Clinical trials: Reflex Syncope
Neurally Mediated Syncope
The Iliac Arterio-venous Fistula for Treatment of Neurally Mediated Syncope Study
The purpose of the study is to investigate the efficacy of the ROX coupler in treating patients with tilt test proven Neurally mediated syncope.
- Trial name
- SHAM-ROX NMS (NCT02388087)
- Testing
- ROX COUPLER, Right heart catheterisation and routine care
- Volunteers
- 20 people
- Sponsor
- East Sussex Healthcare NHS Trust
Cardiac Pacemaker, Arrythmia
Aveir VR Real-World Evidence Post-Approval Study
The purpose of this post-approval study is to evaluate the long-term safety of the single-chamber Aveir VR leadless pacemaker using real-world evidence methods.
- Conditions
- Cardiac Pacemaker, Arrythmia, Bradycardia
- Trial name
- NCT05270499
- Testing
- Aveir VR Leadless Pacemaker System
- Where
- United States
- Volunteers
- 3,427 people
- Sponsor
- Abbott Medical Devices
Vasovagal Syncope (VVS)
Assesment of the Clinical Benefit of Provocation on Tilt-table in SYNCope Patients, TiltSYNC-trial
multicenter prospective randomized controlled comparison of biofeedback with tilt table testing (investigational management strategy) vs biofeedback without tilt table testing (reference management strategy) in patients with…
- Trial name
- TiltSYNC (NCT07459478)
- Testing
- biofeedback and standard of care with tilt table testing, no tilt table testing
- Where
- Netherlands
- Volunteers
- 238 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Syncope, Vasovagal
Cardioneuroablation: Fragmented Atrial Potentials, Intracardiac Echocardiography and Computed Tomography
Cardioneuroablation (CNA) is a new method for the treatment of asystolic reflex syncope, however, optimal methods for identification of presumed sites of ganglionated plexi (GP), which are the target for CNA and are located in…
- Trial name
- Roman5 (NCT06472102)
- Testing
- Cardioneuroablation
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Centre of Postgraduate Medical Education
Syncope, Vasovagal
Cardioneuroablation for Reflex Syncope
Aim. To assess the effects of cardioneuroablation (CNA) on cardiac autonomic regulation and syncope recurrences in patients with vasovagal syncope (VVS), and to compare this novel approach with standard non-pharmacological…
- Trial name
- ROMAN (NCT03903744)
- Testing
- Cardioneuroablation
- Where
- Poland
- Volunteers
- 48 people
- Sponsor
- Centre of Postgraduate Medical Education
Vasovagal Syncope, AV Block-2Nd Degree-Type 1
Cardioneuroablation for Recurrent Vasovagal Syncope and Bradyarrhythmias: The CNA-FWRD Registry
The CNA-FWRD Registry is an international prospective observational multicenter registry of patients with symptomatic vasovagal syncope and bradyarrhythmias managed under routine care by medical therapy and radiofrequency…
- Conditions
- Vasovagal Syncope, AV Block-2Nd Degree-Type 1, Sinus Pause
- Trial name
- CNA-FWRD (NCT06166277)
- Testing
- Ablation procedure
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Rush University Medical Center
Syncope, Vasovagal, Neurally-Mediated
The Tilt Test-Induced REsponse in Closed-loop Stimulation (TIRECS) Study
Multicentre, prospective, double blinded, randomized study designed as an intrapatient comparison to evaluate the effects of the Biotronik Closed-loop Stimulation algorithm on prevalence and timing of haemodynamic variations and…
- Trial name
- TIRECS (NCT02573649)
- Testing
- Closed-loop Stimulation on first, Closed-loop Stimulation off first
- Where
- 2 sites in Italy
- Volunteers
- 30 people
- Sponsor
- Azienda Ospedaliera Cardinale G. Panico
Syncope, Vasovagal
Treatment Strategy of Vasovagal Syncope
This is a prospective, international multi-center, open-labeled, randomized trial. The investigator speculated that CNA prevents more patients with moderate to severe VVS from syncope recurrence compared to midodrine.
- Trial name
- CAMPAIGN (NCT05803148)
- Testing
- Cardioneuroablation, Midodrine Oral Tablet
- Where
- China
- Volunteers
- 184 people
- Sponsor
- China National Center for Cardiovascular Diseases
Syncope
Guideline-based Pacing Therapy for Reflex Syncope
Study hypothesis: Dual-chamber pacemaker therapy with rate-hysteresis features is effective in preventing syncopal recurrences in patients affected by cardioinhibitory (CI) forms of reflex syncope diagnosed by means of carotid…
- Trial name
- SUP2 (NCT01509534)
- Where
- 8 sites in Italy
- Volunteers
- 281 people
- Sponsor
- Gruppo Italiano Multidisciplinare per lo Studio della Sincope
Syncope, Vasovagal
Cardioneuroablation for Reflex Syncope and Exercise Capacity
Cardioneuroablation (CNA) is a new promising method to treat reflex syncope which is due to vagally-induced functional sinus arrest or atrio-ventricular block (AVB).
- Trial name
- Roman3 (NCT06440291)
- Testing
- Cardioneuroablation
- Where
- Poland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Centre of Postgraduate Medical Education
Blood Pressure, Depression
Essential Hypotension and Allostasis Registry
The essential arterial hypotension and allostasis registry is a prospective, observational research that has the purpose of demonstrating that essential blood pressure (BP) disorders and the associated comorbidities are a result…
- Conditions
- Blood Pressure, Depression, Panic Attack, Fibromyalgia
- Trial name
- ESSENTIAL (NCT02018497)
- Where
- Colombia
- Volunteers
- 5,000 people
- Sponsor
- CES University
Syncope, Pacemaker
Syncope-Asystole Latency Time in Tilt Table Test: The SALT-TILT Study
Syncope is a common presenting condition. Pacemaker implantation can significantly reduce syncope recurrences in reflex syncope.
- Conditions
- Syncope, Pacemaker, Asystole, Neurally Mediated Syncope
- Trial name
- SALT-TILT (NCT06356207)
- Testing
- Tilt Table Test
- Where
- Italy
- Volunteers
- 64 people
- Sponsor
- Azienda Ospedaliera di Bolzano
Infertility
Optimal Balloon Catheter Placement During Sonohysterography
Saline infusion sonohysterography and other intrauterine investigations methods may cause uterine cramping, pain and vasovagal reactions.
- Trial name
- NCT01936116
- Testing
- sonohysterography with inflated catheter in uterine cavity, sonohysterography with inflated catheter in cervical cavity
- Where
- Iran
- Volunteers
- 300 people
- Sponsor
- Royan Institute
Orthostatic Hypotension, Reflex Syncope
Fainting Detection And Early Warning In Syncope Evaluation Study (ARISE)
To characterize the impact of orthostatic hypotension (OH) and Vasovagal syncope on signals measured using a wearable Holter monitor in the clinic and ambulatory setting.
- Trial name
- ARISE (NCT07502599)
- Testing
- Wearable holter monitor
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Boston Scientific Corporation
Syncope, Vasovagal
Heart Rate Variation in Females Predicts Tilt Test Results
Head-up tilt test (HUTT) is widely used to evaluate patients with unexplained syncope, but data on clinical predictors of HUTT results are limited.
- Trial name
- NCT06496074
- Testing
- Head-up Tilt Test
- Where
- Brazil
- Volunteers
- 149 people
- Sponsor
- Federal University of Piaui
Syncope, Vasovagal
Detecting Syncope by an Integrated Multisensor Patch-type Recorder
The main purpose of this study is to assess the reliability of a new cuffless patch BP monitor in detecting episodes of hypotensive (pre)syncope during tilt testing.
- Trial name
- Patch-VD (NCT05782699)
- Testing
- BP monitoring during tilt testing
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Istituto Auxologico Italiano
Healthy
Effect of Dietary Salt Supplemantation in Vasovagal Syncope Prophylaxis: A Clinical Trial
Syncope is a syndrome consisting of a relatively short period of temporary and self-limited loss of consciousness caused by transient diminution of blood flow to the brain (most often the result of systemic hypotension).
- Trial name
- NCT00465946
- Testing
- Salt Supplementation
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
Syncope, Syncope, Vasovagal
Head-up Tilt Test in Patients With Reflex Syncope and Asystolic Response Who Received a Dual-chamber Pacemaker With the Closed Loop Stimulation (CLS) and Participated in the BIOSync Trial
The purpose of this study is to explore changes in patients' hemodynamic parameters during the Head-Up Tilt Test ("HUTT") and their timing with respect to onset of the Closed Loop Stimulation (CLS) pacing.
- Trial name
- BIO|Sync-HUTT (NCT06038708)
- Where
- 2 sites in Italy
- Volunteers
- 20 people
- Sponsor
- Biotronik SE & Co. KG
Syncope, Vasovagal, Neurally-Mediated
Clinical Trial for the Prevention of Vasovagal Syncope
The main question in the study is whether people taking fludrocortisone are less likely to faint than people taking an inactive pill called a placebo. Fludrocortisone is a drug that stimulates the body to retain salt and water.
- Trial name
- NCT00118482
- Testing
- fludrocortisone acetate
- Where
- 14 sites in United States, Canada
- Volunteers
- 213 people
- Sponsor
- University of Calgary
Syncope, Vasovagal
Compression Stockings for Treating Vasovagal Syncope Trial
Syncope, a sudden, transient loss of consciousness (TLOC), is a common inconvenience of daily function and quality of life (QoL).
- Trial name
- COMFORTS II (NCT05086679)
- Testing
- Compression Stockings with 25-30 mm Hg pressure, Compression stockings with up to <=10 mm Hg pressure, Lifestyle modification
- Where
- Iran
- Volunteers
- 268 people
- Sponsor
- Tehran Heart Center