Clinical trials: Randomized Controlled Trial (RCT)
Lung, Lung Adenocarcinoma
Reinforced and Non-Reinforced Staple Lines in Fissureless Lobectomy
Prolonged Air Leak (PAL) is a common and serious problem after lung surgery. It can lead to worse patient outcomes, longer hospital stays, and higher costs.
- Conditions
- Lung, Lung Adenocarcinoma, Lung Adenosquamous Carcinoma, Lung Cancer, Non-Small Cell
- Trial name
- NCT06602661
- Testing
- Fissureless Lobectomy with Reinforced Staple Lines, Fissureless Lobectomy with Non-Reinforced Staple Lines
- Where
- Canada
- Volunteers
- 65 people
- Sponsor
- Surrey Thoracic Surgery Group
ACL Injury
Immediate Versus Optional Delayed Surgical Repair for Treatment of Acute ACL Injuries
Currently, most patients with an anterior cruciate ligament injury undergo surgery. There is a general belief that surgical reconstruction is necessary to safely return to sports and to prevent early knee osteoarthritis or…
- Trial name
- IODA (NCT05747079)
- Testing
- Rehabilitation, Optional delayed anterior cruciate ligament reconstruction, Immediate anterior cruciate ligament reconstruction
- Where
- Belgium
- Volunteers
- 280 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Stroke; Sequelae
Postural Decoding for Post-Stroke Shoulder Pain: A RCT.
Brief Summary Purpose of the Study: This clinical trial aims to determine whether Postural Decryption Technique can effectively treat hemiplegic shoulder pain (HSP) in patients recovering from stroke.
- Trial name
- NCT06763796
- Testing
- Postural Decryption Technique, Traditional Chinese Medicine (TCM) Massage Therapy
- Where
- China
- Volunteers
- 48 people
- Sponsor
- Shenzhen Baoan District Fuyong People's Hospital
Metabolic Syndrome, Obesity
An Exercise RCT Targeting African-American Women With Metabolic Syndrome and High Risk for Breast Cancer
Among African-American women, in whom metabolic syndrome (MetS) is very prevalent and breast cancer mortality rates are high, it is hypothesized that intervening on MetS to improve the MetS profile may prove to be a means to…
- Trial name
- NCT02103140
- Testing
- Facility-based Exercise, Home-based Exercise
- Where
- United States
- Volunteers
- 213 people, healthy volunteers welcome
- Sponsor
- Georgetown University
Molluscum Contagiosum
MC RCT - BPO vs Adapalene
Non-blinded randomized controlled trial comparing efficacy of topical benzoyl peroxide 10% (vehicle choice per patient preference: e.g.
- Trial name
- NCT05536882
- Testing
- Benzoyl peroxide, Adapalene Gel
- Where
- United States
- Sponsor
- University of Oklahoma
Neck Pain
Neck Movement Training in a Virtual Reality Headset for People with Neck Pain - a Feasibility Study
The goal of this clinical trial is to learn if a virtual reality (VR) intervention for people with chronic neck pain is feasible.
- Trial name
- NCT06832748
- Testing
- VR neck training, Endurance neck training
- Volunteers
- 20 people
- Sponsor
- Luleå Tekniska Universitet
Community Acquired Pneumonia, Childhood Pneumonia
3 vs. 5 Days of Amoxicillin for Childhood Pneumonia: An RCT
Pneumonia is the most common infection in children and leading to most common cause of mortality and morbidity in in children globally. Bacterial cause is mostly streptococcus pneumonia in children of 3 months to 5 years of age.
- Trial name
- Pnemonia (NCT07647835)
- Testing
- Amoxicillin
- Where
- Pakistan
- Volunteers
- 250 people
- Sponsor
- Khyber Teaching Hospital
COPD Exacerbation
Health Literacy Activation RCT Among the COPD Patients and Designated Support Dyad
This study investigates whether increasing health literacy among COPD patients and their designated health coach during a hospital admission caused by symptoms exacerbation will lead to better health outcomes including increased…
- Trial name
- NCT03721315
- Testing
- Intervention
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Albert Einstein Healthcare Network
General Population (no Specific Condition or Disease)
Effect of Storytelling on Questionnaire Completion and Quality of Collected Data in an E-Cohort
This study is a randomized controlled trial, nested in the SKETHIS e-cohort, aiming to evaluate whether adding a modest, narrative-driven, strorytelling introduction to a Patient-Reported Outcome questionnaire increases…
- Trial name
- PEGASYS (NCT07475338)
- Testing
- Storytelling questionnaire
- Where
- France
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- SKEZI
Stress, Anxiety
A Brief Online Mindfulness Intervention: An RCT Protocol
University students often experience emotional distress that originates from inside or outside academia, and for which treatment would be welcome.
- Conditions
- Stress, Anxiety, Depression
- Trial name
- NCT05882565
- Testing
- A brief (14-day) online mindfulness intervention, Psychoeducation online
- Where
- Indonesia
- Volunteers
- 426 people, healthy volunteers welcome
- Sponsor
- Ka Yan
Multiple Myeloma
Anakinra: Efficacy in the Management of Fever During Neutropenia and Mucositis in ASCT - A Randomized Controlled Trial
Oral and intestinal mucositis are major risk factors for the occurrence of fever during neutropenia and bloodstream infections after intensive chemo- and radiotherapy.
- Trial name
- AFFECT-2 (NCT04099901)
- Testing
- Anakinra
- Where
- 3 sites in Netherlands
- Volunteers
- 88 people
- Sponsor
- Radboud University Medical Center
Tricuspid Valve Regurgitation, Tricuspid Valve Disease
VDyne Transcatheter Tricuspid Valve Replacement Study to Evaluate Safety and Clinical Efficacy in Patients With Symptomatic Severe Tricuspid Valve Regurgitation (TRIVITA Pivotal Trial)
Pivotal trial to evaluate the safety and clinical efficacy of the VDyne System for the treatment of symptomatic severe or greater tricuspid regurgitation.
- Conditions
- Tricuspid Valve Regurgitation, Tricuspid Valve Disease, Cardiovascular Diseases (CVD), Heart Valve Diseases
- Trial name
- TRIVITA (NCT07516444)
- Testing
- Transcatheter Tricuspid Valve Replacement (TTVR) with VDyne System, Transcatheter Tricuspid Valve Replacement (TTVR) with Edwards EVOQUE System
- Where
- United States
- Volunteers
- 730 people
- Sponsor
- VDyne, Inc.
Respiratory Distress Syndrome, Adult, Acute Lung Injury
Perfluorocarbon (PFC) Inhalation Treatment of Acute Lung Injury/Acute Respiratory Distress Syndrome
PFCs (perfluorocarbons, PFC), an ideal liquid respiratory media, has special chemical and biological properties, including high solubility of gas, swiftness of carrying and release, low surface tension, high proportion, almost…
- Trial name
- NCT01391481
- Testing
- Perfluorocarbon, Sterile Water for Injection
- Where
- 2 sites in China
- Volunteers
- 200 people
- Sponsor
- Chinese PLA General Hospital
Bloodstream Infections
RCT Meropenem vs Piperacillin-Tazobactam for Definitive Treatment of BSI's Due to Ceftriaxone Non-susceptible Escherichia Coli and Klebsiella Spp.
No randomized controlled trials (RCTs) have yet been performed comparing different treatment options for AmpC or ESBL-producing Enterobacteriaceae.
- Trial name
- MERINO (NCT02176122)
- Testing
- Meropenem, Piperacillin-tazobactam combination product
- Where
- 31 sites in Australia, Canada and 7 more
- Volunteers
- 391 people
- Sponsor
- The University of Queensland
Pancreatic Insulinoma
EUS-RFA Versus Surgery for Pancreatic Insulinoma (ERASIN-RCT)
The goal of this muticentre randomized controlled trial is to compare endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) with surgery for treatment of pancreatic insulinoma.
- Trial name
- ERASIN-RCT (NCT05735912)
- Testing
- Endoscopic ultrasound-guided radio frequency ablation, Surgery
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Total Knee Arthroplasty
Persona MC vs PS RCT With ROSA
A randomized, controlled study comparing two total knee implant devices, Persona medial congruent (MC) vs posterior stabilized (PS). These surgeries will be performed using the ROSA robotic system.
- Trial name
- NCT05391828
- Testing
- Zimmer-Biomet Persona Medial Congruent (MC) Bearing Design, Zimmer-Biomet Persona Posterior-Stabilized (PS) Bearing Design
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- NYU Langone Health
Helicobacter Pylori Infection
A RCT of Triple Therapy With Proton Pump Inhibitor vs Vonoprazan for Helicobacter Pylori Gastritis
Helicobacter pylori (H. pylori) gastritis is a common bacterial infection among the elderly population. H. pylori infection causes chronic progressive gastric inflammation, peptic ulcer disease and gastric cancer.
- Trial name
- TRIVON (NCT03908619)
- Testing
- Omeprazole 20mg, Esomeprazole 20mg, Rabeprazole Sodium 20mg
- Where
- Singapore
- Volunteers
- 252 people
- Sponsor
- Changi General Hospital
Pain, Acute, Pain, Procedural
RCT of Pain Perception With Fast and Slow Tenaculum Application
This project will be a randomized controlled trial (RCT) measuring pain perception with two different tenaculum placement techniques on the uterine cervix.
- Trial name
- NCT05458037
- Testing
- Speed of tenaculum application
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Women and Infants Hospital of Rhode Island
Withdrawal Syndrome
Protocolized Sedative Weaning VS. Usual Care in Pediatric Critically Ill, RCT
Sedative and analgesic agents are widely used in the ICU. These agents can provide hypnotic effect, pain alleviation, cooperation, and synchronizing ventilatory support.
- Trial name
- NCT03018977
- Testing
- The sedative weaning protocol group, The usual group
- Where
- Thailand
- Volunteers
- 60 people
- Sponsor
- Ramathibodi Hospital
Perineal Trauma, Ritgen Maneuver
Ritgen Maneuver and Birth-Related Perineal Trauma: RCT
Perineal trauma is one of the common complications that may occur during the second stage of labor and can negatively affect women's postpartum recovery and quality of life.
- Trial name
- NCT07713173
- Testing
- Ritgen maneuver, Routine Care Group
- Where
- Turkey (Türkiye)
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Medipol University