Clinical trials: Rds
Acute Respiratory Distress Syndrome, Coronavirus Infection
Vadadustat for the Prevention and Treatment of Acute Respiratory Distress Syndrome (ARDS) in Hospitalized Patients With Coronavirus Disease 2019 (COVID-19)
The purpose of this study is to evaluate the efficacy of vadadustat for the prevention and treatment of acute respiratory distress syndrome (ARDS) in hospitalized patients with Coronavirus Disease 2019 (COVID-19).
- Trial name
- NCT04478071
- Testing
- vadadustat
- Where
- United States
- Volunteers
- 448 people
- Sponsor
- The University of Texas Health Science Center, Houston
Respiratory Distress Syndrome, Intraventricular Haemorrhage
Antenatal Rescue Course of Glucocorticoids in Threatened Premature Birth
Administration of steroid to the mother in imminent preterm delivery is a known effective practice to decrease the risk of respiratory distress syndrome and intraventricular haemorrhage in preterm infants if given with a week of…
- Trial name
- NCT00295464
- Testing
- Betamethasone sodium phos (drug)
- Where
- 10 sites in Finland
- Volunteers
- 440 people
- Sponsor
- University of Oulu
Acute Respiratory Distress Syndrome
Echocardiography Predictive of the Inefficacy and/or of the Unsafeness of Recruitment Maneuvers in Patients With Acute Respiratory Distress Syndrome.
The purpose of the study RVSTAR is to evaluate whether echocardiographic criteria exploring the right ventricle can predict the inefficacy and/or the unsafeness of recruitment maneuvers in patients suffering from acute…
- Trial name
- RV STAR (NCT01768949)
- Testing
- Echocardiography
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Hyalinosis, Hyaline Membrane Disease
Biomarker for Hyaline Fibromatosis Syndrome (BioHFS)
Development of a new MS-based biomarker for the early and sensitive diagnosis of Hyaline fibromatosis syndrome from the blood
- Conditions
- Hyalinosis, Hyaline Membrane Disease, Juvenile Hyaline Fibromatosis, Fibromatosis Hyalinica Multiplex Juvenilis
- Trial name
- BioHFS (NCT03196115)
- Where
- 3 sites in Germany, India and 1 more
- Sponsor
- CENTOGENE GmbH Rostock
COVID-19 Acute Respiratory Distress Syndrome, Cardiovascular Diseases
Comparison of Prone Position and Standard Electrocardiogram in COVID-19 Patients
Prolonged prone position ventilation reduces the 30-day mortality in acute respiratory distress syndrome (ARDS) and in COVID-19 infection.
- Conditions
- COVID-19 Acute Respiratory Distress Syndrome, Cardiovascular Diseases, Arrhythmias, Cardiac
- Trial name
- NCT05047835
- Testing
- electrocardiogram
- Where
- Thailand
- Volunteers
- 60 people
- Sponsor
- Khon Kaen University
Respiratory Distress Syndrome, Newborn
High Flow Nasal Cannula Versus Nasal Continuous Positive Airway Pressure for Respiratory Support of Preterm Neonates
This work is designed to: 1. Evaluate the efficacy of HHHFNC in comparison with nCPAP in preterm neonates. 2. Investigate hemodynamic changes associated with HHHFNC in comparison to nCPAP in preterm neonates during periods of…
- Trial name
- NCT04238273
- Testing
- Functional Echocardiography
- Where
- Egypt
- Volunteers
- 123 people
- Sponsor
- Ain Shams University
Respiratory Distress Syndrome
Fetal Lung Volume and Pulmonary Artery Resistance Index Measurement in Term Diabetic Pregnancy
The aim of this study is to determine cut-off values for fetal lung volume by VOCAL and pulmonary artery resistance index by pulsed Doppler in fetuses of diabetic mothers, and correlate the results with postnatal respiratory…
- Trial name
- NCT02586922
- Testing
- Three-dimensional (3D) ultrasonography
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
ARDS, Critical Illness
Implementation of Nudges to Promote Utilization of Low Tidal Volume Ventilation (INPUT) Study
This study is a large pragmatic stepped-wedge trial of electronic health record (EHR)-based implementation strategies informed by behavioral economic principles to increase lung-protective ventilation (LPV) utilization among all…
- Conditions
- ARDS, Critical Illness, Acute Respiratory Distress Syndrome, Acute Respiratory Failure
- Trial name
- INPUT (NCT04663802)
- Testing
- Default order set, Physician-targeted accountable justification, Respiratory therapist (RT)-targeted accountable justification
- Where
- 5 sites in United States
- Volunteers
- 7,342 people
- Sponsor
- University of Pennsylvania
ARDS
Enteral Nutrition Delivery in Prone Position Ventilated Patients With Moderate to Severe ARDS
This pilot study is aimed to compare and assess the impact, safety, and practical utility of gastric versus postpyloric feeding in moderate to severe ARDS patients with prone position ventilation.
- Trial name
- NCT07362537
- Testing
- enteral nutrition through nasojejunal tube, enteral nutrition through nasogastric tube
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Southeast University, China
Acute Respiratory Distress Syndrome, Corona Virus Infection
Knowledge, Attitude and Practice of Dental Students About COVID-19
Coronavirus disease 2019 (abbreviated "COVID- 19") is a pandemic respiratory disease that is caused by a novel coronavirus and was first detected in December 2019 in Wuhan, China.
- Conditions
- Acute Respiratory Distress Syndrome, Corona Virus Infection, Acute Lung Injury, Fever
- Trial name
- NCT04449081
- Testing
- Knowledge, Attitude, Practice, Awareness, Preference
- Where
- Malaysia
- Volunteers
- 215 people, healthy volunteers welcome
- Sponsor
- Melaka Manipal Medical College
Covid19, COVID-19 Pneumonia
A Retrospective Study of COVID-19 Treatments
Surveys administered to subjects who have recovered from COVID-19 to assess how effective their treatment was.
- Conditions
- Covid19, COVID-19 Pneumonia, COVID-19 Respiratory Infection, COVID-19 Acute Bronchitis
- Trial name
- NCT04949230
- Testing
- No Intervention Used
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- ProgenaBiome
Respiratory Distress Syndrome in Premature Infant
Ventilator Weaning Outcome Between NIV-NAVA and Nasal CPAP (or IMV ) Modes in Premature Neonates
Premature neonates are prone to respiratory distress and need ventilator support because of the rapid breathing and large variations in respiratory patterns.
- Trial name
- NCT04118400
- Testing
- NIV-NAVA, Nasal CPAP or NIMV mode
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Taipei Medical University Hospital
Moderate to Severe Acute Respiratory Distress Syndrome Associated With COVID-19
Intermediate-size Expanded Access Program (EAP), Mesenchymal Stromal Cells (MSC) for Acute Respiratory Distress Syndrome (ARDS) Due to COVID-19 Infection
The objectives of this intermediate-size expanded access protocol are to assess the safety and efficacy of remestemcel-L in participants with ARDS due to coronavirus infection 2019 (COVID-19).
- Trial name
- NCT04366830
- Testing
- Remestemcel-L
- Where
- United States
- Sponsor
- Mesoblast International Sàrl
Respiratory Distress Syndrome, Newborn, Pulmonary Surfactants
Echography-guided Surfactant THERapy (ESTHER) For Preterm Infants With Respiratory Failure
Point-of-care ultrasound (POCUS) is the use of ultrasound by the bedside provider in real time to answer a specific question and guide medical management.
- Conditions
- Respiratory Distress Syndrome, Newborn, Pulmonary Surfactants, Intensive Care Units, Neonatal
- Trial name
- NCT06446453
- Testing
- Echography-guided Surfactant THERapy (ESTHER)
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Connecticut Children's Medical Center
Blood And Marrow Transplantation, Adult Respiratory Distress Syndrome
Mesenchymal Stem Cells (MSCs) for Treatment of Acute Respiratory Distress Syndrome (ARD) in Patients With Malignancies
The goal of this clinical research study is to learn about the safety of giving mesenchymal stem cells (MSCs) to patients who have ARDS.
- Trial name
- NCT02804945
- Testing
- Mesenchymal Stem Cells (MSCs)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- M.D. Anderson Cancer Center
Ventilator-Associated Pneumonia, Acute Respiratory Distress Syndrome
Clinical and Biological Markers in Acute Respiratory Failure
In a recent experimental study, the investigators showed that the growth factor Activin A is expressed in the lungs of rats with the acute respiratory distress syndrome (ARDS) at levels that are comparable with those determined…
- Trial name
- NCT02019095
- Testing
- Bronchoscopy for the sampling of bronchoalveolar lavage (BAL) fluid
- Where
- 2 sites in Greece
- Volunteers
- 55 people
- Sponsor
- University of Athens
Acute Respiratory Distress Syndrome, Hypercapnia
Correction by ECCO2-R of Hypercapnia in Patients With DVP in Moderate to Severe ARDS Under Protective Ventilation.
Pulmonary vascular dysfunction (DVP) is associated with a pejorative prognosis during ARDS. There is no specific therapeutic intervention to thwart it.
- Trial name
- COVAP (NCT03303807)
- Testing
- Extracorporeal CO2 removal (ECCO2-R) (PrismaLung®, Prismaflex ® Baxter)
- Where
- France
- Volunteers
- 8 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Respiratory Distress Syndrome in Premature Infant
The NONA-LISA Trial
The NONA-LISA trial will be an investigator-initiated, multicentre, pragmatic, parallel-group, blinded RCT conducted at four university hospitals across Denmark.
- Trial name
- NONA-LISA (NCT05609877)
- Testing
- Isotonic saline, Less Invasive Surfactant Administration (LISA), Fentanyl
- Where
- 4 sites in Denmark
- Volunteers
- 324 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
COVID-19, Acute Respiratory Distress Syndrome Due to COVID-19
Post-intensive Care Syndromes in Pregnant Patients With Respiratory Failure and COVID-19 Compared to Non-pregnant Patients With Respiratory Failure and COVID-19
The aim of this study is to characterize patients in the Post-Intensive-Care-Syndrome (PICS) outpatient clinic based on routine data and to evaluate their treatment outcome over the course of their treatment.
- Conditions
- COVID-19, Acute Respiratory Distress Syndrome Due to COVID-19, Pregnancy Related
- Trial name
- NCT07051967
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Charite University, Berlin, Germany
Persistent Pulmonary Hypertension, Respiratory Distress Syndrome
Treatment of Elevated Arterial Pulmonary Pressure With Inhaled Iloprost
The purpose of this study is to determine if iloprost is effective in the treatment of elevated arterial pulmonary pressure in children with ventilator treated respiratory distress syndrome.
- Trial name
- NCT00216931
- Testing
- iloprost
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Lund University Hospital