Clinical trials: Rapid Sequence Induction
Pediatric Surgery, Rapid Sequence Induction
High-flow Nasal Cannula Oxygenation During Rapid Sequence Induction in Children
This randomised study aims to compare the utilization of high-flow humidified nasal oxygenation (HFNO) with standard care, using apnoeic facemask oxygenation, during rapid sequence induction (RSI) of anesthesia in young children.
- Trial name
- OPTINECK (NCT05063084)
- Testing
- Optiflow - HFNO, Classic
- Where
- France
- Volunteers
- 44 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Rapid Sequence Induction
Rapid Sequence Induction: Succinyl Choline vs Rocuronium After Pretreatment With Dexmedetomidine
Background: Rapid sequence induction is a well-established anesthetic procedure used in trauma setting and patients with full stomach.
- Trial name
- NCT04709315
- Testing
- dexemedetomidine and rocuronium, 0.9% saline and succinyl choline 1mg/ kg
- Where
- Egypt
- Volunteers
- 240 people
- Sponsor
- South Valley University
Anesthesia, Hypoxia
Preoxygenation With High-flow Nasal Oxygen in Adult Trauma Patients During Rapid Sequence Induction Anaesthesia
Previous studies investigating apnoea oxygenation has shown that delivering oxygen via a high flow can maintain adequate oxygen saturation levels in a patient for over 30 minutes.
- Conditions
- Anesthesia, Hypoxia, Trauma, Rapid Sequence Induction
- Trial name
- PRIOR-Trauma (NCT04926337)
- Testing
- Tight Fitting Facemask, High Flow Nasal Oxygen (HFNO)
- Where
- Sweden
- Volunteers
- 104 people
- Sponsor
- Karolinska University Hospital
Rapid Sequence Induction
Impact of Opioids on Heart Rate During Rapid Sequence Intubation
The patient is seen upstream by an anaesthetists resuscitator (MAR) in order to carry out his anesthesia consultation. If the patient meets the eligibility criteria he will be informed of the study and his signed consent will be…
- Trial name
- CANDY-CRASH (NCT05384665)
- Testing
- Remifentanil, Sufentanil
- Where
- France
- Volunteers
- 3 people
- Sponsor
- Centre Hospitalier Sud Francilien
Hemodynamic Instability, Fluid Therapy
Hemodynamic Stability During Induction of Anaesthesia
The study aim is to investigate if preoperative volume bolus based on lean body weight could preserve mean arterial pressure during target controlled infusion of anaesthesia (TCI) or rapid sequence induction of anaesthesia (RSI)…
- Conditions
- Hemodynamic Instability, Fluid Therapy, Anesthesia; Adverse Effect
- Trial name
- NCT03394833
- Testing
- gelofusine
- Where
- Sweden
- Volunteers
- 80 people
- Sponsor
- Umeå University
Hemodynamic Response
Use of Lidocaine in Rapid Sequence Induction
Lidocaine has been shown to blunt the cardiovascular response to endotracheal intubation. The incidence of hypertension, tachycardia and dysrhythmias due to laryngoscopy may be increased in patients that receive rapid sequence…
- Trial name
- NCT01238718
- Testing
- Lidocaine
- Where
- Greece
- Volunteers
- 76 people
- Sponsor
- University of Athens
Rapid Sequence Induction (RSI), Full Stomach
Which Rapid Sequence Induction Technique Should be Used in Urgent Surgery in Children?
The goal of our study is to compare classical Rapid Sequence Induction (RSI) and modified Rapid Sequence Induction (mRSI) in pediatric patients with a full stomach undergoing urgent surgical procedures.
- Conditions
- Rapid Sequence Induction (RSI), Full Stomach, Pediatric
- Trial name
- NCT07428434
- Testing
- Classical Rapid Sequence Induction, Modified Rapid Sequence Induction
- Where
- Tunisia
- Volunteers
- 100 people
- Sponsor
- Tunis University
Septic Shock
Ketamine Versus Fentanyl for Induction of Anesthesia in Septic Shock
The aim of this work is to compare two protocols (ketamine-midazolam versus fentanyl-midazolam) for induction of anesthesia in patients with septic shock aiming to find the most safe protocol with regards to hemodynamic status of…
- Trial name
- NCT03251170
- Testing
- Ketamine, Fentanyl, Midazolam
- Where
- Egypt
- Volunteers
- 42 people
- Sponsor
- Cairo University
Septic Shock
Ketamine Versus Low Dose Thiopental for Induction of Anesthesia in Septic Shock
The aim of this work is to compare two protocols (ketamine-fentanyl-midazolam versus thiopental-fentanyl-midazolam) for induction of anesthesia in patients with septic shock aiming to find the most safe protocol with regards to…
- Trial name
- NCT03104140
- Testing
- Ketamine, Thiopental
- Where
- Egypt
- Volunteers
- 26 people
- Sponsor
- Cairo University
Hypotension, Induction of Anesthesia
Two Ratios of Propofol-ketamine Admixture for Rapid-sequence Induction Anesthesia for Emergency Laparotomy
Hypotension during anesthesia is associated with serious organ failure and death. The most critical period for intraoperative hypotension is the postinduction period during which, one-third of intraoperative hypotension occurs.
- Trial name
- NCT05166330
- Testing
- Ketofol equal ratio, Ketofol 1:3 ratio
- Where
- Egypt
- Volunteers
- 74 people
- Sponsor
- Kasr El Aini Hospital
Trauma, Rapid Sequence Intubation
Prospective Study of Induction Medications Used in the Trauma RSI
To compare the outcomes of the use of propofol, etomidate, and ketamine as induction agents for adult trauma patients undergoing intubation within 24 hours of admission.
- Trial name
- ProTIM (NCT04291521)
- Testing
- Ketamine, Etomidate, Propofol
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Southern California
High Flow Oxygen in Rapid Sequence Induction, Airway Morbidity
High Flow Oxygen With THRIVE Gives Better Oxygenation in Rapid Sequence Induction Patients
High flow oxygen results in better oxygenation in emergency cases needing rapid sequence induction for anaesthesia. Secondary outcome measure is time for any desaturation.
- Trial name
- THRIVE/RSI 1 (NCT02777840)
- Testing
- face mask oxygen, High flow oxygen
- Where
- United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- St George's, University of London
Non-fasting Patients, Rapid Sequence Intubation
Preoperative Presence of Gastric Content in Non-fasting Patients - an Ultrasound Study
Using bedside ultrasound, the investigators will examine gastric content in non-fasting patients assigned to rapid sequence intubation (RSI). The procedure will be done immediately before intubation.
- Conditions
- Non-fasting Patients, Rapid Sequence Intubation, Anesthesia Intubation Complication
- Trial name
- NCT03685435
- Testing
- Bedside ultrasound
- Where
- Norway
- Volunteers
- 72 people
- Sponsor
- University Hospital, Akershus
Anesthesia, Oxygen
PreOxygenation In RSI Anesthesia
Pre-oxygenation with high-flow nasal cannula oxygen has been evaluated in a limited number of studies and seems to be better than traditional preoxygenation with a tight fitting mask.
- Trial name
- PRIOR (NCT02794532)
- Testing
- High-flow nasal cannula
- Volunteers
- 80 people
- Sponsor
- Karolinska University Hospital
General Surgery
Evaluation of Apnea Tolerance in Bariatric Patients Following Rapid-sequence Induction of Anesthesia
The purpose of this study is to compare the effect of the 25° head-up position versus the 55° head-up position on tolerable apneic time (TAT) in bariatric patients scheduled for laparoscopic adjustable gastric band surgery…
- Trial name
- NCT03056807
- Testing
- 25° head-up position, 55° head-up position
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- University of Kansas Medical Center
Anesthesia, Neuromuscular Blockade
The Effect of Propofol and Remifentanil Sequence on ED50 and ED95 of Rocuronium in Rapid Sequence Induction Anesthesia
Rapid sequence induction (RSI) is a well-known procedure to maintain a safe and rapid airway in patients especially at risk of aspiration. Propofol and rocuronium are generally used agents for RSI.
- Trial name
- NCT02709473
- Testing
- Propofol, Remifentanil, Rocuronium
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 84 people
- Sponsor
- Ankara University
Rapid Sequence Induction and Intubation
Intubation Conditions After RSI Using Rocuronium with Ephedrine Pretreatment
This trial will study if ephedrine pretreatment before low doses of rocuronium (0.6 or 0.8 mg/kg) would provide similar intubating conditions as with the high dose of 1.2 mg/kg in patients undergoing RSII.
- Trial name
- NCT05725031
- Testing
- Ephedrine, Rocuronium 0.6, Rocuronium 0.8
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Ain Shams University
Respiratory Failure, Hypotension and Shock
Using Vasopressor Medication to Support Blood Pressure During Intubation Procedure
The purpose of this study is to investigate whether protocolized vasopressor use for patients with normal blood pressure undergoing rapid sequence intubation improves hemodynamic parameters and mitigates adverse events.
- Conditions
- Respiratory Failure, Hypotension and Shock, Hypotension on Induction, Intubation Complication
- Trial name
- RAPID PRESS (NCT05355974)
- Testing
- Norepinephrine, Lactated Ringers, Intravenous, normal saline
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Wright State University