Clinical trials: Rectal Neoplasms
Rectum Cancer
PRELOOP Trial: Synthetic Versus Biological Mesh for Prevention of Incisional Hernia After Loop-ileostomy Closure
This study compares a synthetic mesh and biological implant in prevention of incisional hernia after loop-ileostomy closure.
- Trial name
- NCT03445936
- Testing
- Parietene Macro, Permacol
- Where
- 4 sites in Finland
- Volunteers
- 100 people
- Sponsor
- University of Oulu
Parastomal Hernia, Rectal Adenocarcinoma
Chimney Trial of Parastomal Hernia Prevention
Chimney trial is designed to compare the effectiveness and safety of specifically designated polyvinylidene fluoride mesh (PVDF, Dynamesh IPST) to controls in a multi center, randomized setting.
- Conditions
- Parastomal Hernia, Rectal Adenocarcinoma, Abdominoperineal Resection
- Trial name
- NCT03799939
- Testing
- Intervention group
- Where
- 7 sites in Finland, Sweden
- Volunteers
- 141 people
- Sponsor
- University of Oulu
Rectal Cancer, Abdominoperineal Resection
APEMESH- Preventing Perineal Complications After Abdominoperineal Resection
Abdominoperineal resection leaves an empty space to be filled by mesh or musculocutaneus flap. Several studies have reported over 30% morbidity with perineal wound healing after abdominoperineal resection.
- Conditions
- Rectal Cancer, Abdominoperineal Resection, Wound Heal
- Trial name
- NCT04334421
- Testing
- Composite mesh
- Where
- Finland
- Volunteers
- 30 people
- Sponsor
- Elisa Mäkäräinen
Rectal Cancer
Efficacy of Stimulation of the Efferent Loop and Rehabilitation of the Pelvic Floor in the Quality of Life of Patients Who Underwent Anterior Resection of the Rectum (ENESP): Randomized Clinical Trial
Many of the patients operated with sphincter preservation will present an alteration of bowel function and defecation. This dysfunction is variable in its symptoms and severity, and manifests itself in the form of urgency…
- Trial name
- ENESP (NCT04569331)
- Testing
- Stimulation of efferent loop, Rehabilitation pelvic floor
- Where
- Spain
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Althaia Xarxa Assistencial Universitària de Manresa
Rectal Cancer
APEMESH II - Perineal Reconstruction
The objective of this pilot study is to assess the safety, functional outcome, feasibility and the potential benefits of synthetic mesh strip and gluteus flap reconstruction in perineum in case-control setting.
- Trial name
- NCT04779125
- Testing
- Gluteus plasty enhanced with Progrip self gripping mesh
- Where
- Finland
- Volunteers
- 30 people
- Sponsor
- University of Oulu
Rectal Cancer
ArtiSential® for Rectal Cancer Surgery
This study aimed to assess efficacy of ArtiSential® in reducing laparoscopic rectal cancer surgery duration. We retrospectively reviewed the data of patients who underwent laparoscopic low or ultralow anterior resection for…
- Trial name
- NCT06236282
- Testing
- ArtiSential®
- Where
- South Korea
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Locally Advanced Rectal Cancer
Short-course Radiation Followed by mFOLFOX-6 Plus COMPOUND 2055269 for Locally-advanced Rectal Adenocarcinoma
The purpose of this study is to show that the addition of COMPOUND 2055269, an immunotherapeutic drug, to Folfox chemotherapy will improve the pathologic complete response rate in patients with locally advanced rectal cancer.
- Trial name
- NCT03503630
- Testing
- COMPOUND 2055269, Radiation Therapy, mFOLFOX
- Where
- 3 sites in Jordan, Lebanon
- Volunteers
- 44 people
- Sponsor
- Ali Shamseddine
Colorectal Neoplasms, Neoplasm Metastasis
Treatment of Colorectal Liver Metastases With Immunotherapy and Bevacizumab
Liver is the most common site of metastases from colorectal cancer. Neoadjuvant chemotherapy with targeted agents is usually recommended for borderline-resectable liver metastases that are technically difficult to resect for…
- Conditions
- Colorectal Neoplasms, Neoplasm Metastasis, Colonic Neoplasms, Rectal Neoplasms
- Trial name
- CLIMB (NCT03698461)
- Testing
- Atezolizumab, Bevacizumab, Oxaliplatin
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Asan Medical Center
Colorectal Cancer, Cancer
Effectiveness and Implementation of mPATH-CRC
Study Investigators are conducting this study to learn how to best implement a new iPad program in clinical practice.
- Conditions
- Colorectal Cancer, Cancer, Rectum Cancer, Colon Cancer
- Trial name
- NCT03843957
- Testing
- mPATH-CRC, mPATH-Checkin, "high touch" Implementation strategy
- Where
- United States
- Volunteers
- 77,145 people
- Sponsor
- Wake Forest University Health Sciences
Rectal Cancer
Total Neoadjuvant Treatment ±Immunotherapy for High Risk Locally Advanced Rectal Cancer (TNTi)
The goal of this clinical trial is to compare the PCR rate between Total Neoadjuvant Treatment ±Immunotherapy in high risk locally advanced rectal cancer.
- Trial name
- NCT06229041
- Testing
- Camrelizumab ＋Immunotherapy
- Where
- China
- Volunteers
- 472 people
- Sponsor
- Peking University Cancer Hospital & Institute
Rectal Neoplasms
No Stoma VS Ghost Stoma in Patients Undergoing Total Mesorectal Excision for Rectal Cancer
This study aimed at comparing the Comprehensive Complication Index (CCI), readmission rates, postoperative hospitalization days, duration of bearing the stoma (months), hospitalization costs, the number of hospitalizations with…
- Trial name
- NCT06225609
- Testing
- Ghost ileostomy, No ileostomy
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- fan li
Metastatic Colorectal Cancer, Colon Cancer
Study of Labetuzumab Govitecan in Participants With Metastatic Colorectal Cancer
The goal of this clinical study is to determine the dosing and safety of labetuzumab govitecan (formerly known as IMMU-130; hMN-14-SN38, antibody-drug conjugate) in participants with colorectal cancer.
- Conditions
- Metastatic Colorectal Cancer, Colon Cancer, Rectal Cancer
- Trial name
- NCT01605318
- Testing
- Labetuzumab Govitecan (LG)
- Where
- 7 sites in United States
- Volunteers
- 92 people
- Sponsor
- Gilead Sciences
Adult Nasal Type Extranodal NK/T-cell Lymphoma, Anaplastic Large Cell Lymphoma
Ipilimumab and Local Radiation for Selected Solid Tumors
This pilot phase 1-2 trial studies the side effects and best of dose ipilimumab when given together with local radiation therapy and to see how well it works in treating patients with recurrent melanoma, non-Hodgkin lymphoma…
- Conditions
- Adult Nasal Type Extranodal NK/T-cell Lymphoma, Anaplastic Large Cell Lymphoma, Angioimmunoblastic T-cell Lymphoma, Cutaneous B-cell Non-Hodgkin Lymphoma
- Trial name
- NCT01769222
- Testing
- Ipilimumab, Radiation therapy
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Stanford University
Low Anterior Resection Syndrome, Rectal Cancer
The Safety and Efficacy of Transanal Irrigation in Patients With Sleep Disturbance From Low Anterior Resection Syndrome After Rectal Cancer Surgery (TraLARS)
The preservation surgery of the anal sphincter muscle has become the standard procedure in the treatment of rectal cancer and, thanks to advancements in surgical techniques, can now be performed for tumors located closer to the…
- Conditions
- Low Anterior Resection Syndrome, Rectal Cancer, Insomnia, Sleep Disorder
- Trial name
- TraLARS (NCT06222255)
- Testing
- Transanal Irrigation (TAI)
- Where
- South Korea
- Volunteers
- 52 people
- Sponsor
- Seoul National University Hospital
Sphincter Ani Incontinence, Rectal Cancer
Patient Reported Outcomes Following Cancer of the Rectum
The surgical management of rectal cancer includes a Total Mesorectal Excison (TME); depending on the height of the tumor, the problem of preservation of the anal sphincter arises, being able to perform a low anterior resection…
- Trial name
- PROCaRe (NCT04936581)
- Testing
- Open Total Mesorectal Excision, Laparoscopic Total Mesorectal Excision, Robotic Total Mesorectal Excision
- Where
- 2 sites in Spain
- Volunteers
- 200 people
- Sponsor
- University Hospital Gregorio Marañón
Rectal Cancer Stage I
Multicenter Observational Study Taulí-T1 Classification for the Management of pT1 Rectal Adenocarcinoma
BACKGROUND: Rectal cancer is the sixth most common neoplasm in Spain. In the early stages (pT1-N0), the treatment of choice is transanal endoscopic microsurgery.
- Trial name
- TAUTEM-pT1 (NCT06218108)
- Testing
- Taulí-T1 versus conventional classifications
- Where
- Spain
- Volunteers
- 317 people
- Sponsor
- Corporacion Parc Tauli
Colo-rectal Cancer
A Phase II Clinical Study of the Efficacy and Safety of Tislelizumab Combined With Fruquintinib and Chidamide in the Treatment of Unresectable or Advanced Microsatellite Stabilized (MSS/pMMR) Colorectal Cancer With Liver Metastases
To explore the Efficacy and Safety of Tislelizumab combined with fruquintinib and Chidamide in the treatment of unresectable or advanced microsatellite stabilized (MSS/pMMR) colorectal cancer with liver metastases
- Trial name
- NCT06218888
- Testing
- Tislelizumab, Fruquintinib, Chidamide
- Volunteers
- 17 people
- Sponsor
- Fujian Cancer Hospital
Rectal Cancer
Quality of Life and Psychosocial Status of Young-onset Patients With Rectal Cancer
Colorectal cancer is one of the leading cancers worldwide. Although the majority of CRC cases are typically diagnosed in individuals older than 50 years of age, recent international studies have highlighted the importance of…
- Trial name
- NCT06216834
- Testing
- No intervention
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Shandong Provincial Hospital
Cancer, Digestive System, Cancer, Rectum
PREHAB - Improving Condition Before Surgery
The pilot research project is focused on the feasibility of a prehabilitation program for two groups of diagnoses (esophageal and stomach cancer, rectal cancer).
- Trial name
- NCT05646043
- Testing
- Physical training, Muscle strength training
- Where
- Czechia
- Volunteers
- 40 people
- Sponsor
- University Hospital Ostrava
Prostate Carcinoma, Rectum Carcinoma
Effect of Irradiation Doses < 10 Gy and of Irradiated Bone Volume on the Variation of Blood Elements of the Complete Blood Count During and After Pelvic Irradiation
Bone marrow is one of the organs at risk of complications during irradiation due to its radiosensitivity. Hematopoietic toxicity remains one of the main toxicities during irradiation of pelvic lymph node areas, especially when…
- Conditions
- Prostate Carcinoma, Rectum Carcinoma, Anal Canal Carcinoma, Endometrium Carcinoma
- Trial name
- MIFADORESOL (NCT04626466)
- Testing
- Biological investigations
- Where
- 3 sites in France
- Volunteers
- 100 people
- Sponsor
- Institut de cancérologie Strasbourg Europe