Clinical trials: Reduction of Inflammation
Pocket, Periodontal, Periodontal Inflammation
Diode Laser Photo Activation for Pocket Reduction Decontamination A Clinical Study
Routine non surgical periodontal thearpy often fails to achieve complete elimination of pathogenic microorganism. This could be attiributable to deep periodontal pockets, root concavities, furcation involvement etc.
- Conditions
- Pocket, Periodontal, Periodontal Inflammation, Periodontal Attachment Loss, Periodontitis
- Trial name
- NCT06404190
- Testing
- Diode laser and 3% hydrogen peroxide
- Where
- India
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Krishnadevaraya College of Dental Sciences & Hospital
Gingival Inflammation
Lactobacillus Reuteri Strains for Gingivitis Reduction
The aim of the present study was to investigate the potential beneficial effects in volunteer young adults of orally administered L. reuteri (DSM 17938 and ATCC PTA 5289) on gingival inflammation.
- Trial name
- NCT06234839
- Testing
- L. reuteri (DSM 17938 and ATCC PTA 5289) in form of oral tablets
- Where
- Mexico
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de San Luis Potosí
Colorectal Cancer, Inflammation
Reducing Metabolic Dysregulation in Dyads
This study is a 6-month randomized controlled trail of diet modification designed to reduce chronic inflammation and reverse metabolic dysfunction among obese individuals with one or more polyps found at a colonoscopy screening.
- Conditions
- Colorectal Cancer, Inflammation, Nutrition Related Cancer
- Trial name
- REMEDY (NCT06117241)
- Testing
- IMAGINE HEALTHY
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- University of South Carolina
Intestinal Inflammation, Metabolic Disease
The Role of Regular Physical Activity in Enhancing Metabolic Health, Reducing Inflammation, and Improving Gut Function
The goal of this clinical trial is to learn if regular physical activity can improve metabolic health, reduce inflammation, and decrease gut permeability in individuals aged 50 and older.
- Trial name
- NCT06606678
- Testing
- Exercise
- Where
- Poland
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Poznan University of Physical Education
HIV-1-infection, Gut Inflammation
Study of Pentasa® for Reducing Residual Systemic Immune Activation in Treated HIV Infection
An open label study will be performed on 80 people with HIV infection who are maintained on effective treatment with antiretroviral drugs.
- Trial name
- NCT03399903
- Testing
- Pentasa vs Align
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- AIDS Healthcare Foundation
Breast Carcinoma
Lifestyle Intervention for the Reduction of Breast Cancer Risk in Normal Weight Women
This trial studies how well a lifestyle intervention works in reducing breast cancer risk through changing body composition and decreasing inflammation in normal weight women.
- Trial name
- NCT04267796
- Testing
- Aerobic Exercise, Dietary Intervention, Quality-of-Life Assessment
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Pulmonary Disease, Chronic Obstructive
Endotoxin Challenge Study For Healthy Men and Women
The proposed study will examine the effect of pre-treatment with inhaled GSK256066 using a lung inflammation model induced by bronchoscopic instillation of bacterial endotoxin (lipopolysaccharide, LPS) in healthy volunteers.Data…
- Trial name
- NCT00515268
- Testing
- GSK256066
- Where
- Germany
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Bloodstream Infections, Short Bowel Syndrome
Enteral Glutamine in Reducing Bloodstream Infections in Short Bowel Syndrome Infants
The purpose of this research study is to evaluate the effects (good and bad) of supplementation with Glutamine to that of a placebo (L-alanine), on your child and their Short Bowel Syndrome.
- Conditions
- Bloodstream Infections, Short Bowel Syndrome, Development, Nutrition
- Trial name
- NCT01576003
- Testing
- Glutamine, L-alanine
- Where
- 2 sites in United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Hyperuricemia, Insulin Resistance
Tart Cherry Juice and Markers of Inflammation, CVD, and Diabetes
In this study, the investigators recruited at-risk individuals (n=26) who were overweight (25.0-29.9 kg/m2) and obese (> 30.0 kg/m2) and likely to exhibit one or more conditions associated with Metabolic Syndrome (MetS).
- Conditions
- Hyperuricemia, Insulin Resistance, Obesity, CVD
- Trial name
- NCT03636529
- Testing
- Tart cherry juice
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Memphis
Delayed Onset Muscle Soreness (DOMS), Inflammation
Effects of Immediate and Delayed Repeated Cold Exposure After Physical Exertion
The goal of this clinical trial is to learn if applying cold therapy can reduce swelling, inflammation, and pain after physical activity in adults who experience muscle soreness (Delayed Onset Muscle Soreness, or DOMS).
- Conditions
- Delayed Onset Muscle Soreness (DOMS), Inflammation, Muscle Pain, Muscle Damage
- Trial name
- NCT06813690
- Testing
- Cold Therapy with Axanova Cold Hot Pearls Maxi Pack
- Where
- Switzerland
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Applied Sciences and Arts of Southern Switzerland
Inflammation, Coagulation
Intervention Study on the Health Impact of Air Filters in Chinese Adults
This study aimed to evaluate whether a short-term indoor air purifier intervention improves cardiopulmonary health based on a randomized double-blind crossover trial
- Conditions
- Inflammation, Coagulation, Blood Pressure, Pulmonary Function
- Trial name
- NCT02239744
- Testing
- Air purifiers
- Where
- China
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Fudan University
Atherosclerosis, Stress
Pilot Study Evaluating the Impact of Stress Reduction on Atherosclerotic : Heart and Mind Study
The plot study aims to evaluate the effect of 8 weeks of stress reducing intervention on atherosclerotic plaque inflammation in adults, as quantified by positron emission tomography (PET) with fluorine-2-deoxy-D-glucose (FDG) in…
- Conditions
- Atherosclerosis, Stress, Inflammation
- Trial name
- NCT04496947
- Testing
- Stress Reduction
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Inflammation, Pain
Efficacy of Tart Cherry Juice in Reducing Muscle Injury and Biomarkers of Muscle Damage Among Healthy Adults
The purpose of this study is to assess the effects of tart cherry juice to reduce serum biomarkers of inflammation and reduce muscle soreness in healthy adults who undergo a bout of controlled eccentric exercise.
- Trial name
- NCT01547949
- Testing
- tart cultivar Montmorency cherry juice
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Gingivitis and Periodontal Diseases
Evaluation of Toothbrush Bristles
The goal of this randomized clinical trial is to investigate two different types of toothbrush bristles. The main questions it aims to answer are the effects of two different bristle types on: how much plaque is on the teeth how…
- Trial name
- NCT07306026
- Testing
- Toothbrush with tapered bristles, Toothbrush with end-rounded bristles
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Bacteremia, Infective Endocarditis
Reducing Risk for Infective Endocarditis
This clinical trial is studying if bacteria found in a participant's bloodstream after brushing their teeth can be prevented with a dental cleaning and more education on how to best brush and care for their teeth.
- Trial name
- PIE-B (NCT05721781)
- Testing
- Oral Hygiene instruction, Dental Cleaning
- Where
- 6 sites in United States
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Dental Calculus, Gingivitis and Periodontal Diseases
Bio-Descaling Toothpaste for Dental Calculus Reduction
Dental calculus is a calcified mineralized plaque composed primarily of calcium phosphate salts covered by an unmineralized bacterial biofilm layer.
- Conditions
- Dental Calculus, Gingivitis and Periodontal Diseases, Periodontal Diseases
- Trial name
- AntiCal (NCT07689071)
- Testing
- Bio-Descaling Powder (BDP) Toothpaste
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Universidad Complutense de Madrid
Crohn's Disease
Drug-Disease Interaction in Crohn's Disease
Objective: To determine the effect of C-reactive protein (CRP) status, and infliximab treatment on the pharmacodynamics and pharmacokinetics of verapamil, a model drug for L-type calcium channel blocking, in Crohn's disease (CD)…
- Trial name
- NCT01261286
- Testing
- verapamil
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Alberta
Intestinal Barrier Function, Chronic Inflammation
Reduction of Obesity-Associated Intestinal Inflammation by Low-Fat Dairy Yogurt
The main objective of this work is to conduct a clinical trial in obese and non-obese individuals testing the ability of low-fat dairy yogurt to improve gastrointestinal health and reduce chronic inflammation.
- Trial name
- NCT01686204
- Testing
- Low fat dairy yogurt, Soy pudding
- Where
- United States
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Plaque, Gingivitis
A Clinical Trial to Test the Effect of Marketed Mouth Rinses on Decreasing Plaque and Gum Inflammation
The reduction of existing plaque and gum inflammation will be evaluated using two marketed mouth rinses along with tooth brushing after 21 days of use compared to a placebo mouth rinse.
- Trial name
- NCT02233998
- Testing
- Mouth Rinse 1, Mouth Rinse 2, Mouth Rinse 3
- Where
- Canada
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Consumer and Personal Products Worldwide
Secondary Hyperalgesia, Inflammation
The Effect of Hyperbaric Oxygen Therapy on Inflammatory Parameters Induced by a Heat Injury Model
Hyperbaric oxygen may reduce neurophatic pain and promote wound healing. Established anti inflammatory effects of HBO may contribute to this effect.
- Trial name
- HBO-SHA (NCT02397343)
- Testing
- Hyperbaric oxygen
- Where
- Denmark
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet