing
- Lansoprazole
- Where
- 20 sites in United States
- Volunteers
- 306 people
- Sponsor
- Johns Hopkins University
Gastroesophageal Reflux
Safety and Efficacy of Lansoprazole in Patients With Reflux Disease
The purpose of this study is to measure the safety, efficacy and quality of life of lansoprazole in patients with reflux disease over a five year period.
- Trial name
- NCT01135368
- Testing
- Lansoprazole
- Volunteers
- 506 people
- Sponsor
- Takeda
Hiatal Hernia, Hiatal Hernia With Gastroesophageal Reflux Disease
Complications of Laparoscopic Hiatal Hernia Repair Complicated by Gastroesophageal Reflux Disease Using the ERAS Protocol
Nissen fundoplication with cruroraphy performed according to ERAS protocols in patients with HH complicated by GERD.
- Trial name
- hiatal hernia (NCT07138235)
- Testing
- laparoscopic hiatal hernia repair
- Volunteers
- 106 people
- Sponsor
- Osh State University
Obesity
Esophageal Manometry and Impedance Study in Obese Patients Before and During Anesthesia
The purpose of this study is to evaluate the effects of anesthesia on the esophageal body in obese patients before and during anesthesia.
- Trial name
- NCT01703897
- Testing
- Manometry and Impedance analysis
- Where
- Sweden
- Sponsor
- Örebro University, Sweden