Clinical trials: Red Blood Cells
Heart Failure
Monitoring Outpatient Blood VolumE in Heart Failure
In patients discharged following heart failure treatment, the consistency of blood volume status and components over time is unknown.
- Trial name
- MOVE-HF (NCT04660396)
- Testing
- BVA-100
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Daxor Corporation
Red Blood Cell Folate
Bioavailability of Folic Acid Fortified Bread
Folic acid is the synthetic form of vitamin folate. Because of its high stability and bioavailability, it is the form of folate added to bread in Canada to reduce birth defects.
- Trial name
- NCT01570088
- Testing
- Folic acid, L-5-MTHF
- Where
- Canada
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Thalassemia Major
Impact of the Preparation Method of Red Cell Concentrates on Transfusion Indices in Thalassemic Patients
This study compares the effects of Packed Red Blood Cells (PRBCs) prepared in two different ways on the transfusion indices in beta(ß)-Thalassemia transfusion-dependent patients.
- Trial name
- NCT03992001
- Testing
- Blood component A, Blood component B
- Where
- Italy
- Volunteers
- 55 people
- Sponsor
- Università degli Studi di Ferrara
Pulmonary Embolism
Thrombus Localization and Accompaying Disorders and Risk Factors
ABSTRACT Pulmonary embolism shows a wide spectrum ranging from clinically asymptomatic thrombus to massive thrombus, leading to cardiogenic shock.
- Trial name
- NCT02388841
- Testing
- Pulmonary embolism
- Where
- Turkey (Türkiye)
- Volunteers
- 148 people
- Sponsor
- Aysel Sünnetçioğlu
Red-Cell Aplasia, Pure, Chronic Renal Failure
Study to Monitor the Incidence of Pure Red Cell Aplasia (PRCA) and/or Antibodies to Erythropoietin Among Participants Receiving Epoetin Alfa or Another Erythropoietin
The purpose of this study is to assess the incidence of pure red cell aplasia (PRCA [suppression of erythropoiesis with little or no abnormality of leukocyte or platelet production]) among participants with chronic renal failure…
- Trial name
- NCT00210951
- Testing
- No Intervention
- Volunteers
- 4,761 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Sickle Cell Disease Without Crisis
The Impact of Oxidative Stress on Erythrocyte Biology
This study will address if red blood cells transfused to a sickle cell patient from a donor with a glucose-6-phosphate-dehydrogenase (G6PD) enzyme deficiency have a different lifespan as measured by the percentage of red blood…
- Trial name
- RBC Survival (NCT04028700)
- Testing
- G6PD Deficient Red Blood Cell Transfusion, Non-G6PD deficient Red Blood Cell Transfusion
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of North Carolina, Chapel Hill
Cardiac Surgery, Erythrocyte Transfusion
Red Cell Storage Duration Study
The RECESS study will compare the effects of transfusing red blood cell units stored <= 10 days vs. red blood cell units stored >= 21 days, in patients who are undergoing complex cardiac surgery and are likely to need a red blood…
- Trial name
- RECESS (NCT00991341)
- Testing
- Red blood cell units stored <= 10 days, Red blood cell units stored >= 21 days
- Where
- 33 sites in United States
- Volunteers
- 1,481 people
- Sponsor
- Carelon Research
Cardiac Arrest
Packed Red Blood Cell Transfusion During Cardiac Arrest
The purpose of this pilot interventional study is to collect preliminary data on administering packed red blood cell (PRBC) during cardiac arrest (CA).
- Trial name
- NCT06462027
- Testing
- Packed Red Blood Cells (1 unit), Packed Red Blood Cells (2 units), Saline
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- NYU Langone Health
Advanced Solid Tumors
Allogeneic WTX-212C in Advanced Solid Tumors
This is a multicenter, open-label, single-arm Phase I study to evaluate the safety, tolerability, pharmacokinetics (PK), immunogenicity, and preliminary antitumor activity of allogeneic WTX-212C, an investigational allogeneic…
- Trial name
- WTX-212C-IIT (NCT07556653)
- Testing
- allogeneic WTX-212C
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Zhejiang Provincial People's Hospital
Sickle Cell Disease
Biotin-RBC Transfusion in SCD
This is a single-arm, mechanistic clinical trial to measure predictors of senescence and the in vivo survival of transfused red blood cells (RBCs) in individuals with sickle cell disease (SCD) receiving chronic transfusion…
- Trial name
- NCT04426591
- Testing
- Biotin Labeled Red Blood Cells, Pathogen-reduced Biotin Labeled Red Blood Cells
- Where
- 3 sites in United States
- Volunteers
- 22 people
- Sponsor
- Marianne Yee
Postpartum Anemia Nos
SMaRT Blood: Single-unit Versus Multiple-unit Packed Red Blood Cell Transfusion in Non-acute Postpartum Anemia
There is a paucity of data on management of non-acute postpartum anemia. Although blood transfusions were historically initiated with 2 units, the most recent recommendation from the American Association of Blood Banks is to…
- Trial name
- SMaRTBlood (NCT03419780)
- Testing
- Blood Transfusion
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- University of Pennsylvania
Healthy
Erythrocyte Omega-3 Fatty Acid Content in Elite Athletes
A suitable concentration of omega-3 fatty acids in relation to omega 6 is considered necessary for a good cell function and prevention of various inflammatory processes.
- Trial name
- O3Sport (NCT02610270)
- Testing
- 2 Gums, 3 Gums
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Centre d'Alt Rendiment
Kidney Diseases
Omega-3 Fatty Acids That Affect the Immune System in Kidney Transplant Patients
The purpose of this study is to evaluate the effectiveness of nutritional supplements in increasing the amount of omega-3 fatty acids (and arginine) in the red blood cell membranes and plasma of kidney transplant patients, and…
- Trial name
- NCT00047983
- Testing
- Canola oil, Arginine, Fish oil emulsion
- Where
- 4 sites in United States
- Volunteers
- 75 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Pyruvate Kinase Deficiency, Anemia, Hemolytic
A Study Evaluating the Efficacy and Safety of AG-348 in Regularly Transfused Adult Participants With Pyruvate Kinase Deficiency (PKD)
Study AG348-C-007 was a multicenter study designed to evaluate the efficacy and safety of treatment with AG-348 in a minimum of 20, with up to 40, participants with pyruvate kinase (PK) deficiency, who were regularly receiving…
- Trial name
- NCT03559699
- Testing
- AG-348
- Where
- 19 sites in United States, Canada and 7 more
- Volunteers
- 27 people
- Sponsor
- Agios Pharmaceuticals, Inc.
Myelodysplastic Syndromes
The Efficacy and Safety of Lenalidomide Monotherapy in Red Blood Cell Transfusion Dependent Subjects With Myelodysplastic Syndrome (MDS) Associated With Del (5q) Abnormality
The purpose of this study is to evaluate the efficacy of lenalidomide treatments to achieve haematopoietic improvement in subjects with low- or intermediate-1 risk International Prognostic Scoring System1 (IPSS) myelodysplastic…
- Trial name
- NCT00874978
- Testing
- lenalidomide
- Where
- United Kingdom
- Volunteers
- 36 people
- Sponsor
- King's College Hospital NHS Trust
Anemia
Pilot Optimizing Transfusion Thresholds in Critically-ill Children With Anaemia
The Pilot Optimizing Transfusion Thresholds in Critically-ill Children with Anaemia (P-OpTTICCA) study is a pilot trial for a large pragmatic international parallel open-label non-inferiority randomised controlled trial.
- Trial name
- P-OpTTICCA (NCT03871244)
- Testing
- Less red blood cell transfusions, More red blood cell transfusion (standard transfusion strategy in PICU)
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- St. Justine's Hospital
Cardiac Surgery Under Extra Corporeal Circulation, Cardiac Surgery Requiring Cardiopulmonary Bypass
Comparison of the Performance and Effectiveness of Two Transfusion-Saving Devices: Cell-Saver and SAME
An observational study comparing two systems of perioperative blood recovery in cardiac surgery, one system allowing red blood cell reinfusion and one system allowing red blood cell and platelet reinfusion.
- Trial name
- SAME-CELL (NCT06766032)
- Testing
- CELL-Saver, SAME
- Where
- France
- Volunteers
- 304 people
- Sponsor
- Nantes University Hospital
Transfusional Iron Overload, Transfusional Hemosiderosis
Evaluating Use of Deferasirox as Compared to Deferoxamine in Treating Cardiac Iron Overload
This is a clinical research study in patients who have iron overload in the heart due to chronic blood transfusions. The study will have 2 treatment groups and will compare the safety and efficacy of chelation therapy with a…
- Trial name
- CORDELIA (NCT00600938)
- Testing
- Core Study: Deferasirox, Core Study: Deferoxamine, Extension: deferoxamine to deferasirox
- Where
- 21 sites in Canada, China and 9 more
- Volunteers
- 197 people
- Sponsor
- Novartis Pharmaceuticals
Hemoglobinuria
Paroxysmal Nocturnal Hemoglobinuria (PNH), Level of CD59 on Red and White Blood Cells in Bone Marrow Failure Syndromes
Examine red and white blood cells of PNH patients with bone marrow failure syndromes.
- Trial name
- EXPLORE (NCT01192425)
- Volunteers
- 5,580 people
- Sponsor
- Alexion Pharmaceuticals, Inc.
Hypertension
The Influence of Red Grape Cells on Blood Pressure Vascular Function in People With Hypertension
The study hypothesis is that 3 Months Daily Supplementation of RGC will effect blood pressure and vascular function. This will be a single-center, double-blind, random, parallel controlled Study.
- Trial name
- RGC (NCT01146470)
- Testing
- RGC
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Tel-Aviv Sourasky Medical Center